The aim of the current study is to investigate the variable thermal conductivity and diffusivity impact on the transient response of an axisymmetric thermodiffusive elastic half-space under axisymmetric thermal, mechanical, and concentration loads in the light of hyperbolic two-temperature generalized fractional thermoelastic diffusion model. With the help of Kirchhoff’s transform, the governing equations are converted into linear form. The resulting equations are solved by imposing the combined Laplace–Hankel transform. In converted space, the solutions for different field quantities are presented in compact form. The copper material is considered for numerical computation. By employing a mathematical inversion procedure, the solutions are converted into the original space. Numerically computed solutions for various physical quantities are illustrated in the form of graphs to show the impact of variable thermal conductivity and diffusivity, hyperbolic two temperature, and fractional parameters. Validation of the obtained results is also presented.