Effect Of Antacids Research Articles

Effect of Rising Intragastric ph Induced by Several Antacids on Serum Gastrin Concentrations in Duodenal Ulcer Patients and in a Control Group

The interrelationship of the effects of antacids and of rising intragastric pH on serum gastrin levels was examined by comparing the effect of three antacids (Mg(OH)2Al(OH)3, and CaCO3), and their nonbuffering chloride compounds (MgCl2, AlCl3, and CaCl2), on serum gastrin and intragastric pH in duodenal ulcer patients. In the case of calcium, the effect of CaCl2 with a pH of 10, and in another group, CaCl2 with a pH of 2, was studied. In the case of magnesium, a control group was also investigated. In another group, the effect of a nonionized suspension (BaSO4) was studied in order to assess the contribution of intragastric volume. Serum gastrin was determined radioimmunologically, and pH measurements were performed in vitro using a glass electrode. Serum gastrin concentrations rose significantly whenever intragastric pH was raised. Serum gastrin also rose after MgCl2, AlCl3, and CaCl2 with a pH of 2, when intragastric pH was not significantly altered. This rise, however, was significantly smaller than after administration of the antacids, except in the MgCl2-Mg(OH)2 and in the CaCl2 pH 10-CaCO3 groups. No significant rise of serum gastrin levels was observed after BaSO4. In nonulcer subjects, gastrin response was smaller than in the duodenal ulcer patients. The results suggest that administration of nonbuffering Mg-, Al-, and Ca-chlorides leads to elevated serum gastrin levels in duodenal ulcer patients; rising intragastric pH, however, exerts an additional serum gastrin response.

Letter: Effects of antacids on naproxen absorption.

Letter: Effects of antacids on naproxen absorption.

Effect of antacids on pH of urine.

To determine the effect of regular administration of usual doses of several antacids for 7 day periods on urine pH, measurements of urine pH were carried out daily on 11 healthy subjects during regular use of antacids and during control periods. On the average, suspensions of aluminum hydrOXide and dihydroxyaluminum glycinate had no significant effect on urine pH. Magnesium hydroxide and calcium carbonate‐glycine suspension increased urine pH by 0.4 to 0.5 U, while aluminum and magnesium hydroxide suspension increased pH by 0.9 U. The increase in urine pH was inversely proportional to the urine pH during the control periods. Regular administration of certain antacids can increase urine pH sufficiently to have pronounced effects on the kinetics of elimination of certain acidic and basic drugs.

Letter: Effect of antacid on absorption of enteric-coated aspirin

Letter: Effect of antacid on absorption of enteric-coated aspirin

Effect of Antacid on Absorption of Enteric-Coated Aspirin

To the Editor.— Modification of the gastrointestinal absorption of one drug by another may be an important factor in patients receiving multiple drug therapy, especially with the increasing use of over-the-counter medications. We report the influence of administration of antacids on the release of aspirin from an entericcoated formulation. Enteric-coated aspirin (Ecotrin) was administered to six healthy subjects (aged 21 to 32 years) with and without coadministration of a magnesium and aluminum hydroxide oral suspension (Maalox) in a crossover manner. At least one week separated each study. After an overnight fast and one hour prior to the administration of the aspirin, 15 ml of antacid suspension was taken with 85 ml of water. At the time of aspirin administration, 15 ml of antacid suspension was again administered with 85 ml ofwater. The control studies consisted of administration of 100 ml of water one hour prior to and concomitantly with

Effects of anticholinergics, antacids, and antrectomy on gastrin production and relation of antral motility to gastrin release

Studies carried out on 5 dogs prepared with Heidenhain pouches and gastric cannulas have revealed that: 1. Oral administration of a commercial antacid (Maalox) consistently increased pouch secretion of hydrochloric acid over that induced by food alone, even when large doses of anticholinergic medication (propanthe-line bromide or glycopyrrolate) were given. This increase was presumably due to an increased release of gastrin. 2. The suppressive effects on pouch secretion of oral propantheline bromide in 0.75 and 1.5-mg./kg. dosages were essentially equivalent to those of glycopyrrolate dosages of 0.1 and 0.2 mg./kg. 3. Prolonged suppression of pouch secretion (presumably reflecting gastrin release) was not achieved by oral propantheline or glycopyrrolate. Very large doses of glycopyrrolate sharply reduced and temporarily abolished pouch secretion without affecting motility. 4. Following antrectomy, pouch secretion was drastically reduced. Oral antacid administration was without effect in causing increased pouch production. 5. Gastrin release is apparently unrelated to antral motility. Propantheline consistently abolished antral motility; glycopyrrolate did not affect antral motility.

USE OF GASTRIC HYPOTHERMIA IN TREATMENT OF DUODENAL ULCER.

MANY therapeutic measures have been used in the treatment of peptic ulcer, but the rationale of all effective treatment has been based upon the decrease or elimination of acid-peptic juice. Antacids are effective if given often enough and in large enough amounts. It is usually necessary to give a patient 1-4 gm, or more, of an effective antacid in powder or tablet form or 15 to 30 cc of a liquid antacid every one half to one hour, or 2-4 ounces of skimmed milk, whole milk, or milk and cream every hour to neutralize the free hydrochloric acid in the stomach. Anticholinergic agents are valuable adjuncts to ulcer therapy because they decrease the output of free hydrochloric acid; however, they do not usually produce achlorhydria. Even in those cases in which achlorhydria is produced, the effect rarely lasts for more than one to one and a half hours. No anticholinergic

THE EFFECT OF ANTACID AND ANTICHOLINERGIC DRUGS ON SECRETION OF GASTRIN AND HYDROCHLORIC ACID IN DOGS WITH HEIDENHAIN AND PAVLOV POUCHES.

THE EFFECT OF ANTACID AND ANTICHOLINERGIC DRUGS ON SECRETION OF GASTRIN AND HYDROCHLORIC ACID IN DOGS WITH HEIDENHAIN AND PAVLOV POUCHES.

Problems Associated with Assessment of the Effects of Diet, Antacids, and Anticholinergic Agents on Gastric and Duodenal Acidity, as Measured by the Glass Electrode in situ

l, 2 with the glass electrode for the continuous measurement of the acidity of the contents of the stomach and duodenum were primarily concerned with extraneous factors that might influence such records. In these early studies concentration of acid in the stomach and duodenum was recorded under basal conditions and after stimulation. In addition, the effects of commonly used antacids were noted, although these were not reported. The rather minor pH responses to antacids that we observed have not been completely confirmed by others. 3-11 Differences in instrumentation, principally the use of electrode shields and pumps, may account for some of the differences between our findings and the results of these investiga­ tors, whose studies deserve careful review. Aspiration studies have in some instances l2 - l4 shown only small changes in pH after the administration of antacids and are more in agreement with our findings. The purpose of this paper is to describe the changes in intragastric and intra­ duodenal pH during the use of diet, antacids, and anticholinergic drugs in the treatment of patients with duodenal ulcer.

The effect of common antacids on intragastric pH. With special reference to dihydroxy aluminium sodium carbonate (Minicid).

Acta Medica ScandinavicaVolume 172, Issue 4 p. 451-457 The Effect of Common Antacids on Intragastric pH With Special Reference to Dihydroxy Aluminium Sodium Carbonate (Minicid) Julius M. Marcussen, Julius M. Marcussen Medical Department A. (Chief: Roald Opsahl, M. D.), Aker Hospital, Oslo, NorwaySearch for more papers by this author Julius M. Marcussen, Julius M. Marcussen Medical Department A. (Chief: Roald Opsahl, M. D.), Aker Hospital, Oslo, NorwaySearch for more papers by this author First published: January/December 1962 https://doi.org/10.1111/j.0954-6820.1962.tb07178.xCitations: 6AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume172, Issue4January/December 1962Pages 451-457 RelatedInformation

A New Highly Reactive Aluminum Hydroxide Complex for Gastric Hyperacidity II : In Vitro Buffering Range and Duration of Action

A new, highly reactive polymeric aluminum hydroxide hexitol complex has been developed and incorporated into an antacid tablet. When tested in comparison with a liquid aluminum hydroxide gel of proved clinical effectiveness, the new Creamalin tablet has an almost identical duration of action and buffering range. When tested in comparison with ten leading aluminum hydroxide tablets using an in vitro method recognized as having good correlation with in vivo experience, the new Creamalin tablet exerts its buffering activity in the optimal range for much longer periods than the others. Effective antacid therapy has been defined as the elevation of gastric pH to between 3.0 and 5.0 with the optimum being 3.5 to 4.5. The new Creamalin tablet should provide a highly effective and convenient antacid for poising gastric hyperacidity within this optimal range.

A Comparative Human In Viko Study of Antacids

The antacid effectiveness of: dihydroxy aluminum sodium carbonate, aluminum hydroxide, calcium carbonate, and sodium bicarbonate in humans has been compared. Samples of gastric contents were- removed over a seventy-five-minute period and evalated for pH and free and total acidity. The usefulness of the four antacids, based upon controlled pH in the order of their decreasing effectiveness, was as follows: dihydroxy aluminum sodium carbonate, aluminum hydroxide, calcium carbonate, and sodium bicarbonate.

A Comparative in Vho Study of Antacids I

This study attempts to draw a comparison between the in vitro and in vivo antacid properties of dihydroxyaluminum sodium carbonate, aluminum hydroxide, sodium bicarbonate, and calcium carbonate. These agents were administered in various doses to dogs prepared with a simple Pavlov fistula. Thus, the resulting data permit a logical comparison between chemical neutralization and in vivo antacid effectiveness.

DAA: its antacid effect and use in peptic ulcer.

DAA: its antacid effect and use in peptic ulcer.

The Antacid Effect of Dihydroxyaluminum Sodium Carbonate (DASC) as Determined in the Gastric-Fistula-Dog

The antiulcer effect of DASC has previously been described by the authors using histamine-induced ulceration of guinea pigs as the criterion. These phenomenaare believed to be due to the increased gastric acid secretion produced by the histamine, therefore, the mechanism of the antiulcer activity of DASC was presumed to be due in part to the antacid effect. Further studies of this compound as an antacid have been undertaken by investigating the effect of dihydroxyaluminum sodium carbonate on the gastric-fistula-dog.

Effect of carbonic anhydrase inhibitors and antacids on the development of gastrointestinal ulcers during treatment with depot‐histamine. A preliminary report

Depot‐histamine‐induced gastrointestinal ulceration in guinea pigs was used as the criterion for the evaluation of antiulcer effect. Dihydroxy aluminum sodium carbonate and dihydroxy aluminum aminoacetate were found to be the most effective of the antacids tested. Two powerful carbonic anhydrase inhibitors proved to be ineffective.

The Effect of Bismuth Carbonate and Other Antacids on the Activity of Pepsin

International Journal of Clinical PracticeVolume 8, Issue 6 p. 370-375 Clinical Articles The Effect of Bismuth Carbonate and Other Antacids on the Activity of Pepsin P. R. Bateson MB, BS, P. R. Bateson MB, BSSearch for more papers by this author P. R. Bateson MB, BS, P. R. Bateson MB, BSSearch for more papers by this author First published: 01 June 1954 https://doi.org/10.1111/j.1742-1241.1954.tb01682.xRead the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume8, Issue6June 1954Pages 370-375 RelatedInformation

An In Vitro Evaluation of the Efficacy of the More Frequently Used Antacids with Particular Attention to Tablets

Summary 1.A comparison of the antacid efficacy of aluminum hydroxide in liquid and tablet form by an ‘in vitro' evaluation technique, shows the liquid form to be superior to the tablet form. 2.Aluminum, in the form of dihydroxy aluminum aminoacetate, evaluated for antacid efficacy in liquid and tablet form, is found to be as effective in both forms as liquid aluminum hydroxide preparations. 3.Mixtures of glycine and calcium carbonate, and of dry skimmed milk and calcium carbonate are found to be effective antacids if used in relatively large amounts. 4.Aluminum hydroxide gel combined with milk of magnesia is a much more effective antacid than aluminum hydroxide gel alone. Varying the milk of magnesia content permits also control of bowel movement.

The increased antacid effect of aluminum hydroxide combined with magnesium trisilicate

A study covering the observations on five antacids— Hypercin, Pink Alkajel, Gelusil, Mag-Sal, and AMT— containing mixtures of aluminum hydroxide and magnesium trisilicate is herewith reported.

Studies on Antacids. IV. Adsorption Effects of Various Aluminum Antacids Upon Simultaneously Administered Anticholinergetic Drugs

A study was made of the possible adsorption of various drugs often given simultaneously with aluminum compounds in the treatment of gastric hyperacidity. The approximate LD90 for each drug upon oral administration to mice was found, and the same dose was then given in admixture with various aluminum preparations to determine if the same LD was obtained. A number of drugs tested were adsorbed by aluminum hydroxide gel, while certain other aluminum antacids did not cause adsorption to the same extent, if at all.