Elevated Stress Research Articles

Mild alkaline conditions affect digester performance and community dynamics during long-term exposure

This paper examines the adaptive responses of microbial communities to gradual shifts in pH toward the mild alkaline range in anaerobic digestion (AD) systems. The results indicate that a pH of 8.0 serves as a critical upper limit for stable AD operation, beyond which microbial efficiency declines, underscoring the importance of microbial resilience against elevated pH stress. Specifically, hydrolysis genera, e.g. Eubacterium and Anaerobacterium, and syntrophic bacteria were crucial for reactor stability. Fibrobacter had also been shown to play a key role in the accumulation of propionate, thus leading to its dominance in the volatile fatty acid profile throughout the experimental phases. Overall, this investigation revealed the potential adaptability of microbial communities in AD systems to mild alkaline pH shifts, emphasizing the hydrolysis bacteria and syntrophic bacteria as key factors for maintaining metabolic function in elevated pH conditions.

Recent Progress in Creep-Resistant Aluminum Alloys for Diesel Engine Applications: A Review.

Diesel engines in heavy-duty vehicles are predicted to maintain a stable presence in the future due to the difficulty of electrifying heavy trucks, mine equipment, and railway cars. This trend encourages the effort to develop new aluminum alloy systems with improved performance at diesel engine conditions of elevated temperature and stress combinations to reduce vehicle weight and, consequently, CO2 emissions. Aluminum alloys need to provide adequate creep resistance at ~300 °C and room-temperature tensile properties better than the current commercial aluminum alloys used for powertrain applications. The studies for improving creep resistance for aluminum casting alloys indicate that their high-temperature stability depends on the formation of high-density uniform dispersoids with low solid solubility and low diffusivity in aluminum. This review summarizes three generations of diesel engine aluminum alloys and focuses on recent work on the third-generation dispersoid-strengthened alloys. Additionally, new trends in developing creep resistance through the development of alloy systems other than Al-Si-based alloys, the optimization of manufacturing processes, and the use of thermal barrier coatings and composites are discussed. New progress on concepts regarding the thermal stability of rapidly solidified and nano-structured alloys and on creep-resistant alloy design via machine learning-based algorithms is also presented.

Expression analysis of Hsp70 genes in the psychrophilic yeast, Glaciozyma antarctica PI12 as biomarkers for thermal stress during heat waves

Heat shock proteins 70 (Hsp70) are potential thermal stress markers as they play a pivotal role in safeguarding cells against heat shock-induced damage. The Hsp70s are present in several variants with each containing its peculiar importance due to their specific functions such as cell protection during elevated thermal stress. The present investigation evaluated the gene expression profiles of all Hsp70 genes in Glaciozyma antarctica PI12 during a heat wave condition. In this study, we exposed G. antarctica PI12 cells to a realistic heat wave to understand the impacts of the extraordinary, unprecedented heat waves that hit Antarctica at nearly 40°C above the average in 2022. The experiment was carried out through eight days where cells were exposed gradually at 0, 2, 4, 8, 12, 16, 20, 25 and 30°C. The gene expression profiles were obtained during the simulated heat wave along with non-stressed control treatments by real-time PCR. Out of the six Hsp70 genes in G. antarctica PI12, five were expressed under the conditions tested. Among the expressed genes, gahsp70-1, gahsp70-5, and gahsp70-6 showed significant upregulation. Specifically, their expression levels increased by five- to eightfold after exposure to heat shock at 4°C. Gene expression patterns at 20°C and 30°C also showed induction with the highest at 3.6 folds and 5.8 folds, respectively. These results indicate that the expression of Hsp70 genes in G. antarctica PI12 was inducible under thermal stress, indicating their importance in cells during the heat waves. These results conclude that the gene expression patterns of Hsp70 during heat waves contribute vital information on thermal adaptation in the Antarctic marine ecosystem under climate stress.

Unveiling Pakistan's transport problems: a call to safeguard public health.

Public transportation is an important mode of transportation in developing countries like Pakistan since it is accessible and convenient. But there are also serious health hazards associated with it, especially when it comes to the transmission of infectious diseases including COVID-19, TB, and Haemophilus influenzae. Worldwide transportation systems are vulnerable, as the COVID-19 pandemic has shown, underscoring the necessity for study and mitigating measures. The danger of disease transmission is increased in Pakistan by crowded metropolitan areas, inadequate sanitation, and low health awareness. In addition, congested public transportation and inadequate ventilation lead to reduced air quality and elevated stress levels among commuters. Comprehensive actions are needed to address these health hazards, such as promoting physical distance, improving cleanliness, enforcing traffic safety laws, and implementing policy changes that support sustainable transportation. Community involvement and advocacy are critical in campaigning for safer and more sustainable transportation networks. Pakistan can enhance public health outcomes and reduce the health hazards linked to public transportation by giving priority to these measures.

Elevated Shear Stress Modulates Heterogenous Cellular Subpopulations to Induce Vascular Remodeling.

Rationale: Elevated shear stress (ESS) induces vascular remodeling in veins exposed to arterial blood flow, which can lead to arteriovenous (AV) fistula failure. The molecular mechanisms driving remodeling have not been comprehensively examined with a single-cell resolution before. Objective: Using an invivo animal mode, single-cell RNA sequencing, and histopathology, we precisely manipulate blood flow to comprehensively characterize all cell subpopulations important during vascular remodeling. Methods: AV loops were created in saphenous vessels of rats using a contralateral saphenous vein interposition graft to promote ESS. Saphenous veins with no elevated shear stress (NSS) were anastomosed as controls. Findings: ESS promoted transcriptional homogeneity, and NSS promoted considerable heterogeneity. Specifically, ESS endothelial cells (ECs) showed a more homogeneous transcriptional response promoting angiogenesis and upregulating endothelial-to-mesenchymal transition inhibiting genes (Klf2). NSS ECs upregulated antiproliferation genes such as Cav1, Cst3, and Btg1. In macrophages, ESS promoted a large homogeneous subpopulation, creating a mechanically activated, proinflammatory and thus proangiogenic myeloid phenotype, whereas NSS myeloid cells expressed the anti-inflammatory and antiangiogenetic marker Mrc1. Conclusion: ESS activates unified gene expression profiles to induce adaption of the vessel wall to hemodynamic alterations. Targeted depletion of the identified cellular subpopulations may lead to novel therapies to prevent excessive venous remodeling, intimal hyperplasia, and AV fistula failure.

Structure and mechanical properties of TiAlTaN thin films deposited by dcMS, HiPIMS, and hybrid dcMS/HiPIMS

The quaternary Ti1-x-yAlxTayN system exhibits superior thin film properties compared to Ti1-xAlxN. Apart from the Ta content, the sputtering method has a crucial effect on the structural and mechanical properties. High power impulse magnetron sputtering (HiPIMS) produces denser thin films with improved hardness compared to direct current magnetron sputtering (dcMS), but at lower deposition rates. However, a hybrid dcMS/HiPIMS process combines the advantages of dcMS and HiPIMS and is, therefore, a suitable method to synthetize Ti1-x-yAlxTayN thin films. To analyze the effect of the sputtering technique on the structural and mechanical properties, Ti1-x-yAlxTayN is sputtered from TiAlTa compound targets with Ta fractions up to 0.2 by dcMS, HiPIMS, and dcMS/HiPIMS.The Ta metal fraction within Ti1-x-yAlxTayN steadily increased up to y ≈ 0.25, while the Al content notably decreased at higher Ta levels. This reduction was most pronounced in HiPIMS, resulting in an order of decreasing Al content as dcMS, dcMS/HiPIMS, and HiPIMS. All thin films exhibit a Ti1-x-yAlxTayN substitutional solid solution with a linearly increasing lattice parameter corresponding to higher Ta contents. At similar Ta contents, HiPIMS-Ti1-x-yAlxTayN and dcMS/HiPIMS-Ti1-x-yAlxTayN show larger out-of-plane lattice parameters compared to dcMS/HiPIMS-Ti1-x-yAlxTayN, indicating elevated compressive stresses within the thin films. The Ti1-x-yAlxTayN thin films show a column-like structure, with HiPIMS promoting the formation of a denser morphology with less columns. The HiPIMS-Ti1-x-yAlxTayN with H = 41 GPa and dcMS/HiPIMS-Ti1-x-yAlxTayN with H = 40 GPa achieve their peak hardness at a lower Ta metal fraction of y ≈ 0.12–0.13, in contrast to dcMS-Ti1-x-yAlxTayN, which reaches H = 38 GPa at y ≈ 0.25. The shift to lower Ta contents for the maximum hardness in HiPIMS-Ti1-x-yAlxTayN and dcMS/HiPIMS-Ti1-x-yAlxTayN is due to higher compressive stresses and smaller crystallite sizes in these films at low Ta metal fractions. The H/E and H3/E2 ratios of the HiPIMS-Ti1-x-yAlxTayN and dcMS/HiPIMS-Ti1-x-yAlxTayN exhibited a similar trend of increasing values, reaching a maximum, and then decreasing with higher Ta content. Consequently, the hybrid dcMS/HiPIMS process produces Ti1-x-yAlxTayN thin films with mechanical properties comparable to pure HiPIMS, making it a suitable sputtering method for the synthesis of Ti1-x-yAlxTayN.

TRPV4 affects visual signals in photoreceptors and rod bipolar cells.

Mechanical sensitive channels expressed in mammalian retinas are effectors of elevated pressure stresses, but it is unclear how their activation affects visual function in pressure-related retinal disorders. This study investigated the role of the transient potential channel vanilloid TRPV4 in photoreceptors and rod bipolar cells (RBCs) with immunohistochemistry, confocal microscopy, electroretinography (ERG), and patch-clamp techniques. TRPV4 immunoreactivity (IR) was found in the outer segments of photoreceptors, dendrites and somas of PKCα-positive RBCs and other BCs, plexiform layers, and retinal ganglion cells (RGCs) in wild-type mice. TRPV4-IR was largely diminished in the retinas of homozygous TRPV4 transgenic mice. Genetically suppressing TRPV4 expression moderately but significantly enhanced the amplitude of ERG a- and b-waves evoked by scotopic and mesopic lights (0.55 to 200 Rh*rod-1 s-1) and photopic lights (105-106 Rh*rod-1 s-1) compared to wild-type mice in fully dark-adapted conditions. The implicit time evoked by dim lights (0.55 to 200 Rh*rod-1 s-1) was significantly decreased for b-waves and elongated for a-waves in the transgenic mice. ERG b-wave evoked by dim lights is primarily mediated by RBCs, and under voltage-clamp conditions, the latency of the light-evoked cation current in RBCs of the transgenic mice was significantly shorter compared to wild-type mice. About 10% of the transgenic mice had one eye undeveloped, and the percentage was significantly higher than in wild-type mice. The data indicates that TRPV4 involves ocular development and is expressed and active in outer retinal neurons, and interventions of TRPV4 can variably affect visual signals in rods, cones, RBCs, and cone ON BCs.

The Factors Affecting the Stability of IOP Homeostasis.

Shear-induced nitric oxide (NO) production by Schlemm's canal (SC) endothelial cells provides a fast, IOP-sensitive feedback signal that normally contributes to IOP homeostasis. Our goal was to analyze the response of this homeostatic system under constant flow perfusion (as occurs in vivo) vs. constant pressure perfusion (as typical for laboratory perfusions). A mathematical model of aqueous humor dynamics, including shear-mediated NO signaling, was formulated and analyzed for stability. The model includes Goldmann's equation, accounting for proximal and distal outflow resistance, and describes how elevated IOP causes narrowing of SC lumen that increases the shear stress on SC cells. Elevated shear stress stimulates NO production, which acts to reduce outflow resistance and relax trabecular meshwork cells to decrease trabecular meshwork stiffness, affecting the SC luminal caliber. During constant flow perfusion, the outflow system is typically stable, returning to baseline IOP after a perturbation. In contrast, during constant pressure perfusion, the outflow system can become unstable and exhibit a time-dependent change in outflow resistance that diverges from baseline. The stability of shear mediated IOP homeostasis is predicted to differ critically between constant flow vs. constant pressure perfusion. Because outflow facility is typically measured at a constant pressure in the laboratory, this instability may contribute to the characteristic time-dependent increase in outflow facility, known as washout, observed in many nonhuman species. Studies of IOP homeostasis should consider how the outflow system may respond differently under constant pressure vs. constant flow perfusion.

Why is surgery not popular among medical students and young doctors? - Review of literature

Introduction: Contemporary medicine is witnessing significant advancements in conservative treatment modalities. However, surgery remains paramount for radical cancer treatment and emergent conditions such as trauma, peritonitis, gastrointestinal obstruction, and cholecystitis. Despite the essential role of surgeons, there is a global trend indicating waning interest among medical students in pursuing surgical specialties. Concurrently, practicing surgeons report heightened levels of professional burnout, and many regions face a looming shortage of surgical professionals, posing a threat to healthcare quality. Brief Overview of Current Knowledge: Research conducted across Poland, Germany, Argentina, the United Kingdom, and Japan highlights the declining inclination towards surgery among medical students. Students cite unattractive working conditions, poor work-life balance, elevated stress levels, and limited avenues for scholarly growth as deterrents. Gender plays a role, with females expressing heightened concerns regarding work-life balance and family aspirations. Furthermore, the surgical work environment, inadequate preparatory training in medical schools, and prolonged working hours are identified as factors exacerbating burnout risk among surgeons. Summary: Professional burnout represents a significant concern among surgeons, impacting both their work satisfaction and patient safety. Despite the strides made in conservative medical therapies, surgery remains indispensable, yet its allure as a specialty is diminishing among medical students. Understanding and addressing the discouraging factors, along with promoting healthy work practices, may mitigate burnout and encourage young physicians to consider surgical careers.

The impact of the COVID-19 pandemic on the socioeconomic gradient of hypertension.

The COVID-19 pandemic has brought into sharp focus the impact of socioeconomic factors on hypertension outcomes. This review examines the implications of the pandemic on the socioeconomic gradient of hypertension and explores the physiological and pathophysiological processes underlying this relationship. Changes in socioeconomic factors have disproportionately affected individuals with lower socioeconomic status, leading to adverse hypertension outcomes. The pandemic-related stressors, coupled with social isolation and disrupted daily routines, have contributed to elevated stress levels among individuals, particularly those with lower socioeconomic status. Equitable access to healthcare, enhancing health literacy and patient empowerment, and addressing social determinants of health are essential components of hypertension management strategies. By recognizing the specific challenges faced by individuals with lower socioeconomic status and implementing targeted interventions, public health efforts can help reduce the socioeconomic gradient of hypertension.

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity.

The clinical success of PARP1/2 inhibitors (PARPi) prompts the expansion of their applicability beyond homologous recombination deficiency. Here, we demonstrate that the loss of the accessory subunits of DNA polymerase epsilon, POLE3 and POLE4, sensitizes cells to PARPi. We show that the sensitivity of POLE4 knockouts is not due to compromised response to DNA damage or homologous recombination deficiency. Instead, POLE4 loss affects replication speed leading to the accumulation of single-stranded DNA gaps behind replication forks upon PARPi treatment, due to impaired post-replicative repair. POLE4 knockouts elicit elevated replication stress signaling involving ATR and DNA-PK. We find POLE4 to act parallel to BRCA1 in inducing sensitivity to PARPi and counteracts acquired resistance associated with restoration of homologous recombination. Altogether, our findings establish POLE4 as a promising target to improve PARPi driven therapies and hamper acquired PARPi resistance.

Influence of temperature, stress, and grain size on behavior of nano-polycrystalline niobium

Abstract Atomic simulations are executed to investigate the creep responses of nano-polycrystalline (NC) niobium established by using the Voronoi algorithm. The effects of varying temperature, applied stress, and grain size (GS) on creep properties and mechanisms are investigated. Notably, the occurrence of tertiary creep is exclusively observed under conditions where the applied stress exceeds 4.5 GPa and the temperature is higher than 1100 K. This phenomenon can be attributed to the significant acceleration of grain boundary and lattice diffusion, driven by the elevated temperature and stress levels. It is found that the strain rate increases with both temperature and stress increasing. However, an interesting trend is observed in which the strain rate decreases as the grain size increases. The stress and temperature are crucial parameters governing the creep behavior. As these factors intensify, the creep mechanism undergoes a sequential transformation: initially from lattice diffusion under low stress and temperature conditions to a mixed mode combining grain boundaries (GBs) and lattice diffusion at moderate stress and mid temperature levels, and ultimately leading to the failure of power-law controlled creep behavior, inclusive of grain boundary recrystallization under high stress and temperature conditions. This comprehensive analysis provides in more detail an understanding of the intricate creep behavior of nano-polycrystalline niobium and its dependence on various physical parameters.

Analysis of converter transformer pressboard insulation degradation under surge using mathematical morphology

Nowadays, with the significant expansion of industrial growth, the bulk power requirement can only be satisfied through high-voltage direct current HVDC transmission. The converter transformer is the utmost vital part of the HVDC transmission. Pressboard insulation is most commonly used as inter-disc insulation in converter transformers. During working conditions due to elevated temperature and different operational stresses, insulation material gets deteriorated. It may cause a risk to the life of the converter transformer. The effects of elevated temperatures as well as frequency on pressboard insulation of the converter transformer are examined in this study. The condition evaluation and morphological changes in pressboard insulation at elevated temperatures can evaluate with the help of frequency domain spectroscopy (FDS) and atomic force microscopy (AFM) techniques. The impact of elevated temperatures on insulation material can be analyzed based on surface roughness and dielectric parameters. In MATLAB Simulink environment, a dual winding single-phase converter transformers valve side star winding 60 discs model is constructed for impulse test. Based upon arrival time and velocity of traveling wave, insulation degradation location can be identified by using mathematical morphology. The simulation results demonstrate that the suggested method can notably located degradation across disc winding.

Understanding the effect of elevated carbon dioxide and heat stress on wheat grain quality under differential nitrogen dose

Understanding the effect of elevated carbon dioxide and heat stress on wheat grain quality under differential nitrogen dose

Small-quantity cooling lubrication in creep-feed grinding: Surface quality and residual stress analysis

Small-quantity cooling lubrication (SQCL) has emerged as a promising eco-friendly alternative to conventional flood cooling in creep-feed grinding processes. This study delves into the influence of various cooling conditions (dry, SQCL, and flood cooling) on the creep-feed grinding dynamics of 420 stainless steel specimens. Key parameters, including friction coefficient, surface texture, and through-thickness residual stresses, are investigated. Both SQCL and flood cooling exhibit marginal reductions in the friction coefficient compared to dry conditions, owing to their lubricating properties. With a smoother surface finish, SQCL grinding exhibits an average roughness of 42 % lower than that of dry grinding. Furthermore, increasing cutting depth and feed rates lead to elevated residual stresses on the specimen's surface, with SQCL cooling demonstrating substantial reductions compared to dry conditions. The SQCL cooling condition yields surface residual stresses 46–48.28 % lower than those observed in the dry condition. This study sheds light on the efficacy of SQCL as an alternative cooling method in enhancing surface quality and mitigating residual stresses in creep-feed grinding processes.

Are Differences Evident in the Ways Boys and Girls Appraise and Interpret Their Traumatic Experiences? A Qualitative Analysis of Youth Trauma Narratives.

The purpose of this study was to explore potential similarities and differences in the ways boys and girls appraise and interpret their traumatic experiences, and better understand how gender roles, performance, and socialization processes may impact trauma experiences, appraisals, and narratives within the context of trauma-focused treatment. We used thematic analysis to analyze the trauma narratives of youth (N = 16) ages 8-16 who had experienced multiple types (M = 5.38) of child maltreatment and who were receiving Trauma-focused Cognitive Behavioral Therapy to address clinically elevated posttraumatic stress symptoms. Four themes emerged: variations in the content of negative cognitions, differences in relational emotion, adoption of socially prescribed gender roles, and symptom differences. Although many similarities existed in youth's trauma narratives, differences emerged that point to the importance of social context and the ways gender role expectations and socialization processes influence youth's appraisal of and responses to traumatic events. Findings indicate the importance of considering distress tolerance, relational emotion, gender identity development, and role socialization within the treatment milieu.

AMELX Mutations and Genotype-Phenotype Correlation in X-Linked Amelogenesis Imperfecta.

AMELX mutations cause X-linked amelogenesis imperfecta (AI), known as AI types IE, IIB, and IIC in Witkop's classification, characterized by hypoplastic (reduced thickness) and/or hypomaturation (reduced hardness) enamel defects. In this study, we conducted whole exome analyses to unravel the disease-causing mutations for six AI families. Splicing assays, immunoblotting, and quantitative RT-PCR were conducted to investigate the molecular and cellular effects of the mutations. Four AMELX pathogenic variants (NM_182680.1:c.2T>C; c.29T>C; c.77del; c.145-1G>A) and a whole gene deletion (NG_012494.2:g.307534_403773del) were identified. The affected individuals exhibited enamel malformations, ranging from thin, poorly mineralized enamel with a "snow-capped" appearance to severe hypoplastic defects with minimal enamel. The c.145-1G>A mutation caused a -1 frameshift (NP_001133.1:p.Val35Cysfs*5). Overexpression of c.2T>C and c.29T>C AMELX demonstrated that mutant amelogenin proteins failed to be secreted, causing elevated endoplasmic reticulum stress and potential cell apoptosis. This study reveals a genotype-phenotype relationship for AMELX-associated AI: While amorphic mutations, including large deletions and 5' truncations, of AMELX cause hypoplastic-hypomaturation enamel with snow-capped teeth (AI types IIB and IIC) due to a complete loss of gene function, neomorphic variants, including signal peptide defects and 3' truncations, lead to severe hypoplastic/aplastic enamel (AI type IE) probably caused by "toxic" cellular effects of the mutant proteins.

Damage characteristics of gas extraction boreholes under different crustal stresses and their effects on gas extraction

AbstractTo investigate the effects of different crustal stresses on the stability of gas extraction boreholes, several equations were deduced. Additionally, the coupled flow‐solid model of gas extraction was constructed, given the elasticity−plasticity deformation of the coal body. Using the numerical simulation and analysis software of Comsol, a study was conducted on the deformation and damage of gas extraction boreholes under different crustal stresses. The results are as follows: with vertical stress increasing, the concentration area of shear stress, deformation amount, and the area of the plastic zone around the hole increase. Varied lateral pressure coefficients led to differing distribution positions of shear stress concentration areas and plastic zones around the hole. An increase in lateral pressure coefficient shifted the distribution positions of shear stress maximum. In addition, plastic zone, and permeability ratio maximum change from the left and right sides of the borehole to the upper and lower sides, and the larger the lateral pressure coefficient is, the worse the stability of the upper and lower sides of the borehole is. Higher lateral pressure coefficients inhibited extraction, with the effect becoming more pronounced over time. Elevated vertical stress and lateral pressure coefficients hindered negative pressure propagation in the borehole.

How leading edge roughness influences rain erosion of wind turbine blades?

Rain erosion of wind turbine blades is observed very commonly and is a concerning issue. Damage on the leading edge of blades leads to loss of aerodynamic efficiency. The mechanisms of damage initiation are not yet fully understood. This study focuses on the effect of existing surface damage or roughness of the leading edge of blades on impact stresses and erosion rates for the protective coating layer. The main mechanisms of interaction between impacting rain droplets and surface irregularities of a polyurethane-based coating are examined through finite element simulations and high-stress areas are identified. The results of the simulations reveal that areas inside erosion pits experience larger von Mises stresses than other undamaged areas. This could be explained by increased velocity as the water flows into erosion pits, observed in the simulations. At the same time, impacts on rough and damaged areas cause large stress values over a larger area than impacts on flat surfaces, due to the interaction with surface damage. These two observations could be the cause for faster erosion rates near damaged areas, as observed in experimental images during rain erosion testing. The predicted elevated stresses due to initial roughness or pre-existing damage could lead to faster damage growth, and to erosion pits growing wider and deeper.

Entropy generation and heat transport performance of a partially ionized viscoelastic tri-hybrid nanofluid flow over a convectively heated cylinder

A wide range of industrial applications where effective heat transport, fluid dynamics, and material adaptability are vital and can be addressed by the deployment of ternary hybrid nanofluids across an extensible cylinder. This work deals with entropy optimized flow and heat transport features of partially ionized and magnetically affected Prandtl fluid loaded with three nanomaterials drifting over a convectively heated cylinder. Three distinct nanomaterials (Al2O3,CuO,TiO2) are dispersed in order to enhance the heat performance rate of functional fluid. The ion and Hall slip effects, Joule heating, non-uniform heat source, and frictional heating are among the initial hypotheses in this computational analysis. The problem is presented quantitatively by taking the Tiwari-Das model to the basic equations. The Keller-Box framework is used to solve the nonlinear equations computationally. The findings reveal that enhancement in the Hall and ion slip effects diminish a rapid growth in entropy, while an opposite trend emerges for the Brinkman and magnetic parameter. The fluid motion is depressed by magnetic field intensity. The flow field and thermal transfer rate are enhanced by uplifting Prandtl first and curvature parameters. The system's irreversibility detracts with Brinkman number. A higher curvature parameter β results an elevated shear stresses and skin friction.