Emotional Abuse Research Articles

Association between self-reported child maltreatment and risk of hospital-treated infectious diseases in middle-aged and older adults: A UK Biobank cohort study.

This study aimed to explore the association between child maltreatment and hospital-treated infectious diseases in middle-aged and older adults. 145,151 participants aged 38-72 years from the UK Biobank between 2006 and 2010 were enrolled and interviewed. Child maltreatment included five types: physical abuse, physical neglect, emotional abuse, emotional neglect, and sexual abuse. Patterns of maltreatment were identified using latent class analysis (LCA). Cox regression was employed to estimate the associations between child maltreatment (number of types, individual types, and patterns) and infectious diseases. Further, we evaluated potential mediators using mediation analysis. Over a median follow-up of 13.4 years, 22,688 participants (12.26 per 1000 person-years) were hospitalized for an infectious disease. Participants reporting any maltreatment had elevated infectious diseases risk (HR 1.18, 95 % CI: 1.15-1.21) than those without maltreatment. A dose-response relationship was observed between the number of maltreatment types and infectious disease (one, HR 1.09 [95 % CI 1.06-1.13]; two, HR 1.17 [95 % CI 1.12-1.23]; three to five, HR 1.48 [95 %CI 1.41-1.55]; Ptrend < 0.001). Each type of maltreatment was associated with increased infectious diseases risk. LCA identified four patterns (low maltreatment, child neglect, child abuse, and poly-maltreatment), with those experiencing poly-maltreatment exhibiting the highest infectious diseases risk (HR 1.51, 95 % CI: 1.43-1.59). The association between child maltreatment and infectious diseases was mediated by C-reactive protein, phenotypic age acceleration, loneliness, psychiatric disorders, and unhealthy lifestyles. Child maltreatment may increase susceptibility to a broad spectrum of infectious diseases in adulthood, highlighting the need for early-life maltreatment prevention policies.

The oral acute toxicity of per- and polyfluoroalkyl compounds (PFASs) to Rat and Mouse: a mechanistic interpretation and prioritization analysis of untested PFASs by QSAR, q-RASAR and interspecies modelling methods

Per- and polyfluoroalkyl substances (PFASs) are widely used in modern industry, causing many adverse effects on both the environment and human health. In this study, for the first time, we followed OECD guidelines to systematically investigated the quantitative structure-activity relationship (QSAR) of the oral acute toxicity of PFASs to Rat and Mouse using simple 2D descriptors. The Read-Across similarity descriptors and 2D descriptors were also combined to develop the quantitative-read across structure activity relationship (q-RASAR) models. Interspecies toxicity (iST) correlation was also explored between the two rodent species. All developed QSAR, q-RASAR and iST models met the state-of-the-art validation criteria and were applied for toxicity predictions of hundreds of untested PFASs in true external sets. Subsequently, we performed the priority ranking of the untested PFASs based on the model predictions, with the mechanistic interpretation of the top 20 most toxic PFASs predicted by both QSAR and q-RASAR models. The two univariate iST models were also used for filling the interspecies toxicity data gap. Overall, the developed QSAR, q-RASAR and iST models can be used as effective tools for predicting the oral acute toxicity of untested PFASs to Rat and Mouse, thus being important for risk assessment of PFASs in ecological environment.

Abuse and neglect as indicators of unhealthy behaviours among 15-year-old schoolchildren in Albania

ObjectiveWe assessed the independent associations of lifetime child abuse and neglect indices with behavioural characteristics of children. Study designA cross-sectional study was conducted in Albania in 2022. MethodsParticipants consisted of a nationwide representative sample of 1877 schoolchildren aged 15 years (55 % girls; response: 96 %). Data on lifetime child abuse and neglect were collected, along with behavioural factors and sociodemographic characteristics. Binary logistic regression was used to assess the independent associations of child abuse and neglect with behavioural factors of schoolchildren. ResultsIrrespective of sociodemographic characteristics, lifetime physical abuse was positively related to lifetime smoking (OR = 1.8, 95%CI = 1.4–2.3), lifetime alcohol consumption (OR = 2.4, 95%CI = 1.9–2.9), and breakfast skipping (OR = 1.3, 95%CI = 1.0–1.6). Furthermore, positive independent factors associated with emotional abuse included lifetime alcohol intake (OR = 1.7, 95%CI = 1.3–2.1) and breakfast skipping (OR = 1.4, 95%CI = 1.0–1.8). Additionally, positive factors associated with lifetime emotional neglect consisted of lifetime smoking (OR = 2.2, 95%CI = 1.6–3.0) and alcohol intake (OR = 2.0, 95%CI = 1.5–2.6), and a lower fruit consumption (OR = 1.7, 95%CI = 1.3–2.3). Positive factors associated with lifetime sexual abuse included lifetime alcohol consumption (OR = 2.4, 95%CI = 1.4–4.1) and especially smoking (OR = 4.3, 95%CI = 2.6–7.3). Also, lifetime witnessing of family violence was positively related to lifetime smoking (OR = 2.7, 95%CI = 1.8–4.1) and alcohol intake (OR = 1.7, 95%CI = 1.2–2.6). ConclusionsWe evidenced strong and consistent links between child maltreatment indices and unhealthy behavioural practices among 15-year-old children in Albania. These findings underscore the potential impact of early trauma on developmental trajectories. The association between child abuse and the adoption of detrimental behaviours highlights the urgent need for comprehensive support and intervention strategies to break the cycle of harm.

Elucidation of molecular mechanisms involved in tadpole toxicity employing QSTR and q-RASAR approach

Tadpoles, as early developmental stages of frogs, are vital indicators of toxicity and environmental health in ecosystems exposed to harmful organic compounds from industrial and runoff sources. Evaluating each compound individually is challenging, necessitating the use of in-silico methods like Quantitative Structure Toxicity Relationship (QSTR) and Quantitative Read-Across Structure Activity Relationship (q-RASAR). Utilizing the comprehensive US EPA's ECOTOX database, which includes acute LC50 toxicity and chronic endpoints, we extracted crucial data such as study types, exposure routes, and chemical categories. Regression-based QSTR and q-RASAR models were developed from this dataset, emphasizing key chemical descriptors. Lipophilicity and unsaturation were significant for predicting acute toxicity, while electrophilicity, nucleophilicity, and molecular branching were crucial for chronic toxicity predictions. Additionally, q-RASAR models integrated with the "intelligent consensus" algorithm were employed to enhance predictive accuracy. The performance of these models was rigorously compared across various approaches. These refined models not only predict the toxicity of untested compounds but also reveal underlying structural influences. Validation through comparison with existing literature affirmed the relevance and robustness of our approach in ecotoxicology.

Halobenzoquinone-induced potential carcinogenicity associated with p53-mediated cell cycle pathway

2,6-Dibromo-1,4-benzoquinone (2,6-DBBQ) and 2,6-dichloro-1,4-benzoquinone (2,6-DCBQ), two emerging halobenzoquinones (HBQs), have the highest detection frequencies and levels in drinking water among all HBQs. They are more toxic than the regulated disinfection byproducts. Quantitative structure toxicity relationship analysis predicted that HBQs are a class of potential bladder carcinogens. However, direct experimental evidence for the carcinogenicity of 2,6-DBBQ and 2,6-DCBQ is lacking and the associated toxicity mechanisms remain unclear. In this study, we confirmed the potential carcinogenicity of 2,6-DBBQ and 2,6-DCBQ using an in vitro malignant transformation assay, evaluated their cytotoxicity and genotoxicity, and investigated their toxicity mechanisms. The results showed that 2,6-DBBQ and 2,6-DCBQ significantly decreased the viability of human uroepithelial SV-HUC-1 cells and induced DNA damage in SV-HUC-1 cells, and chromosomal damage in HepG2 cells, and malignant transformation of SV-HUC-1 cells. Moreover, transcriptome sequencing revealed that 2,6-DBBQ and 2,6-DCBQ activated the p53-mediated cell cycle pathway in bladder cancer. In the p53-mediated cell cycle pathway, 2,6-DBBQ and 2,6-DCBQ induced cell cycle arrest at the S phase by downregulating p53 and upregulating p21. Additionally, 2,6-DBBQ and 2,6-DCBQ may have produced excessive reactive oxygen species, damaging DNA and chromosomes. These results not only first confirm the potential carcinogenicity of 2,6-DBBQ and 2,6-DCBQ but also provide an important reference for exploring the cytotoxicity and genotoxicity mechanisms of these HBQs.

Associations Between Interpersonal Trauma and Intolerance of Uncertainty in an International Multi-Site Sample

AbstractPrior psychologically traumatic experiences have been linked to increased risk for mental health conditions. However, there remain questions about the relationship between prior interpersonal trauma, particularly that of neglect and abuse, and transdiagnostic dimensions such as intolerance of uncertainty (IU: the tendency to find uncertainty aversive). To address this gap, we conducted a secondary analysis of survey data from an international multi-site sample (n = 2510). Questionnaires included: Interpersonal trauma by type (e.g. emotional neglect, physical abuse, psychological abuse, sexual abuse) and IU. The findings revealed that: (1) experiencing different forms of interpersonal trauma was associated with higher IU, and (2) experiencing multiple forms of neglect and abuse was associated with higher IU. When comparing across the interpersonal trauma types and IU, emotional neglect compared to the other types of abuse, was specifically related to higher IU. These effects remained when controlling for broader negative beliefs about the self and others. However, the observed relationships and overall amount of variance explained by IU was rather small. Overall, these findings demonstrate that interpersonal trauma, particularly emotional neglect, is associated with IU. Future longitudinal research is required to examine if, how, and when after adversity, higher IU may emerge.

The impact of psychological violence in the workplace on turnover intention of clinical nurses: the mediating role of job satisfaction

The impact of psychological violence in the workplace on turnover intention of clinical nurses: the mediating role of job satisfaction

Vulnerability Viability of the Girl Child in Selected Single -Sex Secondary Schools of Lusaka District

The purpose of the study was to investigate the vulnerability viability of the girl child in selected single -sex secondary schools of Lusaka district of Zambia. The study objective was to establish the profile of a vulnerable girl child in selected single -sex secondary schools. The used adopted the qualitative approach and used a phenomenological research design. The study population included all the single girls schools in Lusaka district. The sample comprised of 38 participants who included 8 vulnerable girls in each school and 4 guidance teachers. Interviews were used to collect data from the guidance teachers while focused group discussions were used to collect data from pupils. Data was analysed thematically by coding the data, selecting what should be presented under themes which emerged from the study. The study found that the vulnerable viabilities included lack of proper dietary habits and good nutrition. Under household responsibilities, girls were overworked at home and performed many chores which made them to underperform in schools. Meanwhile, economic vulnerability included lack school materials like bookracks, desks, and brooms, lack of money for school upkeep, lack of proper school uniforms, shoes, socks, jerseys, necktie, and no lunch money. The other vulnerability was lack of resources and support for education. The parents of the vulnerable girl children cannot afford school extra tuition, school related books and materials. Lastly was the emotional vulnerability which included various emotional abuses which the learners underwent in the community and school indirectly and directly. The study concludes that secondary school girls were vulnerable differently in the secondary schools and these should be looked at with critical analysis for learners to excel in schools. The study recommends that teachers and parents should work together to ensure that they support their children for them to perform better in the Zambian education system.

Childhood emotional maltreatment predicts social well-being beyond individual well-being: a daily diary study

ABSTRACT Childhood emotional maltreatment can have a profound impact on well-being. However, past research has largely focused on individual well-being, making it noteworthy to examine whether childhood emotional maltreatment predicts social well-being beyond individual well-being. To fill this gap, the current study employed a daily diary approach to investigate the independent effect of childhood emotional maltreatment on social well-being, and examined gratitude’s mediating role in the relationship. A total of 483 participants (Mage = 19.30, SDage = 2.12) completed daily surveys for 14 consecutive days. The results of the multilevel regression analysis indicated that childhood emotional maltreatment negatively and independently predicted social well-being, even after controlling for individual well- being, other forms of maltreatment (i.e. physical and sexual maltreatment), age and gender. Moreover, multilevel mediation analysis elucidated that gratitude served as a mediating factor in this association. In summary, these findings underscore the adverse effects of emotional maltreatment on social well-being and suggest gratitude as a possible intervention focus.

STALKING E CYBERSTALKING CONTRA A MULHER

In contemporary society, there has been a significant increase in the crime of stalking, resulting in the emergence of a new form of cyberstalking. The crime of stalking is characterized as an obsessive and repetitive pursuit directed at a person, with the intention of causing fear, anguish or disruption in their daily life. In the digital context, cyberstalking involves the use of the internet and communication technologies to perpetuate this same type of persecution, expanding its reach and impact. The article focuses on women, who are the main victims of this violence. Although anyone can be both the perpetrator and the victim of stalking, the central issue to be explored will be: to assess what are the factors that contribute to women being the main victims of stalking and cyberstalking? This scientific article has the general objective of analyzing the practices of persecution, known as stalking, and its virtual variant, cyberstalking, with an emphasis on the impact of these forms of violence on the dignity and psychological well-being of female victims. Furthermore, the article investigates how the Maria da Penha Law can be applied in stalking and cyberstalking situations, assessing the effectiveness of these legal protections. The specific objective includes addressing social, cultural and psychological factors that explain this disparity, in addition to examining the consequences faced by women, ranging from psychological suffering to the impact on their personal and professional relationships. The article also investigates how this legislation has been used to prevent and combat psychological and physical violence resulting from obsessive stalking, in addition to identifying possible gaps in the legal protection offered to victims. This article used a deductive and descriptive approach, based on a comprehensive bibliographic review of public documents, books, scientific articles and online sources. The results show that current laws are insufficient to adequately address the problems of stalking and cyberstalking.

“Roses, Bruises, Wholeness” Development and Implementation of a Psychological Healing Program on Depression of Women Victims of Intimate Partner Violence

The study aimed to develop and implement an intervention program for the psychological healing of depression of women victims of intimate partner violence. To lay the groundwork and come up with the data needed to develop an intervention program, the study used the Sequential Explanatory Design. This mixed method suggests gathering and evaluating the quantitative data and qualitative data in two consecutive phases. The data-gathering tools used in the study included the Beck Depression Inventory (BDI-II) to measure the depression level of the participants; a Semi-structured interview and a focus group discussion were conducted to provide the data needed for the qualitative phase. A pretest of the BDI-II was administered to the participants. Results showed that the participants were found to have depression during the time of the administration of the test. The BDI’s results provided the formation of the experimental and the control groups while the individual interview and focus group discussion provided the themes used in the development of the intervention program. These themes were categorized based on Physical Violence, Psychological Violence, Sexual Violence, and Neglect according to the Diagnostic Manual for Mental Disorders 5 (DSM5-TR). The experimental group participated in the eight-session intervention program and the control group did not participate in the sessions. Subsequently, a posttest was administered to the experimental and the control groups. Results showed that the six experimental group participants decreased their depression level significantly, except for one participant who got a four-point increase in her posttest score. There was no significant difference in the pretest and post-test scores of the control group.

Intimate partner violence against women among contraceptive users at a primary health care setting in Southern Ethiopia: a facility-based cross-sectional study.

One in three women experienced intimate partner violence (IPV) worldwide which has remained major public health challenge. Women's reproductive health service utilization has been seriously impacted by IPV. There is a paucity of evidence on the magnitude of IPV among contraceptive users in southern Ethiopia. Hence, the main aim of this study was to determine the level of IPV and its associated factors among married women who were contraceptive users in primary health care settings in Adilo Zuria district in southern Ethiopia. A facility-based cross-sectional study was conducted among systematically recruited 405 married women who were contraceptive users in a primary health care setting in Adilo Zuria district in southern Ethiopia. Data were collected through face-to-face interviews using an adapted tool from existing literature including the World Health Organization IPV survey. Collected data were entered into EpiData 4.6 and exported to SPSS version 26 for cleaning and analysis. Descriptive and logistic regression analyses were performed to determine the level of IPV and identify factors associated with IPV. An adjusted odds ratio (AOR) from multiple logistic regression at a 95% confidence interval (CI) was used to declare a significant association. The prevalence of current IPV among contraceptive users was 72.6% (95% CI; 68.1-76.8%). Current psychological, physical, and sexual violence were 39.3%, 38.5%, and 31.9%, respectively. In multivariable analysis, women's being rural resident (AOR: 3.19, 95%CI: 1.69-6.02), women's formal education (AOR: 0.37, 95%CI: 0.19-0.70), partners alcohol consumption (AOR: 3.32, 95%CI: 1.89-5.84), partners Khat chewing (AOR: 7.22, 95%CI: 4.12-12.65) and poor social support (AOR: 2.47, 95%CI: 1.43-4.27) were significantly associated with current IPV against women. Women's experience of IPV on contraceptive users was found to be unacceptably high in the study area. Women's being rural residents, having poor social support and partners who drank alcohol and Khat chewing were predictors of women's experience of IPV. Thus, interventions in improving women's educational status, strengthen the social support systems, and the behavior of partners who use stimulant substances are highly relevant to tackle IPV among contraceptive users in the primary healthcare setting.

Rg3-lipo biomimetic delivery of paclitaxel enhances targeting of tumors and myeloid-derived suppressor cells.

Liposomal drug delivery systems have revolutionized traditional cytotoxic drugs. However, the relative instability and toxicity of the existing liposomal drug delivery systems compromised their efficacy. Herein, we present Rg3-lipo, an innovative drug delivery system using a glycosyl moiety-enriched ginsenoside (Rg3). This system is distinguished by its glycosyl moieties exposed on the liposomal surface. These moieties imitate human cell membranes to stabilize and evade phagocytic clearance. The Rg3-lipo system loaded with paclitaxel (PTX-Rg3-lipo) demonstrated favorable bioavailability and safety in Sprague-Dawley rats, beagle dogs, and cynomolgus monkeys. With its glycosyl moieties recognizing tumor cells via the glucose transporter Glut1, PTX-Rg3-lipo inhibited gastric, breast, and esophageal cancers in human cancer cell lines, tumor-bearing mice, and patient-derived xenograft models. These glycosyl moieties selectively targeted myeloid-derived suppressor cells (MDSCs) through the glucose transporter Glut3 to attenuate their immunosuppressive effect. The mechanism study revealed that Rg3-lipo suppressed glycolysis and downregulated the transcription factors c-Maf and Mafb overcoming the MDSC-mediated immunosuppressive microenvironment and enhancing PTX-Rg3-lipo's antitumor effect. Taken together, we supply substantial evidence for its advantageous bioavailability and safety in multiple animal models, including nonhuman primates, and Rg3-lipo's dual targeting of cancer cells and MDSCs. Further investigation regarding Rg3-lipo's druggability will be conducted in clinical trials.

Violence and narrative representation of women’s experiences in Sefi Atta’s Swallow and Mariama Bâ’s So Long a Letter

ABSTRACT Violence of diverse forms is often metaphorised in some African literature works as a semblance of culture and religion. Sefi Atta’s Swallow and Mariama Bâ’s So Long a Letter (SLaL) among other African writings experiment with themes of betrayal, conflict (violence), exploitation, hardship, death, and even friendship. These are epitomised in marriage, religio-cultural values, sexual harassment, transnational mobility, and divorce. Through the use of psychoanalytic theory in character and thematic depiction, the study revealed that both texts go beyond physical and psychological violence to the metaphorical and fictional discursive aspects of the female movement to self-actualisation. The representation of women’s experiences of violence in both texts had not only physical but also psychological dimensions portrayed in the narrative. Swallow, set in a stenchy-hustling Lagos, symbolises moral decadence and the insurrection of the unlikely female breadwinning. SLaL portrays the abandonment and vulnerability of brilliant and aspiring women. The estrangement of Ramatoulaye from her husband, despite her love and loyalty, and her subsequent subjugation to the Islamic mourning obligations after her husband’s death speaks volumes about the subtle violence women endure. Friendship becomes a coping strategy for violence in both texts.

Early life adversity blunts the subjective and physiological relaxation response in healthy adults.

While Early Live Adversity (ELA) is a known risk factor for mental and physical diseases, the investigation into the mechanisms behind this connection is ongoing. In the present study, we investigated whether ELA blunts the relaxation response in healthy adults. Using a within-subjects design, we employed a paced breathing exercise (four seconds inhale, six seconds exhale) and a 360° nature video as relaxation interventions while measuring physiological relaxation using heart rate variability and subjective relaxation using the Relaxation State Questionnaire. A total of 103 participants (63.11% female; agemean = 22.73 ± 3.43years) completed the Parental Bonding Instrument and the Childhood Trauma Questionnaire to assess ELA retrospectively. For subjective relaxation, a blunted relaxation reaction was associated with lower scores of paternal care and higher scores of paternal overprotection, physical abuse, physical neglect, and emotional abuse. For heart rate variability emotional abuse in interaction with nicotine consumption was related to a blunted relaxation response. This indicates that experiencing ELA negatively affects the relaxation capability in a healthy sample and emphasizes the importance of assessing relaxation at a physiological and subjective level.

Exploring the impact of childhood maltreatment on epigenetic and brain-derived neurotrophic factor changes in bipolar disorder and healthy control.

Childhood maltreatment may be linked to epigenetics and brain-derived neurotrophic factor (BDNF) changes, which are mechanisms altered in several psychiatric conditions, including bipolar disorder (BD). However, the specific mechanisms connecting childhood maltreatment to the pathophysiology of BD remain unclear. The present study aims to examine the effects of childhood maltreatment on epigenetic and neurotrophic outcomes in BD patients and health controls. History of childhood maltreatment was obtained using the Childhood Trauma Questionnaire (CTQ) from 36 BD outpatients and 46 healthy subjects. DNA methyltransferase (DNMT) activity, HMTH3K9 activity, histone 3 lysine 9 tri-methylation (H3K9me3) levels, histone deacetylase (HDAC)1 levels, HDAC2 levels, histone 3 lysine 14 acetylation (H3K14ac) levels, and mRNA of BDNF were evaluated in peripheral blood mononuclear cells. Plasma BDNF levels were also measured. Total scores of CTQ, as well as the subscale scores of emotional abuse, sexual abuse, and emotional neglect, were predictive of changes in DNMT and HMTh3k9 activity, H3K9m3 levels, BDNF mRNA expression, and BDNF levels. These findings were observed in all our samples and, in some cases, among BD patients. Emotional abuse was the main childhood maltreatment subtype associated with epigenetic alterations in BD. Our results elucidate some mechanisms by which childhood maltreatment can alter epigenetic and neurotrophic markers. Especially in BD subjects, our results suggest childhood maltreatment per se is not a direct cause for epigenetic alterations. In another way, we suppose that the effect of childhood maltreatment could be cumulative and interact with other factors associated with the pathophysiology of BD.

Rumination as a Moderator of the Relation between Childhood Adversity Exposure and College Students’ Psychological Distress

American college students (N = 598) completed self-report questionnaires assessing rumination, psychological distress while attending college (general distress, anhedonic depression, anxious arousal), and exposure to specific types of childhood adversity (i.e., emotional abuse, sexual abuse, physical abuse, emotional neglect, and physical neglect). Latent Moderated Structural Equation Modeling indicated that 1) rumination was associated with all three indicators of psychological distress and 2) rumination moderated associations between childhood adversity exposure and college students’ reports of general distress and anxious arousal such that associations were strongest at higher levels of rumination and weaker at lower levels of rumination. Implications regarding higher education professionals’ efforts to support college student well-being are discussed.

Intergenerational Transmission of Psychological Maltreatment and Adolescent Depression

Intergenerational Transmission of Psychological Maltreatment and Adolescent Depression

Relationship between maltreatment and mental health in adolescents: A school-based study in Indonesia.

Maltreatment affects emotional development in adolescents and inhibits social adjustment. This study aimed to analyze the relationship between maltreatment and mental health among adolescents. A cross-sectional study was conducted on adolescents in the first and second grades of middle school (12-14 years old) and high school (15-17 years old) in eight cities and municipalities in the province, selected through several stages of simple random sampling (N = 1837). The International Society for the Prevention of Child Abuse and Neglect (ISPCAN) Child Abuse Screening Tool for Children (ICAST-C) questionnaire for detecting maltreatment was translated, simplified, and validated by an expert based on a theoretical framework that involved pediatricians, public health, and medicolegal perspectives. The Strengths and Difficulties Questionnaire (SDQ) was used to assess emotional states. ICAST-C and SDQ scores were transformed to logit values using Rasch model analysis. Distribution frequency and linear regression were used for data analysis. The results indicated that 85.6% of adolescents aged 12-14 and 83% of those aged 15-17 experienced physical maltreatment, while 89.4% of the 12-14 age group and 82.9% of the 15-17 age group experienced psychological maltreatment. The emotional states of the two groups were 52.8% and 59.2%, respectively. There was a significant correlation between the experience of physical maltreatment and emotions among 12-14 (r1 = 0.148 (0.190-0.257)) and 15-17 years old (r1 = 0.047 (0.084-0.156)). There was a significant correlation between the experience of psychological maltreatment and emotions among 12-14 years old '(r2 = 0.191 (0.270-0.350)) and 15 to 17 years old (r2 = 0.097 (0.167-0.252)). In conclusion, physical and psychological maltreatment were correlated with mental health states among adolescent students in West Java, Indonesia.

Abstract 4141457: Forms of Childhood Maltreatment and Subclinical Cardiovascular Disease Risk in Black men and women

Background: Exposure to specific forms of childhood maltreatment have been associated with cardiovascular disease (CVD) risk factors and CVD events in adulthood. Heterogenous experiences of childhood maltreatment across race and sex exist, yet there is little evidence regarding these relationships and CVD risk in Black populations. Aims: To investigate the association between various forms of childhood maltreatment (emotional, general, physical, and sexual abuse) and surrogate markers of vascular dysfunction and test whether sex modify these associations. Methods: Forms of childhood maltreatment and indices of vascular function were assessed in a cohort of healthy Black adults without known CVD (n=404) from a large metropolitan southeastern city. Childhood maltreatment was assessed using the Early Trauma Inventory short form (ETISR-SF) consisting of physical, sexual, emotional, and general domains. A trauma severity index score was calculated by summing the indexes for each of the four domains. Higher scores are indicative of higher traumatic life events before age 18 years. Outcomes of central augmentation index (cAIx) corrected for a heart rate of 75 bpm and carotid femoral pulse wave velocity (CfPWV) were measured as indices of wave reflections and arterial stiffness using applanation tonometry (Sphygmocor Inc.), and central pulse pressure (CPP) was calculated as the difference between the aortic systolic and diastolic blood pressures. Associations between each domain and outcomes were assessed using multivariate-adjusted and sex-stratified linear regression models. Results: Mean age of the cohort was 53 + 10.3 years, 61% women. Exposure to emotional [ b = -1.5%, 95%CI: -2.7,-0.3] and physical abuse [ b = -1.3%, 95%CI: -2.5,-0.2] was associated with cAIx overall but not CPP or CfPWV after adjusting for sociodemographic, clinical factors, health behaviors, and depressive symptoms. Significant emotional abuseXsex ( P= 0.014) and physical abuseXsex ( P=&lt; 0.001) interactions were identified for cAIx. Among women, physical abuse was associated with higher cAIx [ b =1.5%, 95%CI: 0.6, 2.4] and among men emotional [ b =-1.6%, 95%CI: -3.2, -0.0] and physical [ b =-1.7%, 95%CI: -3.1, -0.3] abuse was associated with lower cAIx. Conclusions: Exposure to emotional and physical abuse as children was associated with vascular dysfunction; moreover, exposure to physical abuse among women and not men have adverse clinical implications for CVD risk and prospects for enhanced preventive care.