Electric Blanket Research Articles

Carrier-Free Deferoxamine Nanoparticles against Iron Overload in Brain

Carrier-Free Deferoxamine Nanoparticles against Iron Overload in Brain

Exposure to magnetic fields and childhood leukemia: a systematic review and meta-analysis of case-control and cohort studies.

The association between childhood leukemia and extremely low frequency magnetic fields (ELF-MF) generated by power lines and various electric appliances has been studied extensively during the past 40years. However, the conditions under which ELF-MF represent a risk factor for leukemia are still unclear. Therefore, we have performed a systematic review and meta-analysis to clarify the relation between ELF-MF from several sources and childhood leukemia. We have systematically searched Medline, Scopus, Cochrane Database of Systematic Review and DARE to identify each article that has examined the relationship between ELF-MF and childhood leukemia. We have performed a global meta-analysis that takes into account the different measures used to assess magnetic field exposure: magnetic flux density measurements (<0.2µT vs. >0.2µT), distances between the child's home and power lines (>200m vs. <200m) and wire codings (low current configuration vs. high current configuration). Moreover, meta-analyses either based on magnetic flux densities, on proximity to power lines or on wire codings have been performed. The association between electric appliances and childhood leukemia has also been examined. Of the 863 references identified, 38 studies have been included in our systematic review. Our global meta-analysis indicated an association between childhood leukemia and ELF-MF (21 studies, pooled OR=1.26; 95% CI 1.06-1.49), an association mainly explained by the studies conducted before 2000 (earlier studies: pooled OR=1.51; 95% CI 1.26-1.80 vs. later studies: pooled OR=1.04; 95% CI 0.84-1.29). Our meta-analyses based only on magnetic field measurements indicated that the magnetic flux density threshold associated with childhood leukemia is higher than 0.4µT (12 studies, >0.4µT: pooled OR=1.37; 95% CI 1.05-1.80; acute lymphoblastic leukemia alone: seven studies, >0.4µT: pooled OR=1.88; 95% CI 1.31-2.70). Lower magnetic fields were not associated with leukemia (12 studies, 0.1-0.2µT: pooled OR=1.04; 95% CI 0.88-1.24; 0.2-0.4µT: pooled OR=1.07; 95% CI 0.87-1.30). Our meta-analyses based only on distances (five studies) showed that the pooled ORs for living within 50m and 200m of power lines were 1.11 (95% CI 0.81-1.52) and 0.98 (95% CI 0.85-1.12), respectively. The pooled OR for living within 50m of power lines and acute lymphoblastic leukemia analyzed separately was 1.44 (95% CI 0.72-2.88). Our meta-analyses based only on wire codings (five studies) indicated that the pooled OR for the very high current configuration (VHCC) was 1.23 (95% CI 0.72-2.10). Finally, the risk of childhood leukemia was increased after exposure to electric blankets (four studies, pooled OR=2.75; 95% CI 1.71-4.42) and, to a lesser extent, electric clocks (four studies, pooled OR=1.27; 95% CI 1.01-1.60). Our results suggest that ELF-MF higher than 0.4µT can increase the risk of developing leukemia in children, probably acute lymphoblastic leukemia. Prolonged exposure to electric appliances that generate magnetic fields higher than 0.4µT like electric blankets is associated with a greater risk of childhood leukemia.

THE DIFFERENCES IN THE EFFECTIVENESS OF PROVIDING THICK BLANKETS AND ELECTRIC BLANKETS WITH REDUCING SHIVERING INCIDENCE ON POSTOPERATIVE PATIENTS IN SURGICAL INSTALLATIONS DR. SITANALA HOSPITAL TANGERANG, INDONESIA IN 2019

Introduction: Post Anesthetic Shivering (PAS) or the incidence of post-anesthetic shivering is reported to be around 33-65% in patients undergoing general anesthesia and about 33-56,7% in patients undergoing spinal anesthesia. The treatment can be done pharmacologically with drugs and non-pharmacologically one of them with a warm blanket. The purpose of this study was to determine the differences in the effectiveness of giving thick cloth blankets and 380C electric blankets with a reduction in the incidence of shivering in postoperative patients at the Surgical Installation dr. SitanalaTangerang Hospital. Methods: The research method was a quantitative study with a quasi-experimental design with a pre-test post-test with control group design. The number of samples were 30 patients. Data was collected by observing shivering responses. The intervention was carried out by firing 380C electric blankets and thick cloth blankets. Result: The results showed that of the 15 postoperative patients before being given an electric blanket, almost half were 7 (46,7%) having grade 3 shivering, where as in patients given thick cloth blankets almost half were 6 (40%) having grade 2 shivering. Electrical heating is almost half that is 6 (40%) does not experience shivering (grade 0), where as in patients given regular blankets almost half are 6 (40%) experiencing grade 2 shivering. Statistical test results were obtained (p-value = 0.001, ? : 0.05) and (p-value = 0.005, ?: 0.05). Conclusion: there was an electric warm blanket or thick cloth blanket that influences the incidence of shivering in postoperative patients at the Surgical Installation dr. Sitanala Tangerang Hospital, but electric blankets are more effective than thick blankets. Suggestion is that the hospital is expected to make an intervention to provide electric warm blankets with a temperature of 380C postoperatively can be used as a fixed procedure for the service of surgical patients to prevent complications of shivering

Effects of rumen-protected choline supplementation in Holstein dairy cows during electric heat blanket-induced heat stress

Dairy cows experiencing heat stress (HS) attempt to thermoregulate through multiple mechanisms, such as reducing feed intake and milk production and altering blood flow to increase heat dissipation. Effects of choline on energy metabolism and immune function may yield it a viable nutritional intervention to mitigate negative effects of HS. The primary objective of this experiment was to determine if supplementation of rumen-protected choline during, or before and during, an increased heat load would ameliorate the negative effects of HS on production and immune status. Heat stress was induced via an electric heat blanket model with a 3-d baseline period and 7-d HS period for all cows. Multiparous mid-lactation (208 ± 31 days in milk) Holstein cows were fed the same basal herd diet, blocked by pre-experiment milk yield, and randomly assigned to receive one of the following: (1) no rumen-protected (RP) choline (n = 7); (2) RP choline (60 g/d) via top-dress during the HS period (n = 8); or (3) RP choline (60 g/d) via top-dress during the baseline and HS periods (n = 8). Imposing HS via electric heat blanket raised respiration rate with all cows surpassing the HS threshold of 60 breaths/min. The increase in respiration rate tended to be ameliorated with either schedule of RP choline supplementation. Milk yield tended to increase when RP choline was supplemented in both the baseline period and during HS. Supplementation of RP choline tended to reduce blood fatty acid and triglyceride and tended to increase the revised quantitative insulin sensitivity check index. The role of RP choline supplementation to partially ameliorate the effects of HS should be further explored as a potential nutritional strategy to mitigate the negative consequences of HS on health and production.

Acute Effect of Heat Exposure on Brachial Artery FMD: Impact of Modality and Measurement Timeline

Introduction Heat exposure is receiving a lot of attention for its potential to improve endothelial function, as measured by brachial artery flow-mediated dilation (FMD). Although most intervention studies have observed an improvement in brachial artery FMD, the acute effect of heat exposure has been inconsistent. This observation likely stems from the various modalities employed (local limb heating to whole-body heating) and the timing of FMD measurement following the heating intervention (immediately after up to 60 min post-heating). Identifying a heating modality that consistently improves brachial artery FMD and establishing the timeline of the response would facilitate investigations into potential mechanisms mediating heat-induced improvements in brachial artery FMD without the need of more challenging intervention studies. The aims of this study are to 1) determine the acute effect of four heating interventions on brachial artery FMD, and 2) characterize the time-dependent changes in brachial artery FMD following each intervention. Methods On separate days, 11 young and healthy adults (3F/8M; 29±6 y; 66.5±9.4 kg; 1.7±0.1 m) were exposed to: i) 10 minutes of forearm heating using an electric blanket (EB); ii) 30 minutes of forearm heating in 40˚C water (WI); iii) 60 minutes of whole-body heating where the arm used to assess brachial artery FMD was not covered by the water perfused suit (WHB-U), or; iv) was covered for the entire 60 minutes of whole-body heating with the suit (WBH-C). During each trial, brachial artery FMD was measured prior to the heating intervention (baseline), within 5 minutes following the end of the intervention, and every 30 minutes for two hours following the intervention. Results Mean shear rate increased from baseline during the WI (+78±43 s-1, P=0.02), WBH-U (+177±99 s-1, P<0.01) and WBH-C (+140±43 s-1, P<0.01) interventions, but not during EB (+18±35 s-1, P=0.37). Brachial artery FMD was unaffected by the EB intervention (P=0.39). Conversely, there was a main effect of time for FMD during the WI (P=0.03), WBH-U (P<0.01), and WBH-C (P<0.01) interventions. Specifically, FMD was greater relative to baseline, 90 minutes following the WI intervention (+3.7±3.3%, P=0.03, increase in 8/11 participants). A lower FMD relative to baseline was observed within 5 minutes of the end of the WBH-U (-4.5±3.7%, P<0.01, decrease in 9/11 participants) and WBH-C (WBH-C: -6.1±3.5%, P<0.01, decrease in 10/11 participants) interventions. Conclusion These results suggest that 10 minutes of local heating with an electric blanket may not modulate brachial FMD, whereas whole-body heating with or without local heating of the arm causes a temporary reduction in FMD. Forearm immersion in 40°C water for 30 minutes was the only intervention that consistently improved brachial artery FMD, but only when measured 90 minutes following the intervention.

Microglia polarization in heat-induced early neural injury.

In the occurrence and development of heat stroke (HS), factors such as hyperthermia, ischemia and hypoxia are essential to the central nervous system (CNS) inflammatory response, but the main mechanism underlying CNS inflammation remains unclear. The aim of the study was to observe the polarization of microglia in response to heat-induced early nerve injury and to explore its possible mechanism of action. To establish a heatstroke animal model in Beagle dogs, 18 Beagle dogs were divided into control (group A) and experimental groups (group B, group C and group D) according to a random numbers table. The animals in the experimental groups were placed on an electric blanket of an animal body temperature maintaining apparatus. The temperature was set at 40 ±0.5°C, and the rectal temperature was monitored every 5 min until the target body temperature was reached. Once the target temperature was reached, the dogs were transferred to an environment of 26 ±0.5°C and 60 ±0.5% humidity. Western blot analysis was used to detect the expression of microglia-specific markers CD45, iNOS, arginase, and CD206 in normal and heat-damaged brain tissues at different time points (1 h, 6 h, 24 h). The expression of CD45 and arginase was further determined by co-localization with immunofluorescence. CD45 and iNOS protein expression was detected in group A. The two protein markers in group B were significantly higher than those in group A (p < 0.05), and the protein markers in group C were still higher than those in group A (p < 0.05). There was no statistically significant difference among the animals in group A (p > 0.05). Arginase and CD206 protein expression was also detected in group A. Levels of the two protein markers in group B were higher than those in group A (p < 0.05), and the protein marker levels in group C were even higher than those in group A (p < 0.05). Further analysis of the two groups of protein markers in group D showed significantly higher levels than those in group A (p < 0.001). Immunofluorescence co-localization of CD45 and arginase showed significantly increased fluorescence density at 6 h and 24 h after thermal injury (p < 0.001). After heat-induced disease, microglia were found to be active in the brain tissues of dogs. The microglia activated in the early 1-6 h of CNS injury were mainly the M1 type, which were then converted to the M2 type after 6 h. The 24 h M2 type was dominant. The relationship between M1/M2 polarization trends and early brain injury in heat-induced disease may be a key to understanding CNS injury in heat-induced disease.

The Effect of Giving A Warm Blanket to Changes in The Central Temperature of Postoperative Patients with Subarachnoid Block Anesthesia in RSSA Malang

Introduction: Shivering after anesthesia subarachnoid block is a common complication seen with an incidence of 40-60% after anesthesia. One of the post pharmacological shivering management is given a warm blanket. Experimental research was carried out in the Conscious Installation Room of the Central Surgical Installation of RSSA Malang. Aims: The purpose of this study was to determine the effect of providing warm blankets on changes in the central temperature of postoperative patients with subarachnoid block anesthesia. The benefits of this study are to improve the quality of care for patients with surgery, accompanied by shivering events. Methods: The research design was Quasy-Experiment with Random Sampling technique, and the sample size was 20 respondents, two groups: control and treatment. The two groups of respondents' temperature were evaluated and noted before treatment and after giving blankets every 15 minutes to 60 minutes. Result: The test results of the average temperature difference before treatment and the second 60 minutes of the two groups p = 0.0142 with α = 0.05 showed significant differences concluded that temperature changes in post-anesthesia patients subarachnoid block. Conclusions: Non-pharmacological hypothermia treatment after anesthesia subarachnoid block using an electric blanket warmer is more effective because the blanket's temperature can be maintained stable so that the heat transfer process does not decrease the temperature the blanket due to the temperature of the cold environment.

PSVII-6 Effects of heat stress on proteolysis in dairy cattle skeletal muscle

Abstract Heat stress (HS) occurs when internal body temperatures are elevated above a thermoneutral zone in response to extreme environmental temperatures. In the U.S. dairy industry, HS results in economic loss due to decreased feed intake, milk quality, and milk yield. Previous work has demonstrated increased plasma urea nitrogen in heat stressed dairy cattle which is thought to originate from increased skeletal muscle proteolysis, however this has not been empirically established. The objective of this investigation was to determine the extent to which HS promotes proteolysis in skeletal muscle of dairy cattle. We hypothesized HS would increase activation of the calpain and proteasome systems in skeletal muscle. To test this hypothesis, following a 3-d acclimation period in individual box stalls, all lactating dairy cows were held under thermoneutral (TN) conditions for 4-d for collection of baseline measures and then exposed to TN or HS conditions for 7-d followed by a biopsy of semitendinosus (n=8/group). To induce HS, cattle were fitted with electric heating blankets, which they wore for the duration of the heating period. This approach increased rectal temperature 1.1°C (P&amp;lt; 0.05), respiratory rate by 33 bpm (P&amp;lt; 0.05), plasma urea nitrogen by 19% (P=0.08) and milk urea nitrogen by 26% (P&amp;lt; 0.05), and decreased dry matter intake by 32% (P&amp;lt; 0.05) and milk production by 26% (P&amp;lt; 0.05) confirming HS. Contrary to our expectations, we discovered that calpain I and II abundance and activation, and calpain activity were similar between groups. Likewise, protein expression of E3 ligases, MafBx and Murf1, were similar between groups as was total ubiquitinated proteins and proteasome activity. Collectively, and counter to our hypothesis, these results suggest skeletal muscle proteolysis is not increased following 7-d of HS. These data question the presumed dogma that increased blood urea nitrogen is due to elevated proteolysis in skeletal muscle.

186 Young Scholar Presentation: Immunometabolism during periods of negative nutrient balance or heat stress is altered by dietary methyl donor supply in dairy cows

Abstract Our research examined the effects of enhancing methyl donor supply on immunometabolism during periods of negative nutrient balance (NNB) or heat stress (HS). The first experiment examined the effects of post-ruminal choline supply during NNB on production and pathways of 1-carbon metabolism. Ten primiparous rumen-cannulated cows (158±24 DIM) were used in a replicated 5×5 Latin square design with 4d treatment periods and 10d of recovery. Treatments were unrestricted intake with abomasal infusion of water, restricted intake (R; 60% of net energy for lactation requirements) with abomasal infusion of water or R plus abomasal infusion of 6.25, 12.5, or 25 g/d choline ion. Liver tissue was collected at the end of each treatment period. Enhancing choline supply increased milk yields, but decreased liver triacylglycerol. Activity of betaine homocysteine methyltransferase increased with choline, while methionine synthase tended to increase, and cystathionine β-synthase was decreased. These changes were associated with increased liver and plasma Met. Overall, enhanced supply of choline during NNB increases flux through the Met cycle to regenerate Met and reduce liver triacylglycerol. The second experiment examined the effects of rumen-protected Met (RPM) during HS on mTOR (mechanistic target of rapamycin)-related signaling proteins in the mammary gland. Thirty-two multiparous cows (184±59 DIM) were assigned to an environmental treatment, and a dietary treatment [TMR with RPM (0.105% DM) or without (CON)] in a crossover design. There were 2 periods with 2 phases per period. In phase 1 (9d), all cows were in thermoneutral conditions (TN) and fed ad libitum. During phase 2 (9d), group 1 (n=16) was exposed to HS using electric heat blankets while group 2 (n=16) remained in TN but were pair-fed to HS counterparts. After a washout period (21d), the study was repeated (period 2), with environmental treatments being inverted and dietary treatments remaining the same. Mammary tissue was collected at the end of phase 2. Abundance of phosphorylated mTOR was greater with RPM and tended to be greater with HS. Control cows had a greater decrease in milk protein (%) during phase 2 (difference from phase 1) compared with RPM cows, suggesting that RPM supplementation during HS may support greater milk protein synthesis via mTOR activation. The third experiment investigated the effects of RPM during HS on the response of mammary gland explants to lipopolysaccharide (LPS). Twenty-five mg of tissue obtained from cows in the second experiment was incubated with 0 or 3 μg/mL of LPS for 2h. Incubation with LPS increased abundance of genes associated with inflammation, while HS decreased genes associated with antioxidant responses. Expression of NFKB1was greater in LPS-treated explants from non-HS compared with HS cows. These data indicate that HS reduced immune and antioxidant responses while RPM did not attenuate the inflammatory response induced by LPS in vitro. Overall, data indicated a beneficial effect of choline during NNB and Met during HS on immunometabolism in dairy cows.

Effects of a Saccharomyces cerevisiae fermentation product on heat-stressed dairy cows

The objective of this study was to evaluate the effects of supplementing a Saccharomyces cerevisiae fermentation product (SCFP) on body temperature indices, metabolism, acute phase protein response, and production variables during heat stress (HS). Twenty multiparous lactating Holstein cows (body weight = 675 ± 12 kg; days in milk = 144 ± 5; and parity = 2.3 ± 0.1) were used in an experiment conducted in 2 replicates (10 cows/replicate). Cows were randomly assigned to 1 of 2 dietary treatments: control diet (CON; n = 10) or the CON diet supplemented with 19 g/d of SCFP (n = 10; NutriTek, Diamond V, Cedar Rapids, IA). Cows were fed their respective diets for 21 d before initiation of the study. The experiment consisted of 2 periods: thermoneutral (period 1; P1) and heat stress (period 2; P2). During P1 (4 d), cows were fed ad libitum and housed in thermoneutral conditions for collecting baseline data. During P2 (7 d), HS was artificially induced using an electric heat blanket (EHB; Thermotex Therapy Systems Ltd., Calgary, AB, Canada). Cows were fitted with the EHB for the entirety of P2. Rectal temperature, respiration rate, and skin temperature were obtained twice daily (0600 and 1800 h) during both periods. Overall, HS increased rectal temperature, skin temperature, and respiration rate (1.4°C, 4.8°C, and 54 breaths/min, respectively) relative to P1, but no dietary treatment differences were detected. Compared with P1, HS decreased dry matter intake and milk yield (36 and 26%, respectively), and the reductions were similar between dietary treatments. Relative to P1, HS increased milk fat content and milk urea nitrogen (17 and 30%, respectively) and decreased milk protein and lactose contents (7 and 1.4%, respectively). Overall, HS increased (52%) plasma cortisol concentrations of CON, but circulating cortisol did not change in SCFP-fed cows. Heat stress increased circulating lipopolysaccharide binding protein and serum amyloid A (SAA; 2- and 4-fold, respectively), and SCFP supplementation tended to decrease peak SAA (∼33%) relative to CON cows. Overall, although HS did not influence circulating white blood cells and neutrophils, SCFP increased circulating white blood cells and neutrophils by 9 and 26%, respectively, over CON in P2. In conclusion, HS initiated an acute phase protein response and feeding SCFP blunted the cortisol and SAA concentrations and altered some key leukocyte dynamics during HS.

Biological Effects of Atmospheric Fields and Radiation

Our atmosphere is full of electromagnetic fields emitted from wireless communication transmitters. At the same time the bio-systems (including humans, animals &amp; birds and vegetation as well) are complex electrical systems. Naturally therefore, they are likely to have interaction and to be affected in some way or the other. Research into this field started with the knowledge about pleasing presence of negative charges and unpleasant presence of positive charges around us, concentrating effects of static or pulsating fields. Also came the explanation (and experimental verification) of Hindu mythological effects of geomagnetic fields coupled with solar activity. The effects of power line radiation and radiation from video game TV sets, microwave oven and other domestic instruments like electric blankets also figured in the research. At last the fastest emerging mobile telephony overpowered all others. Though the results of researches into possible harmful effects of mobile phone radiation and those of radiation from base station towers remain inconclusive partly because of influencing pressure from manufacturing and service providing companies, some of the researchers conclusively assert the harmfulness of the radiation at some level of field intensity present near the tower or the handset relating it to the specific absorption ratio (SAR) value. Recent increased observation of infertility among young couples is also attributed by some researchers to the effect of radiation from mobile kept in pantaloons pockets which becomes near their genitals affecting sperm or ovum. This review explains all these researches into bio-effects of electromagnetic fields and concludes that there is certainly some possible harmfulness of radiation above some level of intensity of fields.

Study on Thermal Insulation Measures for Construction of Reinforcement Sleeve Grouting Connection in Winter

&lt;p&gt;In this paper, the feasibility of winter construction of steel sleeve grouting connection is studied, and two technical schemes of thermal insulation measures for winter construction are provided. This paper mainly introduces the experimental research work of sleeve grouting by simulating winter construction, including test scheme, test operation flow, test equipment and test data collection and analysis. It is concluded that the thermal insulation measures of prefabricated wall panel covering electric heating blanket, XPS insulation board and sleeve outer wall winding electric companion heat preservation are feasible. Finally, according to the actual project case to verify the feasibility of thermal insulation measures, so that the project can progress smoothly, for similar projects in winter construction to provide reference and reference.&lt;/p&gt;

Effects of dietary electrolytes, osmolytes, and energetic compounds on body temperature indices in heat-stressed lactating cows

Objectives were to determine the effects of a product containing electrolytes, osmolytes, and energetic compounds (EOEC) on body temperature indices in heat-stressed (HS) Holstein cows. Lactating cows were assigned to 1 of 2 treatments: 1) a control diet (n = 10) or 2) a control diet supplemented with 113 g/d of EOEC (n = 10; Bovine BlueLite® Pellets; TechMix LLC, Stewart, MN). The trial consisted of 2 experimental periods (P). During P1 (4 d), cows were fed their respective treatments and housed in thermoneutral conditions. During P2 (4 d), HS was artificially induced using an electric heat blanket (EHB). Overall, HS markedly increased vaginal temperature (Tv), rectal temperature (Tr), skin temperature (Ts), and respiration rate (RR) (P < .01). There were no dietary treatment differences in Tv, Tr, or RR; however, during P2 EOEC-supplemented cows had increased Ts (0.8 °C; P = .04). Compared to P1, HS decreased DMI and milk yield (45 and 27%, respectively, P < .01) similarly amongst treatments. Relative to P1, circulating insulin decreased (41%; P = .04) in CON cows, whereas it remained unaffected in EOEC-supplemented cows, resulting in a 2-fold increase in EOEC compared with CON-fed cows (P < .01) during P2. Relative to P1, HS increased circulating non-esterified fatty acids (NEFA; 63%; P < .01). During P2, there tended to be a treatment by day interaction on circulating NEFA, as concentrations decreased from d 2 to 4 of P2 in EOEC-fed cows but continued to increase in CON cows. In summary, feeding EOEC altered some key aspects of energetic metabolism and increased Ts.

Fire Tests for Representative Combustibles in Residential Facilities for the Development of Field Commander Training Content

In this study, the fire patterns, heat emissions, and smoke generated by means of fire tests developed for representative combustibles in residential facilities were analyzed from among seven fire types. These combustibles were selected in a previous study to simulate real-world situations and professionalism required while dealing with these types of fires and develop the field commander training content. Consequently, the maximum heat dissipation was recorded as 728.6 kW, followed by the dissipation measured from the combination of a mattress and electric blanket, desk and chair, and TV and mattress. The total heat emission of sofas (226.2 MJ) and the combination of mattress and electric blanket (2,259.5 m&lt;sup&gt;2&lt;/sup&gt;) was recorded. In this study, the scope of the tests was limited to the fire characteristics and characteristics of the combustibles, and it is expected that a simulation using various data acquisition methods and FDS would be performed and evaluated at a later stage.

Validating a heat stress model: The effects of an electric heat blanket and nutritional plane on lactating dairy cows

The efficacy of an electric heat blanket (EHB) has previously been confirmed as an alternative method to evaluate heat stress (HS). However, a pair-feeding design has not been used with the EHB model. Therefore, study objectives were to determine the contribution of the nutritional plane to altered metabolism and productivity during EHB-induced HS. Multiparous Holstein cows (n = 18; 140 ± 10 d in milk) were subjected to 2 experimental periods (P); during P1 (4 d), cows were in thermoneutral conditions with ad libitum feed intake. During P2 (4 d), cows were assigned to 1 of 2 treatments: (1) thermoneutral conditions and pair-fed (PF; n = 8) or (2) EHB-induced HS with ad libitum feed intake (n = 10). Overall, the EHB increased rectal temperature, vaginal temperature, skin temperature, and respiration rate (1.4°C, 1.3°C, 0.8°C, and 42 breaths/min, respectively) relative to PF cows. The EHB reduced dry matter intake (DMI; 47%) and, by design, PF cows had a similar pattern and extent of decreased DMI. Milk yield decreased in EHB and PF cows by 27.3% (12.1 kg) and 13.4% (5.4 kg), respectively, indicating that reduced DMI accounted for only ∼50% of decreased milk synthesis. Milk fat content tended to increase (19%) in the EHB group, whereas in the PF cows it remained similar relative to P1. During P2, milk protein and lactose contents tended to decrease or decreased (1.3 and 2.2%, respectively) in both EHB and PF groups. Milk urea nitrogen remained unchanged in PF controls but increased (34.2%) in EHB cows relative to P1. The EHB decreased blood partial pressure of CO2, total CO2, HCO3, and base excess levels (17, 16, 17, and 81%, respectively) compared with those in PF cows. During P2, the EHB and PF cows had similar decreases (4%) in plasma glucose content, but no differences in circulating insulin were detected. However, a group by day interaction was detected for plasma nonesterified fatty acids; levels progressively increased in PF controls but remained unaltered in the EHB cows. Blood urea nitrogen increased in the EHB cows (61%) compared with the PF controls. In summary, utilizing the EHB model indicated that reduced nutrient intake explains only about 50% of the decrease in milk yield during HS, and the postabsorptive changes in nutrient partitioning are similar to those obtained in climate-controlled chamber studies. Consequently, the EHB is a reasonable and economically feasible model to study environmental physiology of dairy cows.

Effects of rumen-protected methionine on lactation performance and physiological variables during a heat stress challenge in lactating Holstein cows

Milk yield, content, and composition are altered by heat stress. Thirty-two multiparous, lactating Holstein cows [balanced by days in milk (mean ± standard deviation; 184 ± 59); body surface area (5.84 ± 0.34 m2)] were randomly assigned to 1 of 2 dietary treatments [total mixed ration with rumen-protected Met (RPM; Smartamine M; Adisseo Inc., Antony, France; 1.05 g of RPM/kg of dry matter intake) or total mixed ration without RPM (CON)], and within each dietary treatment group cows were randomly assigned to 1 of 2 environmental treatment groups in a split-plot crossover design. The study was divided into 2 periods with 2 phases per period. In phase 1 (9 d), all cows were in thermoneutral conditions and fed ad libitum. In phase 2 (9 d), group 1 (n = 16) was exposed to a heat stress challenge (HSC) using electric heat blankets. Group 2 (n = 16) remained in thermoneutral conditions but was pair-fed (PFTN) to HSC counterparts. After a 21-d washout period, the study was repeated (period 2) and the environmental treatments were inverted relative to treatments from phase 2 of period 1, whereas dietary treatments (RPM or CON) remained the same for each cow. Cows were milked 3× per day and samples were taken on d 1, 5, and 9 of each phase. Vaginal temperature was measured every 10 min, rectal temperature and skin temperature were measured 3× per day, and respiration rate and heart rate were recorded once per day. Cow activity was measured using an accelerometer. Paired difference values were calculated for each cow for each period based on the difference between phase 1 baseline means and phase 2 values for each variable. Cows in HSC had a greater increase in vaginal temperature and respiration rate (+0.2°C and +13.7 breaths/min, respectively) compared with cows in PFTN (0.0°C and -1.6 breaths/min, respectively). Cows in PFTN had a greater decrease in dry matter intake and milk yield (-3.9 and -2.6 kg/d, respectively) compared with cows in HSC (-3.2 and -0.9 kg/d, respectively). Cows in CON had a greater decrease in milk protein concentration for PFTN (-0.10 percentage units) and HSC (-0.06 percentage units) compared with cows in RPM for PFTN (0.00 percentage units) and HSC (-0.02 percentage units). Cows in CON for HSC had greater decrease in milk fat concentration compared with cows in RPM for HSC (-0.10 and +0.12 percentage units, respectively). In conclusion, HSC altered physiological and production parameters of cows. Additionally, RPM helped maintain milk protein and fat concentration during HSC, whereas dry matter intake, milk yield, and feed efficiencies were not affected by RPM.

Comprehersive warming nursing measures in perioperative period of neonates

Objective To explore the application effect of warming nursing measures in perioperative period of neonates. Methods From January 2017 to December 2018, 56 neonates who underwent surgery in the Operating Room of Foshan Women and Children Hospital were selected as the study subjects. According to the different thermal protection measures during operation, they were divided into normal temperature group (n=28) and heat preservation group (n=28) . The number of hypothermia, the changes of intraoperative temperature, and the complications of postoperative chills and anxiety were compared between the two groups. Results The number of hypothermia in the normal temperature group was higher than that in the heat preservation group, the difference between the two groups was statistically significant (P<0.05) . The body temperature of the children in the heat preservation group was higher than that of the control group at each time point during operation, and the differences were statistically significant (P<0.05) . The number of anxiety and chills in the heat preservation group was lower than that in the normal temperature group, and the difference between the two groups on the number of chills was statistically significant (P<0.05) . Conclusions The use of external liquid heating, electric blanket heating combined with local warming and surgical instrument pre-warming treatment in the operation process is a effective nursing measure to prevent neonatal hypothermia, which can effectively reduce the occurrence of complications. Key words: Infant, newborn; Perioperative nursing; Hypothermia; Comprehensive nursing

Fast Heating Model for the Aircraft Cabin Air

Maintaining a suitable cabin air temperature distribution is essential for providing an acceptable thermal environment for passengers and crew. However, cabin air may be very cold for the first flight in winter morning. It could be difficult to heat quickly the cabin air and to maintain an acceptable temperature gradient before boarding with the existing environmental control system. This study developed numerical model for predicting the heating process that coupled airflow and heat transfer in a cabin. The model was validated by using the experimental data obtained from an MD-82 airliner. With the validated numerical model, this investigation proposed to use an electric blanket to heat cabin air quickly and to reduce the air temperature gradient.

211 Young Scholar Presentation: Developing and validating a heat stress model in dairy cows

Abstract Heat stress (HS) negatively impacts production parameters, including milk yield and composition, growth and reproduction. Precisely studying HS typically requires expensive climate-controlled facilities, resources often inaccessible to most scientists. Therefore, we evaluated the efficacy of using an electric heat blanket (EHB) as an alternative and cost-effective method to study HS and determine whether EHB-induced hyperthermia affects physiological and production parameters similar to natural HS. This was the first proof of concept study examining this model. Results indicated increased body temperature indices (i.e., rectal temperature and respiration rate) and reduced DMI and milk yield, as well as altered milk composition similar to natural and climate-controlled HS studies. In experiment 2, we examined the EHB model in combination with a pair-feeding (PF) design. By employing the PF design, we clearly illustrated that a lowered nutritional plane explains only approximately 50% of the decreased milk yield in HS cows, with the remaining portion due to changes in post-absorptive changes in nutritional physiology. In addition, the EHB blunted adipose tissue mobilization and increased plasma biomarkers of muscle catabolism. Results from this study validated that the EHB is a valid model to study HS; therefore, experiment 3 was designed to assess nutritional HS mitigation strategies using the EHB model. Dietary electrolyte, osmolyte, and energetic compounds (EOEC) were evaluated as re-hydration therapy on body temperature indices in HS lactating Holstein cows. Skin temperature was increased in EOEC-supplemented cows relative to controls which suggests that EOEC increased heat dissipation. In addition, EOEC-supplemented cows had increased glucose and insulin levels compared with controls which is due to the energetic compounds (i.e., dextrose) present in the EOEC supplement. Collectively, employing EHB model provides an excellent new platform for discovery research and evaluating pragmatic HS mitigation strategies.

Scoping Review of the Potential Health Effects of Exposure to Extremely Low-Frequency Electric and Magnetic Fields.

Previous studies suggest that extremely low-frequency (ELF) electric and magnetic fields (EMFs) may impact human health. However, epidemiologic studies have provided inconsistent results on the association between exposure to ELF EMFs and various health outcomes. This scoping review reports on primary investigations that were published during the ten-year period of 2007-2017 on the association between ELF EMFs and cancer, cardiovascular disease (CVD), reproductive health effects, and neurodegenerative diseases. We identified a total of 361 articles from two bibliographic databases (PubMed and EMBASE). Of these, 39 articles (19 cancer studies, two CVD studies, nine reproductive health studies, and ten neurodegenerative disease studies [with one repeated for two outcomes]) met inclusion criteria. Articles identified in this study focus on three different types of exposure: occupational (22 studies), residential (15 studies), and electric blanket (two studies). This review suggests that ELF EMFs may be associated with neurodegenerative diseases, specifically Alzheimer's disease; however, limited evidence was found to suggest that ELF EMFs are associated with several types of cancer, CVD, and reproductive outcomes. Additional epidemiological studies in large study populations with improved exposure assessments are needed to clarify current inconclusive relationships.