Nerve Compression Research Articles

EFFECTS OF DEEP TRANSVERSE FRICTION MASSAGE ALONG WITH NERVE GLIDING EXERCISES IN THE MANAGEMENT OF CARPAL TUNNEL SYNDROME PATIENTS

Background: Carpal Tunnel Syndrome (CTS) is a prevalent condition characterized by discomfort, pain, and functional impairment due to median nerve compression. Conservative treatment approaches aim to manage symptoms and improve functionality. Among these, manual therapies such as Deep Transverse Friction Massage (DTFM) and Nerve Gliding Exercises (NGEs) have shown promise in addressing both neural and mechanical dysfunctions. This study evaluates the combined effects of DTFM and NGEs in alleviating CTS symptoms and enhancing functional outcomes. Objective: To investigate the effects of Deep Transverse Friction Massage combined with Nerve Gliding Exercises in the management of Carpal Tunnel Syndrome. Methods: This randomized clinical trial employed a non-probability purposive sampling technique to recruit 56 participants aged 20–40 years with CTS, confirmed by positive Phalen’s, Tinel’s, and Duncan’s tests, and moderate pain levels (VAS 4–7). Patients were randomly assigned to Group A (DTFM + NGEs) or Group B (NGEs alone). The intervention spanned four weeks, with two sessions per week. Outcome measures included pain (Visual Analog Scale), wrist range of motion (goniometer), grip strength (handheld dynamometer), and functional disability (Boston Scale). Statistical analyses were conducted using SPSS version 20, employing the Friedman test for intragroup analysis and the Mann-Whitney U test for intergroup comparisons. Results: Group A showed significant improvements across all variables compared to Group B. Pain reduction demonstrated a highly significant difference (p < 0.000) post-intervention, with improved wrist flexion (p = 0.05) and extension (p = 0.056). Grip strength increased significantly (p < 0.000), and functional disability scores were notably better in Group A (p < 0.000). The findings indicate the superior efficacy of the combined intervention over nerve gliding exercises alone. Conclusion: The combination of Deep Transverse Friction Massage and Nerve Gliding Exercises proved significantly more effective than NGEs alone in managing pain, improving wrist mobility, enhancing grip strength, and reducing functional disability in patients with Carpal Tunnel Syndrome.

High-resolution Ultrasound of Peripheral Nerve Disorders.

Peripheral nerve disorders refer to any condition that damages the peripheral nervous system with variable presentations and numerous causes. The diagnosis is usually suspected clinically and then confirmed using electrophysiology. Yet electrodiagnostic studies lack precise anatomical delineation and often cannot determine the underlying cause of the peripheral neuropathy. However, thanks to recent technological advances, high-resolution ultrasound (HRUS) and magnetic resonance (MR) imaging have emerged as exceptional modalities to identify the exact site of pathology and demonstrate the underlying etiology. These developments have led to a multimodality approach to peripheral nerve disorders. Imaging provides anatomical and morphological information while functional evaluation remains derived from electrodiagnostic study. This article reviews the HRUS features of common as well as less frequent peripheral nerve disorders: entrapment neuropathies, traumatic injuries, neuralgic amyotrophy, polyneuropathies, and nerve tumors.

Successful recovery of anterior interosseous nerve palsy caused by blunt trauma at the forearm level: a case report

Anterior interosseous nerve syndrome (AINS) is typically characterized by dysfunction of the pure motor branch of the median nerve, primarily affecting the flexor pollicis longus and the flexor digitorum profundus (FDP) of the index finger, and occasionally involving the FDP of the middle finger and the pronator quadratus. Although various etiologies such as compressive neuropathy and isolated neuritis have been proposed, the most recent review describes AINS as a form of neuralgic amyotrophy. Its treatment remains a matter of debate; the most frequently discussed approach is conservative treatment followed by surgical intervention above the medial epicondyle level if recovery is not achieved. In the case described herein, a hematoma resulting from blunt trauma at the forearm level compressed the anterior interosseous nerve (AIN), with clinical features and diagnostic findings very similar to those of typical AINS. Early surgical removal of the hematoma led to complete recovery without complications. Despite the current understanding of AINS pathophysiology and treatment, this case emphasizes the need to consider the possibility of AIN palsy due to forearm lesions. We report on the clinical course and successful treatment of this case to highlight this important consideration.

Multiparametric Ultrasound Assessment of Carpal Tunnel Syndrome: Beyond Nerve Cross-sectional Area.

Carpal tunnel syndrome (CTS), the most common mononeuropathy, results from compression of the median nerve within the fibro-osseous carpal tunnel. Diagnosis is typically based on clinical evaluation and confirmed by nerve conduction studies. However, ultrasound (US) has emerged as a valuable noninvasive adjunct for CTS confirmation, offering potential advantages over electrodiagnostic testing in terms of patient comfort and diagnostic accuracy. This review begins with a concise summary of carpal tunnel anatomy and CTS pathophysiology as a foundation for exploring the diverse applications of US in CTS evaluation. B-mode US assessment is presented with a focus on cross-sectional imaging and dynamic evaluations, including the transverse translocation and longitudinal gliding of the median nerve. We also review current methods for assessing vascularization in CTS and explore the usefulness of elastography in CTS evaluation. The advantages and limitations of each US method are elucidated, highlighting their practical utility in clinical practice.

Predictors of Facial Synkinesis Severity.

There is a lack of studies exploring factors influencing synkinesis severity. This study aims to identify factors that may contribute to variations in severity of facial synkinesis. Patients with a diagnosis of facial synkinesis presenting between 2009 and 2024 were reviewed. The synkinesis score of the eFACE Facial Nerve Clinician-Graded Scale was analyzed for associations with patient characteristics and facial palsy history using univariable and multivariable analysis. Two-hundred-forty-nine synkinesis patients were included in the study. The etiology of facial palsy was infectious or idiopathic in 185 patients (74%), tumor resection in 40 patients (16%), trauma in 17 patients (7%), and compression of the facial nerve by a benign tumor in seven patients (3%). Factors independently associated with more severe synkinesis scores included age of facial palsy onset over 50 years (-7.4, 95% CI, [-10.9, -3.9]; p < 0.001), diabetes (-8.6, 95% CI, [-14.9, -2.3]; p = 0.007), smoking (-4.9; 95% CI, [-8.0, -1.8]; p = 0.003), and intratemporal facial nerve injury (-19.4; 95% CI, [-27.8, -10.8]; p < 0.001). Other variables including sex, race, hypertension, and etiology were not found to be independently associated with synkinesis severity. Older age at facial palsy onset, diabetes, smoking, and intratemporal facial nerve injury were found to be independently associated with more severe synkinesis. These findings are novel and may aid in prognostication and treatment selection.

Successful surgical and multidisciplinary treatment for complex regional pain syndrome resulting from simple hand laceration: a case report

Complex regional pain syndrome (CRPS) is a chronic pain syndrome characterized by intense hyperalgesia and allodynia, with an unclear etiology and limited definitive treatments. This case involves a 23-year-old female patient who developed CRPS following a simple hand laceration from wine glass shards. After initial primary closure, the patient developed scar contracture at the thumb metacarpophalangeal crease, accompanied by erythema, warmth, heaviness, and hypersensitivity throughout the hand, leading to a CRPS diagnosis. A multidisciplinary approach, including anesthesiology and rehabilitation, confirmed nerve adhesion from scar contracture. Surgical intervention successfully released the adhered scar tissue, fascia, and nerve, followed by rehabilitation therapy. The patient’s functional recovery took nearly 6 months. This case highlights that CRPS can result from minor injuries due to scar-induced nerve entrapment and emphasizes the importance of early diagnosis and interdisciplinary treatment for gradual recovery.

Middle fossa approach for a petrous apex bony spur causing trigeminal neuralgia: illustrative case.

Trigeminal neuralgia (TN) can arise from trigeminal nerve compression at the root entry zone due to neurovascular conflict, which most often presents in the 6th decade of life. The authors report the case of a young patient with TN with a petrous apex bony spur near the entrance of Meckel's cave, causing compression of the proximal trigeminal nerve. A 21-year-old woman presented with a 5-year history of progressive right-sided TN. Axial T2 sampling perfection with application optimized contrast using different flip angle evolution magnetic resonance imaging (MRI) did not reveal vascular compression of the trigeminal nerve. However, sagittal reformats demonstrated a prominent bony ridge along the petrous apex, causing compression of the right trigeminal nerve at the porus trigeminus. Removal of the bony spur via a middle fossa approach completely resolved the patient's symptoms. Although TN is most frequently caused by neurovascular compression, it is vital to examine the entire course of the trigeminal nerve on MRI to identify alternative causes of nerve compression in the absence of neurovascular conflict. Bony compression is a rare cause of TN that should be considered, particularly in younger patients. The presence of prominent osseous structures along the course of the trigeminal nerve can be evaluated reliably on sagittal MRI. https://thejns.org/doi/10.3171/CASE24321.

Rehabilitation of back pain with laser associated with negative or positive pressure massage in workers: A randomized controlled trial

Background and purposeWork-related musculoskeletal disorders (WMSDs) are an array of conditions affecting the human locomotor system, such as muscles, tendons, nerves, bones, and joints. It is related to physiological, kinesiological and biomechanical changes which result in pain, paresthesia, inflammation, weakness, tiredness, heaviness in limbs, fatigue, reduced range of motion and/or compression of peripheral nerves. The aim of this study was to investigate the therapeutic effects of positive (massage gum) or negative pressure (vacuum therapy) combined with laser on the health of workers with back pain, investigating pain intensity, shoulder mobility, spinal flexibility, life quality, and well-being. MethodsTwenty-one workers (female and male) aged between 20 and 60 years and who had medical referral for pain complaint in low back, neck and shoulders due to WMSDs participated in this study and were randomized into 3 groups: (1) Positive Pressure plus Laser Group (PPL): positive pressure using a massage gun was applied after the laser; (2) Negative Pressure plus Laser Group (NPL): negative pressure by vacuum was applied together with the laser and; (3) Control group (CG): without positive and negative pressure treatments or laser therapy. All workers received an educational booklet with postural orientation and suggestions focused on stretching exercises. Anamnesis, visual analogue scale (VAS) to assess pain intensity, and functional tests to assess spine flexibility and shoulders mobility were performed. Quality of life and well-being also were evaluated. The regions of lumbar, thoracic and cervical spine were treated once a week, totaling seven sessions. ResultsThe main result was a reduced pain and an increased spinal flexibility, shoulders mobility, and quality of life in the PPL and NPL groups compared to the CG (p < 0.05). Furthermore, NPL showed better results compared to PPL (p < 0.05) for lumbar and cervical pain, as well as for right shoulder mobility. ConclusionTherefore, laser combined with negative pressure massage was more effective in reducing lumbar and cervical pain and increasing shoulder mobility compared to positive pressure massage in workers.

Spontaneous Postoperative Reduction of Ulnar Aneurism by Simple Decompression of Guyon’s Canal in a Patient with Hypothenar Hammer Syndrome: A Case Report

Background: Guyon’s canal syndrome is a pathological condition caused by compression of the ulnar nerve at the level of the wrist. It is less frequent than other compression syndromes of the upper limb (cubital and carpal tunnel), and different causative agents, including vascular lesions, are described. Among these, aneurysm of the ulnar artery is described in the literature as an infrequent aetiology. Case Presentation: We report the case of a 25-year-old young man with Guyon’s canal syndrome caused by an aneurysm of the ulnar artery, who underwent surgical decompression of the Guyon’s canal without intervening on the aneurysm. The postoperative course was free of complications, and the patient reported satisfaction, with reduced symptoms. Clinical examination and ultrasound imaging showed mass reduction of the aneurysm in the postoperative period, which appears to be an evolution hitherto undocumented in the literature. Conclusions: Many treatments are available for Guyon’s canal syndrome. Past medical and surgical treatments, duration and severity of symptoms, causes, and pathogenesis are important for therapeutic choice. Surgical treatment based on ligament section and lysis of the Guyon’s canal downstream, without any action on the aneurysm and with ulnar artery preservation, determined a reduction in terms of volume, relief of the symptoms, and patient satisfaction. With this case we describe a surgical therapeutic option for the treatment of Guyon’s canal syndrome caused by an aneurysm of the ulnar artery, in which surgery is limited to canal decompression and consequential aneurism mass reduction with concomitant relief of symptoms.

Ultrasound acting as a guiding light in the diagnosis of posterior interosseous nerve entrapment at ligament of Frohse – A case report

Posterior interosseous nerve (PIN) entrapment syndrome is a relatively rare compression neuropathy which leads to weakness of the extensor muscles of hand. This becomes a cause of morbidity to the patient with resultant difficulty in conducting day-to-day activities. Thickening of proximal edge of the superficial head of the supinator muscle which forms the ligament of Frohse can lead to compression of the PIN as it enters the supinator canal. Although nerve conduction studies can indicate the diagnosis, they cannot identify the exact site and cause of compression which is crucial for deciding the further management. Magnetic resonance imaging can identify the cause of entrapment in some cases; however, this is extremely difficult given the small size of the PIN and arcade of Frohse. Ultrasound overcomes these limitations and provides a cost and time effective, efficient, and sensitive diagnostic tool for detecting nerve entrapment. Here, we would like to emphasize the emerging importance of ultrasound by describing a case of ligament of Frohse thickening causing PIN entrapment which was effectively diagnosed by ultrasound and confirmed on surgical exploration, treated with surgical ligament release with a full recovery.

Ultrasound-assisted Trigger Point Injection for Cutaneous Nerve Entrapment Syndrome.

Ultrasound-assisted Trigger Point Injection for Cutaneous Nerve Entrapment Syndrome.

Case Report: Periocular Steroid Injection Combined Vemurafenib Therapy in the Long-term Management of Orbital Involvement of Erdheim-Chester Disease.

Abstract Purpose: To report a rare case of vision loss from Erdheim-Chester Disease (ECD) and long term, follow up, management and results. Case Report: A 62-year-old woman presented with bilateral exophthalmos and deterioration in visual acuity of both eyes. Magnetic resonance imaging studies revealed bilateral intraconal orbital tumors. She was diagnosed optic neuropathy in both eyes. The patient was treated with pegylated interferon and systemic pulse steroid. However, recurrences were common. Subsequently, the patient underwent regular corticosteroid injection directly into the retro-orbital region of both eyes monthly, which led to intermittent improvement of vision. At the 8th month of visual impairment, Vemurafenib was initiated. Results: The visual acuity and visual field scores were stable for 6 years during the follow-up. No major complication was observed. Conclusion: Combined vemurafenib and perioculer steroid injection is a well tolerated therapy with less systemic adverse effects which may benefit patients with orbital involvement of ECD. Key words: Erdheim–Chester disease; compressive optic neuropathy; vemurafenib; Optical coherence tomography; Optical coherence tomography angiography.

Contribution of remote Pacinian corpuscles to flutter-range frequency discrimination in humans

Among the various classes of fast-adapting (FA) tactile afferents found in hairy and glabrous skin, FA2 afferents, associated with Pacinian corpuscles (PC), preferentially signal high-frequency sinusoidal events corresponding with vibration percepts, in contrast to other classes associated with lower frequency flutter percepts. The FA2-PC complex is also uniquely sensitive to distant sources of vibration mechanically transmitted through anatomical structures. In the present study, we used a pulsatile waveform to assess the contribution of FA2 afferents to the perception of flutter-range frequency stimuli (~ 20 Hz) in combination with two methods to abolish local FA inputs and force a dependence on FA2 via transmission from adjacent structures. Firstly, we examined frequency discrimination and perception of vibration applied to the hairy skin overlying the ulnar styloid before and during the blockade of intradermal receptors by local anaesthesia. Secondly, we tested frequency discrimination on the digital glabrous skin before and during the blockade of myelinated fibres by ulnar nerve compression. Despite reliance on vibration transmission to activate remote PCs, we found that flutter-range frequency discrimination was unimpeded across both skin types. Comparisons with stimuli applied to the contralateral side also indicated that perceived frequency was unaffected. This confirms that flutter-range frequency perception can be encoded by the FA2-PC system. Our results demonstrate that input from receptors specialised for low-frequency signalling is not mandatory for flutter-range frequency perception. This explains how the constancy of frequency perception might be achieved across different skin regions, irrespective of the afferent type activated for transmitting these signals.

Common sports-related nerve injuries seen by the electrodiagnostic medical consultant.

The high physiologic demands of sports create dynamic stress on joints, soft tissues, and nerves which may lead to injuries in the athlete. Electrodiagnostic (EDx) assessment is essential to identify the correct diagnosis, localization, and prognosis, to guide management of sports-related neuropathies. A comprehensive review was performed to provide the EDx medical consultant with a practical approach to the common peripheral nerve disorders seen in athletes. Sports-related neuropathies reviewed include transient traumatic irritation of the brachial plexus and/or cervical nerve roots ("Burners and stingers,") suprascapular and axillary neuropathies, ulnar neuropathy at the elbow (UNE) in throwers, ulnar neuropathy at the hand/wrist in cyclists, multi-ligamentous knee injury, and foot/ankle neuropathies including tarsal tunnel syndrome. A thorough understanding of peripheral anatomy, possible entrapment sites, mechanisms of injury, and key physical examination findings is essential for correct diagnosis. EDx assessments beyond routine studies are generally required for sports-related neuropathy, which may not necessarily follow typical entrapment patterns. Adjunct diagnostic imaging, such as point-of-care ultrasound and magnetic resonance imaging, are helpful tools to identify associated musculoskeletal pathology such as compressive cysts or nerve entrapment, which may be amenable to interventional or surgical treatment. When no clear reversible structural pathology exists, management of sports-related neuropathy is athlete-specific and generally multi-modal, involving a combination of physical rehabilitation techniques to address muscle imbalances, load management, protective equipment, and interventional pain procedures.

USO DE TERAPIAS MANUAIS NA REABILITAÇÃO DA FASCITE PLANTAR: UMA REVISÃO SISTEMÁTICA.

Fasciitis is an inflammation of the plantar fascia, a structure that helps support the medial arch of the foot and is designed to absorb much of the impact. Plantar fasciitis can result from a number of factors, including excessive stress and overload, which can result in inflammation, stress fractures of the calcaneus, compressive neuropathy of the plantar nerves, and more. The aim of this study is to to elucidate how manual therapies can be effective in the treatment of plantar fasciitis. In its preparation, a literature review was carried out to evaluate the effectiveness or not of manual therapies in the treatment of plantar fasciitis, the databases used were: Pubmed, SciElo and PEDro , in Portuguese and English, in the period from January 2019 to December 2024. Ten studies were included to be analyzed in this systematic review, and it showed that manual therapy provides significant benefits, such as reducing pain and improving the function of patients with plantar fasciitis. In conclusion, this study offers valuable insight into how an integrated approach can benefit patients with plantar fasciitis . The findings reinforce the need for personalized treatments, emphasizing that combining different modalities may be key to successful recovery. However, there have been few scientific articles on these manual techniques, so it is worth highlighting the importance of encouraging further studies.

The Accuracy of the Clinical Carpal Tunnel Syndrome Diagnosis before the Nerve Conduction Studies

Background and aim: Carpal tunnel syndrome (CTS) is a compressive neuropathy caused by compression of the median nerve in the carpal tunnel. It is the most common entrapment neuropathy. According to different studies, the prevalence of CTS among adults (15–65 years old) in Western Europe ranged from 0.29% to 43%. CTS affects middle-aged active workers and is associated with high healthcare costs and a hefty economic burden. It is thus essential to diagnose CTS early and refer the patient to further investigation and treatment. In this study, we aimed to evaluate the accuracy of the clinical CTS diagnosis before the nerve conduction studies were performed on the referred patients.Methods: The concordance of clinical diagnoses was assessed by comparing referral diagnoses with diagnoses confirmed by electroneuromyography. All the patients referred for electroneuromyography to Mykolas Marcinkevičius Hospital between August 2023 and February 2024 were included in this research. The age, sex, referral and final diagnoses of the enrolled patients were taken from their outpatient charts. The obtained data were summarized and processed with Microsoft Office Excel 365, and the data analysis was performed with IBM SPSS Statistics.Results: The most common reasons that patients were referred to perform NCS were suspected carpal tunnel syndrome (30.7%), cubital tunnel syndrome (13.5%), other upper extremity mononeuropathies (16.2%), and polyneuropathies (15.5%). The most common diagnosis after consultation was carpal tunnel syndrome (42.6%), followed by pathologies of nerve roots or plexuses (14.5%). Out of 91 patients referred to electroneurography due to suspicion of CTS, 67 (73.6%) were confirmed cases, whereas, for 12 (13.2%) patients, no abnormalities were detected during NCS.Conclusion: Our analysis supports the theory that the electrodiagnostic examination is essential to specify and confirm the diagnosis of CTS, thus avoiding hyperdiagnosis and preventing patients from excessive surgical treatment.

Early and Late Intrinsic Hand Muscle Reinnervation After End-to-Side AIN to Ulnar Motor Nerve Transfer.

The "supercharge" end-to-side (SETS) anterior-interosseous-nerve (AIN) to ulnar-motor nerve transfer is used to improve intrinsic muscle recovery in cases of severe ulnar nerve compression or proximal axonotmetic injuries. Previous work has found differing intrinsic muscle recovery after this transfer. The objectives of this study were to examine the patterns of recovery in first dorsal interossei (FDI) and abductor digiti minimi (ADM) and the impact of AIN transfer to a specific fascicular location on the ulnar-motor nerve. A retrospective review of one fellowship-trained surgeon's consecutive patients at a single center from December 2019 to September 2021 was conducted. Patients who had an AIN to ulnar-motor nerve transfer for any indication were included and were excluded if they had less than 9 months follow-up. Seventeen patients were included (88% male, mean age 55 ± 14 years). At early follow-up, compound muscle action potential amplitudes for ADM and FDI did not increase. Compound muscle action potential amplitude for ADM significantly increased at late follow-up (P < .01). Average British Medical Research Council (BMRC) strength increased at early follow-up for FDI (P < .05), but not ADM. The proportion of patients with BMRC ≥ 3 increased for FDI (P < .01) and ADM (P < .05) at late follow-up. Volar-ulnar AIN insertion position did not have a clear effect on outcomes. The SETS AIN to ulnar-motor nerve transfer demonstrates clinical and electrophysiologic evidence of intrinsic muscle recovery and reinnervation, with differing recovery of outcomes. The role of specific fascicular targeting is still unclear and required further examination as does the mechanism behind differing intrinsic recovering.

Efficacy of Integrative Korean Medicine Treatment Including Ultrasound-Guided Pharmacopuncture in Patients with Lumbar Stenosis Accompanied by Peripheral Nerve Entrapments: Considering Double Crush Syndrome in This Report of Three Cases

Efficacy of Integrative Korean Medicine Treatment Including Ultrasound-Guided Pharmacopuncture in Patients with Lumbar Stenosis Accompanied by Peripheral Nerve Entrapments: Considering Double Crush Syndrome in This Report of Three Cases

Comparative Analysis of Comorbidities and Outcomes in Endoscopic versus Open Treatment of Carpal Tunnel Release in Patients with Rheumatoid Arthritis

Abstract Background: Rheumatoid arthritis (RA) is a known risk factor for carpal tunnel syndrome, possibly because the inflammation causes compression of the median nerve. Endoscopic and open carpal tunnel release (ECTR and OCTR) have been studied extensively in the general population but less so in patients with RA. The purpose of our study was to analyze outcomes and patient-specific comorbidities associated with ECTR and OCTR in patients with RA. Methods: We conducted a retrospective cohort study using the PearlDiver database to identify patients with RA who underwent either ECTR or OCTR between 2010 and 2014. Demographic data, comorbidities, and complication rates were analyzed. We used univariate and multivariable analysis to assess differences between the treatment methods. Results: Comparing 4,234 patients who underwent OCTR to 683 patients who underwent ECTR, we found no significant differences in medical comorbidities such as hypertension, obesity, chronic kidney disease, hypothyroidism, and diabetes mellitus. Patients who underwent ECTR were significantly more likely to require a repeat procedure within 90 days of the initial procedure. However, this difference was not consistent in multivariate analysis controlling for comorbidities. Conclusion: Our study found that RA and ECTR were identified as independent risk factors for revision release, with ECTR showing a higher likelihood of repeat procedures within 90 days compared with OCTR. Despite similar demographics and comorbidities in the two study cohorts, use of OCTR outpaced ECTR use in the study period. Future research should explore further characterization of repeat procedures in this higher risk patient subset.

Prevalence and Risk Factors Associated With Carpal Tunnel Syndrome Among Sudanese Females: A Cross-Sectional Study.

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy resulting from compression of the median nerve. This condition is more common in females than in males. The earlier the diagnosis, the better the prognosis and treatment outcomes. This is a cross-sectional hospital-based study conducted at Soba Teaching Hospital in obstetrics and gynecology outpatient clinic in Khartoum in the period from February 2022 to March 2022. A simple random sampling was applied, and an interview was conducted using a four-partquestionnaire. The first part was based on socio-demographic data, the second was lifestyle, and the third and fourth were based on the Boston Carpal Tunnel Questionnaire (BCTQ). The data were analyzed using the statistical package for social sciences (SPSS) software, version 23 (IBM Corp., Armonk, NY) to find the correlation between the various variables. A total of 113 women participated in the study (response rate=100%). The prevalence of CTS was found to be 5%. No significant association was found between lifestyle and medical history, e.g., obesity and oral contraceptives and CTS were p=0.167, 0.841 respectively. Conversely, there was a significant association between age and residency, with p=0.005 and 0.049, respectively. The prevalence of CTS is increasing in Sudan. Therefore, it is essential to thoroughly assess patients for any symptoms related to hand pain by asking detailed questions during consultations. In addition, further studies covering more states are neededto better understand the regional variation in CTS prevalence.