Social media has become a valuable tool in providing an opportunity to stay in touch with one’s social networks, providing reassurance and practical advice to individuals to pre-empt panic and rumors in COVID-19. However, the implications of social media use on the everyday emotion (anxiety and depression) of users especially, international students, are not well understood. Thus, this study sought to examine the impact of social media use on the everyday emotion of international students in China during COVID-19. Using a structured online questionnaire based on modified questions from the generalized anxiety disorder 7 (GAD-7) and the Patient Health Questionnaire 9 (PHQ-9) and social media use instruments, data were collected from 480 participants. Of the total responses received, 474 were further analyzed employing the Partial Least Squares Path Modelling (PLS-PM). This study showed a significant positive relationship between social media use and everyday emotion (B = 0.34, 95% CI (0.26, 0.44)). Additionally, self-rated anxiety and depression associated with social media use among international students were generally mild (n = 249, 52.50% and n = 350, 73.80%, respectively). Moderating effects revealed that age and sex do not significantly moderate the relationship between social media use and everyday emotion in COVID-19. Given the nature of social media among international students, who are also prone to suffering from anxiety and depression associated with social media use, the positive effect of social media use and everyday emotion, especially in COVID-19, has important implications for international students’ education stakeholders. Thus, gaining a deeper understanding of this relationship could enable them to harness social media and use it as a valuable tool to overcome the social distancing constraints in COVID-19.