A possible strategy for increasing the crop productivity is to use some bioregulators, therefore two field experiments were carried out in sandy soil at El-Fayoum Governorate, Egypt, during two successive winter seasons of 2013/2014 and 2014/2015. This study aimed to investigate the response of vegetative growth, yield, and some metabolic constituents of wheat (Triticum aestivum L.) cv. Sakha 93 to exogenously applied of two bioregulators i.e. Benzoic acid (BA; 100, 200 and 400 mg L-1) and Thiourea (TU; 250, 500, and 1000 mg L-1), either alone or in combination. Foliar application of BA and TU alone or in combination significant increased the tiller number and spikes/m2, total plant dry weight/m2, flag leaf area, blades area/plant and yield criteria (spike length, number of grains/spike, number of spike/m2, grain index, grain yield/fed, straw yield per feddan) and these effects were greater with application of BA and/or TU up to 200 and 1000 mg L-1, respectively. Spraying wheat plants by BA and TU, alone or combined significantly improved the nutritional value and quality of wheat grains by increasing oil percent, crude protein, total soluble sugars and total free amino acids contents. In conclusion, the yield-contributing characters and quality of wheat could be improved by application of BA and/or TU up to 200 and 1000 mg L-1, respectively.