Digital Library Research Articles

Adoption of virtual library systems and services in university libraries: an empirical investigation from the Punjab, Pakistan

Purpose This study aims to identify the status of virtual library system development in university libraries. It also attempted to examine the availability of virtual library services and reveal the challenges being faced by university librarians of Punjab province, Pakistan in providing virtual library services. Design/methodology/approach The study used a quantitative research method by using a questionnaire to address the study’s objectives. In total, 62 university libraries in Punjab province, Pakistan were the population of the study. A purposive sampling technique was applied to gather the required data from the respondents. Findings Results showed that most of the study’s respondents are well aware of the potential benefits of virtual library systems in universities for the delivery of innovative smart services to library patrons. The libraries delivered different virtual library services to meet the diverse needs of the library patrons. The respondents faced the challenges of funding, expertise, technical support, leadership, strategic planning and training to adopt virtual library systems and services in university libraries. Originality/value The study has provided a framework based on empirical findings of the study to efficiently adopt virtual library systems and services in university libraries for the delivery of smart services to end users. It has provided pertinent theoretical and practical implications.

The digital library of Arab children's culture for sustainable development (DLACSD)

PurposeThis paper focuses on a project to work on the digital library of Arab children's culture for sustainable development (DLACSD).Design/methodology/approachThis project claims to link the past, present, and future by creating a platform that can grow to include not only works by adults but by children who inspire adults with their imagination and the joys they bring to the world.FindingsThis project addresses in phases the different aspects of the problem of the lack of material for Egyptian/Arab children at different stages in Arabic on the internet (with copyright law in mind). It is time to fill this gap by having a rich repository of stories, plays, games and songs for children in Arabic in a digital library to enrich the life of the child and to inform the world that much that is worthwhile is available in Arabic for parents, teachers, and children to enjoy.Research limitations/implicationsThrough reading samples of the works by Abdel-Tawab Youssef (1928–2015) by using the Dublin Core Elements, it will be informative to see how his writings address the United Nations Goals of Sustainable Development way before these Goals were discussed.Practical implicationsWriters for children, librarians, teachers, psychologists, literary critics, illustrators, and parents need a platform that makes material available to promote children’s culture in the Arab world and to introduce the world to what is of value for children in Arabic.Social implicationsCurrently, communication brings the world together and although the social media and the new technology have introduced problems that are serious, to say the least, collaborators on all levels must play an active role in redressing the social wrongs, especially those affecting children.Originality/valueThis ongoing project by members of a team who believe in interdisciplinarity and multidisciplinarity has taken the first step to create and develop (DLACSD).

Characteristics of natural environment use by occupational therapists working in mental health care: a scoping review.

The objective of this review was to identify and characterize the use of the natural environment/outdoor space by occupational therapists working in mental health care. This included consideration of the characteristics of the environment used, interventions, mental health conditions being treated, and the outcomes being used. Research has demonstrated the link between human health and the environment. The benefits appear to be particularly relevant to people with mental health conditions. Occupational therapists already consider the environment when assessing and developing interventions, and therefore are well placed to consider and use the natural environment in mental health practice. However, the use of the natural environment by occupational therapists working in mental health is unclear. The scoping review included any publication relating to the use of the natural environment/outdoor space in mental health occupational therapy practice. All forms of the natural environment or outdoor space were included, such as hospital gardens and local parks. There were no geographical, gender, or age restrictions. All mental health diagnoses were eligible for inclusion. Seven databases were searched: Embase (Ovid), Emcare (Ovid), MEDLINE (Ovid), PsycINFO (ProQuest), AMED (Ovid), Trip Database, and CINAHL (EBSCOhost). Gray literature was also searched using a selection of websites and digital repositories. Papers written in English were searched, with no time limit set on publication. Titles and abstracts were screened by 2 independent reviewers for assessment against the inclusion criteria, followed by a full-text review and data extraction. Data were extracted using the data extraction tool developed by the authors. Findings were presented in a tabular format, accompanied by a narrative summary describing how the results relate to the review objectives and question. Of peer-reviewed publications, 7 papers used qualitative methods and 7 used mixed methodology. The remaining sources included conference abstracts, unpublished works, a book chapter, and a website article. The environments used included forests, beaches, gardens, and parks. A variety of interventions were delivered in these environments, including gardening and nature-based activities, physical activities, and animal-assisted interventions. Such activity-focused interventions are largely delivered in a group context, thus providing a social element. A diverse range of mental health conditions were treated. Several methods were used to consider the outcomes on the individual, including both qualitative measures and quantitative outcome measurement tools. The review highlights many characteristics of how the natural environment is being used across mental health services by occupational therapists. A variety of conditions are targeted for such interventions, and several outcome measures have been used to understand impact. This review can support further development and implementation of nature-based approaches in mental health occupational therapy.

Perceptions of e-lending in Scandinavian libraries: tension and harmony between institutional logics

ABSTRACT This study examines e-lending dynamics in Scandinavian public libraries, by exploring the relationship between libraries and publishing houses. We ask how representatives of both fields perceive the public library’s role. Public libraries and publishers have traditionally served different roles in the book sphere: the library as a key cultural policy institution providing access to information and culture, and the publishers as involved in the production of books, operating on commercial premises. This relationship is affected by the change from ownership to licensing of digital book collections, which occurs along with changes on the national book markets. As a theoretical and analytical tool, the study uses the institutional logics perspective to explore the relations between different perceptions. We argue that this relationship can be illuminated through the dynamics of public service logic, market logic and digital logic. The study is empirically based on 26 in-depth interviews interviews with representatives of Danish, Norwegian and Swedish major libraries and trade publishers. Findings indicate that the relationship is nuanced and multifaceted, more than if it relied on a simple opposition between the public and the market. Both libraries and publishers share a common understanding of public service and market logics; however, they differ in perceptions of library’s role which is amplified by digital logic. The study also indicates that e-lending dynamics are influenced by cultural policies but with different outcomes in the three countries.

Whole body vibration therapy and diabetes type 2: a systematic review and meta-analysis

BackgroundVibration platforms have demonstrated systemic effects generated by the use of mechanical vibrations, which are similar to those of any physical activity. The effect that whole body vibration (WBV) generates on the organism could be recommended in Diabetes Mellitus 2 (DM 2) patients.ObjectiveTo systematically review and meta-analyze the available evidence on the effects of WBV on glycemic control in patients with DM 2Material and methodsExhaustive bibliographic searches were carried out until October 2023 in different biomedical portals and databases: Public Medline (PubMed), Scientific Electronic Library Online (SciELO), VHL Regional Portal, Cochrane Central and Latin American and Caribbean Literature in Health Sciences (LILACS). Randomized clinical trials based on the effects of Whole Body Vibration on glycosylated hemoglobin levels, with control group and participants were non-insulin dependent were the inclusion criteria. Two reviewers extracted data independently. A third reviewer was available for discrepancies.ResultsSix articles with 223 participants met the criteria and were included in the systematic review; only four of them met the criteria to be part of the meta-analysis. This meta-analysis reveals a positive and significant effect size (μ ê=0.5731), indicating a substantial difference between the groups studied. Although there is some variability between studies (heterogeneity of 30.05%), the overall direction of the effects is consistent. These findings conclusively suggest the presence of a significant influence of the variable evaluated, underscoring the robustness and consistency of the relationship observed in the literature reviewed.ConclusionThere are no conclusive results due to the lack of data for some variables, which prevents comparison; but WBV may be an effective therapy to improve glycemic control in DM 2 patients. More studies with more patients and longer follow-up are needed.

Mapping the evaluation of the electronic health system PEC e-SUS APS in Brazil: a scoping review protocol

BackgroundThe Brazilian Ministry of Health has developed and provided the Citizen’s Electronic Health Record (PEC e-SUS APS), a health information system freely available for utilization by all municipalities. Given the substantial financial investment being made to enhance the quality of health services in the country, it is crucial to understand how users evaluate this product. Consequently, this scoping review aims to map studies that have evaluated the PEC e-SUS APS.MethodsThis scoping review is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) framework, as well as by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Checklist extension for scoping reviews (PRISMA-ScR). The research question was framed based on the “CoCoPop” mnemonic (Condition, Context, Population). The final question posed is, “How has the Citizen’s Electronic Health Record (PEC e-SUS APS) been evaluated?” The search strategy will be executed across various databases (LILACS, PubMed/MEDLINE, Scopus, Web of Science, ACM Digital Library, and IEEE Digital Library), along with gray literature from ProQuest Dissertation and Theses Global and Google Scholar, with assistance from a professional healthcare librarian skilled in supporting systematic reviews. The database search will encompass the period from 2013 to 2024. Articles included will be selected by three independent reviewers in two stages, and the findings will undergo a descriptive analysis and synthesis following a “narrative review” approach. Independent reviewers will chart the data as outlined in the literature.DiscussionThe implementation process for the PEC e-SUS APS can be influenced by the varying characteristics of the over 5500 Brazilian municipalities. These factors and other challenges encountered by health professionals and managers may prove pivotal for a municipality’s adoption of the PEC e-SUS APS system. With the literature mapping to be obtained from this review, vital insights into how users have evaluated the PEC will be obtained.Systematic review registrationThe protocol has been registered prospectively at the Open Science Framework platform under the number 10.17605/OSF.IO/NPKRU.

Designing for Sustained Motivation: A Review of Self-Determination Theory in Behaviour Change Technologies

Abstract Recent years have seen a surge in applications and technologies aimed at motivating users to achieve personal goals and improve their wellbeing. However, these often fail to promote long-term behaviour change, and sometimes even backfire. We consider how self-determination theory (SDT), a metatheory of human motivation and wellbeing, can help explain why such technologies fail, and how they may better help users internalize the motivation behind their goals and make enduring changes in their behaviour. In this work, we systematically reviewed 15 papers in the ACM Digital Library that apply SDT to the design of behaviour change technologies (BCTs). We identified 50 suggestions for design features in BCTs, grounded in SDT, that researchers have applied to enhance user motivation. However, we find that SDT is often leveraged to optimize engagement with the technology itself rather than with the targeted behaviour change per se. When interpreted through the lens of SDT, the implication is that BCTs may fail to cultivate sustained changes in behaviour, as users’ motivation depends on their enjoyment of the intervention, which may wane over time. An underexplored opportunity remains for designers to leverage SDT to support users to internalize the ultimate goals and value of certain behaviour changes, enhancing their motivation to sustain these changes in the long term.

Saudi Digital Library Services in the Light of the National and International Sustainable Development Goals

The study aimed to identify the concept of sustainable development, and to explore the role of digital libraries in achieving SDGs, by shedding light on the reality of the SDL in terms of financial, technical and human capabilities to achieve the Kingdom’s 2030 vision for sustainable development. The study revealed that digital libraries play an active role in achieving SDGs through secure and diverse technical infrastructure, and a variety of digital information sources. Digital libraries enhance the level of information awareness among users. Among digital libraries worldwide, SDL is distinguished in terms of knowledge resources acquired, its platforms, and through the large number of beneficiaries of its services, representing all segments of the academic community in Saudi Arabia's higher education institutions. Based on a solid network, and Saudi Arabia vision 2030, SDL succeeded to link higher education institutions through a huge amount of information sources, and facilitated their access, and provided equal opportunities for all. The study recommended that in order to be the national digital platform and effective development partner, SDL must expand the scope of services to include trade and industrial private and public sectors, and raise the level of research awareness and ethics among Arab scholars and researchers.

An innovative distance learning platform for mathematics education in secondary schools: Design, development and preliminary studies

AbstractThis study addresses the emerging challenges in mathematics education, emphasizing the integration of innovative teaching strategies and tools amidst the evolving educational landscape. The study begins with an analysis of prevalent e-learning and communication systems in distance education, pinpointing their limitations and identifying the gaps in effective remote mathematics instruction. In response, we introduce a novel educational platform designed to facilitate real-time mathematics teaching over the Internet, aiming to replicate the interactive essence of traditional classroom settings within a digital domain. The system features a suite of tools including a mathematical editor, a virtual whiteboard, audio-video communication capabilities, a virtual library, and an evaluation support module, all accessible via a standard web browser. The platform’s effectiveness was assessed through its application in regular mathematics classes at two secondary schools in Romania, as well as in a private tutoring scenario. The paper presents the findings of these preliminary studies, offering insights into the usefulness and usability of the platform and its potential to seamlessly integrate into existing educational frameworks without compromising the quality of instruction.

Adoption of Advanced Systems for Digital Resource Management in Academic Institutions

In educational organizations, digital resource management refers to the organization and enhancement of electronic resources, including databases, libraries, and digital instructional materials. Excellent administration ensures optimal utilization, improves accessibility, and advances learning objectives. To achieve better institutional results, this approach entails incorporating digital tools, handling issues like data security and user training, and adjusting to new technological developments. Using an emphasis on the integration of digital libraries, e-learning platforms, and research databases, this study investigates the technologies and approaches used in maintaining digital resources within higher education circumstances. Through the use of a survey research design, this study employed a quantitative research methodology. Data gathered from a sample of 250 undergraduate students was utilized in this investigation. This study looks at the connections between teaching profile (TP), technology competence (TC), digital technology awareness (DTA), utility perception (UP), and usage motivation (UM). SPSS was utilized statistically to obtain the outcomes. Descriptive, correlation, and regression analysis were used to obtain the results utilizing data gathered from a sample of university participants. Significant of both conceptual and actual consequences have resulted from the findings.According to the study's findings, efficient use of digital resources in academic institutions greatly improves accessibility and resource utilization, both of which contribute to better learning outcomes.

A Synthetic View on Acanthamoeba Keratitis Host Immune Response: Potential Factors Influencing the Development of Chronic Inflammation

Purpose: The purpose of this study was to compile the current knowledge concerning Acanthamoeba keratitis (AK) host immune response to better understand the elements involved in the chronification of inflammation and worse disease outcomes. Methods: A scoping review of the literature on AK host immune response was written after a systematic literature search was performed on the PubMed, Latin American Caribbean Health Sciences Literature, Cochrane Library, Embase, Web of Science, and Scientific Electronic Library Online databases. Recovered articles were screened according to inclusion and exclusion criteria, and the selected studies were analyzed to compile the review. Results: The search strategy yielded a total of 768 articles from all searched databases. After the exclusion of duplicate records, 412 studies were screened according to inclusion and exclusion criteria. Finally, a total of 95 articles were selected to compile this review, of which 15 were included as additional bibliography. As for study type, 45 were experimental, 19 were observational, 23 were case reports, and 8 were reviews. Conclusions: From the literature, both innate and adaptive immune systems seem to play an important role in AK control and resolution. On the other hand, there is also abundant evidence pointing out that the development of chronic and extracorneal inflammation is immune mediated and is influenced by several factors such as individual patient genetic variability, inadequate treatment, and Acanthamoeba strain pathogenicity.

Nursing Staff's Perspectives of Care Robots for Assisted Living Facilities: Systematic Literature Review.

Care robots have been proposed in response to nursing shortages in assisted living facilities (ALFs) and the growing population of older adults. While the use of care robots may improve the general health and well-being of older adults, their introduction changes the work of nursing staff fundamentally, and it has implications for the entire health care system. In developing such technology, it is important to include end users, but so far, the nursing staff's perspectives have largely been ignored. This study aims to examine the literature on nursing staff's attitudes, needs, and preferences related to the use of care robots in ALFs, in order to discover gaps in the literature and guide future research. This review follows the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 protocol. On May 12, 2023, we searched PubMed, CINAHL Plus with Full Text, PsycINFO, the IEEE Xplore Digital Library, and the ACM Digital Library using predetermined search terms. Included publications, written in English, focused on the predevelopment phase, in which information was gathered on nursing staff's attitudes, needs, and preferences regarding care robots for ALFs. Publications were excluded if they did not provide peer-reviewed empirical data. The studies' findings were summarized, coded, and analyzed into major themes using thematic analysis and narrative synthesis. Their quality was assessed using McGill University's Mixed Methods Appraisal Tool and the Joanna Briggs Institute's critical appraisal tools. The final sample included 15 studies. Most of the studies (n=11, 73%) were rated as good quality; however, there was a general lack of reporting on important methodological decisions and sample characteristics. Nursing staff desired care robots that could assist with physically demanding tasks and reduce their workload but had mixed feelings on whether robots could or should assist with social tasks. In addition, nursing staff are concerned about the ethics of care robots, as well as about their safety, accessibility, and operability. The nursing staff's culture, qualification, and role in the facility may influence their perspectives of care robots. The studies lacked theory-driven designs and large sample sizes. Eight (53%) studies mentioned using a participatory design approach, but a lack of established criteria for what constitutes participatory design leads to varying degrees of methodological quality. There was consensus among nursing staff that care robots should serve as nursing assistants to reduce workload. Whether robots could or should assist with social tasks remains a question. Further research is needed to mitigate nursing staff's concerns and understand the socioecological factors that influence their perspectives of care robots and their adoption in ALFs. In addition, theory-driven and large sample size study designs are necessary, as well as work to develop clear criteria for related participatory design research.

FATORES ASSOCIADOS À QUALIDADE DE VIDA DE CUIDADORES DE IDOSOS COM DEMÊNCIA

The objective of this study was to analyze the factors that influence the quality of life of caregivers of elderly people with Alzheimer's dementia. An integrative literature review study was conducted using the secondary databases Virtual Health Library, Latin American and Caribbean Health Sciences Literature, Scientific Electronic Library Online and Online System for Search and Analysis of Medical Literature based on the specific descriptors retrieved in the Health Sciences Descriptors. The factors associated with the quality of life of caregivers of elderly people with Alzheimer's dementia were burden, functional decline and dependence of the elderly to perform activities of daily living, degree of dementia severity, longer time since diagnosis and living with the demented elderly, socioeconomic conditions, psychological stress and decline in social relationships, environment domain, psychological and physical. It is essential that care is also cared for, both from the point of view of health and in relation to public policies of social security and assistance.

FATORES ASSOCIADOS AOS TRANSTORNOS MENTAIS COMUNS ENTRE PROFESSORES

Objective: To identify the main common mental disorders identified among teachers. Materials and methods: This is a literature review with research in several virtual libraries, such as the nursing database (DENF), Latin American and Caribbean Health Sciences Literature (LILACS) and Scientific Electronic Library Online (SciELO). Results: Stress is one of the most common problems faced, characterized by a state of permanent tension, causes an intense imbalance in the body, which can trigger several serious diseases. Conclusion: The lack of motivation to work is one of the main factors that lead many teachers to look for other jobs and suffer from mental illnesses. The revaluation of education professionals, together with better salaries and a decent workload, would lead to a greater demand for the area and a better quality of life.

A scoping review about the portrayal of mental illness in commercial video games

AbstractCurrent research is sparse on the relatively new but highly relevant topic of mental disorders in video games. This scoping review aimed to map the existing research on portrayal of mental illness in video games. PubMed, PsychInfo, PsycArticles, Medline, Scopus and the ACM Digital Library were searched, resulting in the final inclusion of seven records. Prevalences for the representation of mental illness ranged from 12 to 24%. Findings indicate that video games’ portrayal of mental illness is predominantly stigmatizing and negatively connoted. Mental illness frequently serves as a reason for violent behavior and is portrayed in line with paranormal experiences. Yet, some games portray mental illness in a more neutral way, using game mechanics to elicit empathy. While this review emphasizes the need for non-stigmatizing depiction, potentially through the inclusion of experts in the development process, future research should examine how much consumers are affected by the negative or positive portrayal of mental illnesses in video games.

The Efficacy of Manual Therapy on Musculoskeletal Pain in Menopause: A Systematic Review

(1) Background: The aim of this review was to evaluate the effects of manual therapy for musculoskeletal pain in menopausal women. (2) Methods: A comprehensive search of manuscripts published from inception until 29 February 2024 was conducted on PubMed, EBSCO Information Services (EBSCOhost), Physiotherapy Evidence Database (Pedro), Web of Science, Scientific Electronic Library Online (SciELO), Cochrane Central Register of Controlled Clinical Trials, and Scopus using Medical Subject Headings (MeSH) and free terms. Randomized controlled trials (RCT) investigating the effects of manual therapy for musculoskeletal pain in postmenopausal women were included. Articles published in non-English or non-Portuguese languages, case reports, expert opinions, dissertations, conference papers, and gray literature were excluded. Studies were screened for population, musculoskeletal pain, intervention, and pain outcome by two independent reviewers using an ad hoc data extraction form. (3) Results: A total of 5 RCTs (4 with high risk of bias and 1 with low risk of bias) were included (total sample = 245), addressing thumb carpometacarpal osteoarthritis, thoracic kyphosis, chronic neck and backache, knee osteoarthritis, and sternocostal joint pain. The combined results of these studies showed improved musculoskeletal pain in menopausal women; duration of the follow-up was between 4 weeks to 6 months. Conclusions: The majority of studies included in this systematic review were effective in reducing musculoskeletal pain in menopausal women. These results come mainly from studies with a high risk of bias with small sample sizes, and the most representative follow-up period was short-term. Therefore, the results of this systematic review should be interpreted with caution.

Data Analytics in Physical Activity Studies With Accelerometers: Scoping Review.

Monitoring free-living physical activity (PA) through wearable devices enables the real-time assessment of activity features associated with health outcomes and provision of treatment recommendations and adjustments. The conclusions of studies on PA and health depend crucially on reliable statistical analyses of digital data. Data analytics, however, are challenging due to the various metrics adopted for measuring PA, different aims of studies, and complex temporal variations within variables. The application, interpretation, and appropriateness of these analytical tools have yet to be summarized. This research aimed to review studies that used analytical methods for analyzing PA monitored by accelerometers. Specifically, this review addressed three questions: (1) What metrics are used to describe an individual's free-living daily PA? (2) What are the current analytical tools for analyzing PA data, particularly under the aims of classification, association with health outcomes, and prediction of health events? and (3) What challenges exist in the analyses, and what recommendations for future research are suggested regarding the use of statistical methods in various research tasks? This scoping review was conducted following an existing framework to map research studies by exploring the information about PA. Three databases, PubMed, IEEE Xplore, and the ACM Digital Library, were searched in February 2024 to identify related publications. Eligible articles were classification, association, or prediction studies involving human PA monitored through wearable accelerometers. After screening 1312 articles, 428 (32.62%) eligible studies were identified and categorized into at least 1 of the following 3 thematic categories: classification (75/428, 17.5%), association (342/428, 79.9%), and prediction (32/428, 7.5%). Most articles (414/428, 96.7%) derived PA variables from 3D acceleration, rather than 1D acceleration. All eligible articles (428/428, 100%) considered PA metrics represented in the time domain, while a small fraction (16/428, 3.7%) also considered PA metrics in the frequency domain. The number of studies evaluating the influence of PA on health conditions has increased greatly. Among the studies in our review, regression-type models were the most prevalent (373/428, 87.1%). The machine learning approach for classification research is also gaining popularity (32/75, 43%). In addition to summary statistics of PA, several recent studies used tools to incorporate PA trajectories and account for temporal patterns, including longitudinal data analysis with repeated PA measurements and functional data analysis with PA as a continuum for time-varying association (68/428, 15.9%). Summary metrics can quickly provide descriptions of the strength, frequency, and duration of individuals' overall PA. When the distribution and profile of PA need to be evaluated or detected, considering PA metrics as longitudinal or functional data can provide detailed information and improve the understanding of the role PA plays in health. Depending on the research goal, appropriate analytical tools can ensure the reliability of the scientific findings.

Using Immersive Planning Tools to Reimagine Virtual Libraries

Immersive technologies (e.g., Virtual Reality) can both reproduce existing spaces or help bring imagination to life. When considered in relation to the needs of the users, these technologies can facilitate rewarding experiences that encourage repeated usage. However, poorly motivated experiences may result in expensive mistakes. One rewarding experience has been through the creation of immersive sound planning tools to help Professionals of the Built Environment (e.g. urban plannersand designers) consider sound in their work (Yanaky et al., 2023). Using a user-centered design process, we developed a Virtual Reality planning tool, City Ditty. A first evaluation indicated that users, regardless of their experience, could complete both a sound-awareness learning phase and implement their own soundscape designs in under an hour. Feedback was positive, suggesting value for its use in public consultations and participatory approaches towards creating healthier, inclusive, and sustainable communities. Could City Ditty be used to help rethink and prototype new forms of virtual libraries? Libraries host a wealth of information and contribute community space. They also act as community hubs for classes, games, storytelling, community events, etc. Yet, digitally reproducing a navigable 3D library space without consideration for the medium will reproduce the inconveniences of existing spaces, while failing to take advantage of the new medium. Could similar methodologies help engage library users to conceptualize together the future of virtual libraries? How might different users want to utilize immersive virtual libraries? We place this discussion in the context of a hype cycle for emerging technologies to understand potential timelines for change.

Insights from ARCOS-V’s Transition to Remote Data Collection During the COVID-19 Pandemic: A Descriptive Study

Introduction: The ARCOS-V study, an epidemiological study on stroke and transient ischemic attack (TIA), faced the challenge of continuing data collection amidst the COVID-19 pandemic. This study aims to describe the methodological changes and challenges encountered during the transition from paper-based methods to digital data collection for the ARCOS-V study, and to provide insights into the potential of using digital tools to transform epidemiological research. Methods: The study adapted to remote data collection using REDCap and Zoom, involving daily health record reviews, direct data entry by trained researchers, and remote follow-up assessments. The process was secured with encryption and role-based access controls. The transition period was analyzed to evaluate the effectiveness and challenges of the new approach. Results: The digital transition allowed for uninterrupted monitoring of stroke and TIA cases during lockdowns. Using REDCap and Zoom improved data reach, accuracy, and security. However, it also revealed issues such as the potential for systematic data entry errors and the need for robust security measures to protect sensitive health information. Conclusion: The ARCOS-V study’s digital transformation exemplifies the resilience of epidemiological research in the face of a global crisis. The successful adaptation to digital data collection methods highlights the potential benefits of such tools, particularly as we enter a new age of Artificial Intelligence (AI).

DrugSynthMC: An Atom-Based Generation of Drug-like Molecules with Monte Carlo Search.

A growing number of deep learning (DL) methodologies have recently been developed to design novel compounds and expand the chemical space within virtual libraries. Most of these neural network approaches design molecules to specifically bind a target based on its structural information and/or knowledge of previously identified binders. Fewer attempts have been made to develop approaches for de novo design of virtual libraries, as synthesizability of generated molecules remains a challenge. In this work, we developed a new Monte Carlo Search (MCS) algorithm, DrugSynthMC (Drug Synthesis using Monte Carlo), in conjunction with DL and statistical-based priors to generate thousands of interpretable chemical structures and novel drug-like molecules per second. DrugSynthMC produces drug-like compounds using an atom-based search model that builds molecules as SMILES, character by character. Designed molecules follow Lipinski's "rule of 5″, show a high proportion of highly water-soluble nontoxic predicted-to-be synthesizable compounds, and efficiently expand the chemical space within the libraries, without reliance on training data sets, synthesizability metrics, or enforcing during SMILES generation. Our approach can function with or without an underlying neural network and is thus easily explainable and versatile. This ease in drug-like molecule generation allows for future integration of score functions aimed at different target- or job-oriented goals. Thus, DrugSynthMC is expected to enable the functional assessment of large compound libraries covering an extensive novel chemical space, overcoming the limitations of existing drug collections. The software is available at https://github.com/RoucairolMilo/DrugSynthMC.