Wave radiation due to heave, surge, and pitch by a box-type floating structure based on computational fluid dynamics (CFD) simulations using OpenFOAM is analysed. The CFD simulation results include surge and heave forces and response amplitude operator for the heave, surge, and pitch at different wave lengths. The numerical simulation results of heave force due to incoming waves and resulting motion are compared against experimental data and linearized analytical solutions based on velocity potential flow theory. The hydrodynamic effect on the width and draft of the structure in analytical results for vertical wave force, horizontal wave force, and torque are studied whilst, the effect of different wave lengths on heave, surge and pitch forces and response amplitude operator from CFD results are analysed. The comparison shows that the CFD results are in good agreement with the experimental ones and are very close to the analytical ones. The paper concludes that CFD is well capable of simulating wave interaction behaviour of a box-type floating structure for wave energy converters, and the developed analytical model can serve as an efficient middle-fidelity performance evaluation tool for such structures during design development stage.