The non-uniform irradiation pattern causes the partial shading effects and decreases the performance of the solar Photovoltaic (PV) array. The effect of uneven shading condition depends on its pattern and area. The PV array’s performance is determined by the cross ties that are connected within the array. This research proposes eight different PV array tie interconnection configurations to obtain the maximum power output under uneven insolation conditions. Experimental analysis is done in the PV array consists of 16 numbers of 10 W PV panels which has a total capacity of 160 W. The practical results reveal that the losses due to partial shading are influenced by the shade pattern, shade area, and the placement of the cross ties. Overall, among the conventional configurations, the hybrid bridge link total cross tied interconnection pattern produced the best results, followed by the hybrid series parallel total cross tied and bridge link patterns. In the proposed configurations, the plus tie configuration outperformed the others in maximum of the partial shading scenarios. In general, the PLT configuration demonstrated an average power efficiency increase of 19.17%, 8.37%, and 8.28% compared to the series parallel, hybrid series parallel total cross-tied, bridge link, and bridge link total cross-tied configurations, respectively. The effectiveness of the proposed configurations is validated by the practical verifications.