Effect Of Sodium Thiosulfate Research Articles

Changes in vascular permeability and state of the mesenteric mast cells of rats with acute experimental pancreatitis treated with sodium thiosulfate

The object of the present investigation was to establish the role of mast ceils in disturbances of vascular permeability in the mesentery of the small intestine and also to discover the effect of sodium thiosulfate on microvascular permeability in this region in acute experimental pancreatitis. It was shown previously that under similar experimental conditions, sodium thiosulfate significantly prevented the development of edema and damage to blood vessels in the pancreas itself [3].

THE EFFECT OF SODIUM THIOSULFATE AND HYDROXO-COBALAMIN ON RATS FED NITRILE-RICH OR GOITRIN-RICH RAPESEED MEALS

Three experiments were conducted with rats to study the effect of feeding rapeseed preparations supplemented with sodium thiosulfate (Na2S2O3∙5H2O) and hydroxo-cobalamin (vitamin B12a). A significant antidotal effect of 0.1% sodium thiosulfate supplementation was observed with pre-hydrolyzed, freeze-dried (PHFD) raw Midas meal which is rich in nitrile content, but not with Midas meal that was not hydrolyzed. The antidotal effect of sodium thiosulfate was less conspicuous with Tower meal, but addition of 0.1% sodium thiosulfate to PHFD raw Tower meal resulted in slightly improved performance. Addition of sodium thiosulfate to heated Midas or heated Tower meal had no effect on weight gain whether they were pre-hydrolyzed or not. No antidotal effect of hydroxo-cobalamin was observed with meals of high-nitrile or high-goitrin content. The addition of sodium thiosulfate or hydroxo-cobalamin had no significant effect on the weight of thyroid glands. Increased kidney weight was observed in treatments in which meal of high nitrile content (raw Midas meals) was fed. The addition of hydroxo-cobalamin resulted in an increase in kidney weight in some treatments while the addition of sodium thiosulfate caused a decrease in kidney and liver weight in the high-nitrile treatments. A significantly higher thiocyanate content was observed in the serum of rats fed high-nitrile meals supplemented with sodium thiosulfate. Thiocyanate excretion in the urine was reduced when Midas meals were pre-hydrolyzed and freeze-dried, but remained much higher than for the control group.

Effect of sodium thiosulfate on the pancreas in experimental pancreatitis

Histological and histochemical study of the pancreas of albino rats and experimental pancreatitis showed the use of sodium thiosulfate to considerably inhibit the progress of necrotic changes and circulatory disturbance. The preparation prevented recidivation of pancreatitis and inhibited sclerotic changes in the gland. Sodium thiosulfate stimulated the regenerative process including regenerative hypertrophy and expressed epimorphosis.

Graft copolymerization to cellulose. Effect of sodium thiosulfate on hydrogen peroxide initiator system

AbstractThe effect of sodium thiosulfate on the graft copolymerization of methyl methacrylate to cellulose in the hydrogen peroxide initiator system was investigated. The addition of sodium thiosulfate in general was effective for decreasing the per cent grafting and the average molecular weight of grafts and increasing the formation of homopolymer, and the effects became pronounced with increasing hydrogen peroxide concentration. Moreover, the addition of sodium thiosulfate slightly suppressed the formation of grafts at a hydrogen peroxide concentration of 3 mmole/l., but greatly promoted it at 20 mmole/l. Traces of metallic ions present in cellulose could not be eliminated sufficiently by treatment with 3N hydrochloric acid. Such ions were found to interact with hydrogen peroxide and thus participate directly in the initiation and termination of the polymerization reaction. EDTA, the chelating agent, was highly effective for suppressing such participation of metallic ions. In the hydrogen peroxide initiator system applied to the EDTA‐treated samples, sodium thiosulfate caused an effective initiation of graft formation.

On the prevention of the black spot of shrimp: I. effect of some chemical reagents on the black spot of shrimp. II. the isolation and purification of the enzyme related to the formation of black spot

The causes of the black discoloration of three species of shrimp commonly caught off the coast of the State of São Paulo, Brazil, are studied and measures for its prevention are advocated. Landings of shrimp in Santos in 1964 equaled 13% of the total landing, by weight, while economically it is the principal fishery. I - Blackening was effectively prevented by dipping the shrimp in cooled chemical solution for 30 minutes and then storing them at low temperatures. L-ascorbic acid gave the best results, delaying discoloration up to 9 days at 0º to -2ºC and for a longer period at colder temperatures. The effect of Sodium-thiosulfate and EDTA at different temperatures is also discussed. II - Tyrosinase was isolated and assayed by measuring the formation of Dopa-chrome from DL-Dopa at pH 6.8 an 37ºC. Tyrosinase was obtained from the shrimp liver and was purified by approximately 25 times its activity from the initial extract by absorption chromatography through Celite 545, as judged by the rate of dopachrome formation.