Elevated Lipid Profile Research Articles

449: Longitudinal measurements of proprotein convertase subtilisin kexin 9 (PCSK-9) in patients with and without preeclampsia

Cholesterol (CHOL) synthesis is necessary for healthy fetal and placental maturation and growth in pregnancy, and adverse pregnancy outcomes (APO) have been identified in women with significantly elevated or depressed lipid profiles. Proprotein convertase subtilisin kexin 9 (PCSK-9) enzyme degrades the low density receptor (LDL)-receptor found in hepatic and endothelial tissue, thus increases serum LDL through decreased receptor binding and is a surrogate marker for CHOL metabolism. Elevated PCSK-9 levels are associated with hypercholesterolemia and atherosclerosis but its characteristics during pregnancy are not well established. Our goal was to measure PCSK-9 during and late after normal and preeclamptic pregnancy to characterize biomarker levels associated with normal and abnormal pregnancy. We performed a single institution prospective cohort study. Inclusion criteria were women with singleton pregnancies > 23 weeks and diagnosis of preeclampsia with severe features (PEC), per ACOG guidelines. Controls were women with uncomplicated singleton gestations > 23 weeks. We excluded women with known hyperlipidemia. Longitudinal data were collected during pregnancy (2015) and non-pregnancy 4 years later (2019). Statistical analyses were performed using a paired t-test for longitudinal data, and all parametric and nonparametric data were analyzed appropriately with Graphpad, Version 8. The sample size was adequate to detect significance at p< 0.05 with a power of 80%. Demographic characteristics between groups were similar except for race (Table). There was a statistically significant decrease in longitudinal PCSK-9 levels from pregnancy to 4 year follow up (non-pregnancy), (114 (32.3) vs 63 (11.3), p=0.004). In contrast, this longitudinal decrease was not observed in patients with preeclampsia, (83 (19.0) vs 75 (24.4), p=0.381). (Figure) PCSK-9 levels are higher during normal pregnancy than in the non-pregnant state. However, patients with PEC do not have a higher level. PCSK-9 and CHOL metabolism should be further evaluated for associations with APO.View Large Image Figure ViewerDownload Hi-res image Download (PPT)

STUDY OF HBA1C, LIPID PROFILE AND CYCLOPHILIN-A IN DIABETES MELLITUS

Introduction: Diabetes is a chronic disease that occurs when not enough insulin is produced by the pancreas or the body does not use the insulin produced. Because of increased blood glucose levels in the body, serious heart, kidneys, blood vessels, nerves and eyes damage are caused. Report says about 400 million people suffer from diabetes. Therefore present study is aimed to assess levels of HbA1c, Lipid profile and Cyclophilin A in diabetic patient.&#x0D; Material and Methods: The present study includes total 126 subjects comprising of 66 type 2 Diabetes Mellitus patients and 60 healthy individual. Blood samples are collected from the all subjects were processed for HbA1c, Lipid Profile and Cyclophilin A estimation, from OPD and General Medicine Wards. HbA1c is estimated by HPLC, lipid Profile by AU480 and the Cyclophilin A by ELISA method using commercially available Qayee-bio ELISA kit.&#x0D; Conclusion: Present study showed significantly increased levels of HbA1c, Lipid Profile and Cyclophilin A in T2DM patients. The elevated lipid profile may be due to the complication of Diabetic mellitus. CyA is increased as an inflammation marker.&#x0D; Keywords: T2DM: Type 2 diabetes mellitus, HbA1c: Glycosylated Hemoglobin, CyA: Cyclophilin-A

Gastroileostomy for controlling body weight and lipid profile: An experimental rat model

Objectivethere is a direct correlation between development of obesity and elevated lipid profile. Restrictive and malabsorptive mechanisms along with stimulating neuroendocrine signals are major components of current bariatric surgeries. Higher weight loss is achieved by a malabsorptive operation compare to other bariatric procedures. In this study, we aim to investigate the early effects of gastroileostomy on weight reduction and lipid profile in rat model. Materials and methodsGastroileostomies with side-to-side anastomosis were performed on 15 male New Zealand rats. Blood samples were obtained at baseline and one week after the surgery. Blood samples were analyzed for lipid profiles. ResultsThe data showed that gastroileostomy leads to a significant decrease in weight (330 ± 15 vs. 240 ± 25 g before and after surgery, respectively; p = 0.04). The levels of triglycerides decreased in plasma (99.21 ± 29.012 mg/dl before and 95.64 ± 48.668 mg/dl after the surgery respectively; p = 0.807). Total cholesterol (71.14 ± 13.416 mg/dl vs. 72.64 ± 22.455 mg/dl; p = 0.813) and LDL (12.96 ± 4.853 mg/dl vs. 15.36 ± 5.665 mg/dl p = 0.121) had no significant changes after the operation. ConclusionBased on the results of this study, gastroileostomy is effective for weight reduction but has no statistically significant change on lipid profiles in a short time. Therefore, this surgery is a promising surgery for weight reduction like other methods of bariatric surgery.

Effects of Berberis vulgaris Extract on Lipid Profile, Kidney and Liver Function in Experimental Dyslipidemia

The ability of Berberis vulgaris bark extract (BVE) to improve the lipid profile was evaluated in an experimental model of dyslipidemia, along with its effects on liver and kidney functions. Fifty rats divided into five groups of ten animals each were fed with normal or lard-based diet and orally treated with 0.9% saline solution, atorvastatin (2.5 mg/kg per body weight) or extract of BVE (300 and 500 mg/kg/day) for eight weeks. Lipid profile, liver and renal functions were assessed in normal and diet-induced hypercholesterolemic rats. The results were compared between the groups treated with Berberis extract and the group without treatment, respectively that one treated with the standard drug (atorvastatin). Administration of BVE or atorvastatin significantly decreases the elevated serum lipid profile (p [0.05). The extract also protects against dyslipidemia-induced non-alcoholic fatty liver disease (NAFLD). The activities of the plant extract are dose dependent and it compares favorably with the standard drug atorvastatin. Variations in aspartate aminotransferase (AST), alanine aminotransferase (ALT), and urea level measurements were neither different between the two determinations nor between groups, but creatinine values decreased in rats in the BVE or atorvastatin-treated groups. The findings of the current study have suggested that BVE intake suppresses the accumulation of hepatic lipids and lipid parameters and reduce the risk of NAFLD. So, BVE can be useful in hypercholesterolemia.

The relationship between serum uric acid and lipid profile in Bangladeshi adults

BackgroundAlthough the link between elevated uric acid and metabolic syndrome has been reported in some studies; the relationship of serum uric acid (SUA) with lipid profile has not well studied or little is known so far. This study was conducted to assess the relationship between SUA and lipid profile among the general adults in Bangladesh.MethodsIn total, 280 blood samples were collected from general adult participants (male, n = 150 and female, n = 130) and analyzed for serum lipid profile (TC, TG, HDL and LDL) and SUA levels. The study subjects were divided by quartiles based on SUA levels (Q1: ≤225 μmol/L, Q2: 226–285 μmol/L, Q3: 286–340 μmol/L and Q4: > 340 μmol/L). Linear regression modeling was used to evaluate the relationship between SUA and lipid levels.ResultsThe prevalence of hyperuricemia was 9.2% in males and 10.4% in females. The mean level of SUA was significantly higher in male (317 ± 90 μmol/L) than in the female (255 ± 65 μmol/L) subjects (p < 0.001). An increasing trend for elevated lipid profile was observed in both gender with increasing levels of SUA in the quartiles (p < 0.05). In regression analysis, a significant positive correlation was found between SUA and TG, TC and LDL (p < 0.01) while an inverse correlation was observed between SUA and HDL (p < 0.01). After adjusting for potential confounders, lipid profile was linearly associated with SUA levels (p < 0.01 for trend).ConclusionsPresent study showed a significant positive relationship for SUA with TG, TC and LDL levels, and an inverse relationship for SUA with HDL. Early prevention of hyperuricemia and dyslipidemia may be helpful to reduce the incidence of associated cardiovascular diseases.

Impact of Cialis on Haemoglobin Concentration and Lipid Profile of Wistar Male Rats

Erectile dysfunction (ED) is the consistent or recurrent inability of a man to attain and/or maintain a penile erection enough for sexual activity, currently phosphodiesterase (PDE) inhibitors are used in the treatment of erectile dysfunction. This research work is set out to determine the lipid profile and haemoglobin concentration of wistar male rats administered with cialis, forty-five male albino wistar rats with an average weight of 100 g were used for the study. Cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL) and triglycerides concentration increased non-significantly at the 7th, 14th and 21st day following treatment, haemoglobin concentration also increased but its increase was significant as compared to the control animals. The elevated lipid profile with corresponding increase in hematocrit is as a result of reverse cholesterol transport mechanism. However due to the observed effect of the drug on lipid profile, utilization of the drug should be monitored as elevated lipid profile could pose as a risk factor for the development of other diseases.

English

Hyperlipidemia is one of the major health concerns worldwide. The present study aimed at utilizing clinicopathological tools to investigate the possible improving effect of Avena sativa mucilaginous extract (ASE) on lipid metabolic and liver function profiles in albino rats. The rats were rendered hyperlipidemic by 6-week supplementation of high-fat diet ad libitum. The rats were grouped into seven groups; with different treatment applications. Rats of group-I received normal diet and served as normal control; those of group-II were kept on high-fat (cholesterol 1% + coconut oil 2%) diet for 6 weeks and served as diseased control. Rats in group-III were kept on high-fat diet and received ezetimibe (1 mg/Kg B. Wt, orally, daily) and served as standard. Those in group-IV and V were kept on high-fat diet and received ASE at doses of 25 and 50 mg/Kg B. Wt., orally, daily (small and high doses, SD and HD, respectively) and served as treated-SD and treated-HD, respectively. While the last two groups (VI and VII) were kept on normal diet and received SD and HD of ASE. Blood samples for serum were taken for clinicochemical analysis on days 28 (4 weeks) and 42 (6 weeks) of the experiment and tissue specimens were taken for histopathology. ASE significantly (P<0.05) decreased the elevated serum lipid profile parameters, including total lipids, tri-acylglycerols (TAGs), cholesterol, LDL-C, VLDL-C, but significantly (P<0.05) normalized the serum HDL-C concentrations of rats kept on high-fat diet. Administration of A. sativa extract significantly decreased elevated serum liver enzyme activities in samples taken from animals kept on high-fat diet compared to the diseased untreated ones. Observations from histopathological examination were parallel and explanatory to clinicochemical analytical results. These data may suggest that the aqueous mucilaginous extract of A. sativa seed has a good health impact in cases associated with hyperlipidemia indicated by clinical pathology. Key words: Avena sativa, antihyperlipidemic, clinical pathology, liver function, phytotherapy, phytomedicine.

Rosuvastatin plus fenofibrate in diabetic dyslipidemia: a hospital record based study

Background: Cardiovascular diseases (CVD) are the leading cause of death throughout world population each and every year. Focus on dyslipidemia management is urgently required in India to halt the rising tide of CVD. The purpose of diabetic dyslipidemia study is a record based one, to find out the effect of Rosuvastatin plus Fenofibrate, in adult Type 2 diabetes with dyslipidemia, with high TGL/HDL ratio in Lipid profiles, in a tertiary care hospital in the Union territory of Puducherry.Methods: There were 101 patients hospital records were analysed in which male were 45 and females were 56. The various biochemical parameters like serum Total Cholesterol, HDL, LDL, TGL, Non-HDL, TCL/HDL Ratio and TGL/HDL ratio reports were collected before and after 12-weeks of Rosuvastatin 10 mg with Fenofibrate 145 mg combination, for the treatment period once daily for their lipid-lowering therapy.Results: The combination therapies of Rosuvastatin plus Fenofibrate were safe and feasible to achieve more TG goal and proved that has predominately decreased the elevated lipid profiles from the medical resources of our record based study. The use of combination medications of rosuvastatin (10mg) plus Fenofibrate (145mg) is often needed to effectively treat the lipid triad, by the potency of rosuvastatin to lower LDL-C and Fenofibrates effectiveness in lowering TG in treating mixed diabetic dyslipidemia.Conclusions: After Rosuvastatin (10mg) plus Fenofibrate (145mg), the lipid profile data proved that the importance of TGL/HDL ratio apart from the TCL/HDL ratio, for good lipid control in diabetic dyslipidemic patients.

In-vivo anti-diabetic and wound healing potential of chitosan/alginate/maltodextrin/pluronic-based mixed polymeric micelles: Curcumin therapeutic potential

Development of curcumin-loaded mixed polymeric micelles based on chitosan, alginate, maltodextrin, pluronic F127, pluronic P123, and tween 80, by thin-film hydration method has been investigated in Bisphenol A induced diabetics rats. Curcumin (C21H20O6) extracted from rhizomes of the “Curcuma longa” has attracted considerable attention of pharmaceutical researchers due to its low cost, excellent pharmacological activities and lesser side effects. Despite its diverse pharmacological properties, the therapeutic application of curcumin as an oral therapy has been limited due to its poor aqueous solubility, fixed chemical stability, and low bioavailability. In an attempt to overcome these limitations, we developed curcumin-loaded mixed polymeric micelles. Diabetes mellitus is a most common chronic carbohydrate metabolic disorder. The results clearly demonstrated the ability of developed formulation to reduce the elevated blood glucose level and lipid profile (total cholesterol, triglycerides). It maintained the body-weight, HDL cholesterol level, various biochemical parameters and accelerated the wound healing process when treated with these curcumin-based formulations. The treatment of curcumin loaded mixed polymeric formulations allowed a favorable inhibitory effect to these histopathological changes of liver, kidney, and pancreas. The newly developed curcumin-based formulations have proved superior therapeutic potential and excellent healing efficacy as compared to standard drugs and pure curcumin.

Implications of advanced oxidation protein products (AOPPs), advanced glycation end products (AGEs) and other biomarkers in the development of cardiovascular diseases.

ObjectiveTo study the putative effects of Advanced Oxidation Protein Products (AOPPs) and Advanced Glycation End Products (AGEs) in the development and progression of cardiovascular disease (CVD).MethodologyAGEs, AOPPs, e-NOS, lipid profile, circulating stress and inflammatory biomarkers were evaluated among fifty cardiovascular patients and fifty controls. Independent student’s t-test was done for statistical analysis.ResultsThe malondialdehyde mean level in CVD patients (5.45 nmol/ml) was significantly higher than control (1.36 nmol/ml) (p value = 0.018). Nitric oxide in CVD patients (55.72 ng/ml) was remarkably increased as compared to normal subjects (19.19 ng/ml). A significant change in the mean serum level of AGEs in CVD patients (2.74 ng/ml) and normal individuals (0.85 ng/ml) was recorded (p value = 0.000). The AOPPs also showed significant increased levels in CVD group (132.07 ng/ml) in comparison with normal subjects (83.05 ng/ml) (p value = 0.011). The mean eNOS serum level in CVD group (15.50 U/L) was higher than control group (11.28 U/L) (p value = 0.004). Cardiovascular disease patients, in comparison with healthy controls, showed increased level of total cholesterol (5.48 mmol/L vs 4.45 mmol/L), triglycerides (2.59 mmol/L vs 1.24 mmol/L), and low density lipoprotein (2.47 mmol/L vs 2.31 mmol/L) along with decrease in high density lipoprotein (1.39 mmol/L vs 1.74 mmol/L). The mean MMP-11 serum levels in CVD group (98.69 ng/ml) was almost double of control group (45.60 ng/ml) (p value = 0.017). The mean serum level of TNF-α and IL1-α were 32.16 pg/ml and 6.64 pg/ml in CVD patient. The significant decreasing trend of SOD (p value = 0.041), CAT (p value = 0.018), GSH (p value = 0.036) and GRx (p value = 0.029) but increasing drift of GPx (0.023) level was observed in CVD patients.ConclusionThis study provides strong evidence that CVD patients presented with elevated oxidative stress, enhanced inflammation and lipid profile in their serum. Therefore, the study strongly approves that AGEs, AOPPs, inflammatory and lipoxidative biomarkers hold predictive potential in causing and aggravating the disease, thus by controlling these factors CVD progression can be inhibited.

Understanding the Relationship between Atherogenic Index of Plasma and Cardiovascular Disease Risk Factors among Staff of an University in Malaysia.

Background Atherogenic index of plasma (AIP) was found to be one of the strongest markers in predicting the cardiovascular disease (CVD) risk. This study was to determine the AIP and its relationship with other CVD risk factors. Materials and Methods This cross-sectional study was done among 349 staff of a public university in Sarawak. Data were collected using questionnaire, blood sampling, and anthropometric and blood pressure measurement. Data were analyzed using IBM SPSS version 20. Results A total of 349 respondents participated with majority females (66.8%), aged 38.5 ± 7.82 years. Nearly 80% of the respondents were overweight and obese, 87.1% with high and very high body fat, and 46.9% with abnormal visceral fat. For AIP category, 8.9% were found to be in intermediate and 16.4% were at high risk. Elevated lipid profile showed that total cholesterol (TC) is 15.5%, low density lipoprotein (LDL) is 16.1%, and triglyceride (TG) is 10.6%. AIP was significantly correlated with body mass index (r=0.25), visceral fat (r=0.37), TC (r=0.22), LDL (0.24), HDL (r=−0.72), TG (r=0.84), glucose (r=0.32), systolic blood pressure (r=0.22), and diastolic blood pressure (r=0.28). Conclusion It indicated that AIP is associated with other CVD risk factors. Modification of lifestyle is strongly recommended.

Early diagnosis of progressing of diabetic nephropathy in patients with diabetes 1 type using clinical and laboratory indicators

The aim of the study was to determine the general clinical indicators of early diagnosis of the progression of diabetic nephropathy in patients with DM1T by studying the relationship between a set of clinical and laboratory parameters which characterize the kidney function and the lipid profile. A survey of 136 patients with DM1T was performed in the endocrinology department of the «Clinic of the Medical Academy», Dnipro in 2016-2017. The control group consisted of 20 practically healthy persons. Clinical laboratory examination included: general blood analysis, general urine analysis, lipid profile-total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG), blood creatinine level, level of albuminuria (AU). The glomerular filtration rate (GFR) was calculated using the formula CKD-EPI. The results of the study revealed a direct correlation between AU and GFR, which gives reason to consider the level of AU as an important marker of the progression of DN. Analysis of correlation relationships in subgroups of patients with DM1T found that the lipid profile of the blood had medium strength feedbacks with a GFR score. Therefore, the detection of elevated lipid profile indices in patients with diabetes mellitus may indicate a progression of DN. The regression model obtained in the study can be used to predict the GFR score in patients with diabetes.

Ischemia/reperfusion injury in male guinea pigs: An efficient model to investigate myocardial damage in cardiovascular complications

Myocardial ischemia/reperfusion (I/R) injury is the major problem that aggravates cardiac damage. Several established animal models fail to explain the similarity in disease mechanism and progression as seen in humans; whereas guinea pig shows high similarity in cardiovascular parameters. Hence, current study is aimed to develop an animal model using guinea pigs that may best correlate with disease mechanism of human myocardial I/R injury. Male guinea pigs were randomized into three groups: normal diet (ND), high fat diet (HFD) and sham; fed with respective diets for 90 days. Myocardial infarction (MI) was induced by ligating left anterior descending artery (LAD) for 30 min followed by 24 h and 7 days of reperfusion in ND and HFD groups. Electrocardiogram (ECG) showed the alterations in electrical conduction during myocardial I/R injury. Elevated levels of lactate dehydrogenase (LDH) and creatine kinase-MB ((CK-MB)) were higher in HFD compared to ND. Inflammatory markers such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were up-regulated in I/R injury animals compared to sham. Fold change of these protein expression levels were higher in HFD compared to ND. Elevated lipid profile and increased aortic wall thickness in HFD animals depicts the risk of developing cardiovascular complications. ECG analysis strongly confirmed MI through changes in sinus rhythm that are reflected in infarcted tissue as verified through TTC staining. Thus the combination of HFD followed by I/R injury proved to be an efficient model to study pathophysiology of myocardial I/R injury with minimal tissue damage and surgical mortality.

ANALYSIS OF PREDICTIVE FACTORS OF MORTALITY IN HEMORRHAGIC STROKE PATIENTS AT SOEBANDI HOSPITAL JEMBER

Stroke is a cerebrovascular disease that is often found in developed countries and currently also presents in developing countries, and one of them is in Indonesia. The high prevalence of stroke in Indonesia is affected by several risk factors such as obesity, lack of physical activity, unhealthy diet, smoking, high blood pressure, elevated blood sugar, and elevated blood lipid profile. The purpose of this study was to analyze the relationship between predictors of hemorrhagic stroke such as obesity, blood pressure, blood sugar and blood lipid profile with mortality in hemorrhagic stroke patients in RSD dr. Soebandi Jember. This research was a quantitative research with a retrospective approach. The number of samples was 101 medical record data. Univariate analysis was used to identify the description of each variable, a chi-square test was applied to analyze the correlation between variables, and the logistic regression analysis was applied to identify the most dominant factor influencing mortality of hemorrhagic stroke. The result of bivariate test showed p-value of obesity= 0,039, p-value of blood pressure= 0,478, p-value of blood sugar= 0,04, p-value of blood lipid profile= 0,026. Logistic regression obtained p-value for obesity= 0.043, OR = 2.689; p-value of blood sugar= 0,042, OR = 2,656; p-value of blood lipid profile= 0.069, OR = 3,749. There was a significant association between obesity, blood sugar, and blood lipid profile with mortality in hemorrhagic stroke patients. Obesity and blood sugar are predictors that can be used to predict mortality in hemorrhagic stroke patients, where obesity is the most dominant factor affecting mortality in hemorrhagic stroke patients.

Effects of dietary Spirulina on antioxidant status, lipid profile, immune response and performance characteristics of broiler chickens reared under high ambient temperature.

ObjectiveSpirulina has been recognized formerly as a filamentous spiral-shaped blue-green algae but more recently as a genus of photosynthetic bacteria (Arthrospira). This microorganism is considered as a rich source of essential nutrients for human and animals. The present study was conducted to determine potential application of Spirulina for heat-exposed broilers.MethodsTwo hundred and fifty Cobb 500 chicks with male to female in equal ratio with average initial weight of 615.6 g at 17 days of age were divided into 5 treatments with 5 replicates of 10 chicks. Treatment groups were as follows: positive and negative controls with 0% Spirulina supplement and three Spirulina receiving groups with 5 g/kg (0.5%), 10 g/kg (1%), and 20 g/kg (2%) supplementation. Spirulina receiving groups as well as positive control were exposed to high ambient temperature at 36°C for 6 h/d from 38 to 44 days of age. Biochemical variables were measured in serum samples at 35, 38, 42, and 45 days of broiler chickens age.ResultsThe results showed that supplementation of the diet with Spirulina decreased concentration of stress hormone and some serum lipid parameters while enhanced humoral immunity response and elevated antioxidant status whereas it didn’t meaningfully affect performance characteristics. Nevertheless, feed conversion ratio was improved numerically but not statistically in broilers fed with 1% Spirulina under high ambient temperature.ConclusionOverall, the present study suggests that alleviation of adverse impacts due to high ambient temperature at biochemical level including impaired enzymatic antioxidant system, elevated stress hormone and lipid profile can be approached in broiler chickens through supplementation of the diet with Spirulina platensis.

Assessment of changes in lipid profile and related enzymes in children with asthma

Purpose: To investigate the influence of the lipid profile and related parameters on the development of asthma in children aged 10 to 15 years.Methods: Peripheral blood samples were collected from a group diagnosed with asthma as well as from a healthy control group. The lipid profile parameters measured were total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), high-density lipoprotein (HDL), serum total antioxidant capacity (TAC), reduced glutathione (GSH), and malondialdehyde (MDA), and the activities of lecithin–cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP).Results: TC, TG, LDL, and VLDL levels were significantly (p ≤ 0.05) higher in the asthma group compared with the controls, while HDL level was lower. Total TAC and GSH were lower in the asthma group, while MDA level, and LCAT and CETP activities were higher.Conclusion: There is a link between an elevated lipid profile and increased antioxidant capacity in asthmatic children.

Effect of Haemodialysis on Elevated Serum lipid profile in cases of Chronic Kidney Disease

Effect of Haemodialysis on Elevated Serum lipid profile in cases of Chronic Kidney Disease

DOES HYPERCHOLESTOLEMIA PREDISPOSE TO ROTATOR CUFF PATHOLOGIES?

Background: Rotator cuff tear are one of most common orthopedic musculoskeletal problem gaining importance due to large health scale expenditure. Causes of rotator cuff tears are multifactorial and unclear. Previous studies have suggested relation between elevated serum lipid profile and rotator cuff tear in western population. We therefore undertook study in our Indian population to correlate association of hypercholesterolemia with rotator cuff tear.Objective: To find association of rotator cuff pathology with hypercholesterolemia in Indian patients.Materials and methods: After obtaining clearance from institutional ethics committee. We prospectively collected fasting lipid samples of population who came to our hospitals with complaints of shoulder pain during our study period. 50 patients had rupture of rotator cuff which was confirmed by ultrasound of involved shoulder. 50 were seen for non-cuff related complaints. We followed strict inclusion and exclusion criteria.Results: Total cholesterol, Triglycerides and low density lipoprotein concentration of patients with rotator cuff tendon tear were on higher side than control group. High density lipoprotein trend showed being lower than control group. 21 of 50 (42%) had high cholesterol (total cholesterol greater than 240mg/dl) than compared to 18 of 50 (36%) in control group. however P value=0.539 and showed no statistical significance between groups.Conclusion: In Indian population there was no correlation between hypercholesterolemia and rotator cuff tear which is statistically significant.Key words Rotator cuff tear, Hypercholesterolemia, Indian population.

Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High-Fat Diet-Fed Rats.

We evaluated the effects of cinnamon polyphenol extract on hepatic transcription factors expressions including SREBP-1c and LXR-α in rats fed high fat diet (HFD). Twenty-eight Wistar rats were allocated into four groups: (i) normal control: animals fed with normal chow; (ii) cinnamon: animals supplemented with cinnamon polyphenol; (iii) HFD: animals fed a high-fat diet; and (iv) HFD + cinnamon: animals fed a high-fat diet and treated with cinnamon polyphenol. Obesity was linked to hyperglycemia, hyperlipidemia, and oxidative stress as imitated by elevated serum glucose, lipid profile, and serum and liver malondialdehyde (MDA) concentrations. Cinnamon polyphenol decreased body weight, visceral fat, liver weight and serum glucose and insulin concentrations, liver antioxidant enzymes, and lipid profile (P < 0.05) and reduced serum and liver MDA concentration compared to HFD rats (P < 0.05). Cinnamon polyphenol also suppressed the hepatic SREBP-1c, LXR-α, ACLY, FAS, and NF-κB p65 expressions and enhanced the PPAR-α, IRS-1, Nrf2, and HO-1 expressions in the HFD rat livers (P < 0.05). In conclusion, cinnamon polyphenol reduces the hyperlipidemia, inflammation, and oxidative stress through activating transcription factors and antioxidative defense signaling pathway in HFD rat liver.

Modulatory effect of Drosera peltata J.E.Sm on development of metabolic syndrome in tumor bearing mice

The purpose of the study conducted was to know the extent of protection over the cancer associated metabolic syndrome development after administration of ethanol and aqueous extracts of Drocera peltata against Dalton’s ascites lymphoma (DAL) and Ehrlich's Ascites Carcinoma (EAC) bearing mice. Animals were divided into thirteen groups with a normal control, EAC control, DAL control, two groups with standard drug 5-Flurouracil 20mg/kg+ DAL &amp; EAC and eight groups with 250 and 500 mg/kg of ethanol and aqueous extracts of D.peltata + EAC &amp; DAL, for respective cell lines. After 24 hours of both tumor cell inoculation, animals were treated with extracts,once in a day for 14 days continuously. The indicators for the development of metabolic syndrome such as changes in blood glucose, serum hormone and lipid profile were found with both cell line bearing mice. Both ethanol and aqueous extracts of D.peltata at doses of 250 and 500mg/kg significantly reduced the elevated blood glucose, hormonal and lipid profile changes. These results confirmed that ethanol and aqueous extracts can stabilize the tumor induced hormonal, blood glucose and lipid profile changes in tumor bearing mice. This effect might be due to the presence of pharmacologically active phytoconstituents in extracts.