Background and Purpose: Performing suction with complications such as tachycardia or bradycardia, increase or decrease blood pressure, pain, discharge, and decrease arterial oxygen saturation. The aim of this study was to compare the effect of endotracheal tube suctioning to open two different size catheters 12 and 14 on the discharge, pain, heart rate, blood pressure, and blood oxygen saturation in patients admitted to the Intensive Care Unit (ICU). Materials and Methods: This clinical trial compared two interventions of a pre- and post-test, and sampling was random. 36 patients admitted to the ICU in Yasuj martyr Beheshti Hospital iran, in a group of suctioning with catheter size 12 and 14. Changes in heart rate, blood pressure, pain, discharge, and arterial oxygen saturation before, during, 5 min and 20 min after the suction were recorded. Data analysis was performed by analysis of variance with repeated measures and paired t-test. Results: The Heart rate increased during suction catheter 14 than to 12, and the difference was statistically significant (P = 0.000). Suctioning with both catheters decreased oxygen saturation, but the reduction was not significant between both (P = 0.149). Systolic pressure increased after suction, and this increase was significantly in the higher catheter (P = 0.05). Diastolic pressure increased during suction with the highest increase of 5 min. There were no significant differences between the two catheters (P = 0.186). In the third episode, the highest rated pain during suctioning was observed and the difference was significant between large and small catheters (P = 0.000). Post-suction discharge was in the higher catheter was more and statistically significant (P = .000). Conclusion: The use of small size suction catheter To a lesser extent in heart rate, blood pressure, pain and suffering oxygen saturation changed.
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