Effective Tactics Research Articles

Abstract 1817: Epidermal growth factor receptor alters major histocompatibility complex class I expression on pancreatic cancer cells

Abstract Pancreatic cancer is one of the deadliest neoplasms, with a poor 5-year survival rate of just 10%. The ability of pancreatic cancer cells to evade the immune system hinders an anti-tumor response and contributes to the poor survival rate. In some cases, down regulation of major histocompatibility complex (MHC) class I cell-surface expression aids in immune evasion by preventing endogenous tumor antigens from being presented to cytotoxic T cells. The goal of this study is to evaluate the role epidermal growth factor receptor (EGFR) plays in the regulation of MHC class I expression by pancreatic cancer cells. Pancreatic cancer cell lines were treated with epidermal growth factor (EGF) or transforming growth factor alpha (TGF-alpha) to activate EGFR or with the small molecule drug erlotinib to inhibit EGFR. Immunoprecipitation, western blot analysis, and flow cytometry were used to analyze cells' MHC class I expression post treatment. Human pancreatic cancer cell lines (BxPC-3, T3M4, S2-013, Panc-1) were found to decrease MHC class I expression after EGFR activation by EGF. However, activation of EGFR via TGF-alpha led to differential effects on MHC class I expression in a cell line-dependent manner. EGFR inhibition by erlotinib led to increased MHC class I expression by greater than 2.5-fold on both human and mouse pancreatic cancer cells. Mechanistic studies were done to evaluate the role of src homology 2 phosphatase (SHP2) in EGFR's regulation of MHC class I in pancreatic cancer cells, since in head and neck cancer cells SHP2 can be phosphorylated by activated EGFR and subsequently dephosphorylate STAT1 and reduce MHC class I expression. Following SHP2 knockdown by siRNA transfection, a slight increase in MHC class I expression was observed on pancreatic cancer cells, suggesting SHP2 has a minor down-regulatory role in MHC class I expression in these cells. EGFR was found to co-immunoprecipitate with MHC class I, indicating that EGFR might directly affect MHC class I expression by facilitating its endocytosis. However, after EGFR inhibition, no change in the MHC class I cell surface turnover rate was observed. Other potential mechanisms for EGFR regulation of MHC class I expression are currently being evaluated. Our discoveries defining a role for activated EGFR in reducing MHC class I expression and revealing that EGFR inhibitors can boost MHC class I levels on cancer cells could facilitate the adoption of new, more effective therapeutic tactics that combine the use of EGFR inhibitors with immunotherapies to augment patients' immune systems for effective targeting and killing of cancer cells. Citation Format: Shelby M. Knoche, Joyce C. Solheim. Epidermal growth factor receptor alters major histocompatibility complex class I expression on pancreatic cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1817.

COMMUNICATIVE AND CONFLICT-RESOLVING COMPETENCE OF MEDICAL INTERNS IN THE SPECIALTY "NERVOUS DISEASES"

The proper doctor-patient relationship has been proved to be essential prerequisite for rapid recovery. Positive attitude can contribute to positive therapeutic outcomes no less than the expert experience. Today, medical practitioners are experiencing a pressing need to boost communication skills and to master methods and tactics of communicative correction to deal with complex controversial issues. The medical interns who specialize in General Medicine constitutes a professional environment are at the cross-section between students and medical practitioners and, in terms of educational characteristics, between the pedagogical and andragogical educational subjects. The aim of this study is to assess the levels of communicative and conflict-resolving competences in medical interns specializing in nervous diseases. We carried out anonymous questionnaire survey of 50 medical interns (1 year of the internship) by using the Thomas’ method then adapted by N.V. Grishina in order to reveal the individuals with personal traits to uncooperative behaviour and analyzed the empirical data obtained. The study of the uncooperative behaviour indicators in young physicians has shown rather low values due to the deficient propensity to cooperate that is productive behaviour in a situation of conflict resolution. The results of the study point out that it is essential to motivate newly qualified medical doctors not only to obtain professional knowledge, but also to develop the relevant effective behavioural patterns; moreover, principles of effective communication strategies, tactics and techniques should be a component of training process on regular basis to foster the skills for effective health communication intervention. These issues require searching for new ways to correct the social behaviour foundations in medical practice.

PECULIARITIES OF PREGNANCY COURSE IN WOMEN WITH CONCOMITANT OBESITY WHO TAKE THERAPEUTIC AND PROPHYLACTIC COMPLEX AIMED TO PREVENT PREECLAMPSIA

The rapid growth in the incidence of overweight and obesity among women of childbearing age is posing specific issues related to their pregnancy, thereupon choosing adequate and effective tactics for the prevention of preeclampsia in women with concomitant obesity who are at high risk group for this complication is of undoubted relevance. The aim of this study is to assess the occurrence and characteristic of obstetric and prenatal complications in women with concomitant obesity, who receive therapeutic and prophylactic complex designed to prevent the development of preeclampsia. We studied the course of pregnancy of 255 women, who were divided into 3 groups according to the class of obesity, and then, in turn, were subdivided into subgroups taking into account the presence of preeclampsia and the therapeutic and prophylactic complex course. The high efficiency of the therapeutic and prophylactic complex including L-arginine and diosmin for obese women enables to reduce the manifestations of endothelial dysfunction, the occurrence of preeclampsia and its severe forms; to lower down the occurrence of other complications during the pregnancy (risks of premature birth, placental insufficiency, distress and foetal growth retardation); to avoid perinatal mortality and improve the condition of the foetus. Applying this pathogenetically grounded therapeutic and prophylactic complex we elaborated (acetylsalicylic acid, L-arginine, calcium supplements and semisynthetic diosmin) to prevent the occurrence of preeclampsia in pregnant women with concomitant obesity, who are at high-risk group, promotes the reduction of occurrence and intensity of obstetric and prenatal complications resulted from endothelial dysfunction. We can suggest the therapeutic and prophylactic complex for pregnant women with concomitant obesity as effective therapy because no cases of severe and early preeclampsia have been registered.

Black Titanium: On the Use of Black Ti as a Bone Substituting Biomaterial: Behind the Scenes of Dual‐Functionality (Small 24/2021)

Exploiting the potential of the small-scale pillars of black titanium is proved to be a promising strategy for directing the fate of the cells and bacteria. In article number 2100706, Khashayar Modaresifar and co-workers use different combinations of pillars' design parameters (e.g., height and arrangement) to reach a certain gain which is, ideally, promoting the osteogenic response of cells and killing the bacteria simultaneously. In that sense, it is not very different than implementing effective tactics in a chess game.

Ultrathin carbon layer enhanced Cu2Nb34O87 nanowires as high-performance lithium host

Cu2Nb37O87 exhibits excellent electrochemical properties, high theoretical capacity (401 mAh g−1), safe working voltage (~1.7 V) and outstanding rate performance for lithium-ion batteries. However, poor electrical conductivity inhibits its further development. In this study, Cu2Nb37O87@C nano-wires are prepared by combining electrospinning and carbon-coating techniques to mitigate this issue, which breaks through the barrier of low conductivity, improves the ion diffusion rate and relieves the change of crystal volume. Besides, the sample is tested by scanning electron microscopy, transmission electron microscopy and X-ray photoelectron spectroscopy and most importantly, the mechanism of lithium-ion storage is explored by an in-situ X-ray diffraction analysis. Moreover, according to a sequence of electrochemical tests, it is clarified that the electronic conductivity and electrochemical activity of Cu2Nb37O87 are enhanced significantly. All these are inseparable from the synergistic effect of the nano-crystallisation and carbon coating. Therefore, nano-structures and surface cladding provide effective tactics to construct effective ion-migration interfaces and enhance conductivity for the further study of Cu2Nb37O87 and other electrode materials.

Tactical interrogation techniques for extremist crimes committed on the internet

The article deals with the peculiarities of tactical techniques for conducting interrogations on extremist crimes committed on the Internet. The Internet space acts as a social environment that is congruent (attractive) for adherents of extremist activities, where their leading characteristic is a focus on atypical, non — normative, asocial behavior. Tactical interrogation techniques create conditions for obtaining evidence about the circumstances of the case: whether there was a call to violence, whether violence is justified, what is the content of the materials presented in the network, what means (posters, leaflets, etc.) were used. When conducting an interrogation, the use of psychological influence techniques makes it easier to obtain criminally significant information. For individuals who commit crimes of extremist orientation, taking into account the typification of personal characteristics (idealistic, adventurers, non-normative), some effective tactics are described (egress to emotions, naked aggression, exchange of positions, intervention of an authoritative third, etc.) with an approximate list of questions. Techniques are designed to achieve mutual understanding between the investigator and the interrogated, in which the latter, regardless of the current situation, cooperates with the investigator and provides information about the circumstances of the case without distortion or concealment.

Enhanced UV–Vis–NIR composite photocatalysis of NaBiF4:Yb3+, Tm3+ upconversion nanoparticles loaded on Bi2WO6 microspheres

NIR light accounts for 50% of total solar energy, but only a small amount of the energy is applied to photocatalytic reactions. The incorporation of upconversion nanoparticles with semiconductor materials is an effective tactics to exploit NIR-driven photocatalyst. In this work, we report a composite material that can convert NIR light into UV–Vis photons. The light conversion material is composed of NaBiF4: Yb3+, Tm3+ up-conversion nanocrystals. The petal-like Bi2WO6 is used as a semiconductor photocatalyst to directly degrade model pollutants, such as RhB. By controlling the morphology of Bi2WO6, the contact area between the semiconductor photocatalyst and the pollutant molecules is increased. The preparation of “double bismuth” composite material NaBiF4:Yb3+, Tm3+/Bi2WO6 provides the possibility to make full use of sunlight. Under the excitation of simulated sunlight, the photocatalyst of NaBiF4:Yb3+, Tm3+/Bi2WO6 reaches the highest degradation efficiency of 98% in 27 ​min. Compared with Bi2WO6, the prepared composite photocatalyst shows better photocatalytic performance, which is attributed to the effective energy transfer between NaBiF4:Yb3+,Tm3+ and Bi2WO6. The capture tests were used to detect active species used in the degradation process. After four continuous photocatalytic cycles, about 95% of RhB solution is degraded. Under the simulated solar light illumination, the photocatalytic mechanism of the composite photocatalyst is discussed. The results propose a promising system to improve the photocatalytic activity through the efficient use of sunlight.

Evaluating the cost-effectiveness of laparoscopy in the acute abdomen

Cost-effectiveness analysis (CEA) is a tool for selecting an alternative solution to achieve the same quantifi ed objective in physical units of measurement. CEA provides the analytical framework for identifying the most effective tactics for using limited resources. The analysis of the data from the specialized literature, allowed to determine the degree of implementation of the cost-eff ectiveness analysis in the public health system both at international and national level, and its practical application in clinical medicine. The origin of the CEA comes from the military service, where it was first requested to identify the most rational way to use financial resources to achieve the proposed objectives, being subsequently applied in various social fi elds, including the health system, stipulating data on technology, principles of application of the CEA. The need to evaluate the profi tability of surgical interventions is determined by the progressive increase of the costs of the medical services offered, by the appearance of alternative methods of treatment of a pathology, the limitation of the fi nancing of highly specialized technologies. Economic evaluation of the effectiveness of treatment in the acute abdomen is an important goal of clinical medicine. CEA evaluation is a tool for argumentation and promotion laparoscopic methods in the diagnosis and treatment of acute abdomen, compared to traditional classical methods.

A conversation about fat activism among activists in community with Nolose

ABSTRACT Informed by the FaT GiRL Roundtables in FaT GiRL: A Zine for Fat Dykes and the Women Who Want Them, a group of US-based queer and transgender fat activists from diverse races, classes, ages, disabilities, and geographies, some associated with or in community with members of the queer and transgender fat liberation organization, Nolose, discuss fat activism. Activism discussed includes work in burlesque, community organizing, daily interpersonal work, work in higher education, organizing or funding community events, fat culture-making, exercise, and both online and in-person mutual aid and education. Participants raise relationships and events that led them to become fat activists, and talk about challenges in fat activism including the widespread belief that fat people can become thin people, racism and cissexism, internalized oppression, “body positivity” decentering superfat people and people of color and centering smaller white cisgender women. Included is the poem “Impostor Syndrome” by Dr. Sydney Lewis. Participants also talk about opportunities for action, powerful and effective strategies and tactics of fat activists, and possible futures of intersectional radical fat activism; these include mutual aid online organizing, centering Black fat femme people and politics in fat liberation analysis, multiple accessible ways of organizing, and organizing both with cultural and relationship-based work.

Клиника и дифференциальная диагностика рака слизистой оболочки полости рта и красной каймы губ

В статье рассмотрена одна из наиболее актуальных проблем стоматологии — дифференциальная диагностика рака слизистой оболочки полости рта. Подробно описаны дифференциальные признаки язв слизистой оболочки полости рта и красной каймы губ различной этиологии, а также их отличия от раковых язв. Знание этих различий позволит врачу-стоматологу дифференцировать эти поражения слизистой и выбрать правильную, наиболее эффективную тактику их лечения.

Антитеррористические тактики ФРГ к началу 2020-х годов: военно-политические аспекты

In the second half of the 2010 s, the scale of the threat of international terrorism faced by the EU and NATO member states increased significantly. This not only led to a large geographical expansion of the area of anti-terrorist struggle, but also initiated an active search for more effective specialized tactics. The article illustrates this process by the case of Germany, taking into account its growing activity on the world stage. Germany has taken part in the missions in the Mediterranean Sea deployed to prevent the arrival of fighters mimicking refugees into the EU. The paper pays special attention to German participation in anti-terrorist struggle in the countries of Middle East, Central Asia, and Sahel that have been trying to clear their territories of radical illegal armed groups. Germany has not been involved in the first phase of the fight against terrorist groups, during the ini-tial military defeat, but later actively participated in the implementation of anti-terrorist prevention measures. The author indicates the factors that determine Germany’s readiness to use its military potential in the struggle with terrorist structures in a particular country. The article also stresses the de jure non-combat nature of the use of the Bundeswehr and explores the features and also «bottlenecks» in the use of its military contingents and the deployment of its military training missions. The task of the latter is to ensure that local security forces accept the main burden in the fight against illegal armed groups on their territory, while at the same time the FRG controls the training of se-curity forces (first of all army) and the use of troops. The author compares the schemes for the use of military training missions of the Bundeswehr in Mali, Somalia and Iraq. The main conclusion is that Germany is developing an anti-terrorist tactics which include the targeted use of special operations forces in order to reach the «point of no return» in the defeat of the militants.

Обширное инородное тело пищевода с распространением на гортаноглотку и гортань

Foreign bodies of the respiratory tract and esophagus remain one of the pressing problems in medicine, which is associated with the possibility of developing complications that can end in death. We present our clinical observation that demonstrates the long-term presence of a large foreign body fixed in the area of the pharyngeal narrowing of the esophagus and extending into the larynx and the vestibule of the larynx. Patient T., 57 years old, went to the emergency department of the Karachay-Cherkessia Republican Clinical Hospital with complaints of severe sore throat, inability to swallow, excessive salivation, increased body temperature to 37,5 °C, difficulty breathing, mixed shortness of breath, which persist for 3 days. The examination revealed: the epiglottis is mobile, the mucous membrane of the larynx is hyperemic, edematous, with an abundance of saliva, at the level of the vestibular part of the larynx, in the area of the arytenoid cartilage and aryepiglottic folds, an irregular shape was visualized, with smooth edges, a thin, hard whitish plate. Computed tomography of the cervical spine: in the esophagus, at the level of C4-C5 vertebrae, a foreign body with a metallic density of +2900 hU units, elongated, irregular shape, measuring 2.2 by 3.3 cm, with perifocal air bubbles is determined. A preliminary diagnosis was made: Foreign body of the esophagus, laryngopharynx with a spread to the vestibule of the larynx. 3 days after the retention of the foreign body under intubation anesthesia, it is captured using forceps with serrated cups and removed during direct laryngoscopy. There were no complications during the manipulation. The combination of X-ray and endoscopic examinations with the help of innovative medical and diagnostic equipment made it possible to establish a diagnosis in a short time, choose the most effective treatment tactics and remove a foreign body through natural pathways.

Follower‐rated leadership styles, leader behaviours, and leaders' thinking styles: A test of the cognitive experiential leadership model

ObjectiveThe Cognitive Experiential Leadership Model (CELM) predicts that leaders' thinking styles will be related to transformational leadership and effective leadership behaviours, especially influencing tactics and conflict handling styles. However, most of the existing evidence for this model comes from studies that have used self‐report methods where self‐presentational biases may influence the studies' results. Moreover, there is incomplete evidence for the proposed connections in this model between thinking styles, leadership styles, and leadership behaviour.MethodUsing anonymous other‐report surveys, in Study 1, followers (N = 192) rated how their leaders think and lead, and in Study 2 followers (N = 129) rated how their leaders think, influence, and handle conflict.ResultsAs the CELM predicts, leaders' tendency to think rationally and experientially (especially imaginatively) was related to their transformational leadership (Study 1), and their use of effective influencing tactics and conflict management styles (Study 2).ConclusionTogether these studies provide new evidence for the CELM that is not explained by social desirability biases, and suggest a role for follower ratings of leaders' thinking styles in leadership development.

Nicotinamide as Additive for Microcrystalline and Defect Passivated Perovskite Solar Cells with 21.7% Efficiency.

Passivation of electronic defects on the surface and at grain boundaries (GBs) of perovskite films has become one of the most effective tactics to suppress charge recombination in perovskite solar cells. It is demonstrated that trap states can be effectively passivated by Lewis acid or base functional groups. In this work, nicotinamide (NTM, commonly known as vitamin B3 or vitamin PP) serving as a Lewis base additive is introduced into the PbI2 and/or FAI: MABr: MACl precursor solution to obtain NTM modified perovskite films. It has been found that the NTM in the perovskite film can well passivate surface and GBs defects, control the film morphology and enhance the crystallinity via its interaction with a lone pair of electrons in nitrogen. In the presence of the NTM additive, we obtained enlarged perovskite crystal grain about 3.6 μm and a champion planar perovskite solar cell with efficiency of 21.72% and negligible hysteresis. Our findings provide an effective route for crystal growth and defect passivation to bring further increases on both efficiency and stability of perovskite solar cells.

NEW NANOMATERIALS AND DISPERSANTS FOR OIL SPILL RESPONSE

Background Processes associated with oil production, transportation and refining have an impact on the environment. Many traditional methods of large-scale recovery, such as skimmers of oil products paired with constant buoyancy and suction booms, partially mitigate the problem, but they leave residual environmentally hazardous hydrocarbon layers and other pollution on a micrometer scale, so scientific research and development of modern nanomaterials for oil spill response. Aims and Objectives Analysis of modern nanotechnologies for the creation of nanomaterials and dispersants for oil spill response. Results Methods of water purification from oil products using sorption technologies are considered. An analysis of research studies developing effective and safe recovery tactics at both macro and nanoscale is presented; new scientific developments of modern nanomaterials and dispersants for oil spill response. These technologies encompass a variety of mechanisms and compositions, including gels, nanoparticles, electrospinning nanomembranes, nanowire membranes, and magnetic composites. The development of biocompatible nanodispersants, which can be enzymatically decomposed in case of accidental biological absorption, are considered.

Problem aspects of organizational and tactical support of interrogation in the investigation of crimes in tourist industry

It is emphasized that the investigation of crimes in the field of tourism has certain specifics due to the circumstances and mechanism of this crime. A special place among all other sources of evidence is occupied by testimony, which takes the form of evidence only in the case of observance of the rights, freedoms and legitimate interests of persons who have information about the event of a criminal offense and their proper procedural design. However, during interrogations in the investigation of crimes related to tourism, investigators often face difficulties of both procedural and organizational and tactical nature. The most significant problem is the lack of time for full preparation for the interrogation, with the study of legislation in the field of tourism, taking into account all the circumstances to be established and drawing up an interrogation plan. The use by investigators of the full range of tactics recommended by criminology and developed in practice is also not used to a sufficient extent. Investigators lack the time and technical ability to accompany the process of obtaining evidence by audio or video recording. For the most part, suspects withdraw their testimony after some time on the grounds that it was obtained as a result of psychological pressure or physical influence. While audio and video materials could help to refute these statements and prove the legitimacy of the actions of the person conducting the interrogation. It is noted that when interrogating victims, witnesses, suspects in criminal proceedings related to tourism, the investigator should be critical of their testimony and compare them with other evidence. It is important for the investigator to establish whether the interrogated are in a business relationship with the head of a tourist or hotel-restaurant enterprise and what their nature is. This need is due to the prevalence of situations where persons who declare themselves as witnesses are involved in criminal acts. Recommenda-tions on the most effective organization and tactics of interrogation in proceedings of this category are given.

A tentative model on effective army combat tactics

The purpose of this study is to form a model on effective tactics. We selected five theorists, three of which also provided support from quantitative analysis on winning battles. The theorists all advocate the use of maneuver warfare, developed from the German WWII-approach. The analysis indicates the importance of accomplishing a sequence in battle of surprise attacks, followed by shock action, and prompt exploitation in order to accomplish an organizational breakdown of enemy force. Tactical defeat is foremost a result of psychological reactions by the enemy rather than from physical destruction by superior material resources at the point of assault.

Effects of Leader Tactics on the Creativity, Implementation, and Evolution of Ideas to Improve Healthcare Delivery.

Slow progress in quality improvement (QI) has prompted calls to identify new QI ideas. Leaders guiding these efforts are advised to use evidence-based tactics, or specific approaches to address a goal, to promote clinician and staff engagement in the generation and implementation of QI ideas, but little evidence about effective tactics exists. Examine the association between leader tactics and the creativity, implementation outcome, and evolution of QI ideas from clinicians and staff. Prospective panel analysis of 220 ideas generated by 12 leaders and teams (N = 72 members) from federally qualified community health practices in one center over 18 months. Measures were extracted from meeting minutes (note-taking by a member during meetings) and expert panel review. Multi-level models were used. Leader tactics, idea creativity, implementation outcome, evolution pathways, center, and idea-submitter characteristics. Leaders used one of four approaches: no tactic, meeting ground rules, team brainstorming, or reflection on team process. Implemented ideas evolved in three pathways: Plug and Play, Slow Burn, and Iterate and Generate. Compared with no leader tactic, meeting ground rules resulted in ideas not significantly different in creativity, implementation outcome, or evolution pathway. Brainstorming was associated with greater idea creativity, idea implementation, and ideas following a Plug and Play path (low member engagement and implementation over 2 months or less). Reflection on team process was associated with idea implementation (versus not), and ideas following an Iterate and Generate path (high member engagement and implementation over 3 months or more). Two tactics, brainstorming and reflection, are helpful depending on goals. Brainstorming may aide leaders seeking disruptive change via more creative, rapidly implemented ideas. Reflection on team process may aide leaders seeking high-engagement ideas that may be implemented slowly. Both tactics may help leaders cultivate dynamics that increase implementation of ideas that improve healthcare.

Germination ecology of dwarf amaranth (Amaranthus macrocarpus): an emerging weed in Australian cotton cropping systems

AbstractDwarf amaranth (Amaranthus macrocarpus Benth.) is a problematic broadleaf weed in many crops in Australia; however, no information is available on the germination ecology of this species. Seeds from two populations of this species were collected from Hillston, NSW, Australia (D-P-01), and Yandilla, QLD, Australia (D-P-02). Seeds were germinated at a range of constant (20 to 45 C) and alternating temperatures (30/20, 35/25, 40/30, and 45/35 C day/night). For the constant temperature treatments, the highest germination occurred at 35 C for D-P-01 (89%) and D-P-02 (82%). Germination was higher at the alternating day/night temperature of 40/30 C for both populations D-P-01 (91%) and D-P-02 (85%). Seed germination of both populations was stimulated by light, which indicates a great amount of emergence of A. macrocarpus can occur on bare ground such as crop seed beds. Results also revealed that this species tolerates a moderate level of salinity and can germinate in slightly alkaline soil conditions. The emergence of this species was highest (47%) for the seed buried at 0.5-cm depth in grey cracking alkaline soil compared with seed buried at the same depth in acidic red soils. These results suggest that soil inversion by tillage to bury weed seeds below their maximum emergence depth could serve as an important tool for managing A. macrocarpus. The results from this study will help in developing more sustainable and effective integrated weed management tactics for the control of this weed and weeds with similar responses in summer cropping systems.

Hybridizing Gray Wolf Optimization (GWO) with Grasshopper Optimization Algorithm (GOA) for text feature selection and clustering

Text analysis in the field of text mining requires complex techniques for handling several text documents. Text clustering is among the most effective tactics in the field of text mining, machine recruitment and pattern recognition. Computers can start organizing a corpus document in certain organizational structure of conceptual clusters using reasonable text-clustering method. Informative and un-informational functionalities of the text documents contain noisy, inconsequential and superfluous features. The main method of finding a new subset of informative feats for each document is the unsupervised selection of text features. The functional selection technique has two aims: (1) maximize text clustering algorithm reliability, (2) minimize the number of uninformative traits. The proposed technique is that it produces a mature convergence rate and requires minimal computational time and is trapped in local minima in a low dimensional space. The text data is fed as the input and pre-processing steps are performed in the document. Next, the text feature selection is processed by selecting the local optima from the text document and then selecting the best global optima from local optimum using hybrid GWO–GOA.​ Furthermore, the selected optima are clustered using the Fuzzy c-means (FCM) clustering algorithm. This algorithm improves the reliability and minimizes the computational time cost. Eight datasets are used in the proposed algorithm and the performance is envisaged efficaciously. The evaluation metrics used for performing text feature selection and text clustering are accuracy, precision, recall, F-measure, sensitivity, specificity and show better quality when comparing with various other algorithms. When comparing with GWO, GOA and the proposed hybrid GWO–GOA algorithm, the proposed methodology reveals 87.6% of efficiency.