In various cellular systems, including cells of the immune system, a number of biological efiects induced by static magnetic flelds (SMFs) have been reported and difierent mechanisms have been proposed to explain these efiects. Although a number of theoretical mod- els have been proposed, the variety of experimental conditions (intensity, frequency and time windows of the flelds, difiering characteristics of the materials used- cell type, age, treatment) makes contradictory the data present in the literature and the possibility of the replication of the experiments. However, (S)MFs have been reported to perturb distribution of membrane proteins and sugars, cytoskeleton and trans-membrane ∞uxes of difierent ions, especially calcium (Ca 2+ )i. In turn, these alterations could interfere with speciflc physiological activies, like phagocytosis, which are based on receptors, cytoskeleton elements and motor proteins. In a previous work we found that, sinusoidal liver cells quickly recognized and engulfed human lymphocytes exposed for up to 72h to 6mT SMF, by using the same receptors that mediate the clearance of apoptotic cells. Thus, aim of the present work has been to decipher the modiflcations exerted by the SMF on lymphocytes and/or on the process of phagocytose. We analysed the cell surfaces of normal and apoptotic human lymphocytes in the presence or absence of 6mT SMF by immunocyto- chemistry and biochemistry assays. SMF increases, in a time-dependent way, the expression of GD3 ganglyoside and cholesterol on the plasma membrane of normal lymphocytes and prevents GD3 removal on apoptotic-induced cells. Lipid peroxidation of plasma membrane was observed soon after lymphocytes induction of apoptosis and after 72h of SMF exposure. The recognition and the engulfment of the control and apoptotic lymphocytes is modifled by SMF exposure. In fact, normal exposed lymphocytes are recognized by the liver sinusoids at the same extent of the apoptotic non exposed cells. Conversely, the exposure to SMF promoted the binding but delayed the engulfment of apoptotic lymphocytes in in situ as well as in in vitro phagocytose assays. Further studies will clarify the eventual implication of SMF on human health.