Effects Of Overload Research Articles

Enhancing Photodynamic Therapy Efficacy via Photo-Triggered Calcium Overload and Oxygen Delivery in Tumor Hypoxia Management.

Background: Photodynamic therapy (PDT) has emerged as a promising treatment for cancer, primarily due to its ability to generate reactive oxygen species (ROS) that directly induce tumor cell death. However, the hypoxic microenvironment commonly found within tumors poses a significant challenge by inhibiting ROS production. This study aims to investigate the effect of improving tumor hypoxia on enhancing PDT. Result: We employed polylactic-co-glycolic acid (PLGA) as a delivery vector for the encapsulation of indocyanine green (ICG), a photosensitizer, and perfluorohexane (PFH), with surface labeling mannose to facilitate targeted delivery. A potential therapeutic nanoplatform was fabricated, designated as Man-PFH-ICG@PLGA. These nanospheres are capable of localizing at tumor sites and can be tracked using photoacoustic (PA) imaging. Upon laser irradiation, the ROS generated by PDT activated the transient receptor potential cation channel subfamily A member 1 (TRPA1) located on the cell membrane. This activation led to an influx of extracellular Ca2+ and subsequently resulted in calcium overload. The excessive Ca2+ selectively accumulated in mitochondria, disrupting the function of enzymes involved in the mitochondrial respiratory chain. This disruption inhibits cellular respiration and decreases oxygen consumption in tumor cells, ultimately contributing to the alleviation of the hypoxic microenvironment within tumors. Simultaneously, PFH exhibited a high affinity for oxygen and can deliver exogenous oxygen directly to the tumor site through simple diffusion along the concentration gradient. Both the direct and indirect mechanisms synergistically contribute to ameliorating the hypoxic conditions within tumors, thereby augmenting the efficacy of PDT. Conclusions: The synergistic effect of photocontrolled calcium overload from endogenous sources and the oxygen-carrying nanoplatform alleviates tumor hypoxia, thereby enhancing the efficacy of PDT. This approach provides a new perspective on PDT.

Hydraulic Resistance Device for Force, Power, and Force–Velocity–Power Profile Assessment During Resisted Sprints with Different Overloads

This study aimed to evaluate the ability of a hydraulic resistance device (HRD) to assess the force and power output and force–velocity–power profile of short sprints, while examining the effects of hydraulic overload on these outcomes. Twenty-eight amateur athletes performed 20 m sprints under minimal (MiL), moderate (MoL), and high (HiL) overloads. Sprint velocity was measured with the HRD, while resistance force (Fr) was assessed from the pressure via the HRD and from the reaction force via the force plate (FP). Using velocity and Fr during the sprints, maximal velocity (vmax), average horizontal force (Favg), average power (Pavg), and FvP profile variables (F0, v0, and Pmax) were calculated. A two-way ANOVA analysed the effects of overload and calculation method. In addition, a correlation between the HRD and FP measurements was evaluated. For all variables, very high to excellent correlation between the HRD and FP was observed (r ≥ 0.96). However, the Favg, Pavg, F0, and Pmax calculated by the HRD were lower than the FP across all overloads (η2 ≥ 0.51; p < 0.001). Regardless of the method used, Favg, Pavg, and F0 were highest at HiL (η2 ≥ 0.38; p < 0.001), and v0 was highest at MiL (η2 = 0.35; p < 0.001), whereas overload had no significant effect on Pmax (η2 = 0.01; p = 0.770). The HRD is a feasible means for monitoring force and power output during hydraulic resisted sprints but should not be directly compared to other resistance devices. HiL produced the highest Favg, Pavg, and F0 and may be optimal for increasing power output and improving acceleration performance.

When I Receive Too Much Social Support: The Effect of Social Support Overload on Users' Life Burnout and Discontinuance in Fitness Apps.

As fitness apps increasingly incorporate social interaction features, users may find themselves overwhelmed by an excess of received support, struggling to effectively manage it. Highlighting a novel recipient-centric perspective, we aim to investigate the impact of social support overload on users' life burnout and discontinuance within fitness apps. Utilizing Social Support Theory and Basic Psychological Needs Theory, we develop a model to examine how emotional, network, and informational support overload affect life burnout and discontinuance through the frustration of basic psychological needs: autonomy, competence, and relatedness. A total of 443 fitness app users were included in our study, and we employed Structural Equation Modeling (SEM) to empirically test this model. The results highlight the significant mediating role of the frustration of basic psychological needs between social support overload and life burnout/discontinuance. Network and informational support overload positively correlate with frustration of all needs, whereas emotional support overload shows a complex relationship. All need frustrations are linked to life burnout, but only autonomy and relatedness frustrations significantly lead to discontinuance. Additionally, gender and app use proficiency are significant control variables impacting discontinuance. This study adopts a novel recipient-centric perspective to explore social support overload, examining its effects on life burnout and discontinuance and offering practical implications for both users and app managers.

Work Overload, Emotional Exhaustion, Emotional Contagion, And Compassion Fatigue In Nurses During COVID-19 Pandemic: A moderated mediation model

Objective: Burnout is stated as a major problem for nurses. The relationship between work overload and burnout, another problem experienced by nurses, has been examined by different authors. However, the effect of mediation and moderation mechanisms that may affect the relationship between work overload and emotional exhaustion in nurses has yet to be clarified to a great extent. This study aims to fill this research gap by examining the mediating role of compassion fatigue and moderating role of emotional contagion in the relationship between work overload and emotional exhaustion. Methods: This descriptive cross-sectional study was conducted in Istanbul, Turkey, with the participation of 330 nurses. The research model was tested with Hayes' PROCESS macro. Results: The result shows that the indirect effect of work overload on emotional exhaustion through compassion fatigue is positive and significant (b = 0.335, 95% confidence intervals (CIs) = (0.243, 0.430)). Also, the indirect effect was found to vary depending on emotional contagion (Index of moderated mediation (IMM) = 0.076, 95% CIs = (0.029, 0.132)). In this context, the effect of work overload on emotional exhaustion through compassion fatigue is stronger in nurses with high emotional contagion levels. Conclusions: The study's findings revealed that emotional contagion and compassion fatigue variables are important mechanisms for clarifying the relationship between work overload and the emotional exhaustion of nurses.

Absence of gut microbiota alleviates iron overload-induced colitis by modulating ferroptosis in mice.

Iron overload disrupts gut microbiota and induces ferroptosis, contributing to colitis. However, whether gut microbiota directly drives iron overload-induced colitis and its underlying mechanism remain unclear. The study aimed to explore whether gut microbiota can directly regulate iron overload-induced colitis and its underling mechanism. Male C57BL/6N mice were fed with ferrous sulfate to establish an iron overload model. Antibiotics and DSS were used to create germ-free and colitis models, respectively. Results showed that iron overload caused disruption of systemic iron homeostasis via activating pro-inflammation response, which caused induction of ferroptosis and eventually resulted in colitis in mice. Notably, iron overload inhibited System Xc- and activated the nuclear factor E2-related factor 2/heme oxygenase-1 pathway, driving ferroptosis and colitis progression. Similar results were observed in mouse colon epithelial cells, which were treated with high doses ferric ammonium citrate. Additionally, iron overload exacerbated DSS-induced colitis by activating the ferroptosis and increasing harmful bacteria (e.g., Mucispirillum) abundance. Interestingly, eliminating gut microbiota attenuated iron overload-induced colitis, without affecting systemic inflammation through inhibiting ferroptosis of mice. Depletion of the gut microbiota partially mitigated the exacerbating effect of iron overload on DSS-induced colitis through inhibiting ferroptosis of mice. Iron overload activates ferroptosis in colonic cells, increases the relative abundance of harmful bacteria, and exacerbates DSS-induced colitis in mice. Iron overload exacerbates DSS-induced ferroptosis and colitis in a microbiota-dependent manner. Targeting gut microbiota may offer new strategies for managing iron overload-induced colitis.

Fucoidan Attenuates Cardiac Remodeling by Inhibiting Galectin-3 Secretion, Fibrosis, and Inflammation in a Mouse Model of Pressure Overload.

Fucoidan, a sulfated polysaccharide derived from marine algae, is known for its antioxidant and immunomodulatory properties. Galectin-3 (Gal-3), a protein associated with cardiovascular fibrosis, has been identified as a potential therapeutic target in cardiac remodeling. This study aimed to evaluate whether fucoidan could inhibit Gal-3 activity and mitigate cardiac remodeling in a mouse model of pressure overload-induced cardiac hypertrophy. To test this hypothesis, we used transverse aortic constriction (TAC) surgery to induce pressure overload in normotensive mice, replicating the pathological features of cardiac hypertrophy. Mice were treated with fucoidan at a dose of 1.5 or 7.5 mg/kg/day. In vivo assessments of cardiac function, fibrosis, inflammation, and Gal-3 expression were performed. Pressure overload led to significant upregulation of serum Gal-3 levels, increased cardiac collagen deposition, and elevated markers of fibrosis and inflammation. In mice treated with fucoidan, these effects were significantly attenuated. Fucoidan treatment prevented the upregulation of Gal-3, reduced collagen deposition, and decreased inflammatory cell infiltration, suggesting an inhibition of both fibrosis and inflammation. Fucoidan effectively mitigated the adverse effects of pressure overload in this mouse model, including reduced Gal-3 expression, fibrosis, and inflammation. These findings suggest that fucoidan holds promise as a therapeutic agent for preventing or delaying cardiac remodeling and associated complications, such as fibrosis and inflammation, in pressure overload-induced cardiac hypertrophy. Further research is needed to explore the underlying mechanisms and clinical applicability of fucoidan in cardiac disease.

Mitochondrial pathways of copper neurotoxicity: focus on mitochondrial dynamics and mitophagy.

Copper (Cu) is essential for brain development and function, yet its overload induces neuronal damage and contributes to neurodegeneration and other neurological disorders. Multiple studies demonstrated that Cu neurotoxicity is associated with mitochondrial dysfunction, routinely assessed by reduction of mitochondrial membrane potential. Nonetheless, the role of alterations of mitochondrial dynamics in brain mitochondrial dysfunction induced by Cu exposure is still debatable. Therefore, the objective of the present narrative review was to discuss the role of mitochondrial dysfunction in Cu-induced neurotoxicity with special emphasis on its influence on brain mitochondrial fusion and fission, as well as mitochondrial clearance by mitophagy. Existing data demonstrate that, in addition to mitochondrial electron transport chain inhibition, membrane damage, and mitochondrial reactive oxygen species (ROS) overproduction, Cu overexposure inhibits mitochondrial fusion by down-regulation of Opa1, Mfn1, and Mfn2 expression, while promoting mitochondrial fission through up-regulation of Drp1. It has been also demonstrated that Cu exposure induces PINK1/Parkin-dependent mitophagy in brain cells, that is considered a compensatory response to Cu-induced mitochondrial dysfunction. However, long-term high-dose Cu exposure impairs mitophagy, resulting in accumulation of dysfunctional mitochondria. Cu-induced inhibition of mitochondrial biogenesis due to down-regulation of PGC-1α further aggravates mitochondrial dysfunction in brain. Studies from non-brain cells corroborate these findings, also offering additional evidence that dysregulation of mitochondrial dynamics and mitophagy may be involved in Cu-induced damage in brain. Finally, Cu exposure induces cuproptosis in brain cells due mitochondrial proteotoxic stress, that may also contribute to neuronal damage and pathogenesis of certain brain diseases. Based on these findings, it is assumed that development of mitoprotective agents, specifically targeting mechanisms of mitochondrial quality control, would be useful for prevention of neurotoxic effects of Cu overload.

When families overload careers: the critical role of family-interferes-with-work and boundary management

PurposeWhile there has been growing interest in how personal and work-related factors shape employees’ careers, we know little about how family demands affect career intentions. Drawing from role theory and boundary theory, we examine the indirect effect of family-role overload on career intentions via family-interferes-with-work (FIW), as well as the conditional indirect effect of boundary management on these relationships.Design/methodology/approachUtilizing two waves of panel data that were collected in the third and fourth waves of the pandemic in Canada (n = 433), we conducted a structural equation model to test our hypotheses.FindingsOur analysis reveals that FIW mediates the relationship between family-role overload and (1) career change intention and (2) job turnover intention. The results also indicate that the effect of family-role overload on career intentions via FIW strengthens for employees with a low ability to enact preferred boundaries.Originality/valueThis research shows the indirect effect of family-role overload on career intentions via FIW. This research also highlights how boundary management can buffer the effects of family-role overload on career intentions.

Effects of iron overload in human joint tissue explant cultures and animal models.

Osteoarthritis (OA) is a prevalent degenerative joint disease affecting over 530 million individuals worldwide. Recent studies suggest a potential link between iron overload, a condition characterised by the excessive accumulation of iron in the body, and the onset of OA. Iron is essential for various biological processes, and any disruption in its homeostasis can trigger significant health effects, including OA. This study aimed to elucidate the effects of excess iron on joint tissue and the underlying mechanisms associated with excess iron and OA development. Human articular cartilage (n = 6) and synovium (n = 4) were collected from patients who underwent total knee arthroplasty. Cartilage and synovium explants were incubated with a gradually increasing concentration of ferric ammonium citrate for 3days respectively. The effects of iron homeostasis in tissue explants were analysed using a Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS). To further study the effects of iron excess on OA initiation and development, male 3-week-old Hfe-/- and 5-week-old Tfr2-/- mice, animal models of hereditary haemochromatosis were established. Littermate wild-type mice were fed a high-iron diet to induce dietary overload. All animals were sacrificed at 8weeks of age, and knee joints were harvested for histological analysis. The LA-ICP-MS analysis unveiled changes in the elemental composition related to iron metabolism, which included alterations in FTH1, FPN1, and HAMP within iron(III)-treated cartilage explants. While chondrocyte viability remained stable under different iron concentrations, ex vivo treatment with a high concentration of Fe3+ increased the catabolic gene expression of MMP13. Similar alterations were observed in the synovium, with added increases in GAG content and inflammation markers. In vivo studies further supported the role of iron overload in OA development as evidenced by spontaneous OA symptoms, proteoglycan loss, increased Mankin scores, synovial thickening, and enhanced immunohistochemical expression of MMP13, ADAMTS5, and P21 in Hfe-/-, Tfr2-/-, and diet-induced iron overload mouse models. Our findings elucidate the specific pathways through which excess iron accelerates OA progression and highlights potential targets for therapeutic intervention aimed at modulating iron levels to mitigate OA symptoms. KEY MESSAGES: Iron overload alters joint iron metabolism, increasing OA markers in cartilage and synovium. High iron levels in mice accelerate OA, highlighting genetic and dietary impacts. Excess iron prompts chondrocyte iron storage response, signalling potential OA pathways. Iron dysregulation linked to increased cartilage degradation and synovial inflammation. Our findings support targeted therapies for OA based on iron modulation strategies.

Stress mindset and nurses' sleep quality: mediating effects of stress overload and anxiety.

Previous studies have shown that overall sleep quality among Chinese nurses is relatively low, with a sleep disorder prevalence rate of approximately 66.4%. Against the backdrop of healthcare reforms, China has been striving to improve the mental health and sleep quality of nurses. Stress mindset can influence how individuals respond to stress, but there is limited research on how stress mindset affects nurses' sleep quality. This study aims to explore the impact of stress mindset on sleep quality among nurses, as well as the mediating roles of stress overload and anxiety in this relationship. The study was conducted online using a questionnaire from February 18 to February 22, 2024. It utilized the Stress Mindset Measure (SMM), the Stress Overload Scale-Short (SOS-S), the Generalized Anxiety Disorder 7-item scale (GAD-7), and the Pittsburgh Sleep Quality Index (PSQI) to survey 441 nurses in three regions of China: Chongqing, Hunan, and Shandong (M = 34.39, SD = 7.82, 95.7% female). A chain mediation model was employed to examine the mediating roles of stress overload and anxiety in the relationship between stress mindset and sleep quality. The participants' average sleep quality score was 7.18 ± 3.47. Nurses' stress mindset was significantly negatively correlated with both stress overload and anxiety, and significantly positively correlated with sleep quality. Stress overload was significantly positively correlated with anxiety and significantly negatively correlated with sleep quality. Anxiety was also significantly negatively correlated with sleep quality. The direct effect of nurses' stress mindset on sleep quality was significant (effect size = -0.10, 95% CI: -0.19 to -0.01), as were the indirect effects through stress overload (effect size = -0.05, 95% CI: -0.11 to -0.01) and anxiety (effect size = -0.09, 95% CI: -0.13 to -0.05), along with their chain mediation effect (effect size = -0.10, 95% CI: -0.14 to -0.06). Our study demonstrates that a higher level of nurses' stress mindset is associated with better sleep quality, with stress overload and anxiety mediating this relationship. A positive stress mindset helps nurses cope more effectively with professional challenges and reduces anxiety, leading to improved sleep quality. Healthcare institutions should therefore prioritize fostering positive stress mindsets in nurses, encouraging regular psychological training and workshops to support the development of effective coping strategies.

Effect of Hepatic Lipid Overload on Accelerated Hepatocyte Proliferation Promoted by HGF Expression via the SphK1/S1PR2 Pathway in MCD-diet Mouse Partial Hepatectomy.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming a major health problem worldwide. Liver regeneration is crucial for restoring liver function, and is regulated by extraordinary complex process, involving numerous factors under both physiologic and pathologic conditions. Sphingosine-1-phosphate (S1P), a bioactive sphingolipid synthesized by sphingosine kinase 1 (SphK1), plays an important role in liver function through S1P receptors (S1PRs)-expressing cells. In this study, we investigated the effect of lipid overload on hepatocyte proliferation in a mouse hepatic steatosis model induced by feeding a methionine- and choline-deficient (MCD) diet. After 50% partial hepatectomy (PHx), liver tissues were sampled at various timepoints and then analyzed by immunohistochemistry, oil Red-O staining, quantitative-polymerase chain reaction (qPCR), and flow cytometry. In mice fed the MCD-diet, significantly exacerbated hepatic steatosis and accelerated liver regeneration were observed. After PHx, hepatocyte proliferation peaked at 48 and 36 hr in the liver of chow- and MCD-diet fed mice, respectively. By contrast, increased expression of S1PR2 was observed in hepatic neutrophils and macrophages of MCD-diet fed mice. Flow cytometry and qPCR experiments demonstrated that levels of HGF and FGF2 released by neutrophils and macrophages were significantly higher in MCD-diet fed mice. In conclusion, hepatic lipid overload recruits Kupffer cells and neutrophils that release HGF and FGF2 via SphK1/S1PR2 activation to accelerate hepatocyte proliferation.

Temporal dynamics of cardiac remodelling in pressure overload: the key role of visceral adipose tissue

Abstract Background Myocardial fibrosis is a prominent pathological feature of cardiac remodelling in pressure overload. The underlying mechanisms of cardiac remodelling are complex including mechanical, inflammatory and neurohormonal factors. We have recently uncovered a pathological crosstalk between visceral adipose tissue (VAT) and heart in biological aging characterized by profibrotic proteins in both the VAT secretome and the plasma contributing to myocardial interstitial fibrosis. We hypothesize that a model of pressure overload induced by transverse aortic constriction (TAC) is responsible for VAT remodelling and a VAT profibrotic secretome, which in turn worsens cardiac fibrosis and alters cardiac function. Purpose To explore the effect of pressure overload on VAT and identify a crosstalk between heart and VAT. Methods We divided wild-type male mice (5-month-old, n=10/group) into two groups: a visceral Lipectomy group and a Sham group two weeks before a moderate TAC (26G; i.e. gradient between left ventricle and aorta of 30mmHg) or a sham surgery. We sacrificed the mice at 1- and 8-week after TAC. We performed in vivo metabolic tests, echocardiography, and invasive hemodynamics, followed by ex vivo tissue analysis. We then analysed the time-course of the cardiac transcriptomic signature in TAC vs control and the impact of visceral lipectomy in both groups. Results Our results show that TAC induced not only cardiac remodelling affecting the structure and function of the heart, but also VAT fibrosis and inflammation together with activation of adrenergic receptors (Adrb3). VAT became a major source of profibrotic (TGFb and osteopontin) and proinflammatory (TNFa, IL6 and PAI1) factors as early as 1 week after TAC. Interestingly, lipectomy prevented cardiac remodelling and dysfunction. After 1 week of TAC, cardiac transcriptomic profile showed a similar upregulation of profibrotic and prohypertrophic genes in TAC groups in presence or absence of lipectomy. After 8 weeks of TAC, lipectomy prevented the upregulation of those genes and transcriptomic profile of TAC+lipectomy was similar to sham group (Figure). PCR analysis confirmed the lower expression of profibrotic (TGFb, Osteopontin), prohypertrophic (Nppa) and contractility genes (Adr1b) in TAC+Lipectomy vs TAC group after 8 weeks of TAC. Conclusion Our results suggest that VAT is detrimental to cardiac structure and function by releasing a profibrotic and a proinflammatory secretome that aggravates the cardiac remodelling induced by TAC. Conversely, lipectomy prevents the early development of TAC-induced cardiac fibrosis.

Gradual hypertensive response in aortic alterations and myocardial inflammatory activation in progressing HFpEF in mice

Abstract Introduction Hypertension is the most common comorbidity in patients affected by heart failure with preserved ejection fraction (HFpEF). Early effects of pressure overload and its contribution to the gradual development of cardiac and vascular pathology leading to HFpEF are not well recognized, as patients are diagnosed when the disease has already advanced and show symptoms. Several hypertensive HFpEF mouse models possessing the hallmarks of the clinical-like phenotype are available. Nonetheless, initial and gradual pathological manifestations of hypertensive HFpEF have not been comprehensively described. Purpose This study aimed to investigate the gradual progression of HFpEF phenotype development in mice from the early manifestation of cardiac and vascular pathology to global cardiac dysfunction to multiorgan syndrome in response to hypertension. Methods Hypertensive HFpEF was induced by angiotensin II infusion in C57BL/6JOlaHsd 18-20-week-old male mice that were given low, moderate and high doses (0.5mg/kg/day - 1.5 mg/kg/day) subcutaneously for 4 weeks. Cardiac physiology and alterations in haemodynamics were assessed with echocardiography of heart and aorta, weekly ECG monitoring, and blood pressure measurements from the mouse tail. Extensive histology and immunohistochemistry analyses of cardiac tissue, microvasculature, lungs and kidneys were performed. Results In the low dose group, loss of aortic wall flexibility and presence of aortic root dilatation were detected. This group also demonstrated initiation of concentric remodelling process with the upsurge in macrophage infiltration in myocardium, but the signs of diastolic dysfunction were not yet present. The high dose group exhibited characteristic HFpEF features with diastolic dysfunction, left ventricular hypertrophy and fibrosis. Pathology in cardiac conduction system was noticed in all groups, with prominent ECG waveform abnormalities already on week one. However, only the high dose group experienced non-recovery in impulse propagation, accompanied by significant prolongation of ventricular depolarization. Conclusion This study demonstrates that change in aortic root dimensions and aortic wall dynamics are the first hypertension-sensitive alterations together with myocardial inflammatory cell infiltration that may contribute to myocardial remodelling and subsequent development of HFpEF and systemic effects. Hypertensive angiotensin II-induced HFpEF is a relevant mouse model, recapitulating not only hallmarks of cardiac pathology but also an extensive range of vascular and multiorgan alterations, demonstrating similarities with the clinical phenotype.

Numerical Study on Effect of Overload and Unloading on Mechanical Properties of Shield Segmental Lining Bearing Internal Water Pressure

Numerical Study on Effect of Overload and Unloading on Mechanical Properties of Shield Segmental Lining Bearing Internal Water Pressure

The role of family support on the effects of paramedic role overload on resilience, intention to leave and promotive voice

PurposeParamedics have played a critical role in the health care system response to the COVID-19 pandemic as frontline responders. However, in comparison to other health care workers (i.e. nurses), less research has been conducted on how paramedic work has been undertaken and how they manage their resources in the context of high workloads. This study examines several factors that deplete paramedic resources as well as the importance of family support in buffering the effects of low levels of resilience that can impact paramedic intention to leave and promotive voice.Design/methodology/approachData were collected from 648 paramedics employed by Ambulance Victoria, Australia, during the COVID-19 pandemic. We examine five hypotheses: (1) resilience mediates the relationship between role overload and intention to leave; (2) resilience mediates the relationship between role overload and promotive voice; (3) family support moderates the relationship between role overload and resilience; (4) family support moderates the indirect effect of role overload on intention to leave via resilience and (5) family support moderates the indirect effect of role overload on promotive voice via resilience.FindingsWe found that when family support was low, the impact of role overload on turnover intention via resilience was significant. When family support was low, the negative impact of role overload on promotive voice via resilience was significant. When family support was high, such a negative indirect effect was not significant in predicting employee promotive voice via resilience.Practical implicationsWe suggest that organisations should focus human resource management (HRM) policies and practices on family-friendly initiatives to further enhance family support resources to benefit individuals, families and organisations.Originality/valueOur findings demonstrate the importance of family support as a buffer to the negative effects of role overload on employee resilience and promotive voice. There is clear importance of the contextual elements of family support as a resource, and its absence may result in resource depletion and can act as a catalyst in a resource depletion spiral. This demonstrates the importance of organisations understanding and learning to utilise external resources to complement organisational and individual resources to reduce intention to leave and support promotive employee voice. We suggest that organisations should focus HRM policies and practices on family-friendly initiatives to further enhance family support resources to benefit individuals, families and organisations.

Too much work frustrates me! A mediation model of career-related outcomes of work overload

PurposeWork overload implies that there are excessive work demands that cannot be adequately fulfilled within the given deadlines. This research examines the effect of work overload on career outcomes, i.e. career satisfaction and occupational commitment through the mediating role of work frustration.Design/methodology/approachThe data were collected from employees working in the schools of Punjab, Pakistan in three waves. Out of the total, 248 valid responses were analyzed by PROCESS model 4 using SPSS 24.FindingsBased on affective event theory (AET) the results demonstrated that negative workplace events such as work overload create negative emotions like frustration at work and cause poor job outcomes (i.e. low satisfaction and commitment).Research limitations/implicationsHowever, the outcomes should be interpreted in the light of single sector and time-lagged data tested on the mediation-only model.Practical implicationsThe current study has implications for workload management in school staff to retain their career satisfaction and commitment.Social implicationsThis study has implications for society by offering to enhance the career outcomes of school staff that are prime institutions for socio-economic development.Originality/valueThis is one of the initial research studies that have examined the career-related outcomes of work overload based on AET via the mediating role of work frustration.

CONSUMER CONFUSION AND ITS IMPACT ON DECISION MAKING AMONG FEMALE CONSUMERS IN INDONESIA’S ONLINE COSMETICS AND PERSONAL CARE INDUSTRY

This study examines consumer confusion and its impact on decision-making among female consumers in Indonesia's online cosmetics and personal care industry. With the rise of online shopping due to its convenience and extensive product information, consumer confusion—defined as the inability to correctly interpret various aspects of product information—has become a significant issue. A mixed-method approach was used, combining quantitative surveys and qualitative interviews. Data was collected through an online survey and analyzed using PLS-SEM, followed by semi-structured interviews that were manually coded through open, axial, and selective coding. The findings reveal that informational sources—overload, similarity, and ambiguity positively impact overall consumer confusion. Additionally, utilitarian decision-makers show higher levels of confusion compared to hedonic decision-makers. Previous brand experience was found to mitigate the negative effects of overload and ambiguity confusion on decision quality and enhance decision quality in the case of similarity confusion. Furthermore, overload and ambiguity confusion negatively impacts decision quality, whereas similarity confusion shows a positive impact. Finally, all informational sources of confusion positively impact decision postponement and cognitive dissonance. This study extends existing knowledge in marketing and consumer behavior, particularly regarding consumer confusion in the cosmetics sector. It offers practical insights for companies and brand managers to develop strategies that reduce consumer confusion, such as simplifying decision-making processes, providing clear product information, and leveraging previous brand experiences. These strategies aim to enhance decision quality, reduce decision postponement, and mitigate cognitive dissonance among consumers. Finally, the study suggests directions for future research in consumer confusion.

Algorithmic Recommender Systems

Abstract Despite their ethical challenges, recommender systems (RS) are widely endorsed as a necessary solution to the problem of information overload. After clarifying how the harmful effects of information overload can be characterized in distinct ways, I explore the often overlooked potential benefits of abundant online spaces. I argue that these spaces afford valuable opportunities to experience spontaneous freedom. I then put forth a more comprehensive evaluation of the role RS should assume in algorithmically structuring the online space. This evaluation aims to reconcile the dual objectives of mitigating the harms of information overload and preserving opportunities to experience spontaneous freedom.

Differential Effects of Iron Overload and Iron Repletion on Bone and Mineral Metabolism in Growing Mice

Differential Effects of Iron Overload and Iron Repletion on Bone and Mineral Metabolism in Growing Mice

PSYCHOPREVENTIVE PRINCIPAL APPROACHES TO PREVENTING INFORMATION THREATS AMONG YOUTH

The rapid expansion of digital information has heightened the vulnerability of young people to various information threats, necessitating effective prevention strategies. General Background: In an increasingly connected world, the psychological resilience of youth is critical for safeguarding against the adverse effects of information overload and addictive behaviors. Specific Background: This article explores psychoprophylactic approaches aimed at enhancing psychological stability and mitigating negative impacts, focusing on comprehensive strategies that address the multifaceted nature of these threats. Knowledge Gap: Despite existing literature, there remains a lack of cohesive frameworks that integrate medical, educational, and psychosocial models for the prevention of addictive behavior among young individuals. Aims: This study aims to analyze current strategies and measures designed to fortify the psychological defenses of youth and to propose effective prevention frameworks. Results: The findings reveal a range of successful interventions, including programs that enhance social and personal competencies, as well as various prevention approaches that have shown promise in clinical and educational settings. Novelty: This research contributes to the existing body of knowledge by synthesizing diverse models and identifying best practices in the field of information threat prevention. Implications: The insights derived from this analysis can inform policymakers, educators, and mental health professionals in developing targeted initiatives that not only protect young individuals from information-related risks but also promote their overall psychological well-being.