The topological evolution near the turbulent/non-turbulent interface (TNTI) in turbulent mixing layer is studied by means of statistical analysis of the invariants of velocity gradient tensor (VGT) based on direct numerical simulation data. The dynamics of topological evolution is investigated in terms of the source terms of the evolution equations for the invariants, including the pressure effect term, viscous effect term and interaction term among the invariants. It is found that the local topology of fluid particles at the TNTI evolves from non-focal region to focal region in the plane of the second (Q) and the third (R) invariants of the VGT. The topological evolution is mainly associated with the pressure effect term in the TNTI region. According to the analysis of the evolution of enstrophy and dissipation, the enstrophy increase and the dissipation decrease are revealed in the TNTI region, which are caused by viscous vorticity diffusion near the TNTI. A weak correlation between the strain rate and the rotation rate is found in the TNTI region which is related to the reduction of enstrophy production. The alignments between vorticity and strain near the TNTI are investigated and a strong alignment of the vorticity with the extensive eigenvector direction is identified in the TNTI region.