In August 1988, the Nuclear Regulatory Commission (NRC) approved the final version of a revised rule on the acceptance of ECCS entitled “Emergency Core Cooling System; Revision to Acceptance Criteria.” The revised rule states an alternate ECCS performance analysis, based on best-estimate methods, may be used to provide more realistic estimates of plant safety margins, provided the licensee quantifies the uncertainty of the estimates and includes that uncertainty when comparing the calculated results with prescribed acceptance limits. To support the revised ECCS rule, the NRC and its contractors and consultants have developed and demonstrated a method called the Code Scaling, Applicability, and Uncertainty (CSAU) evaluation methodology. The CSAU methodology and an example application, described in this set of six papers, demonstrate that uncertainties in complex phenomena can be quantified. The methodology is structured, traceable, and practical, as is needed in the regulatory arena. It addresses in a comprehensive and systematic manner questions concerned with: (1) code capability to scale-up processes from test facility to full-scale nuclear power plant (NPP). (2) code applicability to safety studies of postulated accident scenario in a specified NPP, and (3) quantifying uncertainties of calculated results. The methodology combines a “top-down” approach to define the dominant phenomena with a “bottom-up” approach to quantify uncertainty. The methedology is able to address both: (1) uncertainties for which bias and distribution are quantifiable, and (2) uncertainties for which only a bounding value is quantifiable. The methodology is general, and therefore applicable to a variety of scenarios, plants, and codes. This paper provides an overview of the CSAU evaluation methodology and its application to a postulated cold-leg, large-break loss-of-coolant accident in a Westinghouse four-loop pressurized water reactor with 17 x 17 fuel. The code selected for this demonstration of the CSAU methodology was TRAC-PF1/MOD1, Version 14.3.