Biomass obtained from microalgae research studies gained momentum in recent years because of their extensive application potential in multiple industries such as high-value nutraceuticals, bioproducts, cosmetics, animal feed industries, and biofuels while being a sustainable and environmentally friendly option. Although they have high biomass yields and rapid growth rates there are some limitations and challenges that remain for large-scale commercialized cultivation and harvesting methods of microalgae. Since there are multiple pathways related to efficient cultivation and harvesting methods to be viable, this study adopted, TOPSIS (Technique for Order Preference by Similarity to Ideal Solution), a multicriteria decision-making tool, to find the most acceptable alternative by using excel spreadsheets to evaluate the information that is derived from literature and pilot-scale studies. As a result, tubular (helical) and plate (flat panel) photobioreactors (PBRs) for cultivation and chemical harvesting (with chitosan) and bio-flocculation for harvesting were deemed suitable, while plastic bag PBR and suspended air flotation were deemed unsuitable.