A theoretical treatment of the turbulent boundary layer with heat transfer, mass transfer, and chemical reactions is presented. The analysis differs from earlier ones, primarily in the way the Spalding mass-transfer number B is related to the thermodynamic characteristics of the flow and in the treatment of the heat-transfer “blocking effect” caused by wall mass addition. The dual role of the mass-transfer number as a similarity parameter of the boundarylayer flow, and as a thermochemical parameter characterizing the reactants, is discussed. The Howarth-Dorodnitsyn coordinate transformation accounts for the effect of variable fluid properties, and, in the present treatment, a relatively easy measurement of the boundarylayer thickness serves to define the reference state. The analysis provides good agreement with experimentally observed heat and mass-transfer rates even at relatively large values of B , where earlier analyses using a “thin-film” approximation are not very accurate. Diffusion-limited turbulent boundary-layer combustion calls for certain modifications in the classicaldiffusion-flame model. The analysis shows that the flow field of the turbulent boundary layer may substantially affect the mixture ratio of the flame. Data relevant to flame position and stoichiometry are cited. It is found that the theory and measurements are qualitatively entirely consistent, and the quantitative agreement is remarkably good. For example, both the theory and the data indicate that the oxidizer-fuel ratio of a Plexiglasoxygen flame approaches a value of about 1.4 at high Reynolds Numbers, whereas the stoichiometric ratio is 1.92. More complete experimental information will be required to establish clearly the quantitative limitations of the theory, but the available data support the general conclusion that the combustion mixture ratio depends to a significant degree on the Reynolds Number of the flow.