Electron Source Research Articles

Evidence for autotrophic growth of purple sulfur bacteria using pyrite as electron and sulfur source.

Microbial utilization of solid-phase substrates constitutes a critical area of focus in environmental microbiology, offering valuable insights into microbial metabolic processes and adaptability. Recent advancements in this field have profoundly deepened our knowledge of microbial physiology pertinent to these scenarios and spurred innovations in biosynthesis and energy production. Furthermore, research into interactions between microbes and solid-phase substrates has directly linked microbial activities to the surrounding mineralogical environments, thereby enhancing our understanding of the relevant biogeochemical cycles. Our study represents a significant step forward in this field by demonstrating, for the first time, the autotrophic growth of purple sulfur bacteria using insoluble pyrite (FeS2) as both the electron and sulfur source. The presented comparative growth profiles, substrate characterizations, and transcriptomic sequencing data shed light on the relationships between electron donor types, photosynthetic reaction center activities, and potential extracellular electron transfer in these organisms capable of anoxygenic photosynthesis. Furthermore, the findings of our study may provide new insights into early-Earth biogeochemical evolutions, offering valuable constraints for understanding the environmental conditions and microbial processes that shaped our planet's history.

Preemptive oral analgesia with steroidal and nonsteroidal anti-inflammatory drugs in periodontal surgery: a systematic review.

Introduction: Periodontal procedures can promote prolonged intense pain, particularly in clinical situations requiring surgical procedures. In this context, preemptive analgesia has also been assessed for its utility in controlling post-operative pain and discomfort in patients undergoing periodontal invasive procedures. This study assessed the efficacy and safety of preemptive oral analgesia with steroidal and non-steroidal anti-inflammatory drugs in periodontal surgeries. Methods: This systematic review performed a search in the following electronic sources: the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (via PubMed), EMBASE (via Ovid), Web of Science, Virtual Health Library and in clinical trials electronic databases for relevant randomized clinical trials (RCTs); published up to July 2023. Primary outcomes assessed were post-operative pain, edema and trismus. A narrative synthesis of the findings was carried out. Results: Six RCTs, involving a total of 250 participants, were included. The studies reviewed had a high risk of bias, particularly due to allocation concealment and blinding of participants and personnel. The RCTs reported only the outcome pain. The preemptive use of dexamethasone 8mg, etoricoxib 90mg or 120mg and ketorolac 20mg seems to be more effective for controlling post-operative pain than placebo. Discussion: The anti-inflammatory drugs evaluated proved to be effective for controlling post-operative pain. However, given the limitations regarding lack of studies, methodological biases, disparities in drugs and doses, report restricted the pain outcome; further RCTs confirming the effectiveness and safety of these drugs in periodontal surgical procedures are warranted.

Digital educational content compilation sources

The development of digitalization of higher education leads to the emergence of new methods and means of learning. At present, information technologies are increasingly used, including distance learning, digital sources are used to create educational content, which opens new prospects for increasing motivation to study disciplines, activation of students’ activity in the learning process and, in general, for the professional success of university graduates. The article analyzes digital sources of spatial educational content compilation in mastering ecological and environmental educational disciplines and materials (by the example of bachelor’s training in the direction 21.03.02 Land management and cadastres). It is important for future specialists in the field of land management and cadastre to be able to use a variety of digital sources of data on the current state of land resources in their daily activities. The information sources in the form of spatial positioning public services, interactive topographic, geological and hydrological map, the map of dangerous exogenous geological processes manifestation, the map of territory functional zoning, the website of the Russian Federation hydrometeorological service management are shown and verified. It is important to use up-to-date geo-ecological and land-cadastral information when studying natural science disciplines, it is inadmissible to study outdated literary materials, inaccurate and unreliable data from electronic sources.

Anoxygenic photosynthesis with emphasis on green sulfur bacteria and a perspective for hydrogen sulfide detoxification of anoxic environments.

The bacterial light-dependent energy metabolism can be divided into two types: oxygenic and anoxygenic photosynthesis. Bacterial oxygenic photosynthesis is similar to plants and is characteristic for cyanobacteria. Bacterial anoxygenic photosynthesis is performed by anoxygenic phototrophs, especially green sulfur bacteria (GSB; family Chlorobiaceae) and purple sulfur bacteria (PSB; family Chromatiaceae). In anoxygenic photosynthesis, hydrogen sulfide (H2S) is used as the main electron donor, which differs from plants or cyanobacteria where water is the main source of electrons. This review mainly focuses on the microbiology of GSB, which may be found in water or soil ecosystems where H2S is abundant. GSB oxidize H2S to elemental sulfur. GSB possess special structures-chlorosomes-wherein photosynthetic pigments are located. Chlorosomes are vesicles that are surrounded by a lipid monolayer that serve as light-collecting antennas. The carbon source of GSB is carbon dioxide, which is assimilated through the reverse tricarboxylic acid cycle. Our review provides a thorough introduction to the comparative eco-physiology of GSB and discusses selected application possibilities of anoxygenic phototrophs in the fields of environmental management, bioremediation, and biotechnology.

Comparison of low versus high (standard) intraabdominal pressure during laparoscopic colorectal surgery: systematic review and meta-analysis

BackgroundTo evaluate outcomes of low with high intraabdominal pressure during laparoscopic colorectal resection surgery.MethodsA systematic search of multiple electronic data sources was conducted, and all studies comparing low with high (standard) intraabdominal pressures were included. Our primary outcomes were post-operative ileus occurrence and return of bowel movement/flatus. The evaluated secondary outcomes included: total operative time, post-operative haemorrhage, anastomotic leak, pneumonia, surgical site infection, overall post-operative complications (categorised by Clavien-Dindo grading), and length of hospital stay. Revman 5.4 was used for data analysis.ResultsSix randomised controlled trials (RCTs) and one observational study with a total of 771 patients (370 surgery at low intraabdominal pressure and 401 at high pressures) were included. There was no statistically significant difference in all the measured outcomes; post-operative ileus [OR 0.80; CI (0.42, 1.52), P = 0.50], time-to-pass flatus [OR -4.31; CI (-12.12, 3.50), P = 0.28], total operative time [OR 0.40; CI (-10.19, 11.00), P = 0.94], post-operative haemorrhage [OR 1.51; CI (0.41, 5.58, P = 0.53], anastomotic leak [OR 1.14; CI (0.26, 4.91), P = 0.86], pneumonia [OR 1.15; CI (0.22, 6.09), P = 0.87], SSI [OR 0.69; CI (0.19, 2.47), P = 0.57], overall post-operative complications [OR 0.82; CI (0.52, 1.30), P = 0.40], Clavien-Dindo grade ≥ 3 [OR 1.27; CI (0.59, 2.77), P = 0.54], and length of hospital stay [OR -0.68; CI (-1.61, 0.24), P = 0.15].ConclusionLow intraabdominal pressure is safe and feasible approach to laparoscopic colorectal resection surgery with non-inferior outcomes to standard or high pressures. More robust and well-powered RCTs are needed to consolidate the potential benefits of low over high pressure intra-abdominal surgery.

Oxidative Metabolism as a Cause of Lipid Peroxidation in the Execution of Ferroptosis.

Ferroptosis is a type of nonapoptotic cell death that is characteristically caused by phospholipid peroxidation promoted by radical reactions involving iron. Researchers have identified many of the protein factors that are encoded by genes that promote ferroptosis. Glutathione peroxidase 4 (GPX4) is a key enzyme that protects phospholipids from peroxidation and suppresses ferroptosis in a glutathione-dependent manner. Thus, the dysregulation of genes involved in cysteine and/or glutathione metabolism is closely associated with ferroptosis. From the perspective of cell dynamics, actively proliferating cells are more prone to ferroptosis than quiescent cells, which suggests that radical species generated during oxygen-involved metabolism are responsible for lipid peroxidation. Herein, we discuss the initial events involved in ferroptosis that dominantly occur in the process of energy metabolism, in association with cysteine deficiency. Accordingly, dysregulation of the tricarboxylic acid cycle coupled with the respiratory chain in mitochondria are the main subjects here, and this suggests that mitochondria are the likely source of both radical electrons and free iron. Since not only carbohydrates, but also amino acids, especially glutamate, are major substrates for central metabolism, dealing with nitrogen derived from amino groups also contributes to lipid peroxidation and is a subject of this discussion.

Angler knowledge of live bait regulations and invasive species: insights for invasive species prevention

The prevention of aquatic invasive species is one of the most cost-effective management strategies for reducing negative ecological, economic, and social impacts to freshwater ecosystems. The release of leftover baitfish via the live bait trade has been identified as a high-risk pathway for introducing invasive species beyond physical barriers (e.g., mountains, dams). To assess differences in behavior surrounding live bait use and angler knowledge of invasive species, we conducted in-person angler surveys at waterbody access sites (i.e. boat ramps with available shore fishing and a shore fishing location with no boat ramp) along the Missouri River, above and below Gavins Point Dam (Yankton, South Dakota, USA). We were primarily interested in whether angler behavior and knowledge differed among fishing locations over the course of a year because of potential variation in risk. Gavins Point Dam is impervious to fish passage and prevents the spread of invasive silver carp Hypophthalmichthys molitrix and bighead carp H. nobilis (collectively known as bigheaded carp), but bigheaded carp could be transported above this dam by the use of live baitfish. Regardless of where respondents fished (above the dam/carp absent, below the dam/carp present, or both), 70% ± 11.12 of anglers used live baitfish and 57% ± 3.14 participated in ‘higher risk’ baitfish practices including release. Knowledge of bigheaded carp was limited, as only 2% ± 1.31 of respondents identified both bigheaded carp as invasive in an image collage, 51.82% ± 4.48 could not identify where invasive carp are present/absent, and 40% ± 3.34 of anglers had not received any information regarding bigheaded carp. These findings highlight limitations in angler knowledge, compliance, and identification of native and invasive species. Future implementable actions could include invasive species and baitfish release outreach via electronic media sources or additional signage that address these knowledge gaps.

Priority directions in the design of a youth culture and leisure center in Khuzhir settlement

We consider the relevance and importance of creating a youth culture and leisure center in the rural locality of Khuzhir. To this end, the results of sociological surveys among the population of the Olkhonsky District and young people of the Russian Federation, who form the main target audience of the youth center, were used. The research also involved a review of electronic sources and publications on the design of culture and leisure centers in the settlements of the Baikal coastal area, statistical data on tourism activities in the area of Olkhon Island and additional education initiatives in Russia, sociological surveys among Olkhon population and residents of the Russian Federation and CIS countries. A review of project proposals for the organization of leisure, culture, and education institutions in rural areas of Pribaikalye was carried out. All these findings were used to identify the main requirements to a youth center in Khuzhir. The analysis of priority areas in the field of additional education specified at the end of 2022 in Russia and the Siberian Federal District was used to determine a set of functions to be performed by the center. The results also formed the basis for the selection of similar objects of domestic and foreign experience for analysis and determination of the most optimal architectural and planning solutions of the designed center. The key stages in the organization of a youth culture and leisure center in Khuzhir were determined taking the needs of the target audience into account.

Identification of material by X-ray fluorescence analysis with a pyroelectric X-ray generator

By changing the temperature of Lithium Tantalate (LiTaO3) single crystal at moderate vacuum conditions leads to generation of strong electric field. The uncompensated polarization during the heating or cooling of the crystal causes the ejection of electrons from either the dielectric layer on the surface of the crystal or from a metal target depending on the polarity. The electrons are accelerated and gain energy of up to 100 keV. The energy of these electrons can be determined by measuring the end-point energy of the X-ray spectrum that resulted from the electron interactions with the target. The conception of a pyroelectric accelerator enabled us to develop compact (portable) electron source, which does not require an external high-voltage and the use of hazardous materials. The compact and portable nature of pyroelectric-driven particle sources holds significant promise for applications in materials science, particularly for materials analysis methodologies. The research demonstrates the feasibility of utilizing the X-ray signal generated by irradiation with electrons to identify elements in each sample. It is revealed that employing only the electron beam enables the successful acquisition of quantitative information regarding the sample structure through pyroelectric driven PD-PIXE analysis. These findings set the stage for the development of a compact and versatile apparatus for elemental analysis of materials based on a pyroelectric source.

Effectiveness Effectiveness of Wearable Electronic Device for Fall Risk Prevention in Community Elderly: A Literature Review

The increasing incidence of falls in the elderly has become a global health issue. The development of wearable electronic device technology is able to monitor daily activities, measure step counts, physical activity levels, and even sleep patterns of the elderly, while providing early warnings when changes occur that may increase the risk of falls. The aim is to see the effectiveness of using wearable electronic devices in preventing the risk of falls in the elderly in the community. PICO in this study is Population: Community-dwelling elderly, Intervention: wearable electronic device, Comparisons: none, and Outcome: fall prevention. Researchers used 3 search data sources, namely Embase, Pubmed, and Science Direct. The inclusion and exclusion criteria of this study are literature published in electronic data sources from 2018-2023, is a type of quantitative research, the elderly population in the community, English language and available in full text. This literature review includes ten articles that discuss the utilization of wearable electronic device technology, the types of wearable devices used include Inertial Measurement Units (IMU), biosensors, and accelerometers to evaluate the mobility, gait, and balance of the elderly. This literature review shows that wearable electronic device technology can effectively detect falls and motorize the incidence of falls in the elderly

The clinical effectiveness of elexacaftor/tezacaftor/ivacaftor (ETI) for people with CF without a F508del variant: A systematic review and meta-analysis

BackgroundAccess to elexacaftor/tezacaftor/ivacaftor (ETI) for people with cystic fibrosis (PwCF) without a F508del variant is limited due to lack of clinical data supporting efficacy. MethodsIn this systematic review and meta-analysis, we examined patient-level data from studies reporting the clinical response to ETI for PwCF with non-F508del CFTR variants. We searched electronic data sources including Embase, MEDLINE, and CENTRAL from January 1st, 2019 to May 14th, 2024. FindingsOur search results identified 4,795 studies and 20 met the eligibility criteria. 120 of 164 (73 %) individuals had a positive clinical response to ETI, defined by a sweat chloride (SwCl) decrease of ≥10 mmol/L or percent-predicted FEV1 (ppFEV1) improvement of ≥5 %. 51 unique ETI-responsive variants were represented across these 120 individuals and 27 of these variants (53 %) have not been previously approved by the U.S. FDA. For variants with at least 10 individuals treated with ETI to date, a consistent positive clinical response was observed for N1303K and G85E. For N1303K (n = 48), the median increase in ppFEV1 was 16 % (IQR: 8 %, 29 %), with a median decrease in SwCl of -9 (IQR: -4, -22) mmol/L. For G85E (n = 16), the median increase in ppFEV1 was 13.5 % (IQR: 8 %, 19 %) with a median decrease in SwCl of -46 (IQR: -39, -66) mmol/L. ConclusionAdditional ETI-responsive variants were identified following a comprehensive review of ETI clinical use in PwCF without F508del. This data can be used by the CF community in efforts to expand the labelled indications or to help advocate for off-label ETI reimbursement.

Understanding family-centered care in the NICU: a scoping review protocol.

This scoping review will aim to identify and categorize the definitions of neonatal intensive care unit (NICU) family-centered care (FCC) and its associated concepts. It also aims to identify and categorize the practices and interventions that comprise NICU FCC, and catalog the metrics used to evaluate NICU FCC. FCC has been identified as an important element of care for neonates and infants admitted to the NICU, and there is clear evidence that the incorporation of families in care improves clinical outcomes. However, FCC has been linked to numerous associated terms and concepts and lacks a unifying definition or framework, thus limiting the ability to categorize, prioritize, and identify practices and interventions to optimize both institutional approaches for individual centers and for the field at large. Studies that include or apply at least one FCC concept or its associated terms will be considered eligible for inclusion. Studies not related exclusively to the NICU will be excluded. The review will follow the JBI methodology for scoping reviews and will be reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Several electronic databases and sources of gray literature will be searched from 1992 to the present day. The review will include only full-text studies in English and will be independently screened by a minimum of 2 authors. Data will be extracted using a modified JBI data extraction tool and presented using narrative summaries; concept mapping; and categorization of practices, interventions, and metrics.

ركوب جيرودو ولبس توبينج في عادات الزفاف بـــ جمبي في ضوء أحاديث التصوير

The interaction and exchange between local culture and Islamic culture dominate in influencing the social system. This research aims to explore the perspective of Hadith on the Gerudo and Topeng celebrations in Jambi. This research relies on an analytical descriptive method based on collecting library data from various paper and electronic sources and field data through observation and interviews. The researcher then used thematic methods in the takhrīj of hadith, involving the search for hadiths based on sentences related to the topic. In analyzing hadith texts, the researcher has employed a contextual method with comparison approach and has compared them with the opinions of ‘ulamā’ who are both supportive and critical of these approaches. The key finding of this research is that the taṣwīr prohibited by the Prophet Muhammad refers to taṣwīr that contains an 'illah or reason for its prohibition. This prohibition applies to taṣwīr used as a rival to Allah's creation, for worship, or due to elements in its form that contradict Islam. Therefore, Gerudo and Topeng are not considered prohibited taṣwīr because current practices no longer embody the reasons for their prohibition.

Vulnerability and Dependence in Slavery and Post-Slavery Societies: A Historicisation of the Enslaved Children (Pon Pekpen) from the Bamum Kingdom (West Cameroon)

This article is a reflection on the history of enslaved children (Pon pekpen) in African slavery and post-slavery societies, such as the Bamum Kingdom. This traditional monarchy of the Grassfields of Cameroon, founded in 1394 by Nchare Yen, was one of the largest providers of captives transported to the Atlantic coast and used locally to meet the needs of traditional slavery. In this kingdom, slaves and their descendants, as well as enslaved peoples, represented nearly 80% of the total population. The trade of captives and servile practices left indelible traces, particularly where enslaved children were concerned. So, what did enslaved children represent in African slavery and post-slavery societies, such as the Bamum Kingdom? The aim of this study is to show that the enslaved children were the most vulnerable and dependent members of slavery and post-slavery systems. This study is based on oral, archival iconographic, written and electronic sources, using theories of social dominance and subaltern studies. It clearly shows that the vulnerability and dependence of enslaved children (Pon pekpen) made them special, weak and hopeful links in the slavery system and the persistence of slavery practices. They were mainly victims of traditional slavery and of the trans-Saharan and transatlantic slave trades. Despite the formal abolition of the slave trade and slavery between the 19th and 20th centuries, enslaved children and the descendants of enslaved people continue to be victims of a kind of subalternisation because they are usually considered second-class citizens.

Resilience in inter-organizational networks of red buses: dealing with their daily disruptions in critical infrastructures

This research aims to determine how the inter-organizational (supply) system that serves and oversees the critical infrastructures might lessen the negative effects of routine interruptions. Furthermore, this research aims to gain insight into the types of disruptions that Red Buses experience and their strategies to manage them. The subject matter of this discourse pertains to the domains of science, numbers, and statistics. This research employs a quantitative research methodology to examine the effects of routine disruptions on inter-organizational systems and to evaluate the corresponding hypotheses. The individuals involved in this investigation work and operate the Red Bus Service in Karachi. By random sampling, a sample of 152 workers and drivers was selected from the Red Bus Service in Karachi. Data was collected from both electronic and non-electronic sources. Data was collected using Google Forms distributed via various internet channels such as WhatsApp and email addresses. Data was analyzed by Structural Equation Modeling (SEM); we used SmartPLS 4 software for that. The finding shows that disturbance co-occurrence has a negative relationship with CI resilience to focal disruption, a positive relationship with non-routineness, and a negative relationship with economic performance.

Fabrication and Characterization of Field Emission Electron Source Based on Deploying Multiwall Carbon Nanotubes in Micro Dine Point Capillary Tubes

Fabrication and Characterization of Field Emission Electron Source Based on Deploying Multiwall Carbon Nanotubes in Micro Dine Point Capillary Tubes

Nanoscale heterojunctions of InGaN/GaN photocathodes for electron sources

The design of the photocathode is crucial for generating high-quality electron beam in electron sources. In this study, InGaN/GaN heterojunction nanowire photocathodes were proposed, and the photoemission theoretical model was developed. The results demonstrate that the built-in electric field along the axis enables the heterojunction nanowire photocathode to achieve higher collection efficiency across the response spectrum compared to In0.5Ga0.5N nanowire photocathodes. The variation of incidence angle results in distinct peaks in quantum efficiency and collection efficiency for the heterojunction nanowire photocathode. Meanwhile, the “additional electric field” has the potential to decrease the number of laterally emitted electrons from the nanowires, consequently reducing the shielding effect of adjacent nanowires. With an incidence angle of 15° and an “additional electric field” of 2 V/μm, the collection efficiency of photoelectrons at the collection end can be maximized to 47.6 %. This indicates that the heterojunction nanowire array photocathode has potential for use in high-performance vacuum electron sources.

Use of the Sentinel System to Examine Medical Product Use and Outcomes During Pregnancy.

While many pregnant individuals use prescription medications, evidence supporting product safety during pregnancy is often inadequate. Existing electronic healthcare data sources provide large, diverse samples of health plan members to allow for the study of medical product utilization during pregnancy, as well as pregnancy, maternal, and infant outcomes. The Sentinel System is a national medical product surveillance system that includes administrative claims and electronic health record databases from large national and regional health insurers. In addition to these data sources, Sentinel develops and maintains a sizeable selection of analytic tools to facilitate epidemiologic analyses in a way that protects patient privacy and health system autonomy. In this article, we provide an overview of Sentinel System infrastructure, including the Mother-Infant Linkage Table, parameterizable analytic tools, and algorithms to estimate gestational age and identify pregnancy outcomes. We also describe past and future Sentinel work that contributes to our understanding of the way medical products are used and the safety of these products during pregnancy.

Data Flow Construction and Quality Evaluation of Electronic Source Data in Clinical Trials: Pilot Study Based on Hospital Electronic Medical Records in China.

The traditional clinical trial data collection process requires a clinical research coordinator who is authorized by the investigators to read from the hospital's electronic medical record. Using electronic source data opens a new path to extract patients' data from electronic health records (EHRs) and transfer them directly to an electronic data capture (EDC) system; this method is often referred to as eSource. eSource technology in a clinical trial data flow can improve data quality without compromising timeliness. At the same time, improved data collection efficiency reduces clinical trial costs. This study aims to explore how to extract clinical trial-related data from hospital EHR systems, transform the data into a format required by the EDC system, and transfer it into sponsors' environments, and to evaluate the transferred data sets to validate the availability, completeness, and accuracy of building an eSource dataflow. A prospective clinical trial study registered on the Drug Clinical Trial Registration and Information Disclosure Platform was selected, and the following data modules were extracted from the structured data of 4 case report forms: demographics, vital signs, local laboratory data, and concomitant medications. The extracted data was mapped and transformed, deidentified, and transferred to the sponsor's environment. Data validation was performed based on availability, completeness, and accuracy. In a secure and controlled data environment, clinical trial data was successfully transferred from a hospital EHR to the sponsor's environment with 100% transcriptional accuracy, but the availability and completeness of the data could be improved. Data availability was low due to some required fields in the EDC system not being available directly in the EHR. Some data is also still in an unstructured or paper-based format. The top-level design of the eSource technology and the construction of hospital electronic data standards should help lay a foundation for a full electronic data flow from EHRs to EDC systems in the future.

Improvement of the thermionic emission properties of C12A7 electride

Calcium aluminate electride (named as C12A7) has become an active topic as a material for electron emission in the research field of electron sources, especially for electric propulsion, in recent years. Whereas the initially predicted, extremely low work function of 0.6 eV could not be confirmed experimentally at technically relevant surface current densities, the material remains an attractive emitter. Besides C12A7 emitting electrons at lower temperatures compared to LaB6, it appears to be resistant to poisoning and even iodine compatible as only known low work function material. On the other hand, the ceramic electride nature of the emitter introduces challenges related to the thermal, mechanical and electrical properties. Therefore, C12A7 has been investigated experimentally as a candidate material for thermionic emitters in space applications. The aim of this study was to enhance the thermionic emission by material modifications such as surface treatments, electrical contacting methods and doping of the C12A7. The performance improvement was quantified in a thermionic diode configuration, in which the emission current was determined as a function of temperature over multiple heating cycles to observe time dependent effects. The surface treatment such as grinding or polishing affects the emission properties of the C12A7 negatively. In contrary, the doping of the C12A7 lattice as well as the contacting of the back side (heater side) significantly improved the emission as well as the measured current density.