Effects of anticholinergics, antacids, and antrectomy on gastrin production and relation of antral motility to gastrin release

Abstract

Studies carried out on 5 dogs prepared with Heidenhain pouches and gastric cannulas have revealed that: 1. Oral administration of a commercial antacid (Maalox) consistently increased pouch secretion of hydrochloric acid over that induced by food alone, even when large doses of anticholinergic medication (propanthe-line bromide or glycopyrrolate) were given. This increase was presumably due to an increased release of gastrin. 2. The suppressive effects on pouch secretion of oral propantheline bromide in 0.75 and 1.5-mg./kg. dosages were essentially equivalent to those of glycopyrrolate dosages of 0.1 and 0.2 mg./kg. 3. Prolonged suppression of pouch secretion (presumably reflecting gastrin release) was not achieved by oral propantheline or glycopyrrolate. Very large doses of glycopyrrolate sharply reduced and temporarily abolished pouch secretion without affecting motility. 4. Following antrectomy, pouch secretion was drastically reduced. Oral antacid administration was without effect in causing increased pouch production. 5. Gastrin release is apparently unrelated to antral motility. Propantheline consistently abolished antral motility; glycopyrrolate did not affect antral motility.