Four spectra of methane in natural isotopic abundance in the 4100–4300 cm−1 region were recorded by using a Fourier transform spectrometer in Reims, France at long paths (202 m, 602 m, 1604 m and 1804 m) and different pressures. Additional spectra of 12CH4 covering the same region were obtained at 100–123 K for different pressures, 93 m path length at Synchrotron SOLEIL in Paris for different pressures and were used to measure low-J lines. Spectra of 12CH4 and 13CH4 obtained at 80 K at JPL in Pasadena were used for additional frequency calibrations. Line positions and intensities were retrieved by non-linear least-squares curve-fitting procedures and analyzed using effective Hamiltonian and effective dipole transition moment models. A new measured line list contains positions and intensities for 12,378 features. Quantum assignments were made for more than 11,520 new transitions, which represent ∼99% of the integrated line intensity observed in this region. Some of 4556 hot band transitions for (Dyad – Tetradecad) system were assigned. The resulting list of lines is significantly more accurate than previous empirical compilations. All assigned 6963 line positions were fitted to RMS standard deviations of 0.0015 cm−1. The sum of the observed intensities between 4100 and 4300 cm−1 falls within 5% of the predicted value from ab initio variational calculations reported in the TheoReTS database (http://theorets.univ-reims.fr; http://theorets.tsu.ru).