Congenital hyperplasia of the adrenals in the female (female pseudohermaphrodism); the report of a case treated with cortisone and estrogen.

Abstract

Case Reports1 April 1954CONGENITAL HYPERPLASIA OF THE ADRENALS IN THE FEMALE (FEMALE PSEUDOHERMAPHRODISM): THE REPORT OF A CASE TREATED WITH CORTISONE AND ESTROGENJOHN R. TOBIN JR., M.D.JOHN R. TOBIN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-4-797 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOf the relatively uncommon symptom complexes which comprise the adrenogenital syndrome, female pseudohermaphrodism is the most frequently encountered. An almost uniform abnormality of sex differentiation characterizes female pseudohermaphrodism and suggests that the excessive production of androgen by hyperplastic adrenals begins in the third to fifth month of embryonic development.1, aAt birth these infants have ovaries, their müllerian duct system has undergone normal female development to form fallopian tubes, uterus and vagina, and the wolffian ducts have disappeared; but the genital duct continues to open into the urethra, forming a persistent urogenital sinus as in the male. After birth, rapid...Bibliography1. Wilkins L: The diagnosis and treatment of endocrine disorders in childhood and adolescence, 1950, Charles C Thomas, Springfield, Illinois, (a) p. 222, (b) Chapter XV, figure 3. Google Scholar2. WilkinsGardnerCriglerSilvermanMigeon LLIJFSHCJ (a) : Further studies on the treatment of congenital adrenal hyperplasia with cortisone. I. Comparison of oral and intramuscular administration of cortisone, with a note on the suppressive action of compounds F and B on the adrenal, J. Clin. Endocrinol. 12: 257, 1952. (b) Wilkins, L., Crigler, J. F., Jr., Silverman, S. H., Gardner, L. I., and Migeon, C. J.: Further studies on the treatment of congenital adrenal hyperplasia with cortisone. II. The effects of cortisone on sexual and somatic development, with an hypothesis concerning the mechanism of feminization, J. Clin. Endocrinol. 12: 277, 1952. CrossrefGoogle Scholar3. DreketerPearsonBartczakMcGavak IJSETH: A rapid method for the determination of total urinary 17-ketosteroids, J. Clin. Endocrinol. 8: 295, 1948. Google Scholar4. KelleyElyRaile VCRSRB: Metabolic studies in patients with congenital adrenal hyperplasia. Effects of cortisone therapy, J. Clin. Endocrinol. 12: 1140, 1952. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Spokane, Washington*Received for publication August 19, 1953.From the Department of Medicine of the Rockwood Clinic, Spokane, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1954Volume 40, Issue 4Page: 797-803KeywordsAndrogensBirthEstrogensGenital anatomyInfantsOvariesUterusVagina ePublished: 1 December 2008 Issue Published: 1 April 1954 PDF downloadLoading ...