Effects Of Low-dose Radiation Research Articles

Review of Cohort Studies Among Radiologists, Radiological Technologists, and Nuclear Workers

A number of epidemiological studies have been conducted to investigate the health effects of low-dose radiation. The author reviewed epidemiological studies among radiologists, radiological technologists, and nuclear workers. Because the results of many epidemiological studies on these subjects have been published, and many studies have measured radiation doses, there is little uncertainty. In the studies among radiologists and radiological technologists, high risks for leukemia, skin cancer, and breast cancer were found in populations that began work before around 1950, but not seen such a tendency for those starting work recent years. The results of the studies among nuclear workers were inconsistent with some reporting that a risk was seen, while others reported no risk. The reason for this may be due to the different analysis methods among the studies.

EFFECT OF LOW DOSE GAMMA IRRADIATION ON NUMBER AND RATIO OF SOME PERIPHERAL BLOOD CELLS IN HATCHED CHICKS

The presented research was carried out to investigate hematological response to low dose gamma radiation in chickens hatched from irradiated eggs. A total of 700 Ross-308 eggs were divided into the experimental group (N=360) and control group (N=340). The experimental group was irradiated one hour before incubation with a cobalt-60 (60Co) panoramic irradiator, and control group was sham irradiated. Blood samples for the red blood cell (RBC) and white blood cell (WBC) counts and differential blood counts were taken on the 1st, 3rd, 5th, 7th and 10th day of life. Blood cell counting was performed using the Natt and Herrick method. Leukocytes were differentiated using amicroscopic examination of stained blood smears and a heterophil:lymphocyte (H/L) ratio was calculated. Our results demonstrate a reduced RBC and WBC indicating negative effects of low-dose radiation on the blood cell counts in chicks during the first week after hatching. Significant decrease in the number of red blood cells on the 5th and 7th day and in the number of white blood cells on the1st and 3rd day, were obtained. Moreover, the number of lymphocytes in one-day-old chicken blood increased, while the number of heterophils decreased in response to radiation, suggesting better stress response in the exposed group. Further research is necessary to investigate the value of H/L ratio as a diagnostic indicator for radiation stress response and to evaluate cells and tissue reactions in specific time frames and across different taxonomic groups challenged by the low radiation dose. Extent of embryonic oxidative damage and recovery mechanisms should be also further investigated.

Biological effects of low-dose γ-ray irradiation on chromosomes and DNA of Drosophila melanogaster.

While the damage to chromosomes and genes induced by high-dose radiation (HDR) has been well researched in many organisms, the effects of low-dose radiation (LDR), defined as a radiation dose of ≤100 mSv, are still being debated. Recent research has suggested that the biological effects of LDR differ from those observed in HDR. To detect the effect of LDR on genes, we selected a gene of Drosophila melanogaster, known as the multiple wing hair (mwh) gene. The hatched heterozygous larvae with genotype mwh/+ were irradiated by γ-rays of a 60Co source. After eclosion, the wing hairs of the heterozygous flies were observed. The area of only one or two mwh cells (small spot) and that of more than three mwh cells (large spot) were counted. The ratio of the two kinds of spots were compared between groups irradiated by different doses including a non-irradiated control group. For the small spot in females, the eruption frequency increased in the groups irradiated with 20–75 mGy, indicating hypersensitivity (HRS) to LDR, while in the groups irradiated with 200 and 300 mGy, the frequency decreased, indicating induced radioresistance (IRR), while in males, 50 and 100 mGy conferred HRS and 75 and 200 mGy conferred IRR. For the large spot in females, 75 mGy conferred HRS and 100–800 mGy conferred IRR. In conclusion, HRS and IRR to LDR was found in Drosophila wing cells by delimiting the dose of γ-rays finely, except in the male large spot.

Low dose ionizing radiation effects on the immune system

Ionizing radiation interacts with the immune system in many ways with a multiplicity that mirrors the complexity of the immune system itself: namely the need to maintain a delicate balance between different compartments, cells and soluble factors that work collectively to protect, maintain, and restore tissue function in the face of severe challenges including radiation damage. The cytotoxic effects of high dose radiation are less relevant after low dose exposure, where subtle quantitative and functional effects predominate that may go unnoticed until late after exposure or after a second challenge reveals or exacerbates the effects. For example, low doses may permanently alter immune fitness and therefore accelerate immune senescence and pave the way for a wide spectrum of possible pathophysiological events, including early-onset of age-related degenerative disorders and cancer. By contrast, the so called low dose radiation therapy displays beneficial, anti-inflammatory and pain relieving properties in chronic inflammatory and degenerative diseases. In this review, epidemiological, clinical and experimental data regarding the effects of low-dose radiation on the homeostasis and functional integrity of immune cells will be discussed, as will be the role of immune-mediated mechanisms in the systemic manifestation of localized exposures such as inflammatory reactions. The central conclusion is that ionizing radiation fundamentally and durably reshapes the immune system. Further, the importance of discovery of immunological pathways for modifying radiation resilience amongst other research directions in this field is implied.

Cell stress response to low-dose neutron radiation

Background. It is a point of discussion whether low-dose ionizing radiation has harmful or stimulating impact on cell. According to high relative biological effectiveness of neutron radiation there is a need of description of any process triggered in the cell by neutrons. Objective. The aim of current work is the investigation of the low dosed neutron radiation effects on human cells by indicators of cell stress such as state of chromatin and cell membrane permeability. Materials and methods. Human buccal epithelium cells from 3 male donors (21, 24, 25 years old) were exposed to fast neutron radiation in dose range 2.3–146.0 mSv from 239Pu-Be source. State of chromatin was evaluated by count of heterochromatin granules quantity in 100 nuclei stained with 2% orcein in 45% acetic acid; ratio of cells with increased membrane permeability stained with 5 mM indigocarmine in 300 cells. Results. Changes in level of heterochromatin granules quantity and in cell membrane permeability revealed wave-shaped dependency with maximum effects at 36.5 mSv. Further increase of dose resulted in return of both chromatin state and membrane permeability levels closely to control or even lower. Conclusion. Membrane restoration and chromatin decompaction under doses higher than 36.5 mSv together can be a sign of hormetic (stimulating) effect of low-dose neutron radiation.

A New Approach to the Stimulation of the Body’s Defense Systems with Low Radiation Doses

The article considers the effects arising after exposure to low doses of radiation in vitro and in vivo, as well as the mechanisms of their formation. Analysis of the literature shows that the result of the action of low-dose radiation depends on the cell type, radiation sources, assessment methods, etc. This action differs from the effects of high doses and is associated with the activation of defense systems. Stimulation of the endogenous antioxidant system and repair was detected in normal cells after exposure to low doses. At the level of the organism, the response to the effect of low radiation doses is also accompanied by activation of the immune system. This leads to an increase in the resistance of normal cells to the action of genotoxic factors (the radio-adaptive response), which can be used to protect the normal tissues surrounding the tumor from the effects of high radiation doses during radiation therapy. The resistance of most malignant cells after irradiation with low doses did not change. However, the fractionated effect of low-dose radiation on the tumor could induce an increase in radio-sensitivity in malignant cells. The review presents data that show the change in the expression of a number of genes and regulatory RNA after exposure to low-dose radiation. These epigenetic parameters make it possible to explain individual differences in the magnitude of the radio-adaptive response. The paper discusses the prospects of the use of low-dose radiation for the treatment of certain human pathological conditions.

Organ-Specific Effects of Low Dose Radiation Exposure: A Comprehensive Review.

Ionizing radiation (IR) is a high-energy radiation whose biological effects depend on the irradiation doses. Low-dose radiation (LDR) is delivered during medical diagnoses or by an exposure to radioactive elements and has been linked to the occurrence of chronic diseases, such as leukemia and cardiovascular diseases. Though epidemiological research is indispensable for predicting and dealing with LDR-induced abnormalities in individuals exposed to LDR, little is known about epidemiological markers of LDR exposure. Moreover, difference in the LDR-induced molecular events in each organ has been an obstacle to a thorough investigation of the LDR effects and a validation of the experimental results in in vivo models. In this review, we summarized the recent reports on LDR-induced risk of organ-specifically arranged the alterations for a comprehensive understanding of the biological effects of LDR. We suggested that LDR basically caused the accumulation of DNA damages, controlled systemic immune systems, induced oxidative damages on peripheral organs, and even benefited the viability in some organs. Furthermore, we concluded that understanding of organ-specific responses and the biological markers involved in the responses is needed to investigate the precise biological effects of LDR.

Effects of Low Dose Radiation on Biological Processes in Peri-tumoral and Tumoral Areas n Squamous Cell Skin Cancer

Very low dose ionizing radiation (LDR) may have paradoxically beneficial effects via an adaptive response. This adaptive response can mitigate against the potential adverse effects of high-dose radiation therapy and chemotherapy. In this study we aimed to:1.identify the specific molecular details behind the adaptive response to LDR and2.integrate the LDR adaptive response into clinical practice. Our aim was to determine how low dose radiation modifies genetic expression in both healthy and tumor tissue. To determine this, a human clinical trial (n=8) was conducted in 2018 to ascertain the biological effects of integrating 0.1Gy of LDR into standard radiotherapy (2Gy fractions) over the first two weeks of radiation treatment for epidermoid skin cancers. RNA was obtained from skin biopsies and processed for genetic expression using Affymetrix Human gene chips Clarion-D (138K genes). 8 patients with squamous skin cancer, were studied according to the experimental design showed in Figure 1. Biopsy samples were collected and total RNA preparation (100 ng), labeled cRNA synthesis, hybridization, scanning, and image analysis were performed. Changes in biological response were measured using Affymetrix microarrays. Experiments 17F1 and 17F2 were performed in duplicate, and experiments 18F3 and 18F4 were performed in triplicate. Pathway analysis was performed using the Affymetrix Transcriptome Analysis Console software and the Wikipaths database. Comparisons were performed as noted in Table 1. The difference in gene expression in healthy tissues due to LDR exposure is quite low (only 325 genes, mostly downregulated) as noted in Figures 2A and 3A and Tables 2 and 3. The 20 most important biological processes enriched are shown in Figure 4 and include Senescence and Autophagy in malignant cells, and the Genotoxicity Pathway (both downregulated). The difference in gene expression in tumor tissue due to LDR exposure is significantly more pronounced (5,651 genes, mostly upregulated) as noted in Figures 2C and 3C. The 20 most important biological processes enriched are shown in Figures 5 and 6 and Tables 4-6, and include the Allograft rejection pathway in skin cancer (upregulated). Our results suggest that very low doses of radiation (0.1Gy) have a narrow effect on gene expression when applied in the healthy peritumoral area. Down regulated genes predominate, and DNA repair mechanisms are stimulated by the first low dose in healthy tissue.

ESTIMATION OF PHOTON ENERGY AND DIRECTION DISTRIBUTIONS AT JAPANESE NUCLEAR POWER PLANTS BASED ON LITERATURE SURVEY FOR J-EPISODE STUDY.

In order to reconstruct organ-absorbed dose from recorded dose for risk estimation in nuclear worker cohort, the preceding study of the International Agency for Research on Cancer (IARC) 15-Country Collaborative Study estimated the organ dose conversion factor from the recorded dose of Hp(10) under the assumption that on average, in the nuclear power plants (NPPs), 10% of the dose received by workers was due to photon energies ranging from 100 to 300 keV and 90% from photon energies ranging from 300 to 3000 keV, with the average geometry being 50% in the antero-posterior geometry and 50% in the isotropic geometry. Similar examination was conducted at the Japanese Epidemiological Study on Low-Dose Radiation Effects (J-EPISODE).Literature survey disclosed that Japanese electric power companies had jointly conducted the research on energy distribution and incidence direction distribution of gamma rays in working environments during periodical inspection and maintenance as well as during operation in the 1980s. The analysis of the survey results on photon energy and geometry distribution of Japanese NPPs demonstrated appropriateness in applying the IARC study assumption for nuclear workers in Japan and reconstructing organ-absorbed dose in the J-EPISODE. These results in Japan also provide strong evidence to support the robustness and generality of the IARC study assumption, which was estimated based on the judgment of experts at nuclear facilities around the world.

The effect of chronic low-dose environmental radiation on organ mass of bank voles in the Chernobyl exclusion zone

Purpose Animals are exposed to environmental ionizing radiation (IR) externally through proximity to contaminated soil and internally through ingestion and inhalation of radionuclides. Internal organs can respond to radioactive contamination through physiological stress. Chronic stress can compromise the size of physiologically active organs, but studies on wild mammal populations are scarce. The effects of environmental IR contamination on organ masses were studied by using a wild rodent inhabiting the Chernobyl exclusion zone (CEZ). Material and methods The masses of brain, heart, kidney, spleen, liver and lung were assessed from bank voles (Myodes glareolus) captured from areas across radioactive contamination gradient within the CEZ. Relative organ masses were used to correct for the body mass of an individual. Results Results showed a significant negative correlation between IR level in the environment and relative brain and kidney mass. A significant positive correlation between IR and relative heart mass was also found. Principal component analysis (PCA) also suggested positive relationship between IR and relative spleen mass; however, this relationship was not significant when spleen was analyzed separately. There was no apparent relationship between IR and relative liver or lung mass. Conclusions Results suggest that in the wild populations even low but chronic doses of IR can lead to changes in relative organ mass. The novelty of these result is showing that exposure to low doses can affect the organ masses in similar fashion as previously shown on high, acute, radiation doses. These data support the hypothesis that wildlife might be more sensitive to IR than animals used in laboratory studies. However, more research is needed to rule out the other indirect effects such as radiosensitivity of the food sources or possible combined stress effects from e.g. infections.

Effects of low-dose irradiation on chromosomal damage and oxidative stress in cultured human peripheral blood

Effects of low-dose irradiation on chromosomal damage and oxidative stress in cultured human peripheral blood

Transcriptional Changes in the Ovaries of Perch from Chernobyl.

Fish have been highly exposed to radiation in freshwater systems after the Chernobyl Nuclear Power Plant (NPP) accident in 1986 and in freshwater and marine systems after the more recent Fukushima NPP accident in 2011. In the years after the accident, the radioactivity levels rapidly declined due to radioactive decay and environmental processes, but chronic lower dose exposures persisted. To gain insights into the long-term effects of environmental low dose radiation on fish ovaries development, a high-throughput transcriptomic approach including a de novo assembly was applied to different gonad phenotypes of female perch: developed gonads from reference lakes, developed/irradiated from medium contaminated lake, and both developed/irradiated and undeveloped from more highly contaminated lakes. This is the most comprehensive analysis to date of the gene responses in wildlife reproductive system to radiation. Some gene responses that were modulated in irradiated gonads were found to be involved in biological processes including cell differentiation and proliferation (ggnb2, mod5, rergl), cytoskeleton organization (k1C18, mtpn), gonad development (nell2, tcp4), lipid metabolism (ldah, at11b, nltp), reproduction (cyb5, cyp17A, ovos), DNA damage repair (wdhd1, rad51, hus1), and epigenetic mechanisms (dmap1). Identification of these genes provides a better understanding of the underlying molecular mechanisms underpinning the development of the gonad phenotypes of wild perch and how fish may respond to chronic exposure to radiation in their natural environment, though causal attribution of gene responses remains unclear in the undeveloped gonads.

Gene Expression and Cellular Markers of Occupational Radiation Exposure in Chernobyl Shelter Construction Workers

Low-dose radiation effects were studied in Ukrainian personnel of the Chernobyl exclusion zone. The aim of this study was to determine the influence of borderline exposure to annual professional limits and age on expression of molecular markers. Study groups included 300 radiation workers performing construction work on the New Safe Confinement (Arch) upon the Chernobyl "Shelter" [external dose, 26.1 ± 18.1 mSv; age, 43.1 ± 10.3 y overall and 48.7 ± 5.9 y for 69 control persons]. Methods included gene expression using RT-PCR, flow cytometry of lymphocyte antigens, gamma-H2AX, Cyclin D1 expression, and relative telomere length using flow-FISH. A statistically significant upregulation of VEGFA BAX, DDB2, NFKB1 was shown at doses below 35 mSv. In workers aged under 40 y with doses higher than 35 mSv, an upregulation of 16 genes was revealed-VEGFA, TERF2, TERF1, BIRC5, BAX, TP53, DDB2, CDKN1B, CDKN2A, NFKB2, MAPK14, TGFBR1, MKNK2, CDKN1A, NFKB1, TP53I3; and four genes were downregulated-MADD, FASL, CSF2, and TERT. In workers older than 40 y, 8 genes were upregulated and 12 were downregulated. All groups showed an increased and dose-dependent gamma-H2AX expression. Downregulation of CCND1 genes in older groups was accompanied by lower numbers of Cyclin D1 protein expression and lower CD3 and CD4 cell counts. Upregulation of CSF2 in those over 40 y old positively correlated with B-cell and NK-cell counts. A non-linear type of gene expression response was demonstrated: in doses over 35 mSv for those over 40 y, the increased expression of gamma-H2AX is associated with upregulation of cell survival positive regulators-BIRC5, BRCA1, DDB2, CCND1, TERT genes, and longer telomeres; the younger age group was characterized by TERF1 and TERF2 upregulation and telomere shortening.

The Double Threshold: Consequences for Identifying Low-Dose Radiation Effects.

Prior to observing low-dose-induced cell signaling and adaptive protection, radiogenic stochastic effects were assumed to be linearly related to absorbed dose. Now, abundant data prove the occurrence of radiogenic adaptive protection specifically at doses below ∼ 200 mGy (with some data suggesting such protection at a dose even higher than 200 mGy). Moreover, cells do not thrive properly when deprived of radiation below background dose.Two threshold doses need be considered in constructing a valid dose-response relationship. With doses beginning to rise from zero, cells increasingly escape radiation deprivation. The dose at which radiation-deprived cells begin to function homeostatically provides dose Threshold A. With further dose increase, adaptive protection becomes prominent and then largely disappears at acute doses above ∼ 200 mGy. The dose at which damage begins to override protection defines Threshold B.Thresholds A and B should be terms in modeling dose-response functions. Regarding whole-body responses, current data suggest for low-LET acute, non-chronic, irradiation a Threshold B of about 100 mGy prevails, except for leukemia and probably some other malignancies, and for chronic, low dose-rate irradiation where the Threshold B may well reach 1 Gy per year. A new Research and Development Program should determine individual Thresholds A and B for various radiogenic cell responses depending on radiation quality and target.

Application of the buccal micronucleus cytome assay on child population exposed to sinus X-ray

PurposeDiagnostic X-ray examinations of paranasal sinuses use a low-dose ionizing radiation to achieve medically indicated purposes. The effects of low-dose radiation are still controversial, making it a highly prioritized field of research. As there is a need to evaluate the effects of low-dose ionizing radiation and that children might be a more vulnerable population, we performed simultaneous physical dosimetry and buccal cell micronucleus cytome assay on pediatric patients before and after an X-ray examination of the sinuses. MethodsThe study comprised 20 subjects aged 11.9 ± 3.6 years, and BMI < 25 kg/m2. Physical dosimetry was performed using radiophotoluminiscent (RPL) glass dosimeters placed on four positions on the head. The buccal cell micronucleus cytome assay was performed before and 14 ± 1 days after the X-ray exam, to monitor DNA damaging, replicative, cytostatic, and cell death effects. ResultsThe doses in the primary beam ranged 371–1106 μGy and were several fold higher than at the other positions on the head. As for biological changes, we did not observe any DNA damaging effects. However, a significant increase in cells with condensed chromatin was observed, indicating more cells undergoing early stages of apoptosis. We also observed inter-individual differences between the subjects. A correlation between the doses detected and biological effects was not observed. ConclusionAlthough we did not observe significant increase in DNA damage, further studies are needed to increase the statistical power of the results and ensure patients’ safety and optimal health care.

Hepatic effects of low-dose rate radiation in natural mouse populations (Apodemus uralensis and Apodemus agrarius): comparative interspecific analysis

Hypothesis: Natural mouse populations in radioactive contamination zone provide adequate information about dose loads and biological effects for ‘non-human biota’. The comparative analysis of the responses of different species of mice allows us to reveal the possible variation in the effects of low-dose rate radiation relative to the ecological-physiological and functional-metabolic features of the species.Materials and methods: Objects of study – two sympatric rodent species [pygmy wood mouse (Apodemus uralensis Pallas, 1811) and striped field mouse (Apodemus agrarius Pallas, 1771)] caught on the territory of the East-Ural radioactive trace (EURT). The EURT zone is consequence the Kyshtym accident in South Urals in 1957. Nowadays, the main dose-forming radionuclide is β-emitting 90Sr. The individual dose rate of impacted mice caused by internal exposure to 90Sr varied from 0.021 to 0.152 mGy/day. The baseline functional-metabolic characteristics of the liver were researched: protein-, lipid-, and glycogen-synthesizing processes; glycolysis; aerobic synthesis of ATP; lipid peroxidation; and the H2O2-scavenging enzymatic status; and the functional activity of the genome.Results: The hepatic shifts for impacted populations are amplified with increasing dose rate of irradiation, regardless of which species is considered. But, the response of closely related species of rodents to irradiation is different both in the vector and the level (in A. agrarius sample was 2 time higher than that for A. uralensis).Conclusion: The radiation-induced hepatic shifts in A. uralensis from the EURT area correspond to the chronic response under stressful environmental conditions. The impacted population of A. agrarius can be considered the more reactive species to the radiation burden, demonstrating an acute effect. The interspecies contrast in the radiation response is associated with the original interspecies differences (background rodents’ samples in 28 km from the impact study site), and also the degree of residency of the species in the impact plots.

Unloading-Induced Cortical Bone Loss is Exacerbated by Low-Dose Irradiation During a Simulated Deep Space Exploration Mission.

Spaceflight-induced bone losses have been reliably reproduced in Hind-Limb-Unloading (HLU) rodent models. However, a considerable knowledge gap exists regarding the effects of low-dose radiation and microgravity together. Ten-week-old male C57BL/6J mice, randomly allocated to Control (CONT), Hind-Limb Unloading (HLU), and Hind-Limb Unloading plus Irradiation (HLUIR), were acclimatized at 28°C, close to thermoneutral temperature, for 28 days prior to the 14-day HLU protocol. HLUIR mice received a 25mGy dose of X-ray irradiation, simulating 14days of exposure to the deep space radiation environment, on day 7 of the HLU protocol. Trabecular bone mass was similarly reduced in HLU and HLUIR mice when compared to CONT, with losses driven by osteoclastic bone resorption rather than changes to osteoblastic bone formation. Femoral cortical thickness was reduced only in the HLUIR mice (102μm, 97.5-107) as compared to CONT (108.5μm, 102.5-120.5). Bone surface area was also reduced only in the HLUIR group, with no difference between HLU and CONT. Cortical losses were driven by osteoclastic resorption on the posterior endosteal surface of the distal femoral diaphysis, with no increase in the numbers of dead osteocytes. In conclusion, we show that low-dose radiation exposure negatively influences bone physiology beyond that induced by microgravity alone.

Health Effects of Low Dose Radiation: Health Promotion by Radon Hot Spring and Its Risk

Health Effects of Low Dose Radiation: Health Promotion by Radon Hot Spring and Its Risk

Effects of low dose radiation on immune cells subsets and cytokines in mice.

Whole-body exposure to low-dose radiation due to diagnostic imaging procedures, occupational hazards and radiation accidents is a source of concern. In this study, we analyzed the effects of single and long-term low-dose irradiation on the immune system. Male Balb/c mice received a single whole-body dose of irradiation (0.01, 0.05, 0.2, 0.5 or 1Gy). For long-term irradiation, mice were irradiated 10 times (total dose of 0.2, 0.5 or 1Gy) over a period of 6weeks. Two days after single or long-term irradiation, the numbers of splenic macrophages, natural killer cells and dendritic cells were reduced, and the spleen organ coefficient was decreased. At 2Days after long-term low-dose irradiation, the number of white blood cells in the peripheral blood of the mice decreased. Between 7 and 14Days after long-term low-dose irradiation, the number of immune cells in the thymus and spleen began to increase and then stabilized. Th1/Th2 cytokines and reactive oxygen species-related proteins first decreased and then increased to a plateau. Our results show a significant difference in the effects of single and long-term low-dose irradiation on the immune system.

CONVERSION FACTOR FROM DOSEMETER READING TO AIR KERMA FOR NUCLEAR WORKER USING ANTHROPOMORPHIC PHANTOM FOR FURTHER CONVERSION FROM AIR KERMA TO ORGAN-ABSORBED DOSE.

Estimation of cancer risk based on the organ-absorbed dose is underway for the Japanese Epidemiological Study on Low-Dose Radiation Effects (J-EPISODE). The reconstruction method for the organ-absorbed dose follows the approach adopted in the IARC 15-Country Collaborative Study, which examined the dosemeter response to photon exposure for the old film badge (FB) type, a multi-element FB and a thermoluminescence dosemeter. Until 2000, the dosemeters used in Japan were almost the same in the IARC study, so IARC study data could be used as they were. However, since 2000, the type of dosemeter has been replaced with active personal dosemeters (hereafter called electronic personal dosemeters), radio-photoluminescent glass dosemeters (Glass badge) and optically stimulated luminescence dosemeters (Luminess badge). Hence, it was necessary to collect these data again. A dosemeter response experiment was conducted using a device that irradiated an anthropomorphic phantom in the Japan Atomic Energy Agency calibration laboratories. The aim of the paper is to provide a conversion factor from reading in terms of Hp(10) to air kerma for realistic conditions for further conversion from air kerma to organ-absorbed dose. The obtained dosemeter responses for the dosemeter types currently used in Japan were consistent with those in the IARC study. These data will be utilized for J-EPISODE in reconstructing the organ-absorbed dose.