Context. The study analyses how cultural values on the entrepreneurial intentions of university students in public and private institutions in Jalisco, Mexico, may lead a path to social innovation, based on the Theory of Planned Behavior. Problem. Despite the growing emphasis on entrepreneurship education, the impact of cultural values on students' entrepreneurial intentions remains unclear. This research explores how autonomy, hierarchy, and egalitarianism shape students' aspirations. Purpose. The research seeks to examine the multidisciplinary nature of cultural values and their relationship with entrepreneurial intentions. It specifically addresses SDGs 4, 8 and 9. Methodology. A quantitative survey was distributed to 1,438 university students in Jalisco, Mexico, during 2023-2024. The data were examined through exploratory factor analysis and linear regression to identify the relationships between cultural values and entrepreneurial intentions. Reliability was assessed using Cronbach's alpha, while validity was established through factor loadings. Theoretical and Practical Findings. Cultural values like integration and mastery positively influence entrepreneurial intentions, while egalitarianism showed a negative impact. These results contribute to the understanding of how cultural contexts shape entrepreneurial behavior, with practical implications for fostering entrepreneurship in educational settings, aligned with the SDGs; leading students´ behavior to a social innovation path. Originality based on a multidisciplinary approach that promotes innovation for sustainable development. This research integrates multidisciplinary perspectives to promote social innovation and sustainable development, highlighting the unique role of cultural values in shaping entrepreneurial intentions. Conclusions and limitations. The study concludes that while cultural values significantly impact entrepreneurial intentions, though the influence varies by dimension. However, as the research focuses on a single region, future studies should explore other cultural contexts to generalize findings.