Efficient Dissolution Research Articles

Enhanced Dissolution and Bioavailability of Curcumin Nanocrystals Prepared by Hot Melt Extrusion Technology.

Curcumin nanocrystals (Cur-NCs) were prepared by hot melt extrusion (HME) technology to improve the dissolution and bioavailability of curcumin (Cur). Cur-NCs with different drug-carrier ratios were prepared by one-step extrusion process with Eudragit® EPO (EEP) as the carrier. The dispersed size and solid state of Cur in extruded samples were characterized by dynamic light scattering (DLS), scanning electron microscope (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The thermal stability of Cur was analyzed by thermogravimetric analysis (TGA) and high performance liquid chromatography (HPLC). Dissolution and pharmacokinetics were studied to evaluate the improvement of dissolution and absorption of Cur by nano-preparation. Cur-NCs with particle sizes in the range of 50~150 nm were successfully prepared by using drug-carrier ratios of 1:1, 2:1 and 4:1, and the crystal form of Cur was Form 1 both before and after HME. The extrudate powders showed very efficient dissolution with the cumulative dissolution percentage of 80% in less than 2 min, and the intrinsic dissolution rates of them were 13.68 ± 1.20 mg/min/cm2, 11.78 ± 0.57 mg/min/cm2 and 4.35 ± 0.20 mg/min/cm2, respectively, whereas that of pure Cur was only 0.04 ± 0.00 mg/min/cm2. The TGA data demonstrated that the degradation temperature of Cur was about 250 °C, while the HPLC results showed Cur was degraded when extruded at the temperature over 150 °C. Pharmacokinetic experiment showed a significant improvement in the absorption of Cur. The Cmax of Cur in the Cur-NC group was 1.68 times that of pure Cur group, and the Cmax and area under the curve (AUC0-∞) of metabolites were 2.79 and 4.07 times compared with pure Cur group. Cur-NCs can be prepared by HME technology in one step, which significantly improves the dissolution and bioavailability of Cur. Such a novel method for preparing insoluble drug nanocrystals has broad application prospects.

Synthesis of microalgae-based methyl ester using calcium glyceroxide catalyst derived from duck eggshells and crude glycerol in the n-hexane co-solvent system

Abstract The synthesis of microalgae-based methyl ester has attracted the interest of researchers since microalgae have a high lipid content and can proliferate. Chlorella vulgaris, with its 63% lipid content on a dry basis, holds promise for methyl ester production. Heterogeneous catalysts, particularly calcium glyceroxide (Ca[O(OH)2C3H5]), play a crucial role in ester manufacturing due to their high catalytic activity. The synthesis of the calcium glyceroxide catalyst involves duck eggshells as a calcium source and crude glycerol. Optimal methyl ester production is achieved by employing n-hexane as a co-solvent for efficient microalgae oil dissolution. This research focuses on synthesizing and characterizing the calcium glyceroxide catalyst derived from duck eggshells and crude glycerol, emphasizing its application in manufacturing microalgae-based methyl esters with n-hexane as the co-solvent. Methyl ester synthesis variables include a 55°C reaction temperature, a 1.5% microalgae-derived catalyst, and a 9:1 methanol to microalgae ratio. FTIR functional group analysis identifies hydroxyl (O-H) groups from crude glycerol bound to calcium at 3345.71 cm−1, along with C-H group vibrations from crude glycerol bound to calcium at 2941.80 cm−1. SEM morphological analysis reveals aggregate formation on the calcium glyceroxide catalyst, indicating potential active sites. Utilizing the calcium glyceroxide catalyst for methyl ester synthesis yields a promising 62.42% yield. GC characterization demonstrates a methyl ester purity of 72.09%, with methyl palmitate as the predominant component at 30.927%. This study underscores the efficient use of the synthesized calcium glyceroxide catalyst for microalgae-based methyl ester production, showcasing its potential for sustainable biodiesel synthesis.

Selective extraction of molybdenum from an industrial powdery tungsten-molybdenum mixture scraps through ultrasonic-assisted electrochemical dissolution mechanism

Extraction and recovery of W and Mo from waste scraps hold significant importance for sustainable resource utilization and environmental protection. Ultrasonic-assisted leaching was demonstrated to be a clean and efficient method for metal dissolution and separation, and the research emphasis of this work was focused on ultrasonic electrochemical behaviors. The HNO3 leaching behaviors of W and Mo under conventional and ultrasonic-assisted processes from powdery W-Mo mixture scraps generated in the powder metallurgy process were investigated. It’s demonstrated that Mo and W can be selectively separated by the regulation of lixiviant concentration and temperature, in which the Mo is converted into the soluble ions (MoO22+) while the W particle is kept in original metallic state and covered with insoluble WO3·H2O. Experiment results indicated that 96.38 % Mo and 8.03 % W were rapidly leached in 2 mol/L HNO3 within ultrasonic-assisted leaching for 10 min at 25 °C, showing a favorable pre-separation effect. Phase transformation and microstructure evolution of the leaching residues under conventional and ultrasonic-assisted leaching processes were analyzed. It’s suggested that Mo can precipitate in the form of molybdenum oxide hydrates, covering the unreacted particle surfaces and further hindering the Mo leaching, especially at higher temperature. This unfavorable situation can be relieved by the introduction of ultrasonic cavitation effect. Importantly, the electrochemical dissolution behaviors of pure W, pure Mo, and W-Mo alloy sheets in HNO3 solution were compared employing the potentiodynamic polarization and electrochemical impedance spectroscopy testing to reveal the ultrasonic intensifying mechanism in this study. Eventually, the ultrasonic electrochemical intensifying mechanism can be referential for the efficient dissolution of metal-based scraps for resource recycling.

Mixing of endogenous CO2 and meteoric H2O causes extremely efficient carbonate dissolution

Karst corrosion of carbonate rocks by water with dissolved gases proceeds in most cases along two major scenarios: (i) meteoric water absorbs CO2 from soil and atmosphere, or (ii) ascending water of deep circulation carries with it dissolved endogenous gases, mainly CO2 and H2S. We have observed a peculiar variant where meteoric water absorbs ascending endogenous gases at a natural gas vent on a travertine mound in Slovakia. Carbonate dissolution's extreme effectiveness is demonstrated by mineralization of rainwater ponded at a gas vent, rising to 3.2 g/L of dissolved solids shortly after the rainfall. One liter of water ponded at the vent and mixing with the venting gas, dissolved up to 800 mg of calcium at a rate exceeding 5.8 mg/L·min. Limestone tablets placed at the vent show signs of significant corrosion, at rates up to 126 mm/ka. The rate is comparable to those in coastal karst, where freshwater is mixing with seawater and to those in sulfuric acid speleogenesis (SAS), both the highest hitherto known rates of karst corrosion in carbonates. The geomorphic effects of the process described are depressions on the surface of travertine near the vents of endogenous CO2. This type of corrosion seems to be universal and probably occurs everywhere where endogenous CO2 is exhaled to the surface from carbonate rocks.

Aqueous AlCl3/ZnCl2 solution room-induced the self-growing strategy of expanded topological network for cellulose/polyacrylamide-based solid-state electrolytes

The green synthesis strategy for cellulose-containing hydrogel electrolytes is significant for effectively managing resources, energy, and environmental concerns in the contemporary world. Herein, we propose an all-green strategy using AlCl3/ZnCl2/H2O solvent to create cellulose/polyacrylamide-based hydrogel (AZ-Cel/PAM) with expanded hierarchical topologies. The aqueous AlCl3/ZnCl2 facilitates the efficient dissolution of cellulose at room temperature, and the dispersed Al3+-Zn2+ ions autocatalytic system catalyzes in-situ polymerization of acrylamide (AM) monomer. This expands the AM network within the cellulose framework, forming multiple bonding interactions and stable ion channels. The resulting hybrid hydrogel exhibits improved mechanical properties (tensile strength of 56.54 kPa and compressive strength of 359.43 kPa) and enhanced ionic conductivity (1.99 S/m). Furthermore, it also demonstrates excellent adhesion, freeze resistance (−45 °C), and water retention capabilities. Quantum simulations further clarify the mechanical composition and ion transport mechanism of AZ-Cel/PAM hydrogels. The assembled supercapacitor with the hydrogel electrolyte, demonstrates an ideal area-specific capacitance of 203.80 mF/cm2. This all-green strategy presents a novel approach to developing sustainable energy storage devices.

Optimising Recycling Processes for Polyimine-Based Vitrimer Carbon Fibre-Reinforced Composites: A Comparative Study on Reinforcement Recovery and Material Properties.

We investigated the recycling process of carbon fibre-reinforced polyimine vitrimer composites and compared composites made from virgin and recycled fibres. The vitrimer matrix consisted of a two-component polyimine-type vitrimer system, and as reinforcing materials, we used nonwoven felt and unidirectional carbon fibre. Various diethylenetriamine (DETA) and xylene solvent ratios were examined to find the optimal dissolution conditions. The 20:80 DETA-xylene ratio provided efficient dissolution, and the elevated temperature (80 °C) significantly accelerated the process. Scaling up to larger composite structures was demonstrated. Scanning electron microscopy (SEM) confirmed effective matrix removal, with minimal residue on carbon fibre surfaces and good adhesion in recycled composites. The recycled nonwoven composite exhibited a decreased glass transition temperature due to the residual solvents in the matrix, while the UD composite showed a slight increase. Dynamic mechanical analysis on the recycled composite showed an increased storage modulus for nonwoven composites at room temperature and greater resistance to deformation at elevated temperatures for the UD composites. Interlaminar shear tests indicated slightly reduced adhesion strength in the reprocessed composites. Overall, this study demonstrates the feasibility of recycling vitrimer composites, emphasising the need for further optimisation to ensure environmental and economic sustainability while mitigating residual solvent and matrix effects.

Synthesis, Characterization and Dissolution behavior of Nitrides of U-Zr and U-Pu-Zr metallic alloy fuels for Aqueous reprocessing

The aqueous based PUREX process is an alternate choice to pyro-reprocessing of metallic alloy fuels (U-Zr/U-Pu-Zr). Direct dissolution of metallic alloy fuels in a nitric acid medium is not feasible due to vigorous reaction exhibited by the alloys when exposed to this medium. Conversion of metallic alloys into their oxides is a challenging method due to poor dissolution of oxides in nitric acid. Excellent dissolution of nitrides compared to oxides of metallic alloy fuels lead to exploit the nitride route for aqueous reprocessing. Hence, a novel method was adopted to prepare the nitrides of unirradiated U-Zr and U-Pu-Zr alloys via hydridation using UH3, as source-cum-getter instead of hydrogen cylinder. In this context, nitrides of unirradiated U-Zr/U-Pu-Zr metallic alloys were prepared by nitridation via hydridation. Initially, nitrides of U and Zr metals were synthesized and the formation of ZrN and U2N3 and UN phases were confirmed by powder X-ray diffraction measurements. Subsequently, nitrides of unirradiated U-Zr and U-Pu-Zr alloys were synthesized and characterized by X-ray diffraction, scanning electron microscopy and particle analyzer. The dissolution behavior of nitrides of Zr, U, U-Zr and U-Pu-Zr alloys were examined in nitric acid (12 M) medium under reflux conditions at 383 K for 8 h. The present study highlights the potential of the nitride route for efficient dissolution of actinides (U and Pu) and it is very important to develop flow sheets for the aqueous reprocessing of metallic alloys fuels.

Simultaneously efficient dissolution and structural modification of chrysanthemum pectin: Targeting at proliferation of Bacteroides

Pectic polysaccharide is a bioactive ingredient in Chrysanthemum morifolium Ramat. ‘Hangbaiju’ (CMH), but the high proportion of HG domain limited its use as a prebiotic. In this study, hot water, cellulase-assisted, medium-temperature alkali, and deep eutectic solvent extraction strategies were firstly used to extract pectin from CMH (CMHP). CMHP obtained by cellulase-assisted extraction had high purity and strong ability to promote the proliferation of Bacteroides and mixed probiotics. However, 4 extraction strategies led to general high proportion of HG domain in CMHPs. To further enhance the dissolution and prebiotic potential of CMHP, pectinase was used alone and combined with cellulase. The key factor for the optimal extraction was enzymolysis by cellulase and pectinase in a mass ratio of 3:1 at 1 % (w/w) dosage. The optimal CMHP had high yield (15.15 %), high content of total sugar, and Bacteroides proliferative activity superior to inulin, which was probably due to the cooperation of complex enzyme on the destruction of cell wall and pectin structural modification for raised RG-I domain (80.30 %) with relatively high degree of branching and moderate HG domain. This study provided a green strategy for extraction of RG-I enriched prebiotic pectin from plants.

Oxidative Dissolution Process of Sphalerite in Fe2(SO4)3-O3 System: Implications for Heavy Metals Removal and Recovery.

Metal sulfides in waste rocks and tailings are susceptible to serious soil and water contamination due to the generation of acid mine drainage (AMD) during stockpiling. The hydrometallurgical process is one of the most essential heavy metal remediation technologies through harmless disposal and resource utilization of the waste sulfides. However, atmospheric hydrometallurgy of sulfides still faces great challenges due to low leaching efficiency and high cost. In this work, we proposed a cooperative leaching system (Fe2(SO4)3-O3) and investigated the oxidative dissolution process of sphalerite (ZnS). Under the optimal conditions, the extracted zinc reached 97.8%. Reactive oxygen species (ROS) (·OH, 1O2 and ·O2-) were identified in the radical quenching experiments. The dissolution of sphalerite did not show passivation due to the ozone's capability to oxidize the sulfur in sphalerite to sulfate. In addition, stirring rate, O3 inlet concentration, and Fe2(SO4)3 concentration had a significant effect on the dissolution of sphalerite. Meanwhile, the apparent activation energy was 24.11 kJ/mol based on kinetic fitting, which indicated that the controlling step of the reaction was mainly a diffusion process. This work demonstrated the cooperative effect of sphalerite leaching in the O3-Fe2(SO4)3 system and provided a theoretical reference for efficient and atmospheric dissolution of sphalerite.

PH-switchable W/O drag reducer emulsions based on dynamic covalent stabilizers for efficient stabilization and rapid dissolution of drag reducers

As the global emphasis on shale oil extraction grows, there is a rising demand for slickwater fracturing fluids for reservoir stimulation. Polyacrylamide drag reducers plays a crucial role in slickwater and are available in two primary forms: powder and emulsion. Powder-based drag reducers suitable for long-term transportation and storage, but increasing their dissolution rate remains a challenge. While emulsion-based drag reducers are valued for the efficient dissolution facilitated by hydrophilic phase-inversion surfactants, the incorporation of the surfactants compromise the stability of W/O emulsions. In this work, an imine-functionalized pH-switchable stabilizer was synthesized, and the W/O emulsion constructed with the stabilizer underwent demulsification at a pH of 4.9. The pH-switchable emulsion system was optimized, and inverse emulsion polymerization using the stable monomer emulsion was performed for preparing pH-switchable drag reducer emulsions. The drag reducer emulsion features remarkable resistance to instability even after 30 days of storage owing to the absence of phase-inversion surfactants. The imine bond on the stabilizer was cleaved in acid solution, allowing the switchable drag reducer emulsion to be rapidly released and dissolved in water at pH 2.75, boasting an impressive dissolution rate of only 150 s. Furthermore, the pH-switchable drag reducer emulsion demonstrated effective drag-reduction performance, achieving a drag-reduction rate as 73 % at a concentration of 0.06 wt%. The pH-switchable drag reducer emulsion effectively resolves the conflict between rapid dissolution and efficient stabilization of drag reducer, thus offering potential improvements in the formulation process of slickwater and the efficiency of shale oil development.

Efficient and Selective Dissolution of Li from Lithium-Ion Battery LiFePO4 Cathode by Natural Deep Eutectic Solvents

Efficient and Selective Dissolution of Li from Lithium-Ion Battery LiFePO₄ Cathode by Natural Deep Eutectic Solvents

Chalcopyrite Leaching in Ferric Sulphate: The Effect of Fe3O4-CuFeS2 Galvanic Couple on the Cu Dissolution

Galvanic interactions present alternative strategies to achieve a more efficient Cu dissolution from CuFeS2. The present work studied the interaction between chalcopyrite–magnetite (CuFeS2-Fe3O4) in acidified ferric sulphate Fe2(SO4)3-H2SO4 at a solution pH of 1.8 and a temperature of 25 or 50 °C. The addition of Fe3O4 to CuFeS2 forms a galvanic couple, which positively impacts the dissolution of Cu. The results showed that the presence of Fe3O4 led to high and fast Cu dissolution rates and decreased significantly the activation energy, from 83 to 57 kJ/mol. In addition to that, the solid residues revealed that CuFeS2 dissolution produced intermediate Cu-S-rich phases: CuS, Cu2S and Cu5FeS4, which appeared to envelop CuFeS2, had no observable intermediate phase while in the presence of Fe3O4. The results showed that 94% of Cu could be recovered after 5 h of leaching at 50 °C at a Fe3O4/CuFeS2 ratio of 4:1 and a 460 mV Ag/AgCl solution potential. The findings of this study present an option for efficient Cu dissolution from CuFeS2 in ferric sulphate at atmospheric pressure.

Efficient dissolution of cellulose in slow-cooling alkaline systems and interacting modes between alkali and urea at the molecular level

The dissolution of microcrystalline cellulose (MCC) in a urea-NaOH system is beneficial for its mechanical processing. The apparent MCC solubility was greatly improved to 14 wt% under a slow-cooling condition with a cooling rate of −0.3 °C/min. The cooling curve or thermal history played a crucial role in the dissolution process. An exotherm (−54.7 ± 3 J/g MCC) was detected by DSC only under the slow-cooling condition, and the cryogenic dissolution of MCC was attributed to the exothermic interaction between MCC and solvent. More importantly, the low cooling rate promoted the dissolution of MCC by providing enough time for the diffusion of OH− and urea into MCC granules at higher temperatures. The Raman spectral data showed that the intramolecularly and intermolecularly hydrogen bonds in cellulose were cleaved by NaOH and urea, respectively. XPS and solid-state 13C NMR results showed that hydrogen bonds were generated after dissolution, and a dual-hydrogen-bond binding mode between urea and cellulose was confirmed by DFT calculations. Both the decrease of enthalpy and increase of entropy dominated the spontaneity of MCC dissolution, and that is the reason for the indispensability of cryogenic environment. The high apparent solubility of MCC in the slow-cooling process and the dissolution mechanism are beneficial for the studies on cellulose modification and mechanical processing.

Supercritical carbon dioxide systems for sustainable and efficient dissolution of solutes: a review

Supercritical carbon dioxide systems for sustainable and efficient dissolution of solutes: a review

Extraction of PGMs from insoluble Fe-Si-PGMs alloy by combined thermochemical and mechanochemical leaching: Sustainable, efficient, and scalable

Platinum group metals (PGMs) are scarce critical materials, and recovering PGMs from spent automotive catalysts (SAC) is economically and ecologically important. However, dissolving the Fe-Si-PGMs alloy derived from SAC is challenging, impeding PGMs recovery. This study aims to develop a more sustainable, efficient, and scalable leaching scheme. We demonstrate efficient leaching of Fe-Si-PGMs alloy using a thermochemical combined with mechanochemical leaching method with a HCl + FeCl3 + H2O2 solution. Kinetics parameters studies optimize the leaching process. The main obstacles to leaching are the chemical inertness of the alloy and the SiO2 encapsulation formed. Ultimately, efficient dissolution of 99 % Pd, 95 % Pt and 88 % Rh was achieved, increasing PGMs leaching by 17 % compared to single thermochemical leaching. Additionally, this work remedies the scalability limitations of mechanochemical leaching and provides valuable insights for PGMs recovery.

Highly efficient dissolution and reinforcement mechanism of robust and transparent cellulose films for smart packaging

The packaging of fresh foods increasingly focuses on renewable and eco-friendly cellulose films, but their low dissolution efficiency and weak mechanical strength greatly limit their wide application, which also cannot be used for smart packaging. Here, a highly efficient synergistic chloride-salt dissolution method was proposed to fabricate robust, transparent, and smart cellulose films. Cellulose films with appropriate Ca2+ concentration exhibited robust mechanical strength, better thermal stability, high transparency and crystallinity. The metal chelation of Ca2+ with cellulose chains could induce cellulose chain arrangement during the cellulose regeneration process. Particularly, compared to pure cellulose films, the tensile strength and elongation at break of cellulose films with suitable Ca2+ were increased by 167 % and 200 %, respectively. Moreover, optimal cellulose films can be used to reflect the quality of the fruit by detecting changes in ethanol gas. Hence, a novel strategy is presented to fabricate robust and transparent cellulose films with great potential application for smart packaging.

Selective separation of aluminum, silicon, and titanium from red mud using oxalic acid leaching, iron precipitation and pH adjustments with calcium carbonate

Red mud discharged from alumina production is a valuable metal resource of great importance in the context of the requirement to reduce the impact of mining on the environment and resource consumption. The efficient dissolution of iron from red mud by oxalic acid has been reported. Although the concentrations of aluminum, silicon, and titanium were also high in the red mud-oxalic acid leachate after iron precipitation, they have received little attention. The present study aims to recover aluminum, silicon, and titanium from red mud-oxalic acid leachate after the precipitation of iron. The leaching efficiencies of aluminum, silicon, and titanium in 1.0 mol/L oxalic acid at 80 °C, reached 63–75% after 2 h. Sodium hydroxide, calcium oxide, and calcium carbonate were chosen to adjust the pH of the oxalic acid leachate, and the effective separation of silicon and titanium from the oxalic acid leachate could be achieved at pH 4.0 by stepwise separation using calcium carbonate. A silicon dioxide primary product with a purity of 70.8% was obtained in addition to the aluminum hydroxide primary product. The stepwise selective separation of aluminum, silicon, and titanium from red mud-oxalic acid leachate could assist the values recovery and simultaneously minimize environmental hazards of the acidic leachate.

Multifunctional Asymmetric Bacterial Cellulose Membrane with Enhanced Anti-Bacterial and Anti-Inflammatory Activities for Promoting Infected Wound Healing.

An asymmetric wound dressing acts as a skin-like structure serves as a protective barrier between a wound and its surroundings. It allows for the absorption of tissue fluids and the release of active substances at the wound site, thus speeding up the healing process. However, the production of such wound dressings requires the acquisition of specialized tools, expensive polymers, and solvents that contain harmful byproducts. In this study, an asymmetric bacterial cellulose (ABC) wound dressing using starch as a porogen has been developed. By incorporating silver-metal organic frameworks (Ag-MOF) and curcumin into the ABC membrane, the wound dressing gains antioxidant, reactive oxygen species (ROS) scavenging, and anti-bacterial activities. Compared to BC-based wound dressings, this dressing promotes efficient dissolution and controlled release of curcumin and silver ions. In a full-thickness skin defect model, wound dressing not only inhibits the growth of bacteria on infected wounds but also regulates the release of curcumin to reduce inflammation and promote the production of epithelium, blood vessels, and collagen. Consequently, this dressing provides superior wound treatment compared to BC-based dressing.

Bioleaching of polymetallic sulphidic mining residues: influence of increasing solid concentration on microbial community dynamics and metal dissolution

Within the European research project NEMO, a bioleaching strategy was developed for efficient metal extraction from bioleach residue currently heap-leached at Sotkamo (Finland) that still contains sulphidic minerals and valuable metals (Ni, Zn, Co, Cu). The strategy of gradually increasing the solid content with 5% steps allowed the adaptation of the consortium up to 20% (w/w) solid content, with efficient metal dissolution and same dominant bacteria. Largest proportions of Sulfobacillusthermosulfidooxidans while Eh increased suggested it to be most involved in iron oxidation. Acidithiobacilluscaldus was rather found when pH stabilized, in line with a production of protons from sulphur oxidation that maintained low pH. ‘Acidithiomicrobium’ P2 was favoured towards the end of the runs and at 20% (w/w) solids possibly due to its tolerance to Ni. The use of gene abundance to evaluate biomass in the pulp provided complementary results to classical cell counts in the liquid phase, and suggested a key role of bacteria associated to mineral particles in iron oxidation. Scaling-up in 21-L stirred-tank reactor at 20% (w/w) solids had no detrimental effect on bioleaching and confirmed metal extraction rates. ‘Acidithiomicrobium’ P2 and Sb. thermosulfidooxidans remained main actors. However, the biological activity was considerably reduced at 30% (w/w) solid concentration, which may be due to a too drastic environmental change for the bacteria to adapt to higher solid concentration. Efficient bioleaching of Sotkamo bioleaching residue at high solid concentration was demonstrated, as well as the robustness of the selected moderately thermophilic consortium, at laboratory and pilot scales.

A modified strategy to improve the dissolution of flavonoids from Artemisiae Argyi Folium using ultrasonic-assisted enzyme-deep eutectic solvent system

In this study, enzyme-deep eutectic solvent-assisted ultrasonic extraction technique (EnDUE) was developed for the efficient dissolution of flavonoids from Artemisiae Argyi Folium. The extraction results of Artemisiae Argyi Folium flavonoids (quercetin, luteolin, and isorhamnetin) were used as indicators to investigate the influencing factors through single factor experiment, Placket-burman design, and Box-behnken design, so as to obtain satisfactory yields. After systematic optimization, the optimal conditions for extraction of the target flavonoids were: Choline chloride/1,4-butanediol with a water content of 25%, cellulase+pectinase with a concentration of 1.6%, solid-liquid ratio of 1/32 g/mL, pH of 4.2, ultrasonic frequency of 80 kHz, ultrasonic power of 160 W, ultrasonic temperature of 40 °C, and ultrasonic time of 25 min, respectively, which derived a total yield of 8.06 ± 0.29 mg/g. Compared with the reference techniques, the proposed EnDUE technique showed significant advantages in the yield and extraction efficiency of flavonoids. In addition, after preliminary purification, the Artemisiae Argyi Folium flavonoids showed good antioxidant activity. Deep eutectic solvent (DES) can degrade the cell wall components and increase the action site of enzyme, and enzyme can promote the penetration of DES into the cell wall matrix, which is mutually beneficial to the dissolution of intracellular components. Therefore, the extraction technique proposed in this work (EnDUE) greatly promotes the dissolution of flavonoids from Artemisiae Argyi Folium, and provides theoretical support for the further application of plant flavonoids.