There are numerous factors contributing to the ineffective collaboration of multicultural flight crews. This study presents an overview of Crew Resource Management history, CRM training courses, and communication challenges among flight crews. The national, organizational, and professional cultures of crew members have a significant impact on flight safety. Although the primary focus is on Saudi Arabian Airlines, the findings are applicable to any multicultural airline. Research has demonstrated the effectiveness of CRM training for pilots and flight attendants in foreign flying environments when considered separately. The authors examine accidents resulting from inadequate communication between pilots and flight attendants. A survey involving 30 pilots and 30 flight attendants working for Saudi Arabian Airlines was conducted which revealed that the participants recognized the importance of cultural differences as crucial aspects addressed in safety training and cooperation among crew members. Additionally, it was disclosed that effective communication significantly influences teamwork efficiency and safety outcomes. As a recommendation, it is suggested that the airline should establish an annual joint CRM training program for both pilot and cabin crew groups.