ABSTRACT College students are experiencing increasing rates of mental health problems, with difficulties exacerbated by the effects of the COVID-19 pandemic. Mindfulness-Based Stress Reduction (MBSR) has demonstrated efficacy in treating psychological problems and promoting well-being within this population. Less well-understood, however, are MBSR participants’ perceptions of the mechanisms underlying this therapeutic change. The current qualitative study examined nonclinical college students’ experiences participating in a randomized controlled trial of an online adaptation of MBSR, administered during the fall 2020 COVID-19 pandemic lockdown. In-depth, semi-structured interviews were conducted with nine participants who had recently completed the MBSR course. The qualitative data were analyzed using thematic analysis. Participants described greater self-awareness, relational awareness, present-moment awareness, and body awareness as resulting in improved emotion regulation, empathy, communication, and well-being, while reducing anxiety and physical pain. These findings support and extend other theoretical models of change in mindfulness-based interventions. The results further suggest that online MBSR adaptations may be beneficial in promoting mental health for college students and that cultivating greater awareness may help in bolstering psychological well-being within this population.