A study was initiated to ascertain whether gaseous air pollutants can influence gastric secreto-motor activities. The investigation was conducted to determine the effect of various exposures to S02, N02, CO, and 03 on gastric motor activity of the conscious unrestrained rat by means of a chronic intragastric bajloon. Tfie effects produced upon gastric secretory volume and total titratable acid secretion produced by these gases were also studied in rats which were pylorus-ligated subsequent to exposure. Rats exposed to 1 ppm S02 for 5 days, 60 ppm CO for 2 hours, 0.5 ppm N02 for 2 hours, or 0.25 ppm 03 for 2 hours showed no change while there was gastric inhibition at 300 ppm S02 for 2 hours, 1400 ppm CO for 1 hour, 26 ppm N02 for 2 hours and 1.5 ppm 03 for 2 hours. In most instances following chamber flushing recovery was complete within minutes. To evaluate the site and nature of stimulation, rats were also exposed to oil of mustard, benzaldehyde, hydrogen peroxide, amyl acetate, and “Old Spice” after sh...
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