Effect Of Low-level Laser Research Articles

The effectiveness of low-level laser on postoperative pain and edema in secondary palatal operation

ObjectiveThe postoperative period after palatal surgery is usually very painful, requiring the use of pain-relieving drugs. Hence, the aim of this study was to evaluate the efficacy of Low-level laser therapy (LLLT) in post-operative pain control and edema after secondary palatal operations. MethodsA randomized double blinded clinical study on 20 children undergoing secondary palatal operations between 2013 and 2015 was done. Patients were randomly divided on two groups 10 patients each. In one group patients received local application of therapeutic laser immediately after surgery while patients received nothing in the control group. The mean age was 5.22 years ± 2.53 SD in the laser group and 6.42 years ± 0.76 in the control group. Postoperative pain was assessed by using visual analog scale scores and by recording the need of analgesics. The degree of postoperative edema was also recorded. ResultsThe pain scale showed significantly less postoperative pain in the laser group than in the control group from the first day (P-value = 0.006) to the 6th day (P-value = 0.014). The number of postoperative analgesic doses needed were significantly less in the laser group in the second and third days (P-value = 0.014). The postoperative edema was significantly higher in the control group from the 2nd (P-value = 0.004) to the 7th (P-value = 0.014) postoperative days. ConclusionsPreliminary results showed that low-level laser therapy is effective in the reduction of postoperative pain and edema, and minimizing the need of analgesic medication after secondary palatal operations.

Effectiveness of low-level laser on carpal tunnel syndrome: A meta-analysis of previously reported randomized trials.

Background:Low-level laser therapy (LLLT) has been applied in the treatment of carpal tunnel syndrome (CTS) for an extended period of time without definitive consensus on its effectiveness. This meta-analysis was conducted to evaluate the effectiveness of low-level laser in the treatment of mild to moderate CTS using a Cochrane systematic review.Methods:We conducted electronic searches of PubMed (1966–2015.10), Medline (1966–2015.10), Embase (1980–2015.10), and ScienceDirect (1985–2015.10), using the terms “carpal tunnel syndrome” and “laser” according to the Cochrane Collaboration guidelines. Relevant journals or conference proceedings were searched manually to identify studies that might have been missed in the database search. Only randomized clinical trials were included, and the quality assessments were performed according to the Cochrane systematic review method. The data extraction and analyses from the included studies were conducted independently by 2 reviewers. The results were expressed as the mean difference (MD) with 95% confidence intervals (CI) for the continuous outcomes.Results:Seven randomized clinical trials met the inclusion criteria; there were 270 wrists in the laser group and 261 wrists in the control group. High heterogeneity existed when the analysis was conducted. Hand grip (at 12 weeks) was stronger in the LLLT group than in the control group (MD = 2.04; 95% CI: 0.08–3.99; P = 0.04; I2 = 62%), and there was better improvement in the visual analog scale (VAS) (at 12 weeks) in the LLLT group (MD = 0.97; 95% CI: 0.84–1.11; P < 0.01; I2 = 0%). The sensory nerve action potential (SNAP) (at 12 weeks) was better in the LLLT group (MD = 1.08; 95% CI: 0.44–1.73; P = 0.001; I2 = 0%). However, 1 included study was weighted at >95% in the calculation of these 3 parameters. There were no statistically significant differences in the other parameters between the 2 groups.Conclusion:This study revealed that low-level laser improve hand grip, VAS, and SNAP after 3 months of follow-up for mild to moderate CTS. More high-quality studies using the same laser intervention protocol are needed to confirm the effects of low-level laser in the treatment of CTS.

The Effect of Low Level Laser with Repositioning Appliance in the Management of Temporomandibular Joint Disc Displacement with Reduction

The Effect of Low Level Laser with Repositioning Appliance in the Management of Temporomandibular Joint Disc Displacement with Reduction

Erythrocyte sedimentation rate of human blood exposed to low-level laser.

This study is designed to investigate in vitro low-level laser (LLL) effects on rheological parameter, erythrocyte sedimentation rate (ESR), of human blood. The interaction mechanism between LLL radiation and blood is unclear. Therefore, research addresses the effects of LLL irradiation on human blood and this is essential to understanding how laser radiation interacts with biological cells and tissues. The blood samples were collected through venipuncture into EDTA-containing tubes as an anticoagulant. Each sample was divided into two equal aliquots to be used as a non-irradiated sample (control) and an irradiated sample. The aliquot was subjected to doses of 36, 54, 72 and 90J/cm(2) with wavelengths of 405, 589 and 780nm, with a radiation source at a fixed power density of 30mW/cm(2). The ESR and red blood cell count and volume are measured after laser irradiation and compared with the non-irradiated samples. The maximum reduction in ESR is observed with radiation dose 72J/cm(2) delivered with a 405-nm wavelength laser beam. Moreover, no hemolysis is observed under these irradiation conditions. In a separate protocol, ESR of separated RBCs re-suspended in irradiated plasma (7.6 ± 2.3mm/h) is found to be significantly lower (by 51%) than their counterpart re-suspended in non-irradiated plasma (15.0 ± 3.7mm/h). These results indicate that ESR reduction is mainly due to the effects of LLL on the plasma composition that ultimately affect whole blood ESR.

Low-level laser effects on bacterial cultures submitted to heat stress

Low-level lasers have been used worldwide to treat a number of diseases, pain relief, and wound healing. Some studies demonstrated that low-level laser radiations induce effects depending on the physiological state and DNA repair mechanisms of cells. In this work we evaluated the effects of low-level red and infrared lasers on Escherichia coli cells deficient in SOS responses submitted to heat stress. Exponential and stationary E. coli cultures of wild type (AB1157), RecA deficient (AB2463) and LexA deficient (AB2494), both SOS response deficient, were exposed to low-level red and infrared lasers at different fluences and submitted to heat stress (42 °C, 20 min). After that, cell survival and morphology were evaluated. Previous exposure to red, but not infrared lasers, increases survival fractions and decreases the area ratios of E. coli AB1157 cells submitted to heat stress. Our research suggests that a low-level red laser increases cell viability and protects cells from morphological alteration in E. coli cultures submitted to heat stress depending on laser wavelength and SOS response.

Photobiomodulation Protects and Promotes Differentiation of C2C12 Myoblast Cells Exposed to Snake Venom.

BackgroundSnakebites is a neglected disease and in Brazil is considered a serious health problem, with the majority of the snakebites caused by the genus Bothrops. Antivenom therapy and other first-aid treatments do not reverse local myonecrose which is the main sequel caused by the envenomation. Several studies have shown the effectiveness of low level laser (LLL) therapy in reducing local myonecrosis induced by Bothropic venoms, however the mechanism involved in this effect is unknown. In this in vitro study, we aimed to analyze the effect of LLL irradiation against cytotoxicity induced by Bothrops jararacussu venom on myoblast C2C12 cells.MethodologyC2C12 were utilized as a model target and were incubated with B. jararacussu venom (12.5 μg/mL) and immediately irradiated with LLL at wavelength of red 685 nm or infrared 830 nm with energy density of 2.0, 4.6 and 7.0 J/cm2. Effects of LLL on cellular responses of venom-induced cytotoxicity were examined, including cell viability, measurement of cell damage and intra and extracellular ATP levels, expression of myogenic regulatory factors, as well as cellular differentiation.ResultsIn non-irradiated cells, the venom caused a decrease in cell viability and a massive release of LDH and CK levels indicating myonecrosis. Infrared and red laser at all energy densities were able to considerably decrease venom-induced cytotoxicity. Laser irradiation induced myoblasts to differentiate into myotubes and this effect was accompanied by up regulation of MyoD and specially myogenin. Moreover, LLL was able to reduce the extracellular while increased the intracellular ATP content after venom exposure. In addition, no difference in the intensity of cytotoxicity was shown by non-irradiated and irradiated venom.ConclusionLLL irradiation caused a protective effect on C2C12 cells against the cytotoxicity caused by B. jararacussu venom and promotes differentiation of these cells by up regulation of myogenic factors. A modulatory effect of ATP synthesis may be suggested as a possible mechanism mediating cytoprotection observed under laser irradiation.

The effect of laser and botulinum toxin in the treatment of myofascial pain and mouth opening: A randomized clinical trial

This study conducted a randomized clinical trial in 15 patients, who sought care at the Dental Clinic of the University of Passo Fundo, in order to compare the use of low-level laser and botulinum toxin in the treatment of myofascial pain and whether they alter the mouth opening of patients with temporomandibular disorder. The patients were divided into two groups: the Laser group received low-level GaAlAs laser, 100mW of power at a wavelength of 830nm in continuous light emission; and the Toxin group received 30U of botulinum toxin type A (BTX-A) in the first session, and 15U after fifteen days. The assessments were performed by measuring pain with Visual Analogue Scale (VAS), and mouth opening with a digital caliper. Data were submitted to Student's t test at 5% significance level. Regarding pain symptoms, the results indicate that groups treated with laser and toxin registered 7U in VAS, at day 5 the scores were 4.75 and 4.86U, respectively. The laser worked faster (day 12) at 2.75U, and the group treated with BTX-A registered 2.86U at day 30. Both therapies investigated were effective in reducing pain, but the effect of low-level laser was faster than the use of BTX-A. Both treatments showed no statistically significant improvement in mouth opening.

In Vitro Mean Red Blood Cell Volume Change Induced by Diode Pump Solid State Low-Level Laser of 405 nm.

Objective: This study was conducted to investigate the effects of low-level laser (LLL) doses on human red blood cell volume. The effects of exposure to a diode pump solid state (DPSS) (λ = 405 nm) laser were observed. Background data: The response of human blood to LLL irradiation gives important information about the mechanism of interaction of laser light with living organisms. Materials and methods Blood samples were collected into ethylenediaminetetraacetic acid (EDTA)-containing tubes, and each sample was divided into two equal aliquots, one to serve as control and the other for irradiation. The aliquot was subjected to laser irradiation for 20, 30, 40, or 50 min at a fixed power density of 0.03 W/cm2. Mean cell volume (MCV) and red blood cell (RBC) counts were measured immediately after irradiation using a computerized hemtoanalyzer. Results: Significant decrease in RBC volume (p < 0.05, p < 0.0001, p < 0.0001, and p < 0.05, respectively) was induced with variation in laser doses.The highest response was observed with an exposure time of 40 min. This result was reproduced in RBCs suspended in a buffered NaCl solution. In contrast to this finding, laser-induced RBC volume change was completely abolished by suspending RBCs in a solution containing a higher concentration of EDTA. Conclusions: It was suggested that LLL can reduce RBC volume possibly because of the increased free intracellular Ca+2 concentrations, which activate Ca+2-dependent K+ channels with consequent K+ ion efflux and cell shrinkage.

Efficiency of low-level laser therapy within induced dental movement: A systematic review and meta-analysis

The low level laser is widely used in Dentistry, in particular, to decrease pain and increase the speed of tooth movement. This study was to perform a systematic literature search to investigate the effectiveness of low level laser and low energy density therapy of the induced tooth movement.This research was performed following the PRISMA instructions and was registered in the PROSPERO. The articles were searched in six electronic databases, with no date and language restriction. Only randomized clinical trials were selected. Articles that did not use the extraction of first premolars as orthodontic planning were excluded, as well as articles using high energy density laser therapy. The articles were assessed for risk of bias and individual quality. The results were analyzed using meta-analysis, using randomized effect.The initial sample consisted of 161 articles. Six articles remained eligible for qualitative analysis and five for quantitative analysis. According to the individual quality, most articles were classified as high quality. Three articles detected statistically significant differences in induced movement by comparing the orthodontic movement between the experimental and control groups. For the maxilla, there was a statistically significant influence of the laser in three months and, for the mandible, in one month.It may be concluded that there is no evidence that laser therapy can accelerate the induced tooth movement.

Remineralization effect of low-level laser and amorphous sodium–calcium–phosphosilicate paste in teeth with fixed orthodontic appliances

Purpose The aim of the present study was to evaluate enamel remineralization with NovaMin (amorphous sodium–calcium–phosphosilicate paste) and low-level laser (LLL) for white spot lesions after orthodontic therapy. Materials and methods A total of 20 premolars divided into four groups were submitted to three phases: (i) placement fixed orthodontic appliances; (ii) demineralizing solution; and (iii) remineralization for groups (group A, control; group B, NUPRO Sensodyne with NovaMin; group C, LLL; and group D, NovaMin and LLL). In each stage, elemental analysis (calcium, phosphorus, and sodium) was measured under a scanning electron microscope; the data were tested to find significant differences between mineral changes during phases by using the Bonferroni test and Tukey's test between groups. Results Calcium and sodium decreased and phosphorus ions increased in all groups at stage 2. In stage 3, all minerals increased for all the tested groups, recording greater values in group B. Calcium showed a statistically significant difference on comparing stage 1 with stage 2 (P = 0.025) and stage 2 with stage 3 (P = 0.019). On the other hand, using the Bonferroni analysis, phosphorous recorded a significant difference on comparing stage 1 with stage 3 (P = 0.013). Applying Tukey's test, a statistical significant difference between groups A and B was recorded as regards the calcium level (P = 0.004) and the phosphorus level (P = 0.003), which also showed a significant difference between group A and group C (P = 0.052). As regards the sodium distribution, no significant differences were found. Conclusion According to the results obtained in the current study, using NUPRO Sensodyne with NovaMin than using LLL proved to be the better treatment for white spot lesions, leading ion incorporation and providing an effective alternative for dental demineralization.

Early results of low-level laser application for masticatory muscle pain: a double-blind randomized clinical study.

BackgroundTo evaluate the effect of Low Level Laser (LLL) application at the points of greatest pain in patients with chronic masticatory muscle pain.MethodsA total number of 30 (21 women, 9 men, with a mean age of 39.2) were selected after the diagnosis of MPDS according to the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD). The patients were randomly divided into three groups; laser group I (n = 10); patients received the LLL at the point of greatest pain, laser group II (n = 10); patients received LLL at pre-established points in the effected muscles and placebo group (n = 10). LLL and placebo were applied three times per week, for a total of 12 sessions. Mandibular mobility was examined, masticator muscles tenderness were assessed and PPT values were obtained. Subjective pain levels were evaluated using VAS. The measurements performed before the treatment and after the completion of the therapy. Descriptive statistics (mean, standard deviation, and frequency) Student’s t-test, Mann–Whitney U-test and paired-sample t-tests were used for analysis.ResultsIn both laser groups, there was a statically significant reduction in PPT values of the muscles, number of muscles without any pain on palpation increased significantly, mandibular movements’ ranges were improved. Laser group I demonstrated statistically better results than the Laser group II in all of the measured values. Plasebo group did not show any statistically difference in any of the measured values.ConclusionsLLLT can be accepted as an alternative treatment modality in the management of masticatory muscle pain and direct irradiation seems to effect better.Trial registrationCurrent Controlled Trials ISRCTN31085, Date of registration 28/08/20145.

Low-level red laser therapy alters effects of ultraviolet C radiation on Escherichia coli cells.

Low-level lasers are used at low power densities and doses according to clinical protocols supplied with laser devices or based on professional practice. Although use of these lasers is increasing in many countries, the molecular mechanisms involved in effects of low-level lasers, mainly on DNA, are controversial. In this study, we evaluated the effects of low-level red lasers on survival, filamentation, and morphology of Escherichia colicells that were exposed to ultraviolet C (UVC) radiation. Exponential and stationary wild-type and uvrA-deficientE. coli cells were exposed to a low-level red laser and in sequence to UVC radiation. Bacterial survival was evaluated to determine the laser protection factor (ratio between the number of viable cells after exposure to the red laser and UVC and the number of viable cells after exposure to UVC). Bacterial filaments were counted to obtain the percentage of filamentation. Area-perimeter ratios were calculated for evaluation of cellular morphology. Experiments were carried out in duplicate and the results are reported as the means of three independent assays. Pre-exposure to a red laser protected wild-type and uvrA-deficient E. coli cells against the lethal effect of UVC radiation, and increased the percentage of filamentation and the area-perimeter ratio, depending on UVC fluence and physiological conditions in the cells. Therapeutic, low-level red laser radiation can induce DNA lesions at a sub-lethal level. Consequences to cells and tissues should be considered when clinical protocols based on this laser are carried out.

Effect of low-level diode laser on proliferation and osteogenic differentiation of dental pulp stem cells

This study assessed the effect of low-level laser irradiation (LLLI) on the proliferation and osteogenic differentiation of dental pulp stem cells (DPSCs). DPSCs were exposed to 810 nm laser light (0.1, 0.2, or 0.3 J cm−2) for 7 d (60 s daily). The negative control group (cells in regular medium) and positive control group (cells in osteogenic medium (OM)) were not lased. One group of cells in OM was irradiated with laser operated at 0.2 J cm−2. Cell viability was evaluated at 24 h and one week after the last day of laser irradiation using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Osteogenic differentiation was assessed using real-time reverse transcriptase polymerase chain reaction (RT-PCR) and alizarin Red S staining. Cell proliferation was not affected by laser irradiation at 24 h except in one group (cells in OM exposed to laser at 0.2 J cm−2). However, one week after the last day of laser irradiation, it was significantly increased in groups exposed to laser at 0.1 or 0.2 J cm−2 and decreased in groups containing OM (P < 0.05). Osteoblast marker expression was observed in groups containing OM. LLLI at 0.2 J cm−2 dramatically enhanced cell differentiation. Laser at 0.3 J cm−2 increased bone sialoprotein (BSP) and decreased alkaline phosphatase (ALP). Mineralized nodules were only observed in groups containing OM. Considering these findings, LLLI may be used as a novel approach for preconditioning of DPSCs in vitro prior to bone tissue engineering.

Low-level lasers affect Escherichia coli cultures in hyperosmotic stress

Physical characteristics and practical properties have made lasers of interest for biomedical applications. Effects of low-level lasers on biological tissues could occur or be measurable depending on cell type, presence of a pathologic process or whether the cells are in an adverse environment. The objective of this work was to evaluate the survival, morphology and filamentation of E. coli cells proficient and deficient in the repair of oxidative DNA lesions exposed low-level red and infrared lasers submitted to hyperosmotic stress. Wild type and endonuclease VIII deficient E. coli cells in exponential and stationary growth phase were exposed to red and infrared lasers and submitted to hyperosmotic stress. Cell viability, filamentation phenotype and cell morphology were evaluated. Cell viability was not significantly altered but previous laser exposure induced filamentation and an altered area of stressed cells depending on physiologic condition and presence of the DNA repair. Results suggest that previous exposure to low-level red and infrared lasers could not affect viability but induced morphologic changes in cells submitted to hyperosmotic stress depending on physiologic conditions and repair of oxidative DNA lesions.

Comparison of the Effect of Low-Level Laser and Phenytoin Therapy on Skin Wound Healing in Rats.

Different modalities have been used to achieve better results in wound healing among which are laser and pharmacological agents. To our knowledge, there is no investigation to compare phenytoin and laser together. In this study, we aimed to evaluate laser and phenytoin efficacy and compare their effect on wound healing. We used 60 rats. The animals were divided into 4 groups, 15 rats in each and each group was subdivided into 3 subgroups for which postoperative evaluation was performed on days 3, 7, and 14. After general anesthesia and back hair shaving of each rat, an excisional wound was made. The wounds in group 2 were treated with 1% phenytoin cream. In group 3, the wounds were irradiated with diode laser. The wounds of group 4 were treated with both phenytoin cream and laser administration. The animals of group 1 served as control. For histopathological evaluation, hematoxylin and eosin staining was used. Polymorphonuclear leucocytes (PMNs), re-epithelization, fibroblasts, new vessels and collagen were evaluated. Faster reduction in polymorphonuclear cells after 7 and 14 days and more collagen fibers on the third day in laser treated group was statistically significant (P < .05) .The result for the phenytoin treated group were not better than control group. When both laser and phenytoin were used samples showed more collagen fibers on the third day, which was statistically significant (P < .05). It seems that low level laser is effective in skin wound healing and have better results than phenytoin application.

Effect of low-level laser on the rate of tooth movement

Low-level laser therapy (LLLT) has been introduced in orthodontic procedures with its initial purpose to alleviate the pain after adjustment of the appliances and to enhance healing of the sore spot caused by appliance impingement. Recent studies have shown that LLLT may increase the differentiation and proliferation of the cells associated with bone remodeling machinery and therefore affect the rate of orthodontic tooth movement. The effects of LLLT in regards to orthodontic tooth movement have been controversial. This article reviews the previous studies on the biological effects of LLLT on orthodontic tooth movement in animals and human subjects, and thereby aims to set the optimal protocol to accelerate tooth movement in orthodontic avenue.

Phototherapeutic Effect of Low-Level Laser on Thyroid Gland of Gamma-Irradiated Rats.

One inescapable feature of life on the earth is exposure to ionizing radiation. The thyroid gland is one of the most sensitive organs to gamma-radiation and endocrine disrupters. Low-level laser therapy (LLLT) has been used to stimulate tissue repair, and reduce inflammation. The aim of this study was to gauge the value of using Helium-Neon laser to repair the damaged tissues of thyroid gland after gamma-irradiation. Albino rats were used in this study (144 rats), divided into control, gamma, laser, and gamma plus laser-irradiated groups, each group was divided into six subgroups according to time of treatment (total six sessions). Rats were irradiated once with gamma radiation (6 Gy), and an external dose of laser (Wavelength 632.8 nm, 12 mW, CW, Illuminated area 5.73 cm(2), 2.1 mW cm(-2) 120 s, 1.4 J, 0.252 J cm(-2)) twice weekly localized on thyroid region of the neck, for a total of six sessions. Animals were sacrificed after each session. Analysis included thyroid function, oxidative stress markers, liver function and blood picture. Results revealed improvement in thyroid function, liver function and antioxidant levels, and the blood cells count after LLLT.

Topical Gel Application and Low Level Laser Therapy on Related Soft Tissue Traumatic Aphthous Ulcers: A Randomized Clinical Trial

Objective: To evaluate the effect of low level laser and Fitostimuline gel® application on pain and healing of orthodontic related traumatic aphthous. Materials and methods: In this double blind and randomized clinical trial, 60 subjects reported traumatic aphthous lesions and the same day they appear immediately they were placed in :G1: (control group) at 13 patients in which only the traumatic factor of the lesion was removed.G2: (Fitostimuline®) 14 patients treated with Fitostimuline® 3 times a day, until the lesion disappeared.G3: (Laser) 14 patients treated with LLLT (Low Level Laser Therapy). G4: (Laser + Fitostimuline®) 15 patients treated with LLLT application and Fitostimuline® 3 times per day, until the lesion healed completely. ANOVA was applied for parametric data, and non-parametric ANOVA (Kruskal-Wallis test - Friedman) and Mann-Whitney U test were made. Past statistical software version 2010 for Excel was used. Results: Higher diameter aphthous ulcer measures and pain significantly reduced for the Fitostimuline Gel®and Laser treated groups or both combined if compared with the control group. The medicament effect its slow if compared to laser therapy, nonetheless when used simultaneously the effect does not differ from the one obtained by laser only application. Fitostimuline Gel® application does not increase laser effect on healing. Conclusions: Topical Fitostimuline Gel® and LLLT therapy are highly efficient treatment options for aphthous ulcer and pain generated by orthodontic treatment, when compared to a control group. LLLT therapy, it’s more effective than Fitostimuline Gel® for orthodontic related aphthous ulcer treatment. Combining therapies do not improve nor enhance treatment results.

Histopathological Study Of The Effect Of Low Level Laser And Biatain Ag Non-Adhesive Dressing On The Avulsion Wound Healing In Rabbits

The aims of this study was to compare between the effect of Low level Laser and Biatain Ag non-adhesive dressing on healing of avulsion wound in rabbits. Eighteen adult healthy rabbits were used. It is divided in to two equal groups , Laser group , and Biatain Ag group, also each group divide into three equal sub group for histopathological study at 1 week , 2 week and 3 week post operation. The avulsion wound was done on the back(dorsal) after general anesthesia by blade 1 cm . post-operation , in laser group, the rabbits were exposed to low level laser for 5 minute/daily to period 1week, 2week ,3week continuously , but in Biatain Ag group, the avulsion wound was dressing by Biatain Ag non-adhesive dressing and it fixed on wound by blaster and continuous to 1week, 2week, 3week.The histopathological examination appear in first week, both groups showed ulceration but in biotin group showed more ulceration than laser group. In two week, laser group some animals showed absence of ulceration with dermal fibrosis. In two week, in biatain group showed reduce the size ulcer with dermal fibrosis. In three week, laser group showed complete healing with moderate thickening of epidermis and hyperkeratosis with dermal fibrosis. While biatain group showed complete healing with marked dermal fibrosis but presence of foci of hair folliculitis. Conclusion In two week, laser group all showed healing of ulcer except one animal while biatain group there was only reduce size of ulcer but not complete healing..

Treatment of upper limb lymphedema with low-level laser: a systematic review

Introduction Low-level lasers have been suggested as a complement to lymphedema treatment. However, this therapy’s mechanism of action and its effects are poorly understood up to the present. Objective To conduct a systematic literature review to analyze the effects of low-level laser in the treatment of upper-limb lymphedema in women submitted to breast cancer surgery. Material and methods Randomized clinical trials were included, in Portuguese, English and Spanish, from January 1990 to July 2013. The article search was carried out in the Pubmed, Lilacs and PEDro electronic databases, with the following descriptors:Terapia a Laser de Baixa Intensidade, Linfedema, Câncer de Mama, Low-level laser therapy, Lymphedema, Breast Neoplasms and also through a manual search. Results and discussion Low-level lasers have been used for treating several acute and chronic conditions. However, its application for managing post breast cancer surgery is still recent, often based on empirical evidence. Treating upper-limb lymphedema with low-level laser presented positive results, with reduction in the circumference or volume of the affected limb. Conclusion More studies of high methodological quality are needed in order to better understand the mechanism of action of low-level laser on the lymphatic system and its effects on lymphedema treatement.