End of life vehicle (ELV) is a significant renewable resource with enormous economic value and environmental value. This paper introduced a novel approach that combines the gray correlation and Decision Making Trial and Evaluation Laboratory (DEMATEL) with an interactive technique in order to consider both quantitative and qualitative features simultaneously in ELV plant facility layout problem. The gray interval number of gray correlation is used as the expert’s evaluation score of the impact factor of the ELV dismantling plant, DEMATEL constructs a direct impact matrix by analyzing the causal relationship between various influencing factors in the system. The proposed approach is applied to the case of a realistic ELV dismantling plant, and the evaluation framework for an ELV plant layout alternatives and design assessment analysis also conducted. The results show that it provides a systematic decision support tool and a feasible approach for evaluation of ELV disassembly plant layout alternatives.