Endocrine Disorders In Children Research Articles

29. Application of high-resolution capillary gas chromatography to the evaluation of urinary steroid-spectra in different endocrine disorders of childhood

29. Application of high-resolution capillary gas chromatography to the evaluation of urinary steroid-spectra in different endocrine disorders of childhood

Syndrome of ocular and facial anomalies, telecanthus, and deafness

adolescence, ed. 2, Springfield, II1., 1957, Charles C Thomas, Publisher, p. 348. 8. Wilkins, L., BIizzard, R. M., and Migeon, C. J., editors: The diagnosis and treatment of endocrine disorders in childhood and adolescence, ed. 3, Springfield, Ill., 1965, Charles C Thomas, Publisher, p. 418. 9. Wilkins, L., Blizzard, R. M., and Migeon, C. J., editors: The diagnosis and treatment of endocrine disorders in childhood and adolescence, ed. 3, Springfield, Ill., 1965, Charles C Thomas, Publisher, p. 419.

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence.

Lawson Wilkins was putting the final touches on the third edition of his celebrated textbook when death overtook him in the autumn of 1963. His colleagues and successors, Drs. Robert Blizzard and Claude Migeon have performed an invaluable service by updating certain sections and carrying the final editorial tasks through to completion. Thus, this revision is not only the final monument to the man who founded the modern school of pediatric endocrinology, but also the most up-to-date textbook of endocrinology now available. The format and subject headings of the third edition have not been changed substantially from the second edition, although there are 90 additional pages of text. The entire book has been thoroughly revised and in nearly every section are incorporated new data, new value judgements, and new formulations of previous thinking. The sections on abnormalities of sex differentiation; the adrenal, calcium, and phosphate metabolism; carbohydrate metabolism; and the

Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

Virilizing congenital adrenal hyperplasia: twenty-five years later.

Article1 May 1961VIRILIZING CONGENITAL ADRENAL HYPERPLASIA: TWENTY-FIVE YEARS LATERJOHN E. JOHNSON JR., M.D.JOHN E. JOHNSON JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-924 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the most remarkable advances in clinical endocrinology has been the elucidation of the pathogenesis, clinical features, and treatment of congenital adrenal hyperplasia.1-3In the fetal adrenal cortex of affected persons, synthesis of hydrocortisone is defective owing to a deficiency of specific hydroxylating enzymes. A larger amount of adrenocorticotrophin (ACTH) stimulation of the adrenal is necessary to produce that blood level of hydrocortisone which will in turn suppress and regulate pituitary production of ACTH. Thus, an equilibrium is established at a supranormal level of ACTH release, which causes morphologic hyperplasia of the adrenal cortex. The functional concomitant is increased...Bibliography1. BartterAlbrightForbesLeafDempseyCarroll FCFAPAEE: The effects of adrenocorticotropic hormone and cortisone in the adrenogenital syndrome associated with congenital adrenal hyperplasia: an attempt to explain and correct its disordered hormonal pattern. J. Clin. Invest. 30: 237-251 (March) 1951. CrossrefMedlineGoogle Scholar2. Jailer JW: Virilism. Bull. N. Y. Acad. Med. 27: 377-394 (May) 1953. Google Scholar3. WilkinsBongiovanniClaytonGrumbachVan Wyk LAMGWMMJJ: Virilizing adrenal hyperplasia: its treatment with cortisone and the nature of the steroid abnormalities, in Ciba Foundation Colloquia on Endocrinology, Vol. 8. Little, Brown and Company, Boston, pp. 460-486 (June) 1954. Google Scholar4. Wilkins L: The diagnosis and treatment of endocrine disorders in childhood and adolescence. Charles C Thomas, Springfield, Ill., 1957, pp. 347-348. Google Scholar5. EberleinBongiovanni WRAM: Congenital adrenal hyperplasia with hypertension: unusual steroid pattern in blood and urine. J. Clin. Endocr. 15: 1531-1538 (Dec.) 1955. CrossrefGoogle Scholar6. O'Farrell JM: Hereditary hermaphroditism: report of three cases, J. A. M. A. 104: 1968-1972 (June 1) 1935. CrossrefGoogle Scholar7. JohnsonRemmersClaytonGregory JEARGWR: Brief recording: the short term effect of amphenone in a patient with congenital adrenal hyperplasia, Tex. Rep. Biol. Med., 15: 381-385 (Fall) 1957. MedlineGoogle Scholar8. Young HH: Genital abnormalities, hermaphroditism and related adrenal diseases. The Williams & Wilkins Co., Baltimore, 1937. Google Scholar9. HamwiSerbinKruger GJRAFA: Does adrenocortical hyperplasia result in adrenocortical carcinoma? New Engl. J. Med. 257: 1153-1157, 1957. CrossrefMedlineGoogle Scholar10. ChildsGrumbachVan Wyk BFMMJJ: Virilizing adrenal hyperplasia; a genetic and hormonal study. J. Clin. Invest. 35: 213-223, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Galveston, Texas*Received for publication October 20, 1960.From the Department of Internal Medicine and the John Sealy Memorial Laboratory for Clinical Research, The University of Texas—Medical Branch, Galveston, Tex.Requests for reprints should be addressed to John E. Johnson, Jr., M.D., Assistant Professor of Medicine, The University of Texas—Medical Branch, Galveston, Tex. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFertility among women with classical congenital adrenal hyperplasia: Report of seven cases where treatment was started after 9 years of ageAdrenogenital syndrome: absence of the vagina with pregnancy and successful delivery 1 May 1961Volume 54, Issue 5Page: 924-937KeywordsAdrenal cortexAdrenocorticotropic hormoneCongenital adrenal hyperplasiaCorticosteroid therapyEndocrinologyEnzymesExcretionGenital anatomyPathogenesisResearch laboratories Issue Published: 1 May 1961 PDF downloadLoading ...

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence.

This is a revised edition of a book which has proved itself an excellent clinical reference source during the past seven years. The book is written for the clinician, and each subject is approached from the standpoint of the clinician faced with the differential diagnosis of a congenital anomaly or an endocrine disorder which may be helped by treatment. New chapters discuss the chemistry and physiology of the thyroid and adrenal hormones. The therapeutic use of cortisone in the adrenogenital syndrome stems from the author's pioneer work in this syndrome, which established its basic etiology. The author shows his acumen in withholding judgment of the clinical significance of the chromatin test in various genital malformations. He suggests that the term "intersex" be reserved for those cases which are not due to adrenal disorders. A chapter entitled "Diagnostic Methods: Hormones, Assays and Tests" explains chemical nomenclature, discusses the general principles of

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

ENDOCRINE DISORDERS IN CHILDREN

It is obvious that endocrine disorders in childhood and infancy covers such a vast field that it can not be covered in a short introductory paper. In the following an attempt is made to discuss these disorders from a general and especially paediatric point of view, mentioning some of the problems encountered by the author.

Endocrine Disorders in Childhood and Adolescence

Endocrine Disorders in Childhood and Adolescence

Congenital hyperplasia of the adrenals in the female (female pseudohermaphrodism); the report of a case treated with cortisone and estrogen.

Case Reports1 April 1954CONGENITAL HYPERPLASIA OF THE ADRENALS IN THE FEMALE (FEMALE PSEUDOHERMAPHRODISM): THE REPORT OF A CASE TREATED WITH CORTISONE AND ESTROGENJOHN R. TOBIN JR., M.D.JOHN R. TOBIN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-4-797 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOf the relatively uncommon symptom complexes which comprise the adrenogenital syndrome, female pseudohermaphrodism is the most frequently encountered. An almost uniform abnormality of sex differentiation characterizes female pseudohermaphrodism and suggests that the excessive production of androgen by hyperplastic adrenals begins in the third to fifth month of embryonic development.1, aAt birth these infants have ovaries, their müllerian duct system has undergone normal female development to form fallopian tubes, uterus and vagina, and the wolffian ducts have disappeared; but the genital duct continues to open into the urethra, forming a persistent urogenital sinus as in the male. After birth, rapid...Bibliography1. Wilkins L: The diagnosis and treatment of endocrine disorders in childhood and adolescence, 1950, Charles C Thomas, Springfield, Illinois, (a) p. 222, (b) Chapter XV, figure 3. Google Scholar2. WilkinsGardnerCriglerSilvermanMigeon LLIJFSHCJ (a) : Further studies on the treatment of congenital adrenal hyperplasia with cortisone. I. Comparison of oral and intramuscular administration of cortisone, with a note on the suppressive action of compounds F and B on the adrenal, J. Clin. Endocrinol. 12: 257, 1952. (b) Wilkins, L., Crigler, J. F., Jr., Silverman, S. H., Gardner, L. I., and Migeon, C. J.: Further studies on the treatment of congenital adrenal hyperplasia with cortisone. II. The effects of cortisone on sexual and somatic development, with an hypothesis concerning the mechanism of feminization, J. Clin. Endocrinol. 12: 277, 1952. CrossrefGoogle Scholar3. DreketerPearsonBartczakMcGavak IJSETH: A rapid method for the determination of total urinary 17-ketosteroids, J. Clin. Endocrinol. 8: 295, 1948. Google Scholar4. KelleyElyRaile VCRSRB: Metabolic studies in patients with congenital adrenal hyperplasia. Effects of cortisone therapy, J. Clin. Endocrinol. 12: 1140, 1952. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Spokane, Washington*Received for publication August 19, 1953.From the Department of Medicine of the Rockwood Clinic, Spokane, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1954Volume 40, Issue 4Page: 797-803KeywordsAndrogensBirthEstrogensGenital anatomyInfantsOvariesUterusVagina ePublished: 1 December 2008 Issue Published: 1 April 1954 PDF downloadLoading ...

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence.

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence.

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence. Lawson Wilkins

Previous articleNext article No AccessNew Biological BooksThe Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence. Lawson Wilkins William M. SeaboldWilliam M. Seabold Search for more articles by this author PDFPDF PLUS Add to favoritesDownload CitationTrack CitationsPermissionsReprints Share onFacebookTwitterLinkedInRedditEmail SectionsMoreDetailsFiguresReferencesCited by The Quarterly Review of Biology Volume 26, Number 4Dec., 1951 Published in association with Stony Brook University Article DOIhttps://doi.org/10.1086/398594 Views: 1Total views on this site PDF download Crossref reports no articles citing this article.

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence

Endocrinology of Childhood

The article illustrates the special problems of endocrinology in childhood, where disturbances of growth and development may be explained by disorders of the endocrine organs. To-day, as a result of early diagnosis and effective treatment the understanding of the spontaneous course of some classical endocrine disorders in children is known essentially from historical descriptions. This article also describes the historical development of childhood endocrinology in Denmark.