Objective To investigate the effects of treatment compliance and nursing intervention with continuous positive airway pressure (CPAP) therapy in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).Methods 260 patients were randomly divided into two groups,both groups were implemented with CPAP treatment,but intervention group was added with out-of-hospital comprehensive care guide by ways of phone contact,internet and in person,control group took oral conventional general education.Results The follow-up showed intervention group had 125 cases of adherence to treatment,3 cases with interruption of treatment,two cases gave up; control group had 90 cases of adherence to treatment,22 cases of interruption of treatment,18 cases of complete giving up.Compared with control group,the intervention group' s all indicators improved significantly,patients tended to be normal sleep architecture,and snoring rating,respiratory disturbance index,arousal,such as average air leakage rates were significantly lower than those of control group.Conclusion Application of CPAP therapy in patients with OSAHS comprehensive nursing intervention can significantly improve patients' respiratory status,effectively improve CPAP treatment compliance. Key words: Obstructive sleep apnea-hypopnea syndrome; Continuous positive airway pressure; Compliance; Nurse