This article, grounded in the Triple Helix theory framework, systematically examines the significant challenges encountered by students at Qiqihar University in Heilongjiang Province during their employment and entrepreneurial endeavors, and offers appropriate solutions. The Triple Helix theory underscores the crucial interactive relationships between universities, industries, and government agencies, which are vital for promoting knowledge innovation and technological transformation. Through literature reviews and surveys, this article uncovers the various difficulties faced by students in employment and entrepreneurship, such as low entrepreneurial motivation, a disconnect between entrepreneurial and professional education, the ineffective functionality of entrepreneurial education practice bases, and a lack of external social support. To address these issues, it proposes strategies including enhancing innovative entrepreneurship course development, optimizing the entrepreneurship environment, strengthening service platform construction, and implementing fiscal and tax support policies. The article argues that through close collaboration among governments, universities, and businesses, significant breakthroughs can be achieved in alleviating the challenges faced by students in employment and entrepreneurship, thereby fostering healthy socio-economic development and providing valuable theoretical and practical insights for higher education institutions tackling similar issues.