Climate risks have posed a major threat to many local communities living in low-lying coastal megacities across the globe, including Ho Chi Minh City, Vietnam. Hence, this study first aimed to contribute towards a comprehensive understanding of temporal trend patterns of annual rainfall and absolute extremes in Ho Chi Minh City over the last 4 decades (1980-2022) through multiple non-parametric statistical trend tests. We employed the quantile delta mapping (QDM) method to develop daily bias-corrected rainfall data based on the outputs in the latest Coupled Model Intercomparison Project phase 6 (CMIP6) under 8 shared socio-economic pathway (SSP) greenhouse gas emission scenarios. Evaluation of model performance was implemented by repeatedly omitting 5 successive years in turn for estimating testing errors. The outcomes indicate the high applicability of well-calibrated transfer functions, even for high quantiles, to the production of future rainfall scenarios. The projected changes in annual rainfall and absolute extremes were obtained by estimating multi-model medians from CMIP6 models for future periods (i.e. 2021-2040, 2041-2060, 2061-2080, and 2081-2100), with reference to the base period (1995-2014). In general, annual rainfall in Ho Chi Minh City is projected to increase substantially, and Thu Duc station consistently shows the highest increases in annual rainfall. Projected changes are approximately 30.9% (8.3 to 77.8%) under the high-end scenario (i.e. SSP5-8.5) by the end of the 21st century. It is expected that these findings will yield several solid arguments for mitigating climate-related risks in Ho Chi Minh City.