Endocrine Pharmacology Research Articles

O-42 - Endocrine pharmacology of reproduction (Report 41): Influence of uterine extracts from intact and indomethacin-treated rats on ovarian steroidogenesis

O-42 - Endocrine pharmacology of reproduction (Report 41): Influence of uterine extracts from intact and indomethacin-treated rats on ovarian steroidogenesis

Medical Therapy for Endometriosis: Endocrine Pharmacology

Medical Therapy for Endometriosis: Endocrine Pharmacology

Why do inadvertent pregnancies occur in oral contraceptive users?--Effectiveness of oral contraceptive regimens and interfering factors

Inadvertent pregnancies in combined pill users are not uncommon, and are usually due to errors of tablet taking. However, many factors may contribute to 'pill failure'. In this review the endocrine pharmacology of pill use and the changes reported with missed pills have been considered in detail. The influences of other factors including drug interactions have been reviewed and a series of recommendations made for reducing the risk of pregnancy in each of these circumstances.

Basic and Clinical Pharmacology

This book succeeds Review of Medical Pharmacology , by Meyers, Jawetz, and Goldfien. Edited by B. G. Katzung, some of the important areas covered include drug receptors and pharmacodynamics, pharmacokinetics of absorption and biotransformation of drugs, autonomic pharmacology of cholinergic and adrenergic receptor stimulants and antagonists, antihypertensive agents, cardiac glycosides and other agents used in the treatment of congestive heart failure, therapeutic drugs for cardiac arrhythmias, diuretics, pharmacology of the CNS drugs such as anticonvulsants and anesthetics, antidepressants, narcotic analgesics, nonsteroidal anti-inflammatory agents, endocrine pharmacology, antimicrobial and antimycobacterial drugs, antiprotozoal and antihelmintic drugs, cancer chemotherapy, and drugs and the immune system. Written by several prominent researchers and scientists, each chapter begins with a section on the basic pharmacology, chemistry, pharmacokinetics, and pharmacodynamics of the agents under discussion. This is followed by a section on clinical pharmacology, which deals with relevant information regarding the clinical use of drugs on the various

Bromocriptine: endocrine pharmacology and therapeutic applications

Bromocriptine: endocrine pharmacology and therapeutic applications

Why do inadvertent pregnancies occur in oral contraceptive users?: — Effectiveness of oral contraceptive regimens and interfering factors

Inadvertent pregnancies in combined pill users are not uncommon, and are usually due to errors of tablet taking. However, many factors may contribute to ‘pill failure’. In this review the endocrine pharmacology of pill use and the changes reported with missed pills have been considered in detail. The influences of other factors including drug interactions have been reviewed and a series of recommendations made for reducing the risk of pregnancy in each of these circumstances.

Endocrine Pharmacology of SHR (Report 5) : Retardation in the development of spontaneous hypertension by gonadectomy before or after adrenal enucleation

Spontaneously hypertensive male rats (SHR) of Kyoto-Wistar (KW) strain were divided into 3 groups : castration (cast) performed at 4 weeks old (W) and adrenal enucleation (enucl) at 10 W as group 1, cast at 4 W and enucl at 22 W as group 2, and enucl at 10 W and cast at 22 W as group 3. Systolic blood pressure (BP) was measured by an indirect tail cuff method. Group 1:4 W cast rats showed a significantly lower BP as compared with intact SHR up to 22 W ; 10 W enucl rats showed a significantly higher BP over intact SHR up to 22 W ; and cast plus enucl rats showed a significantly higher BP over cast only-rats, but they showed a significantly lower BP compared to enucl only-rats. Group 2 : Rats bearing cast at 4 W and enucl at 22 W manifested progressively significantly BP, and values reached a level comparable to that of cast plus enucl rats as shown in group 1. The BP of these two groups were significantly below those of intact SHR until 35 W. Group 3 : Rats that received enucl at 10 W showed significant elevation in BP over the intact SHR up to 22 W ; but BP did not rise following cast at 22 W, and the BP was significantly below that of enucl only-rats. These values reached a level comparable to that of intact SHR. These results suggest that 1) enucl in the presence or absence of gonad increases significantly BP in both SHR and KW, 2) gonadectomy decreases significantly BP in enucl SHR and retards significantly BP in intact SHR ; however, 3) gonadectomy did not alter the BP in KW rats. It is concluded that gonad or gonadal hormones play an important role in the genesis of essential hypertension.

Danazol: Endocrine pharmacology and therapeutic applications

The options for the medical management of endometriosis have been expended by the introduction of the synthetic steroid, danazol. The results of large clinical studies suggest that danazol treatment produces significant improvement in the symptoms, signs, and laparoscopic findings of endometriosis. The original studies of the phamacology of danazol concluded that danazol was a strong antigonadotropin with mild androgenic effects and no other hormonal proparties. Recent studies which emphasize the molecular pharmacology of danazol suggest that this steroid has direct effects on hypothalamic-pituitary function, multiple classes of steroid receptors, gonadal steroidogenesis, and endogenous steroid metabolism. These studies demonstrate that: (1) danazol prevents the midcycle surge of luteinizing hormone (LH) and follicle-stimulating hormone (FSH): (2) danazol does not significantly suppress basal LH or FSH in gonadalfy intact human beings; (3) in castrated animals danazol can prevent the compensatory increase in LH and FSH; (4) danazol binds to androgen, progesterone, and glucocorticold receptors; (5) danazol does not bind to estrogen receptors; (6) danazol binds to sex hormone-binding globulin and corticosteroid-binding glubulin; (7) danazol inhibits multiple enzymes of steroidogenesis; (8) danazol increases the metabolic clearance rate of progesterone; and (9) metabolites of danazol are hormonally active. Given the complex pharmacology of danazol it is inappropriate to continue to refer to danazol as a “selective antigonadotropin.”

212 - Endocrine Pharmacology of Reproduction(23);Regulatory effects of Prolactin and PGF2O1 on luteinized ovary in rats.

212 - Endocrine Pharmacology of Reproduction(23);Regulatory effects of Prolactin and PGF2O1 on luteinized ovary in rats.

An Endocrine Pharmacology Course for the Clinically-Oriented Pharmacy Curriculum

An Endocrine Pharmacology Course for the Clinically-Oriented Pharmacy Curriculum

Pharmacologic alteration of steroid hormone functions.

A large number of compounds can modify the function, synthesis, or metabolism of steroid hormones. These are not necessarily otherwise related chemically or pharmacologically. The drugs used as examples in this review were selected to show the wide variety of potential sites and modes of action. While many compounds have been shown to interfere with one or another step in the biosynthesis of corticosteroids, the number of known substances having any profound effect on gonadal steroidogenesis is surprisingly few. On the other hand, many more compounds are known either to mimic or modify the end‐organ response to gonadal than to adrenal steroids. The field of endocrine pharmacology is being rapidly widened as systematic searches are now being made for drugs which affect endocrine function either as a primary or incidental action.

Studies in endocrine pharmacology. Biologic actions of some natural steroids on the liver.

Studies in endocrine pharmacology. Biologic actions of some natural steroids on the liver.

Endocrine pharmacology of methyl reserpate derivatives.

Five derivatives of methyl reserpate were compared with reserpine in rats concerning the effects on growth, organ weights, estrus, fertility, ACTH release, blood pressure in adrenal regeneration hypertension, and on electrolyte and water excretion. The relative potency of the new compounds differed markedly both among themselves and from reserpine, depending on the parameters measured. Tetrahydropyranyl methyl reserpate (Su-7064) showed the greatest specificity in suppressing estrus and fertility, in stimulating ACTH release and in altering kidney function. In these respects its activities equaled or exceeded those of other compounds which had greater sedative, hypotensive and growth-retarding potencies. Under the conditions used, the ACTH-releasing effect of reserpine was blocked by iproniazid, whereas that following exposure to cold was only partially blocked.

Endocrine pharmacology.

Endocrine pharmacology.

Ergotoxine inhibition of deciduoma formation and its reversal by progesterone.

ArticleErgotoxine Inhibition of Deciduoma Formation and Its Reversal by ProgesteroneM. C. ShelesnyakM. C. ShelesnyakFrom the Department of Experimental Biology, Weismann Institute of Science, Rehovoth, IsraelPublished Online:31 Oct 1954https://doi.org/10.1152/ajplegacy.1954.179.2.301MoreSectionsPDF (880 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByANNIVERSARY REVIEW: 50 years since the discovery of bromocriptineEuropean Journal of Endocrinology, Vol. 179, No. 2TIDAL WAVES: Network mechanisms in the neuroendocrine control of prolactin releaseFrontiers in Neuroendocrinology, Vol. 35, No. 4Dopamine Agonist Therapy for HyperprolactinemiaClinical Obstetrics and Gynecology, Vol. 46, No. 2Electrochemical oxidation of lysergic acid-type ergot alkaloids in acetonitrile. Part 1. Stoichiometry of the anodic oxidation electrode reactionAnalytica Chimica Acta, Vol. 282, No. 2Effect of Hypo and Hyperprolactinemia on the Testicular Maturation of Wistar Rats During Puberal Transition26 September 2008 | Archives Internationales de Physiologie et de Biochimie, Vol. 97, No. 5SterilitätA History of Research on NidationAnnals of the New York Academy of Sciences, Vol. 476, No. 1 NidationThe History and Pharmacology of Dopamine Agonists18 September 2015 | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Vol. 11, No. S1Dopamine agonists and Parkinson's diseaseClinical Neurology and Neurosurgery, Vol. 86, No. 3Bromocriptine: endocrine pharmacology and therapeutic applicationsFertility and Sterility, Vol. 39, No. 6Hormones as Etiological Agents in NeoplasiaProlactin: Synthesis, Fate and ActionsControl of Proclactin SecretionInhibitors of Prolactin SecretionEffects of (-)-Trans-Δ 9 -Tetrahydrocannabinol on Serum Prolactin in the Pseudopregnant Rat7 August 2009 | Endocrine Research Communications, Vol. 9, No. 1Bromocriptine and Its Use in Parkinsonism27 April 2015 | Journal of the American Geriatrics Society, Vol. 29, No. 6The endocrine profile of bromocriptine: Its application in endocrine diseasesJournal of Neural Transmission, Vol. 51, No. 1-2Dopamine receptor topographyBiochemical Pharmacology, Vol. 28, No. 20Pharmacology of Ergot Alkaloids in Clinical Use1 November 1978 | Medical Journal of Australia, Vol. 2, No. S2_Part2Ergot alkaloids and the modulation of hypothalamic functionIntroduction to the Pharmacology of Ergot Alkaloids and Related Compounds as a Basis of Their Therapeutic ApplicationToxicologic ConsiderationsEffects on the Central Nervous SystemInfluence on the Endocrine SystemEndocrine profile of ergot alkaloidsLife Sciences, Vol. 21, No. 11Bile, Prolactin, and the Maternal PheromoneScience, Vol. 196, No. 4285The Implantation ReactionBromocriptineInhibitory Effects of 2-Br-α-Ergocryptine (CB 154) on Prolactin Secretion in the Crested Newt.12 November 2009 | Bolletino di zoologia, Vol. 43, No. 1-2Galactorrhea-Amenorrhea, Brom-Ergocryptine, and the Dopamine ReceptorNew England Journal of Medicine, Vol. 293, No. 9GENE FREQUENCIES AND HISTORYThe Lancet, Vol. 305, No. 7915BROMOCRIPTINEThe Lancet, Vol. 305, No. 7915Hormones as Etiological Agents in NeoplasiaCommentsChapter 1 The Ergot AlkaloidsMaternal pheromonePhysiology & Behavior, Vol. 13, No. 3Influence of ergot alkaloids on pituitary prolactin and prolactin‐dependent processesJournal of Pharmaceutical Sciences, Vol. 62, No. 5Endocrine control of the maternal pheromone in the postpartum female ratPhysiology & Behavior, Vol. 10, No. 1Growth Hormone and Prolactin from Rat Pituitary Tumor Cells11Preparation of this review and the results of original experiments described were supported in part by a research grant from the USPHS (AM 11011). P. S. Dannies is a Postdoctoral Research Fellow of The Arthritis Foundation.Effects of 2-Br-α-ergocryptine on plasma prolactin level and milk yield in cowsExperientia, Vol. 28, No. 5Pharmacological Control of Reproduction in WomenEffects of Drugs on Neuroendocrine ProcessesStudies on the mechanism of ergocornine interference with decidualization and nidation III urinary steroids after administration of ergocornine to womenLife Sciences, Vol. 2, No. 1Carbonic Anhydrase in the Deciduoma of the RatNature, Vol. 184, No. 4691 More from this issue > Volume 179Issue 2October 1954Pages 301-304 Copyright & PermissionsCopyright © 1954 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1954.179.2.301PubMed13218163History Received 23 February 1954 Published online 31 October 1954 Published in print 31 October 1954 Metrics