Emulsion Technology Research Articles

Microgels for bioprinting: recent advancements and challenges.

Microgels have become a popular and powerful structural unit in the bioprinting field due to their advanced properties, ranging from the tiny size and well-connected hydrogel (nutrient) network to special rheological properties. Different microgels can be fabricated by a variety of fabrication methods including bulk crushing, auxiliary dripping, multiphase emulsion, and lithography technology. Traditionally, microgels can encapsulate specific cells and are used for in vitro disease models and in vivo organ regeneration. Furthermore, microgels can serve as a drug carrier to realize controlled release of drug molecules. Apart from being used as an independent application unit, recently, these microgels are widely applied as a specific bioink component in 3D bioprinting for in situ tissue repair or building special 3D structures. In this review, we introduce different methods used to generate microgels and the microgel-based bioink for bioprinting. Besides, the further tendency of microgel development in future is introduced and predicted to provide guidance for related researchers in exploring more effective ways to fabricate microgels and more potential bioprinting application cases as multifunctional bioink components.

Cinnabaris modified with SiO2 nanoparticles stabilized Pickering emulsion to improve the photostability of volatile oil: A Lingzhu San case study

The pharmacological activity of volatile oils (VOs) is significant, but they can generate peroxides under light conditions, reducing the VO content and affecting their stability. This study aims to introduce Pickering emulsion technology to enhance the antioxidant activity of VOs and improve the photostability and efficacy of solid formulations. In this work, Cinnabaris was used as a stabilizer in the formulation of Lingzhu San to prepare Pickering emulsions using high-speed shearing. By controlling the duration of light exposure, the retention rate, degree of oxidation, and changes in volatile components of the volatile oil of Acorus tatarinowii Schott (AT-VO) were compared between the crude oil group and the Pickering emulsion group. Compared with the crude oil group, the Pickering emulsion group significantly improved the retention rate, reduced the degree of oxidation, and mitigated the changes in volatile components. GC–MS analysis of the quantitative and qualitative changes showed that the volatile components of the oil retained by the Pickering emulsion were closer to the untreated AT-VO in the light environment. In addition, the Pickering emulsion with water as the outer phase and oil as the inner phase retarded the formation of peroxides in the VOs and achieved the goal of maintaining the photostability of the VOs.

Enhanced micro-explosion to improve the yield of light oil in catalytic cracking of water-in-heavy oil emulsion prepared by continuous membrane emulsification

Membrane emulsification provides new ideas for improving the atomization performance of high viscosity heavy oil in catalytic cracking process, thereby improving the distribution of catalytic cracking products. A comprehensive understanding of the micro-explosion characteristics and catalytic cracking of low water content heavy oil emulsion is the key to the application of membrane emulsification technology in heavy oil catalytic cracking process. Therefore, different water droplet sizes and water content of heavy oil emulsion were controllably prepared by continuous membrane emulsification, and their micro-explosion characteristics and catalytic cracking performance were investigated. The evaporation of heavy oil emulsion droplets (water content over 3 vol%) only underwent the heat transfer stage and the fluctuating evaporation stage due to the strong micro-explosion. The micro-explosion delay time of emulsion droplets decreased from 2.631 to 0.434 s/mm2 with increased temperature (300–600 ℃), increased from 0.645 to 1.042 s/mm2 with increased water content (1–5 vol%), and increased from 0.642 to 1.237 s/mm2 with increased average droplet size (1.80–14.6 μm). The child droplets generated after micro-explosion were characterized, and the different heating behaviors were quantitatively distinguished by the average size of the child droplets. Additionally, the micro-explosion performance (i.e. child droplets size and strong micro-explosion probability) of emulsion droplets improved with increasing water content and average water droplet size, while it initially decreased and then increased when the temperature increased. Furthermore, the improvement of micro-explosion performance by membrane emulsification can increase the yield of light oil (up to a maximum increase of 10.82 %) and reduce the yield of coke (up to a maximum decrease of 5.99 %) in the heavy oil emulsion catalytic cracking.

Enhanced O/W emulsion stability and betanin protection using yeast protein and chitooligosaccharide: Comparative insights from complex coacervation and layer-by-layer methods

Emulsions play a pivotal role in food and related industries, yet oil-in-water (O/W) emulsions, a staple emulsion, are plagued by instability issues like aggregation, flocculation, and gravitational separation during storage. Stabilizing these emulsions has often involved the use of proteins or polysaccharides. Within this context, this research delves into comparing two distinctive stabilization strategies for emulsions. The yeast protein (YP), chitooligosaccharide (COS), and betanin were employed to formulate a complexation emulsion (CE) using a complex coacervation method, and a bilayer emulsion (BE) through a layer-by-layer method. The effects of these divergent methods on the emulsion's physicochemical properties, microscopic structure, and the stability of betanin was assessed. The findings indicate that the yeast protein-chitooligosaccharide-betanin (YCB) emulsion prepared using the layer-by-layer method demonstrated the smallest droplet size and the greatest absolute ζ-potential. After a storage period of seven days, this emulsion showed the lowest emulsification index, indicating excellent storage stability. In tandem, an increase in apparent viscosity was observed, with the emulsion exhibiting weak gel-like behavior. The incorporation of betanin has improved the physical stability of emulsions, and concurrently, the emulsion presented an improved storage stability of betanin. These results provide insightful perspectives for the development of emulsions based on bilayer interfaces, contributing to the expansion of novel fungal protein applications in the fields of emulsion technology, food processing, and the stabilization of bioactive molecules.

Safety considerations of static sensitization emulsification technology for Kings-type emulsion explosives based on quadratic linear programming algorithm

Abstract This paper collects data on the static sensitization emulsification process flow of Kings-type emulsion explosives, analyzes the collected data by combining the indicator factors and probability density functions in the time-domain analysis, and designs a safety monitor for the static sensitization process flow. In order to pursue more rigorous production safety, the static sensitization process optimization objective function was determined, and the function was constrained as well as quadratically linearized to construct a static sensitization process safety optimization model based on quadratic linear programming. After analysis, it is concluded that the safety factors affecting the static sensitization process are temperature, sensitizer, number of sensitizer stages and pressure. Other conditions are the same, the foaming density can finally reach 1.23g/cm 3 when low-temperature static sensitization, but the time spent is longer 14h, and the foaming density decreases from 1.41g/cm 3 to 1.09g/cm 3 as the amount of sensitizer increases.

Assessment of curcumin self-emulsion containing high methoxyl pectin-whey protein complex: Quality stability by thermal, freeze-thaw treatment, and release characteristics

Polysaccharide-protein complexes have been commonly used in recent years to improve the quality and stability of emulsions. In this study, we evaluated the effect of high methoxyl pectin-whey protein complex (HWC) on the storage stability and in vitro release characteristics of curcumin self-emulsion systems. The droplet size and loading of the curcumin self-emulsion system were approximately 306.60–353.45 nm and 2.21 mg/mL, respectively, with good dispersibility. The thermal stability of HWC was significantly increased (p < 0.05) by the formation of amide groups at pH 5, as confirmed by Fourier transform infrared spectroscopy. After three rounds of freeze-thaw cycles, the stability and retention rate of curcumin approached 92.98 and 97.83%, respectively (p < 0.05). The retention rate increased from 43.81 to 51.76% during a 20-day storage test in a light environment by adding whey protein to improve photostability. In the in vitro gastrointestinal test, the release rate in simulated gastric fluid decreased from 67.71 to 47.50% in 60 min and increased from 62.22 to 73.17% in simulated intestinal fluid in 90 min. Thus, emulsification technology can be used to improve the quality and stability of curcumin processing and can be applied to health food development.

Stability of Hydroxy-α-Sanshool in Medium-Chain Triglyceride Oil and Corresponding Oil/Water Emulsions.

The pungent component of sansho (Japanese pepper, Zanthoxylum pipritum) is sanshool, which is easily oxidized and decomposed. We have previously reported several sanshool stabilizers, such as α-tocopherol (α-Toc). Sansho pericarp powder treated with middle-chain triglycerides (MCTs) can be used to obtain extracts containing hydroxy-α-sanshool (HαS). Although HαS is stabilized when α-Toc is added to the MCT extracts, the loss of HαS is accelerated when it is mixed with a powder such as lactose. The separation of α-Toc from sanshools was thought to inevitably lead to their oxidation. Therefore, using sansho pericarp MCT extracts with or without α-Toc, oil/water (o/w) emulsions were prepared by adding a surfactant, glycerin, and water to these extracts. In both emulsions, HαS was stable in accelerated tests at 50 °C. However, when lactose powder was added to the emulsions and an accelerated test was performed, HαS in the emulsion containing α-Toc was stable, but HαS in the emulsion without α-Toc was unstable. These results highlight the importance of maintaining the close proximity of HαS and α-Toc in the emulsion. The stabilization of sanshools using emulsion technology can facilitate the production of various processed beverages, foods, cosmetics, and pharmaceuticals containing Japanese pepper.

Emulsion Technology in Nuclear Medicine: Targeted Radionuclide Therapies, Radiosensitizers, and Imaging Agents.

Radiopharmaceuticals serve as a major part of nuclear medicine contributing to both diagnosis and treatment of several diseases, especially cancers. Currently, most radiopharmaceuticals are based on small molecules with targeting ability. However, some concerns over their stability or non-specific interactions leading to off-target localization are among the major challenges that need to be overcome. Emulsion technology has great potential for the fabrication of carrier systems for radiopharmaceuticals. It can be used to create particles with different compositions, structures, sizes, and surface characteristics from a wide range of generally recognized as safe (GRAS) materials, which allows their functionality to be tuned for specific applications. In particular, it is possible to carry out surface modifications to introduce targeting and stealth properties, as well as to control the particle dimensions to manipulate diffusion and penetration properties. Moreover, emulsion preparation methods are usually simple, economic, robust, and scalable, which makes them suitable for medical applications. In this review, we highlight the potential of emulsion technology in nuclear medicine for developing targeted radionuclide therapies, for use as radiosensitizers, and for application in radiotracer delivery in gamma imaging techniques.

Safety of Tazarotene 0.045% Lotion and Hyperpigmentation Improvements in Black Participants With Moderate-to-Severe Acne

Introduction: Post-inflammatory hyperpigmentation (PIH) that results from acne in patients with skin of color may be more distressing than the acne itself, and likely impacts patients with higher skin phototypes more greatly than those with lower skin phototypes. Topical retinoids, a mainstay of acne treatment, can also reduce hyperpigmentation. For example, significant PIH improvements with a cream formulation of the retinoid tazarotene (0.1%) were observed following 16 weeks of treatment in patients with acne. However, skin irritation and other skin reactions may limit use of some tazarotene gel and cream formulations. A hydrating, lower-dose tazarotene 0.045% lotion formulation utilizes polymeric emulsion technology to allow for more efficient delivery of tazarotene into dermal layers while reducing potential for skin irritation. This pooled, post hoc analysis evaluates safety of tazarotene 0.045% lotion and its effect on hyperpigmentation in Black individuals with acne.&#x0D; Methods: In two identical phase 3 randomized, double-blind, vehicle-controlled, studies (NCT03168321; NCT03168334), participants aged ≥9 years with moderate-to-severe acne (Evaluator's Global Severity Score of 3/4) were randomized (1:1) to once-daily tazarotene 0.045% or vehicle lotion for 12 weeks. Safety evaluations included adverse events (AEs) reports and investigator-assessed hyperpigmentation (4-point scale: 0 [none] to 3 [severe]). Post hoc analyses were based on participants’ self-identification of race, including ‘Black or African American’ (herein referred to as Black).&#x0D; Results: Of 1,614 participants randomized in the two phase 3 studies, 262 (16%) self-identified as Black. The safety population comprised 253 Black participants. The most common TEAEs with tazarotene 0.045% lotion were at the application site: pain (6.6%), exfoliation (5.0%), and dryness (3.3%). No Black participants reported application site irritation or dermatitis with tazarotene lotion. Hyperpigmentation rates in Black participants, which were high at baseline, decreased by week 12 with tazarotene treatment (40.5% to 31.4%) compared to vehicle (37.9% to 37.2%).&#x0D; Conclusions: Acne regimens that maximize efficacy while mitigating irritation is key to managing acne in patients with skin of color, given the higher pigmentary alteration risk in melanin-rich skin. Tazarotene 0.045% lotion was safe and well tolerated in Black participants, with no application-site irritation or dermatitis after 12 weeks of once-daily treatment. Tazarotene also led to improvements in hyperpigmentation, an inflammation-associated sequala of acne. As PIH can take longer than 12 weeks to resolve with treatment, additional improvements in hyperpigmentation may be expected with continued tazarotene 0.045% lotion use.&#x0D; Support: Ortho Dermatologics.

Microencapsulation of extra virgin olive oil by sequential emulsification and freeze drying processes: Effect of wall materials composition and emulsification method

AbstractFor a long time, olive oil has been considered for formulation of biopharmaceuticals and received a prestigious place in cuisine for its unique organoleptic and nutritional properties. Nevertheless, oxidation of fatty acids in olive oil provides short shelf-life and undesirable organoleptic properties. Thus, microencapsulation of olive oil is a considerable promising approach to maintain its quality and biological activities. The objective of this investigation was to prepare extra virgin olive oil microcapsule by sequential technologies, such as water emulsification of olive oil with wall material (matrix) and freeze drying of emulsion. The effect of wall material composition was examined to prepare microcapsule of extra virgin olive oil. Different ratios of wall materials such as maltodextrin (MD), carboxymethyl cellulose (CMC), and gum arabic (GA) were used. Furthermore, effects of emulsification technologies, such as homogenisation with rotor–stator homogeniser (RSH) and cross-flow membrane emulsification (CFME) were investigated. The stability of emulsion was higher when emulsion was prepared by RSH; however, the droplet mean diameter (D32) was lower in case of RSH compared to CFME. The highest encapsulation efficiency (EE) was found as 68.96 ± 2.6% when CFME was adopted and composition of wall materials was 15 g MD, 15 g GA, and 5 g CMC.

Hydrophilic TiO2@MXene membrane for direct generation of monodisperse submicron water-in-diesel emulsion and its microexplosion performance

Hydrophilic membrane interfaces, especially that of particle-packed ceramic membranes, are generally not suitable for use as emulsification media for generating monodisperse water-in-oil emulsions. This is because their short adjacent pore distances tend to cause droplet coalescence. In this study, a facile in situ oxidation strategy was proposed to develop ceramic-based hydrophilic TiO2@MXene membranes for directly generating monodisperse submicron water-in-diesel emulsions using membrane emulsification technology at room temperature. Through the in situ oxidation process, numerous TiO2 nanoparticles were grown on the surface of MXene nanosheets to form a novel TiO2@MXene composite structure with a membrane pore size of 12.2 nm. This structure is characterized by abundant transport channels, remarkably robust stability, and high water permeance of 154.8 L m−2 h−1 bar−1. Because of the long horizontal distance between adjacent nanosheets and the substantially reduced transport resistance, water droplets can roll smoothly along the TiO2@MXene nanochannels and then converge with the diesel, thus reducing the risk of emulsion coalescence. The mean droplet size of the emulsions can be controlled from ∼100 to 500 nm by regulating the emulsification conditions. The optimal emulsions exhibited excellent monodispersity with an average droplet size of 157.2 nm and possessed relatively excellent long-term stability (up to 45 days). Moreover, the emulsions showed a positive microexplosion phenomenon during heating. The maximum microexplosion strength of the emulsions reached 6.31 m s−1 (at 20% water content), which provides a reliable theoretical basis for research on emulsified diesel as an alternative to traditional fuels.

Development and Application of Field Mixing Process and Intelligent Mixing Vehicle for Plateau Type Emulsified Explosives for Open Pit Mining

Abstract To improve mine production efficiency, reduce blasting costs, and meet the needs of mine capacity expansion, the use of an on-site mixing emulsion explosives truck for open pit iron ore deep hole step blasting charging operation. This paper firstly briefly introduces the process flow of emulsion explosives production and makes a detailed introduction to the working principle and process control requirements of each section of emulsion explosives production. Based on the analysis of the basic principle of adaptive control, the adaptive PID controller is designed to control the discharge temperature and density of emulsion explosives production and to achieve self-tuning of parameters, which improves the control accuracy of production parameters and product quality. The research results show that the use of field mixing emulsion explosives, and blasting operations personnel was reduced by 40% to 50%, and the drilling workload was reduced by about 7%. The application of field mixing emulsion technology improves the blasting effect, increases shovel loading efficiency, reduces the labor intensity of workers, saves comprehensive mining costs, and reduces the cost of temporary explosives depot guarding and disposal of used packaging in mines.

Fabrication of Poly Dopamine@poly (Lactic Acid-Co-Glycolic Acid) Nanohybrids for Cancer Therapy via a Triple Collaboration Strategy.

Breast cancer is a common malignant tumor among women and has a higher risk of early recurrence, distant metastasis, and poor prognosis. Systemic chemotherapy is still the most widely used treatment for patients with breast cancer. However, unavoidable side effects and acquired resistance severely limit the efficacy of treatment. The multi-drug combination strategy has been identified as an effective tumor therapy pattern. In this investigation, we demonstrated a triple collaboration strategy of incorporating the chemotherapeutic drug doxorubicin (DOX) and anti-angiogenesis agent combretastatin A4 (CA4) into poly(lactic-co-glycolic acid) (PLGA)-based co-delivery nanohybrids (PLGA/DC NPs) via an improved double emulsion technology, and then a polydopamine (PDA) was modified on the PLGA/DC NPs' surface through the self-assembly method for photothermal therapy. In the drug-loaded PDA co-delivery nanohybrids (PDA@PLGA/DC NPs), DOX and CA4 synergistically induced tumor cell apoptosis by interfering with DNA replication and inhibiting tumor angiogenesis, respectively. The controlled release of DOX and CA4-loaded PDA@PLGA NPs in the tumor region was pH dependent and triggered by the hyperthermia generated via laser irradiation. Both in vitro and in vivo studies demonstrated that PDA@PLGA/DC NPs enhanced cytotoxicity under laser irradiation, and combined therapeutic effects were obtained when DOX, CA4, and PDA were integrated into a single nanoplatform. Taken together, the present study demonstrates a nanoplatform for combined DOX, CA4, and photothermal therapy, providing a potentially promising strategy for the synergistic treatment of breast cancer.

Effect of a turmeric-based fertilizer on tomato production at green-house level

Inorganic fertilizers have impacts on the availability of nutrients and the content of organic matter in the soil, as well as on its native microbiota. A turmeric fertilizer (TF) with added food residues and wood ashes was developed to evaluate its effects on tomato production and crop soil properties. The TF was prepared by emulsion technology using three turmeric concentrations expressed as 1.0, 2.5 and 3.0 % w/v; it was characterized according to its rheological (apparent viscosity, consistency and flow behavior indexes) and physical (z-average droplet size) characteristics. Nitrogen, phosphorus and potassium (NPK) levels and moisture-holding capacity were measured in crop soil. Colour, soluble solid content, acidity, diameter and the number of tomatoes were evaluated. The photosynthetic index of the leaves of tomato plants was determined. It was observed that when turmeric concentration increased (&gt; 1.0 % w/v), the droplet size decreased enhancing the physical stability of TF. NPK levels and moisture-holding capacity of the soil improved, especially with turmeric concentrations &gt; 1.0% w/v. Positive effects on the tomato fruit properties (soluble solid content, acidity, diameter and tomato number) and photosynthetic index of tomato plant leaves were observed with turmeric concentrations of 2.5 and 3.0 % w/v. The TF positively influenced the crop soil and the metabolic process of the tomato plants, and the characteristics of its fruits.

Development of the epoxy resin phase change proppant based on the Pickering emulsification technology

Since the conventional solid proppant has many defects, such as poor migration and its rigid structures easy to plug cracks, liquid proppant has become a key development direction. A phase change proppant is developed based on the emulsified thermosetting resin system and evaluated in this paper. On the basis of the bisphenol A type epoxy resin, the phase change proppant system adopts the adduct of diethylene triamine and butyl glycidyl ether as epoxy resin curing agent and the SiO2 particles (1% of the resin mass) as the emulsifier, and then adds the hollow glass microspheres (1.25% of the resin mass) and the absolute ethyl alcohol (25% of the resin mass) as the thinner to reduce resin density and dilute resin. Proppant particles with major sizes of 4.5mm, 3mm, 2-2.5mm, 2mm, 1mm and 0.5mm are obtained through process optimization. After evaluation, the obtained proppants are of low density and high compressive strength, and their migration capability and flow conductivity are qualified for the exploitation of unconventional reservoirs with high closure pressures.

Electric-field-mediated morpho-dynamic evolution in drop–drop coalescence phenomena in the inertio-capillary regime

When two drops collide, they may either exhibit complete coalescence or selectively generate secondary drops, depending on their relative sizes and physical properties, as dictated by a decisive interplay of the viscous, capillary, inertia and gravity effects. Electric field, however, is known to induce distinctive alterations in the topological evolution of the interfaces post-collision, by influencing a two-way nonlinear coupling between electro-mechanics and fluid flow as mediated by a topologically intriguing interfacial deformation. While prior studies primarily focused on the viscous-dominated regime of the resulting electro-coalescence dynamics, several non-intuitive features of the underlying morpho-dynamic evolution over the intertio-capillary regime have thus far remained unaddressed. In this study, we computationally investigate electrically modulated coalescence dynamics along with secondary drop formation mechanisms in the inertio-capillary regime, probing the interactions of two unequal-sized drops subjected to a uniform electric field. Our results bring out an explicit mapping between the observed topological evolution as a function of the respective initial sizes of the parent drops as well as their pertinent electro-physical property ratios. These findings establish electric-field-mediated exclusive controllability of the observed topological features, as well as the critical conditions leading to the transition from partial to complete coalescence phenomena. In a coalescence cascade, an electric field is further shown to orchestrate the numbers of successive stages of coalescence before complete collapse. However, an increase of the numbers of cascade stages with the electric field strength and parent droplet size ratio is non-perpetual, and the same is demonstrated to continue until only a threshold number of cascade stages is reached. These illustrations offer significant insights into leveraging the interplay of electrical, inertial and capillary-driven interactions for controllable drop manipulation via multi-drop interactions for a variety of applications ranging from chemical processing to emulsion technology.

Fabrication of gelatin-EGCG-pectin ternary complex stabilized W/O/W double emulsions by ultrasonic emulsification: Physicochemical stability, rheological properties and structure

Double emulsions have very promising application prospects in the pharmaceutical, cosmetic, and food industries. Nevertheless, its usage in the food industry is restricted mainly due to its immense stability problems. Here, W 1 /O/W 2 double emulsion was prepared by two-step emulsification method using ultrasonic emulsification technology. The physicochemical stability, rheological properties, thermal stability, and microstructure of the double emulsion were investigated. The results revealed that W 1 /O/W 2 double emulsion with optimum stability was prepared on the parameters that the ratio of W 1 (gelatin)/O primary emulsion to the external aqueous phase (gelatin-EGCG-high methoxyl pectin ternary complex) was 6:4, ultrasonic power was 80 W, ultrasonic time was 6 min, and ternary complex concentration was 0.75%. The double emulsion produced under these conditions had the smallest particle size (1143 nm) and the maximum absolute zeta potential value (39.17 ± 0.50 mV). The results of full-featured stability analyzer manifested that the emulsion system no longer underwent phase separation. Confocal laser scanning microscopy (CLSM) successfully observed a uniformly dispersed double emulsion. Furthermore, dynamic rheological properties demonstrated that the cohesive strength of W 1 /O/W 2 double emulsion was strength than that of W 1 /O primary emulsion. Differential scanning calorimetry (DSC) analysis suggested that both remained stable throughout the temperature change, while the W 1 /O/W 2 double emulsion was more thermally stable. Hence, the gelatin-EGCG-high methoxyl pectin ternary complex can act as an effective emulsion stabilizer to stabilize the W 1 /O/W 2 double emulsion. • W/O/W double emulsions were prepared by ultrasonic emulsification method. • Ultrasonic treatment improves the physical stability of the emulsion. • The optimally stable double emulsion system no longer exhibits phase separation. • Ternary complex can be used as emulsion stabilizer to stabilize double emulsion. • Cohesive strength of the double emulsion is enhanced after ultra-sonication.

Protein-Based High Internal Phase Pickering Emulsions: A Review of Their Fabrication, Composition and Future Perspectives in the Food Industry.

Protein-based high internal phase Pickering emulsions (HIPEs) are emulsions using protein particles as a stabilizer in which the volume fraction of the dispersed phase exceeds 74%. Stabilizers are irreversibly adsorbed at the interface of the oil phase and water phase to maintain the droplet structure. Protein-based HIPEs have shown great potential for a variety of fields, including foods, due to the wide range of materials, simple preparation, and good biocompatibility. This review introduces the preparation routes of protein-based HIPEs and summarizes and classifies the preparation methods of protein stabilizers according to their formation mechanism. Further outlined are the types and properties of protein stabilizers used in the present studies, the composition of the oil phase, the encapsulating substances, and the properties of the constituted protein-based HIPEs. Finally, future development of protein-based HIPEs was explored, such as the development of protein-based stabilizers, the improvement of emulsification technology, and the quality control of stabilizers and protein-based HIPEs.

Research on Pickering emulsification technology based on the concept of “combination of medicine and adjuvant” to improve the pH stability of volatile oil in solid preparations—taking Lingzhu Pulvis as an Example

Lingzhu Pulvis are widely used in clinical practice because of their therapeutic effects, but their stability and efficacy are affected by the easy oxidation and volatility of Acorus calamus. In this study, we combined the idea of “combination of medicine and adjuvant” and introduced Pickering emulsion technology to use the ingredients of Lingzhu Pulvis as the stabilizer of Pickering emulsion. Pearl powder was selected as the stabilizer by the type of emulsion formation and the state of emulsion layer, and the optimal preparation method was 0.065 g·ml− 1 of pearl powder and 45% oil, prepared using high-pressure homogenization method (500 bar, three times). The malondialdehyde and peroxide contents in the crude oil and Pickering emulsion groups were analyzed under different pH environments, and it was clear that the Pickering emulsion group possessed higher antioxidant properties. The volatile oil of Acorus calamus in different groups was analyzed using GC-MS, and seven differential components were screened by processing the analytical data with R language, which were further determined that the differential components changed more slowly and had significantly improved stability in the Pickering emulsion group. This study provides a reference for the improvement of stability of other solid formulations containing oil in Chinese medicine.

ГРАНУЛИРОВАННЫЕ КОСТНОПЛАСТИЧЕСКИЕ МАТЕРИАЛЫ НА ОСНОВЕ ТРИКАЛЬЦИЯ ФОСФАТА И ВОЛЛАСТОНИТА

An important area of modern materials science is the development of synthetic materials for bone grafting, providing gradual restoration of damaged hard tissues. In this work, a series of ceramic granular materials with varying contents of tricalcium phosphate and wollastonite were obtained using emulsion technology. It is shown that the synthesized particles have a spherical shape, polydisperse composition (0.1 – 4 mm) and open porosity in the range of 50 – 56%. These characteristics will make it possible to use the developed materials in maxillofacial surgery, traumatology and orthopedics to restore bone defects of any complex shape and location.