Technology Initiative Research Articles

Atomic Quantum Technologies for Quantum Matter and Fundamental Physics Applications

Physics is living an era of unprecedented cross-fertilization among the different areas of science. In this perspective review, we discuss the manifold impact that state-of-the-art cold and ultracold-atomic platforms can have in fundamental and applied science through the development of platforms for quantum simulation, computation, metrology and sensing. We illustrate how the engineering of table-top experiments with atom technologies is engendering applications to understand problems in condensed matter and fundamental physics, cosmology and astrophysics, unveil foundational aspects of quantum mechanics, and advance quantum chemistry and the emerging field of quantum biology. In this journey, we take the perspective of two main approaches, i.e., creating quantum analogues and building quantum simulators, highlighting that independently of the ultimate goal of a universal quantum computer to be met, the remarkable transformative effects of these achievements remain unchanged. We wish to convey three main messages. First, this atom-based quantum technology enterprise is signing a new era in the way quantum technologies are used for fundamental science, even beyond the advancement of knowledge, which is characterised by truly cross-disciplinary research, extended interplay between theoretical and experimental thinking, and intersectoral approach. Second, quantum many-body physics is unavoidably taking center stage in frontier’s science. Third, quantum science and technology progress will have capillary impact on society, meaning this effect is not confined to isolated or highly specialized areas of knowledge, but is expected to reach and have a pervasive influence on a broad range of society aspects: while this happens, the adoption of a responsible research and innovation approach to quantum technologies is mandatory, to accompany citizens in building awareness and future scaffolding. Following on all the above reflections, this perspective review is thus aimed at scientists active or interested in interdisciplinary research, providing the reader with an overview of the current status of these wide fields of research where cold and ultracold-atomic platforms play a vital role in their description and simulation.

Digital payments Impact on Indian Economy through Banking systems & Global Comparisons

India’s financial sector has witnessed a significant digital transformation, particularly in the realm of payments. The shift towards digital payment systems has reshaped transactional practices and contributed to financial inclusion. The adoption of digital payment systems like UPI and e-wallets has led to a surge in online transaction volumes, indicating a gradual move towards a cashless economy. Government initiatives and the COVID-19 pandemic have played crucial roles in promoting digital payments. However, challenges remain in achieving complete financial inclusion with approximately 190 million unbanked adults in India. Fintech companies are addressing this by providing a wide range of financial services and utilizing alternative data sources to evaluate creditworthiness. The key factors driving the adoption of digital payments in India include increased awareness, favorable government policies, quick onboarding and ease of use, smartphone proliferation and internet expansion, regulatory support, and improved technology. These factors, coupled with the enabling role of various entities and technologies, are shaping the future of digital payments in India. The rapid growth of digital payment systems, driven by a combination of technological advancements, government initiatives, and changing consumer preferences, is revolutionizing the financial landscape. As the fintech sector continues to evolve, it promises to bring about further innovations, making financial services more accessible and inclusive. The journey towards a digital economy is well underway, and with continued efforts, India is poised to emerge as a global leader in digital payments. The impact of this digital revolution extends beyond the financial sector, influencing various aspects of the economy and society, and paving the way for a more inclusive and efficient future.

Technical support as a catalyst for innovation and special project success in oil and gas

In the dynamic landscape of the oil and gas industry, technical support emerges as a pivotal force driving innovation and ensuring the success of special projects. This paper explores the multifaceted role of technical support in this sector, shedding light on its significance in maintaining operational efficiency, safety, and fostering innovation. Amidst the ever-evolving challenges faced by the industry, from fluctuating market demands to stringent regulatory requirements, technical support stands as a cornerstone in navigating complexities and driving progress. Drawing from real-world examples and industry insights, the paper elucidates the challenges and opportunities encountered in fostering innovation within the oil and gas sector. It highlights the critical role of technical support in identifying technological gaps, spearheading research and development initiatives, and facilitating the implementation of innovative solutions. Moreover, the paper delves into the realm of special projects, exploring their importance in driving strategic growth and competitive advantage. It examines the challenges inherent in executing special projects and underscores the indispensable role of technical support in mitigating risks and ensuring successful outcomes. Through a comprehensive analysis of best practices and case studies, the paper elucidates strategies for leveraging technical support as a catalyst for innovation and special project success in oil and gas. It emphasizes the importance of integrating technical support into innovation initiatives, fostering collaboration across multidisciplinary teams, and investing in advanced technologies and expertise. Ultimately, the paper underscores the transformative potential of technical support in shaping the future of oil and gas operations, driving sustainable growth, and fostering resilience in an ever-changing landscape. Keywords: Technical Support, Catalyst for Innovation, Special Project Success, Oil and Gas.

Prototyping industry 4.0: enhancing efficiency and productivity in small enterprises through iteration and low-cost solutions

AbstractThis paper explores the implementation of Industry 4.0 technologies in Small Enterprises (SEs), focusing on the unique challenges they face. It presents four case studies demonstrating how low-cost, low-effort solutions can enhance efficiency and productivity in small companies. The solutions, developed in a local makerspace, address specific manufacturing challenges that lack affordable or existing off-the-shelf solutions. The paper highlights the value of iterative prototyping in implementing Industry 4.0 solutions and discusses how this approach can help SEs overcome adaptation challenges.

How does market-incentive environmental regulation affect enterprises green growth? The mediating role of R&D investment and innovation output

Manufacturing enterprises is a country's economic mainstay. However, their longtime extensive growth pattern of “high growth and high emission” has brought huge environment pollution and restricted sustainable development. Under the circumstance of carbon reduction and global green development, market-incentive environmental regulation (MER) has attracted the attention of scholars and become a kind of important methods of encouraging manufacturing enterprises green growth. Presently, two fairly distinct viewpoints of “Follow Cost” and “Porter Hypothesis” both have their own supportive research results, and the explanation for the role of MER is completely opposite. What's more, empirical research at the enterprise level is scarce. Therefore, this study makes a further analysis from the perspective of enterprises heterogeneous innovation ability. Guided by the classic theory of “Follow Cost” and “Porter Hypothesis”, this study aims to evaluate the applicable conditions of MER's environmental improvement effect, and testing the differential impact mechanism of MER on enterprise Green Total Factor Productivity (GTFP), enterprise Green Technological Change (GTC) and enterprise Green Efficiency Change (GEC). All these give theoretical and empirical supplementation for the rationality of related theories. This study examines the hypotheses and mechanism according to 1220 Chinese manufacturing listed companies data 2011–2020. The empirical results indicate that: (1) In short term, MER has a significant positive impact on GTC, and a significant negative impact on GTFP and GEC. (2) As innovation driven factors, both enterprise R&D investment and innovation output play the mediating role. (3) Heterogeneity analysis indicates that the impact mechanism varies depending on enterprise industry-type, location and digital level. Thus, policymakers should develop appropriate MER policies, and manufacturing enterprises should strengthen technological innovation to help achieve environmental sustainability and profit performance.

Development of financial system for technology enterprises based on sensor networks and adaptive genetic algorithm

In the evolution of enterprises, the emergence of the information age and advancements in related technologies have significantly amplified the significance of financial data generated through enterprise activities for their overall development. As data processing and information technology continue to advance, enterprises are increasingly prioritizing the development of financial systems. The focus of attention is shifting towards leveraging data in the development and utilization of financial systems. This signifies a gradual transition towards a data-driven approach in the development and utilization of financial systems within enterprises. Some basic activities of data processing can be carried out on the network platform. For the development of an enterprise, the scale of production and operation of the enterprise and the technology of system development will directly affect the speed of enterprise development. In the context of the development of the new era, Internet technology has been developed at a deeper level. The development of Internet technology and the construction of network platforms have changed the way enterprises develop systems to a certain extent, providing more advanced technology for enterprise development systems. Embedded system can provide people with excellent human-computer interaction experience, and it also has very powerful data processing capabilities. It has been the focus of research by researchers in various countries in recent years. This article analyzes the use of embedded systems and genetic algorithms, and provides a new technical direction for enterprises to develop high-performance financial systems.

INNOVATIVE TYPE OF USE OF INVESTMENTS

The innovative type of use of investments is a direction in which investments are directed to stimulate and support innovation. This includes funding scientific research, developing new products, technologies and processes, supporting start-ups and entrepreneurship, modernizing enterprise technology bases, education and training, and creating innovation infrastructure and ecosystems. Innovative investments play an important role in stimulating economic growth, improving the competitiveness of companies and creating new jobs, contributing to the development of new technologies and solving complex problems.

Impact of natural resource dependence on green technology development: Role of digital governance in mitigating resource-curse using big data

The pursuit of a green economy as a strategy to counteract the “resource curse' phenomenon represents a burgeoning paradigm shift. A sophisticated digital governance infrastructure is vital, serving as an integral mechanism for ensuring transparency, enhancing data efficacy, and fostering public involvement—all crucial components of sustainable environmental stewardship. In light of this context, our analysis examines the interplay between natural resource dependence and green technological innovation, as well as delineating the potential pathways interlinking the two, through an empirical assessment using provincial data from China spanning the years 2011–2021. Employing advanced techniques in big data text mining, we have devised a government digital transformation index calibrated to elucidate the impacts of digitalization on the twin variables of natural resource reliance and the propagation of green technologies. Our findings indicate a marked deleterious influence of natural resource dependence on the evolution of green technological initiatives at the regional level, a trend most pronounced in China's central and western provinces as well as in locales with comparatively low economic development metrics. Furthermore, our research ascertains that the impeding force of natural resource dependence on green technology ascension is primarily exercised through diminished regional research and development capabilities, stagnation of industrial structure progression, and limited openness to external economic integration. Finally, the study posits that the implementation of digital governance measures holds the capability to substantially mitigate the restrictive impact of natural resource dependence on green technology advancement. This underscores the imperative for a digital governance architecture that actively neutralizes and meticulously monitors the adverse outcomes associated with resource consumption.

Addressing health disparities through IT: A review of initiatives and outcomes

This paper provides a comprehensive review of information technology (IT) initiatives to address health disparities and evaluate their outcomes. Health disparities, defined as unequal health outcomes and access to healthcare across different population groups, are a persistent challenge globally. IT, including telehealth, electronic health records (EHRs), mobile health (mHealth) applications, and data analytics, presents innovative opportunities to mitigate these disparities. The review discusses the successes and challenges of these IT initiatives, highlighting their potential to enhance healthcare access, improve the quality of care, and promote health equity. Telehealth has been instrumental in bridging the gap for remote and underserved populations, while EHRs have improved care coordination. mHealth applications offer personalized health interventions, and data analytics is crucial in identifying and addressing health disparities. However, the effectiveness of these IT solutions is hindered by barriers such as the digital divide, lack of digital literacy, and privacy concerns. The paper calls for continued investment in accessible and equitable IT initiatives. It emphasizes the need for a multidisciplinary approach involving policymakers, healthcare providers, and IT professionals to implement effective solutions. Through this review, the paper aims to contribute to understanding how IT can be leveraged to combat health disparities, offering insights for future research and policy development.

Peningkatan Kompetensi Guru dalam Pengelolaan Kelas melalui Teknologi Digital

Training in digital technology for elementary school teachers is a solution to enhance classroom management skills and teaching quality. This study aims to evaluate the impact of digital technology training on teachers' skills and social changes within the educational community. The methods used include initial surveys, practice-based training, and post-training evaluations with qualitative and quantitative approaches. The results show a significant improvement in teachers' technology skills and positive changes in classroom management. Teachers reported increased confidence and practical skills in using technology tools, and the formation of support groups and technology-based learning communities. The program also facilitated the emergence of local leaders who spearhead technology initiatives in their schools. These findings emphasize the importance of participatory and sustainable training in creating positive changes within the educational environment.

How do executive excess compensation affect enterprise technological innovation: Evidence from a panel threshold model of chinese biopharmaceutical companies

This study examines the levels of executive excess compensation (EEC) that stimulate the quality and efficiency of enterprise technology innovation (ETI). Using a behavioral agency perspective, we investigate how companies achieve superior ETI by providing sufficient incentives to motivate executives to perform to the best of their abilities. We use a panel threshold model based on a sample of Chinese-listed biopharmaceutical companies and find that: (1) providing an EEC between 0.0592 and 0.1907 significantly affects the promotion of ETI quality; (2) regarding ETI efficiency, executives generally do not receive the compensation that they deserve; and (3) the existing EEC has a weak negative impact on ETI efficiency, gradually disappearing as compensation increases. Heterogeneity analysis reveals that restricting EEC to the eastern area and strengthening the supervision of EEC in state-owned enterprises are effective measures for stimulating ETI. We advance the literature by providing guidance on compensation plans to companies in different regions.

Adapting Businesses to the 6G Security Paradigm: Insights from Commerce 5.0

Within the context of Commerce 5.0, this study examines organizations' potential and difficulties when adjusting to the 6G security paradigm. The primary goals are to look into how 6G technology is developing, assess cybersecurity opportunities and problems, pinpoint strategic imperatives for business adaptation, investigate using Commerce 5.0 to gain a competitive edge, and look at upcoming trends and things business leaders should know. The approach used is a thorough analysis of the knowledge and insights from Commerce 5.0. Key findings point to the revolutionary potential of 6G technology for enterprises, new cybersecurity requirements, and strategic imperatives. The report emphasizes the significance of valuing ethics and cybersecurity readiness and embracing hyperconnectivity, customization, and innovation. The consequences of policy point to the need for infrastructure spending, cybersecurity best practices promotion, encouragement of innovation and teamwork, and the creation of regulatory frameworks for new technology. This study offers insightful information to industry stakeholders, legislators, and corporate executives trying to make sense of the intricacies of the 6G security paradigm while promoting innovation and expansion in the digital economy.

Views of Parents on Using Technology-Enhanced Toys in the Free Play of Children Aged One to Four Years

New technology has brought about a novel approach to play termed digital play. Digital play shares many characteristics with traditional play but also presents new possibilities (e.g., building concepts and skills about STEM, opportunities for physical, outdoor activities). Despite new toys with technological characteristics being popular, there is limited research on this specific area for children under four years old and their parents. This study explored parental perspectives and was part of a larger investigation that examined 68 (38 boys and 30 girls) very young children’s (1–4 years) engagement with technology-enhanced toys (TETs) in early childhood settings. A sequential explanatory design was employed, wherein parents completed questionnaires before and after their children engaged with TETs. Statistical and thematic analysis revealed that family demographics play an important role in children ‘s use of TETs and digital technologies (e.g., on the quality of engagement with their children during playing with TETs). Parents noted improvements in their children’s skills, including fine motor skills, language, and creativity. This study underscores the importance of considering parental backgrounds in digital technology initiatives for early childhood development. Policymakers and educators may benefit from these insights to tailor digital integration and support children’s digital competence effectively.

Fostering Innovation: Exploring Key Factors and Their Relationship on Organizational Performance Towards Innovation Management Culture

Employee creativity positively impacts organizations’ ability to foster innovation and influences organizational learning, as the 4.0 industry promises more innovative, sustainable, and smarter productivity. This study addresses the importance of innovation culture in the technology industry’s business landscape. Despite the growing attention given to innovation culture, there is a need to explore its relationship with corporate performance. A descriptive research design with a quantitative approach using regression analysis was used. Furthermore, 398 respondents from Chinese technological enterprises were investigated. Based on these findings, the workforce in the technology sector hires people of different ages and positions. Those who belong to the supervisory level focus more on quality control and process improvement. The findings also demonstrated that innovative culture significantly impacts firm performance through its influence on factors such as organizational learning, creativity and empowerment, value orientation, and market orientation. Thus, it emphasizes the importance of aligning innovation strategies at all organizational levels and effectively allocating resources to verify how innovation stimulates innovative behavior in organizations. Organizational learning can improve the shared values and behaviors of an organization and further improve organizational performance. A strong correlation between corporate culture and organizational performance. Moreover, the more effort a company puts into building its culture and the more it achieves, the greater its advantage in financial and non-financial performance, and the higher sustainability for innovation management culture will be evident.

Value Creed: Emerging Technology and Digitalization Initiatives Create Post-pandemic Joyous Workplace

In March 2020, Nitesh Raj, the Co-Founder and Managing Director of Value Creed, was keenly observing the changes around the world due to the COVID-19 pandemic. Small to mid-size companies such as Value Creed, with specialized offerings, faced a harder time retaining their employees and often lost them to bigger multinational companies. Value Creed’s core expertise lies in Information Technology Consulting, focusing on the energy trading and risk management)/commodity trading and risk management industry. During this tough period, Nitesh aimed to overcome challenges and achieve a future-ready workplace with low employee turnover, high retention and satisfaction. This case is in two parts: Part A describes the Dilemma of Nitesh Raj and Part B describes how emerging technology and digitalization initiatives have supported innovative HR strategic initiatives for introducing technology-driven employee welfare programmes focusing on managing the uncertainty after the COVID-19 pandemic, thus creating a workplace of joy.

THE STRATEGIC VALUE OF BUSINESS ANALYSTS IN ENHANCING ORGANIZATIONAL EFFICIENCY AND OPERATIONS

Business analysts play a crucial role in enhancing organizational efficiency and operations by bridging the gap between business needs and technological solutions. This review explores the strategic value of business analysts in driving organizational success through effective analysis, communication, and stakeholder engagement. Business analysts act as key facilitators in organizations, translating business objectives into actionable requirements for technology solutions. By conducting thorough analysis of business processes, systems, and data, business analysts identify opportunities for improvement and recommend strategic solutions to enhance operational efficiency. Their role extends beyond mere problem-solving; they also play a pivotal role in aligning business goals with technology initiatives, ensuring that projects deliver tangible value to the organization. Furthermore, business analysts excel in communication and stakeholder engagement, acting as liaisons between business units, IT teams, and external vendors. Their ability to translate complex technical concepts into clear, understandable language enables them to facilitate collaboration and consensus among diverse stakeholders. This skill is particularly valuable in Agile environments, where collaboration and communication are key principles. Moreover, business analysts are instrumental in driving organizational change and transformation. By conducting impact assessments, developing change management strategies, and providing training and support, business analysts ensure that technology implementations are successful and sustainable. Their holistic approach to problem-solving and their focus on delivering value make them invaluable assets to organizations seeking to improve efficiency and operations. In conclusion, the strategic value of business analysts in enhancing organizational efficiency and operations cannot be overstated. Their unique blend of analytical skills, communication prowess, and stakeholder engagement abilities make them indispensable in driving organizational success. By leveraging the expertise of business analysts, organizations can streamline processes, improve decision-making, and achieve their strategic objectives with greater efficiency and effectiveness. Keywords: Strategic Value, Business Analysts, Enhancing, Organizational Efficiency, Operations.

A group decision-making method for technology selection of petrochemical enterprises

Selecting appropriate energy conservation and emission reduction technologies is essential for the sustainable developments of petrochemical enterprises. It usually involves experienced experts from multi-domain and thus can be regarded as a large-scale group decision-making problem. Existing methods assumed that different experts use the same linguistic term set following the same semantics to express their evaluation values, and derived the ranking of alternatives by an indirectly obtained group preference matrix. Such an approach may induce information loss. To avoid these defects, this study introduces a model based on rank centrality and expert differences to choose appropriate technologies for petrochemical enterprises. First, an attitude parameter is introduced into a linguistic scale function to unify different judgment benchmarks of experts regarding the same linguistic term. Next, a direct weight elicitation method based on rank centrality is developed to deduce the individual rank vector of alternatives. A grey clustering method based on the similarities of individual rank vectors is extended to cluster experts into small groups, and the silhouette coefficient is used to determine clusters weights. Afterwards, the rank vectors of alternatives corresponding to subgroups and the global rank vector are calculated by the weighted averaging operator. Alternatives are ranked by the rank vector of the global group. Finally, four technologies were evaluated by the model, and the preferred technology was identified. The findings indicate that the proposed technology selection model alleviates information loss, elevates group consensus level, and provides a perspective for petrochemical enterprises in search of energy conservation and emission reduction technologies.

Cloud-Based Accounting Information Systems and Financial Reporting Quality of Listed Information and Communication Technology Firms in Nigeria

The confluence of cloud-based Accounting Information Systems (AIS) adoption and financial reporting quality within Nigeria's Information and Communication Technology (ICT) sector is explored in this study. Given the dynamic landscape of the ICT industry characterized by technological advancements, evolving market dynamics, and regulatory shifts, ICT firms are increasingly turning to cloud-based AIS to streamline their accounting processes and adapt to changing business requirements. The population of the study consists of all eight (8) Information and Communication Technology (ICT) enterprises that are listed on the Nigerian Exchange Group as of 31st December 2022. As a result, this study delves into the impact of Cloud-Based AIS adoption on the Financial Reporting Quality of Listed ICT Firms in Nigeria over a decade-long period from 2013 to 2022. Utilizing a Panel Regression Technique (Random Effect Model), the study identifies a significant overall effect of Cloud-Based AIS on the Financial Reporting Quality of Listed ICT Firms in Nigeria. Moreover, it highlights the significant influence of Cloud Security Investment on financial reporting quality among ICT firms in Nigeria, while Cloud Expenditure Growth is found to have no statistically significant effect. The study emphasizes the need for strategic resource allocation and exploration of cost optimization opportunities, given that cloud expenditure growth may not directly impact financial reporting quality. However, the study recommends for prioritizing cloud security investments to safeguard financial data integrity, mitigate cybersecurity risks, and enhance trust in financial reporting practices, thereby bolstering investor confidence.

Examining the impact of green technological specialization and the integration of AI technologies on green innovation performance: evidence from China.

China's commitment to achieving carbon neutrality by 2060 has sparked scholars' interest in examining the environmental ramifications of green technologies in the digital era. While plenty of them provide eco-efficiency policy such as increasing R&D investment or stimulating green exports, little attention has been paid to the firm-level technological management and recombination strategies such as differentiation/specialization of green portfolios along with AI integration, which can significantly impact the pace of net-zero transitions. To address these gaps, this study investigates the moderating effect of technological specialization on levels of AI integration into green technologies estimated by green-AI technological distance and enterprises' innovation performance in Chinese contemporary contexts. Regression results of fixed-effect model in Chinese patent data (2011-2020) indicate that enterprises' green innovation performance is significantly improved as AI integrates more into the green technologies due to the legitimacy and the inability to appropriate more green values. Interestingly, specialized green-technological enterprises demonstrate superior performance in integrating distant AI technologies. This occurrence could potentially be driven by the governments' incentives and the organization's risk attitudes, shaping green innovation outcomes. Hence, the study underscores the importance of considering both the AI integration and green specialization in shaping innovation outcomes amidst green transitions.

Efficacy and immunogenicity following dengue virus-1 human challenge after a tetravalent prime-boost dengue vaccine regimen: an open-label, phase 1 trial

Dengue human infection models (DHIMs) are important tools to down-select dengue vaccine candidates and establish tetravalent efficacy before advanced clinical field trials. We aimed to provide data for the safety and immunogenicity of DHIM and evaluate dengue vaccine efficacy. We performed an open-label, phase 1 trial at the University of Maryland (Baltimore, MD, USA). Eligible participants were healthy individuals aged 18-50 years who either previously received a tetravalent dengue purified inactivated vaccine prime followed by a live-attenuated vaccine boost (ie, the vaccinee group), or were unvaccinated flavivirus-naive participants (ie, the control group). Participants in the vaccinee group with detectable pre-challenge dengue virus-1 neutralising antibody titres and flavivirus-naive participants in the control group were inoculated with dengue virus-1 strain 45AZ5 in the deltoid region, 27-65 months following booster dosing. These participants were followed-up from days 4-16 following dengue virus-1 live virus human challenge, with daily real-time quantitative PCR specific to dengue virus-1 RNA detection, and dengue virus-1 solicited local and systemic adverse events were recorded. The primary outcomes were safety (ie, solicited local and systemic adverse events) and vaccine efficacy (ie, dengue virus-1 RNAaemia) following dengue challenge. This study is registered with ClinicalTrials.gov, number NCT04786457. In January 2021, ten eligible participants were enrolled; of whom, six (60%) were in the vaccinee group and four (40%) were in the control group. Daily quantitative PCR detected dengue virus-1 RNA in nine (90%) of ten participants (five [83%] of six in the vaccinee group and all four [100%] in the control group). The mean onset of RNAaemia occurred on day 5 (SD 1·0) in the vaccinee group versus day 8 (1·5) in the control group (95% CI 1·1-4·9; p=0·007), with a trend towards reduced RNAaemia duration in the vaccinee group compared with the control group (8·2 days vs 10·5 days; 95% CI -0·08 to 4·68; p=0·056). Mild-to-moderate symptoms (nine [90%] of ten), leukopenia (eight [89%] of nine), and elevated aminotransferases (seven [78%] of nine) were commonly observed. Severe adverse events were detected only in the vaccinee group (fever ≥38·9°C in three [50%] of six, headache in one [17%], and transient grade 4 aspartate aminotransferase elevation in one [17%]). No deaths were reported. Participants who had tetravalent dengue purified inactivated vaccine prime and live-attenuated vaccine boost were unprotected against dengue virus-1 infection and further showed increased clinical, immunological, and transcriptomic evidence for inflammation potentially mediated by pre-existing infection-enhancing antibodies. This study highlights the impact of small cohort, human challenge models studying dengue pathogenesis and downstream vaccine development. Military Infectious Disease Research Program and Medical Technology Enterprise Consortium and Advanced Technology International.