The results from methanol/water droplet combustion experiments conducted on two separate spacebased investigations are analyzed and compared against the predictions of a detailed numerical model. These two investigations (Fiber Supported Droplet Combustion Investigations 1 and 2) were conducted aboard Space Shuttle Columbia missions STS-73 and STS-94 in November 1995 and July 1997, respectively. In these experiments, pure methanol droplets and methanol/water droplets of 2–7 mm were suspended on a silicon carbide fiber and ignited with a hot wire. In some cases, droplets burned for over 40 s, and flame extinction was observed at small but finite droplet diameters. In other cases, droplets ignited but the flames rapidly extinguished. Each of the experiments is compared against the results of a detailed numerical model that simulates the time-dependent, spherically symmetric combustion of a multicomponent liquid droplet in an infinite oxidizing environemnt. The model includes detailed chemistry, multicomponent molecular diffusion and radiative heat transfer. The model quantitatively reproduces (without modifications or adjustments) measured burning rate, flame position, and extinction diameter for a wide range of initial diameters and initial water content. The results show that the effect of radiative heat loss is significant in experiments with initial diameters greater than 3 mm. Specifically, decreased burning rate and a nonlinear increase in extinction diameter are observed with increasing initial diameter. Moreover, a critical radiative extinction diameter of 6 mm, predicted in a previous study for methanol droplet combustion in 1-atm air, is verified experimentally.