This study aims to explore the factors affecting students' learning performance in blended learning in nursing and vocational education. Emphasizing the human capacity for self-directed learning and behavior, this research investigates the impacts of learning motivation, behavioral engagement, cognitive engagement, emotional engagement, agentic engagement, and feedback on students' learning performance. The study aims to assess the current levels of these variables, design and implement intervention strategies (strategic plans) to enhance them, and determine any changes in these variables before and after the implementation of the strategic plan. The research design was a sequential exploratory mixed-methods design, combining qualitative and quantitative methods to develop an instrument for data collection. The target population consisted of nursing students from three public colleges in Shanghai, with a sample size of 1494 students. Preliminary findings revealed that the learning motivation, behavioral engagement, cognitive engagement, emotional engagement, agentic engagement, and feedback levels were generally low. A multiple regression analysis showed that learning motivation (p<0.01), behavioral engagement (p<0.01), cognitive engagement (p<0.01), emotional engagement (p<0.01), agentic engagement (p<0.01), and feedback (p<0.01) significantly predicted learning performance. Experts developed and validated a theoretical model based on the findings, laying the foundation for future interventions to enhance nursing students' learning performance.