Effect Of Size Reduction Research Articles

Effect of class size on student achievement in the COVID‐19 “new normal”

ABSTRACTThe COVID‐19 pandemic implied measures, such as school closures at the outbreak of the pandemic, negatively affected children's human capital. However, in some places, the situation later resulted in a reduction in class sizes in order to avoid the spread of SARS‐Cov‐2 in schools. We take advantage of this unexpected event to evaluate the effect on school performance of a significant class size reduction implemented in Spain, when schools were reopened. We find a positive and significant effect of the class size reduction of 0.11 standard deviations on overall students' performance. Given the situation and nature of our data, we interpret our estimates as a lower bound for the true effect of the reduction in class size. We conclude that the reduction in class size served, on average, to at least compensate for the other negative effects on learning. Our findings also point out the importance of evaluating the quality of the new and inexperienced additional teachers that need to be hired when implementing a general reduction of class size.

The effect of grain size and rolling reduction on microstructure evolution and annealing hardening response of a Mg-3Gd alloy

Mg-3Gd (wt.%) samples with different initial grain sizes were prepared to evaluate the grain size effect on microstructural evolution during cold rolling and subsequent annealing hardening response. The deformation behavior and mechanical response of the as-rolled and annealed samples were systematically investigated by a combination of electron microscopy and microhardness characterization. The results show that the twinning activities were highly suppressed in the fine-grained samples during rolling. Upon increasing the rolling reduction to 40%, ultra-fine grain structures with a volume fraction of ∼28% were formed due to the activation of multiple slip systems. Conversely, twinning dominated the early stages of deformation in the coarse-grained samples. After a 10% rolling reduction, numerous twins with a volume fraction of ∼23% were formed. Further increasing the rolling reduction to 40%, high-density dislocations were activated and twin structures with a volume fraction of ∼36% were formed. The annealing hardening response of deformed samples was effectively enhanced compared to that of the non-deformed samples, which was attributed to the enhanced Gd segregation along grain boundaries, twin boundaries and dislocation cores. Moreover, the grain size and rolling reduction were found to affect the microstructure evolution during annealing, resulting in a notable difference in the annealing hardening response of Mg-3Gd alloy between samples of different grain sizes deformed to different strains. These findings highlight the crucial importance of microstructural and processing parameters in the design of high-strength, cost-effective Mg alloys.

Investigation of the Properties of Hydrocarbon Natural Gases Under Confinement in Tight Reservoirs Due to Critical Properties Shift

Pure components exhibit different phase behavior and critical properties shift when confined, primarily due to increased molecules-pore wall interactions. While extensive research has focused on modeling this behavior for pure components, there is a need to extend these models to hydrocarbon gas mixtures in tight and shale reservoirs to understand the deviation of gas properties from bulk behavior. The study utilizes the Peng–Robinson equation of state to calculate gas properties, considering the shift in critical properties of pure components due to confinement in EOS parameter calculations. Trend analysis investigates the effect of pore size reduction on gas properties, introducing the concepts of the confinement impact factor and specific pore radius. Correlation analysis explores the relationships between variables. Nonlinear regression analysis leads to the development of a new correlation that accounts for confinement effects on gas properties. The findings reveal that the deviation from bulk properties depends on the pore radius, pressure, temperature, and gas composition. The magnitude of deviation ranges from negligible to exceeding 15% under specific conditions of high pressure, low temperature, small pore radius, and rich gas composition. Gas viscosity experiences the most significant alteration, followed by density, while the gas compressibility factor also displays a noticeable impact. The isothermal gas compressibility coefficient demonstrates minimal to no response to confinement. Decreasing pore radius increases the gas compressibility factor, while gas viscosity and density decrease. The obtained results are crucial for shale and tight reservoir engineering calculations, particularly in adjusting gas properties in reservoir simulation and production modeling software.

Simple and Efficient Hydrogen Bond-Assisted Unit Exchange for Constructing Highly Soluble Covalent Organic Frameworks.

The majority of COFs synthesized using current methods exist as insoluble powders, which is unfavorable for processing and molding and greatly limits their practical applications. The syntheses of solution-processable or soluble COFs are challenging but hold immense promise and potential. Herein, for the first time, we have developed a simple and high-efficiency solvothermal-treated unit exchange approach to convert insoluble COF powders into smaller, highly soluble COFs via a hydrogen bond-assisted strategy. Due to the enhanced backbone-solvent hydrogen-bonding interactions between COFs and protic solvents and the effect of grain size reduction, the COFs after unit exchange can be easily dissolved in various protic solvents while remaining as insoluble powders in nonprotic solvents. The obtained soluble COFs exhibit remarkable fluorescence quenching upon detection of iodine in aqueous solution, with a detection limit as low as 75 nM, and can be fabricated into membranes for the efficient treatment of iodine-contaminated solutions.

Surface modification of PVDF hollow fiber ultrafiltration membranes for biopharmaceutical products, virus, and bacterial phage removal technology

In this study, radicals were chemically formed at the hydroxyl (-OH) sites on the surface of polyvinylidene fluoride (PVDF) hollow fiber membranes, and anionic-hydrophilic and hydrophobic materials were grafted onto the surface through -OH radical reaction to generate anions (−28, −41 mV). These membranes were then used as biomembranes (BMs) and showed excellent properties. We also studied the effects of chemical surface modification and reduction in pore size (60–130 nm) according to molecular weight. After anionic modification, the electrostatic repulsion between the pore surface and the bacteria prevents adsorption when anionic bacteria pass through the pores. Particles do not pass through the asymmetric pores due to agglomeration, resulting in separation. The hydrophilic membrane had a high initial water flux, but the flux gradually decreased due to fouling. In contrast, the hydrophobic modified membrane had a low initial water flux that eventually stabilized due to excellent fouling resistance. The protein recovery ratio (PRR) was 98.8 % for hydrophilic particles and 99.2 % for hydrophobic molecules, showing a higher PRR than the pristine membrane (96.4 %). An evaluation of removal of the gram-negative bacteria Brevundimonas diminuta (Bd) showed that no bacteria in membrane-purified solutions, confirming 100 % removal efficiencies. The developed membrane can be used in biopharmaceutical production and removal of proteins, retro viruses, and bacteria.

Realized volatility, price informativeness, and tick size: A market microstructure approach

This study examines the effects of tick size reduction on price volatility and microstructure noise terms embedded in stock prices. Comparing the realized variances and microstructure noise autocovariance before and after the tick size reduction and stock split, it is found that a smaller tick size induces a significant decline in price fluctuations at a 1-min frequency. Regressing the realized variances and microstructure noise autocovariance against trading activities, it is found that the decrease in the execution of large trades due to tick size reduction is primarily accountable for the shrinkage in price volatility. This effect exceeds the increase in the number of small trades that introduce higher price volatility. A less tick-constrained environment encourages order splitting, alleviates order clustering, weakens microstructure noise contamination, lowers its role in price variation, and thus improves price informativeness.

Reduced-Size Left Lateral Segment Grafts in Infants Weighing

Live donor liver transplantation for infants weighing <10 kg has unique complexities, as patient/graft size discrepancies may cause vascular perfusion deficiencies. Failure of the abdominal closure further complicates this already challenging procedure. To overcome these potential problems, several techniques for graft size reduction-either anatomic or nonanatomic-have been proposed in the literature. Technically easier and less time-consuming, nonanatomic size reductions have the advantage of avoiding the risk of injury to the portal pedicle. This study aimed to evaluate and compare the effects of nonanatomic graft size reduction in infants weighing <10 kg with a large estimated preoperative graft recipient weight ratio. We enrolled 106 infants weighing <10 kg. Of these infants, 50 received reduced-size grafts. The outcomes were compared between the groups. No difference was observed between the groups according to survival and vascular or biliary complications. None of the patients required an open abdomen or mesh closure. Nonanatomic size reduction of left lateral segment grafts can be safely applied without compromising vascular supply, graft function, and patient survival with comparable vascular and biliary complication rates. This technique is safe and efficient in overcoming the complications caused by large-for-size syndrome in infants weighing <10 kg.

Effect of ball milling and subsequent size reduction of graphite flakes on the surface mechanical properties of graphitized Al-1100 alloy

Current study explains about ball milling and subsequent mechanical insertion of graphite particles into aluminium (Al-1100) surface for forming composites on surface through an electrical resistance heat supported pressing procedure. Ball milling of as-received 60 mesh graphite particles was carried out which successfully reduced the particle size. After that surface of the aluminium is coated with ball-milled graphite by solution casting. For impregnation, the interface of graphite/aluminium is locally heated by the assistance of an electrical resistance heating followed by mechanical pushing. Heat generation and thus level of aluminium surface softening can be structured by process factors like current and heating time. SEM, TEM, Raman spectroscopy and XRD were employed for microstructural characterization. Successful impregnation and agglomeration of graphite particles inside aluminium matrix is revealed from microstructural characterization. Impregnated graphite particles when characterized with Raman spectroscopy shows band shifting and increased intensity ratio (ID/IG). Presence of intermetallic compound (Al4C3) was not detected from the XRD and TEM study. Surface and subsurface mechanical characterization was carried out nanoindentation and microhardness respectively. The modified surface while shows an improvement of more than 120 % in mechanical properties, 130 % improvement is also observed in Young’s modulus. The projected method can be utilized as surface modification technique in solid-state by fabricating surface composites fabricated through mechanical insertion of particulate reinforcement at sub-melting temperatures of substrate and under open producing environment.

Mixed polymerization approach to GO-derived carbon foil-supported porous SiO2/C random nanocomposite films for Li-ion battery anodes with extraordinarily enhanced capacities by cycle-dependent size-reduction effect

As starting materials, tetraethyl orthosilicate, resorcinol and formaldehyde were used to prepare a distinctive composite film of SiO2/C two-phase interpenetrated porous nanostructures on the surface of carbon foil ((SiO2/C)@Cf) when the mixed polymerizations (condensations) on the surface of graphene oxide and subsequent heat treatment were carefully manipulated. The microstructures of as-prepared films were characterized by FESEM, TEM, EDS element mapping, BET, etc and their charging/discharging behaviors and electrochemical impedance spectra were quantitatively analyzed. It has been found that (SiO2/C)@Cf shows extraordinary capacity enhancement featured with excellent cycling capacity and rate performance as anode materials of Li-ion batteries, such as 1274 mAh g−1 after 2000 cycles at 1 A g−1 and 463.5 mAh g−1 at 5 A g−1, in comparison with the layered SiO2/C composite films. More interestingly, the CV curves of (SiO2/C)@Cf before and after 2000 cycles of charge/discharge evidently shows a remarkable initial pseudo-capacitive capacity and its unusual enhancement with increasing number of cycles, which should be attributed to the small size effect of SiO2 domains embedded in carbon phase and their gradual refinement, leading to an increase in the effective electrochemical reaction area and apparent diffusivity of Li-ions.

Whiting (Merlangius merlangus) Grows Slower and Smaller in the Adriatic Sea: New Insights from a Comparison of Two Populations with a Time Interval of 30 Years

Nowadays, overexploitation and climate change are among the major threats to fish production all over the world. In this study, we focused our attention on the Adriatic Sea (AS), a shallow semi-enclosed sub-basin showing the highest exploitation level and warming trend over the last decades within the Mediterranean Sea. We investigated the life history traits and population dynamics of the cold-water species whiting (Merlangius merlangus, Gadidae) 30 years apart, which is one of the main commercial species in the Northern AS. The AS represents its southern limit of distribution, in accordance with the thermal preference of this cold-water species. Fish samples were collected monthly using a commercial bottom trawl within the periods 1990–1991 and 2020–2021. The historical comparison highlighted a recent reduction in large specimens (&gt;25 cm total length, TL), which was not associated with trunked age structures, therefore indicating a decrease in growth performance over a period of 30 years (L∞90–91 = 29.5 cm TL; L∞20–21 = 22.8 cm TL). The current size at first sexual maturity was achieved within the first year of life, at around 16 cm TL for males and 17 cm TL for females. In the AS, whiting spawns in batches from December to March, showing a reproductive investment (gonadosomatic index) one order of magnitude higher in females than in males. Potential fecundity (F) ranged from 46,144 to 424,298, with it being heavily dependent on fish size. We hypothesize that the decreased growth performance might be related to a metabolic constraint, possibly related to the increased temperature and its consequences. Moreover, considering the detrimental effects of size reduction on reproductive potential, these findings suggest a potential endangerment situation for the long-term maintenance of whiting and cold-related species in the AS, which should be accounted for in setting management strategies.

Effect of micronisation on colour and optical properties of ceramic colourants for inkjet printing

The advent of inkjet printing (IJP) as the main used decoration technique for ceramic products has changed the technological requirements for pigments and the way they are obtained. To meet IJP and durability requirements, it is necessary to micronise the colourants to achieve particles smaller than 1 μm (median particle diameter d50 ∼300 nm). The high-energy milling process induces microstructural changes that affect the colour properties. In order to understand the effect of particle size reduction on chromatic properties, an in-depth study was carried out by simulating the industrial milling process on a pilot scale. The effect of micronisation was investigated for four ceramic pigments (yellow zircon, brown spinel, pink malayaite, and green eskolaite) and one dye (blue olivine) by UV–vis–NIR optical spectroscopy (DRS), chromatic coordinates and XRPD analyses (Rietveld method). This study was carried out on the colourants both as they were and mixed with glass, reproducing the industrial firing process. The results obtained led to the definition of the main aspects responsible for the colour evolution derived from the milling process.

Efficacy comparison of anthracycline and taxane when added to immune checkpoint inhibitor in neoadjuvant chemotherapy of triple negative breast cancer: Clinical evidence from size-reduction measurement by ultrasound.

e12584 Background: Most chemotherapeutics can improve responses to immune checkpoint inhibitors (ICI) by increased immunogenicity. Anthracycline(AC), taxane(T) and platinum (CDDP) has most direct cytotoxic effect in neoadjuvant chemotherapy (NAC) of triple negative breast cancer (TNBC), but which one deserve the most immunostimulatory activity linked to their capacity of to kill cancer cell still unknown. Methods: A total of 91 patients with complete data of size measurement by ultrasound (US) were identified for the study from 363 consecutive TNBC patients received NAC between November 2010 to August 2022. They were divided into 3 groups. The 1st group patients received AC first, then T with CDDP, 2nd group in reverse sequence (T and CDDP first) and 3rd group, sequence as group 2 but adding ICI (pembrolizumab). Tumors size measured by US before chemotherapy, after 1st and after 2nd regimen of chemotherapy. Percentage of size reduction of tumor maximal diameter (cm), surface area (transverse x longitudinal diameter, cm2) and volume (measured by 1/6 p x transverse x longitudinal x height cm3) were calculated. Statistically significant was calculated using the Mann-Whitney U test for percentage of size reduction and Pearson's chi-squared test for pCR rate, p-value &lt; 0.05 was considered significant. Results: There were 14, 56 and 21 patients in group 1, 2 and 3, respectively. The significant difference of pathologic complete response rates 7.1%, 44.6% and 76.2% in each group as shown. The volume, surface area and maximal tumor size reduction percentage after 1st regimen chemotherapy in group 1 (AC), group 2 (T+CDDP) and group 3 (ICI+T+CDDP) were -67.24, -55.43, -31.13; -85.45, -72.13, -45.61 and -87.13, -69.75, -45.02, respectively, and size reduction after 2nd regimen chemotherapy in group 2 (AC) were, -42.19, -30.19, -21.13; and group 3 (ICI+AC) were -77.78, -50.76, -30.65; respectively. A statistical non-significant trend of greater size reduction in ICI+ AC than AC alone was found. Conclusions: The study is the first, direct evidence demonstrated the synergistic effect of size reduction after NAC for TNBC with AC and ICI, but not T. It supports the potential benefit of combining chemotherapy with immunotherapy such as Tonic trial reported. [Table: see text]

Effect of Porosity in Activated Carbon Supports for Silicon-Based Lithium-Ion Batteries (LIBs).

Activated carbon supports for Si deposition with different porosities were prepared, and the effect of porosity on the electrochemical characteristics was investigated. The porosity of the support is a key parameter affecting the Si deposition mechanism and the stability of the electrode. In the Si deposition mechanism, as the porosity of activated carbon increases, the effect of particle size reduction due to the uniform dispersion of Si was confirmed. This implies that the porosity of activated carbon can affect the rate performance. However, excessively high porosity reduced the contact area between Si and activated carbon, resulting in poor electrode stability. Therefore, controlling the porosity of activated carbon is essential to improving the electrochemical characteristics.

Antioxidant, Antibacterial and Antibiofilm Activity of Nanoemulsion-Based Natural Compound Delivery Systems Compared with Non-Nanoemulsified Versions.

This study aimed to develop nanoemulsions with a focus on improving the bioactivity of oregano essential oil (OEO), carvacrol and thymol for possible food applications. Nanoemulsions were prepared with acoustic cavitation using ultrasound. The nanodroplets had average diameters of 54.47, 81.66 and 84.07 nm for OEO, thymol and carvacrol, respectively. The main compound in OEO was carvacrol (74%), and the concentration in the nanoemulsions was 9.46 mg/mL for OEO and the isolated compounds. The effects of droplet size reduction on antioxidant, antibacterial and antibiofilm activity were evaluated. Regarding antioxidant activity, the nanoemulsions performed better at the same concentration, with inhibitions >45% of the DPPH radical and significant differences compared with their non-nanoemulsified versions (p < 0.05). The nanoemulsions' minimum inhibitory concentration (MIC) and non-nanoemulsified compounds were evaluated against foodborne pathogens with inhibition ranges between 0.147 and 2.36 mg/mL. All evaluated pathogens were more sensitive to nanoemulsions, with reductions of up to four times in MIC compared with non-nanoemulsified versions. E. coli and S. Enteritidis were the most sensitive bacteria to the carvacrol nanoemulsion with MICs of 0.147 mg/mL. Concerning antibiofilm activity, nanoemulsions at concentrations up to four times lower than non-nanoemulsified versions showed inhibition of bacterial adhesion >67.2% and removal of adhered cells >57.7%. Overall, the observed effects indicate that droplet size reduction improved the bioactivity of OEO, carvacrol and thymol, suggesting that nanoemulsion-based delivery systems for natural compounds may be alternatives for food applications compared with free natural compounds.

Laser-generated nanoparticles from Fe-based metallic glass in water and its amorphization control by pulsed laser processing

The laser synthesis and processing of colloids represents a group of scalable and “green” synthesis methods of crystalline metal oxides, that have recently made encouraging progresses in preparing amorphous as well as defect-rich nanoparticles. The relevant conditions and mechanisms that allow the design of amorphous metal oxides (AMOs) remain unknown. Consequently, in this work the synthesis of Fe-based partially amorphous oxide nanoparticles (NPs) by pulsed laser ablation in water was studied. Furthermore, both laser pulse duration and the number of laser pulse in pulsed laser fragmentation in liquid (LFL) allow a precise control of amorphization of AMOs in water. Hereby, a high-fluence nanosecond-LFL provides a significantly higher amorphization rate, whereas picosecond-LFL always presents minor fractions of crystalline α-Fe even with a higher specific energy input and laser intensity. Consequently, the laser fluence required for the repeated melting and quenching of NP appears to be the decisive parameter to control amorphization. During laser synthesis and processing of colloids, the amorphization of AMOs appears to be linked to the apparent size reduction effect, while a complete full amorphization of AMOs may be attributed to the stronger oxidation effects. This work will stimulate future studies using laser-generated AMO NPs for further functional purposes.

Influence of gold nanoparticles size for photocatalytic NO oxidation in low loading Au/TiO2 catalysts

Gold nanoparticles (AuNPs) supported on TiO2 are one of the most investigated photocatalysts, however, the positive effect of AuNPs size reduction on Au/TiO 2 activity is clear for conventional catalysis, but this relationship not strictly happens in photocatalysis. The present work investigates how small changes in the lower size range of AuNPs can affect the Au/TiO2 photoactivity in order to maximize the performance of photocatalysts with low metal loadings (<1 wt%). Precipitation–deposition methods and a speciation-controlled incipient wetness impregnation (ScIWI) method have been employed for preparing Au/TiO 2 photocatalysts that exhibited a NOx elimination capacity significantly higher than pristine TiO2. Comparing the photocatalysts, ScIWI method achieved the highest gold dispersion and Au–TiO2 contact perimeter providing the most active photocatalysts, confirming the positive effect of AuNPs size reduction in the average sizes around 2 nm. In addition, on the basis of the results obtained, it has been proposed that the adsorption of nitrogen oxides species on gold has a relevant role on the NO photooxidation process.

Integrated poultry waste management by co-digestion with perennial grass: Effects of mixing ratio, pretreatments, reaction temperature, and effluent recycle on biomethanation yield

This work aims to enhance the efficiency of integrated poultry waste management in bio-circular-green economy by maximizing the co-digestion of chicken manure and its digestate-grown biomass. In a series of batch assays, Napier grass (NG) was mixed with chicken manure (CM) at various proportions (100:0, 80:20, 60:40, 50:50, 40:60, 20:80 and 0:100) to identify co-substrate synergism, followed by physiochemical conditioning (size reduction and ultrasonication) of NG before co-digestion. Results indicated that NG mix of at least 80% was required to gain a full methanation potential of the individual substrates; no synergistic ratio above unity was found. However, the combined effect of size reduction and sonication was found to markedly improve the co-substrate’s biodegradability by 88.7%. The findings were then used to run continuous co-digestion at various operating regimes. In optimal continuous co-digestion condition, NG particle size of 0.6–2.4 mm combined with sonication intensity at 1111 kJ/kgTS improved biomethanation yield as high as 106.3%. Sub-thermophilic digestion at 45 °C was shown to give a higher and more stable CH4 yield than at 55 °C. Finally, it was also found that recycling liquid effluent at 40% to replace freshwater in feed, although showed no significant difference in CH4 yield (α = 0.05), noticeably increased system buffer capacity. This optimized biodegradation regime could give co-digestion waste management a higher overall plant efficiency and economic return.

The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly Soluble Drugs with Different Acid-Base Character.

Particle size reduction is a commonly used process to improve the solubility and the dissolution of drug formulations. The solubility of a drug in the gastrointestinal tract is a crucial parameter, because it can greatly influence the bioavailability. This work provides a comprehensive investigation of the effect of the particle size, pH, biorelevant media and polymers (PVA and PVPK-25) on the solubility and dissolution of drug formulations using three model compounds with different acid-base characteristics (papaverine hydrochloride, furosemide and niflumic acid). It was demonstrated that micronization does not change the equilibrium solubility of a drug, but it results in a faster dissolution. In contrast, nanonization can improve the equilibrium solubility of a drug, but the selection of the appropriate excipient used for nanonization is essential, because out of the two used polymers, only the PVPK-25 had an increasing effect on the solubility. This phenomenon can be explained by the molecular structure of the excipients. Based on laser diffraction measurements, PVPK-25 could also inhibit the aggregation of the particles more effectively than PVA, but none of the polymers could hold the nanonized samples in the submicron range until the end of the measurements.

Characterization of the electrocardiogram of microminipig in comparison with that of Clawn miniature swine: impacts of miniaturization of body size on electrocardiographic indices.

Effects of body size reduction on electrocardiographic indices were examined using microminipigs in comparison with Clawn miniature swine (Clawn). Electrocardiogram was recorded using Holter electrocardiograph in conscious state for 24 hr for microminipigs (male: 11.6 ± 0.1 kg, 12-17 months, n=5; and female: 9.9 ± 0.4 kg, 6 months, n=5) and Clawn (female: 20.3 ± 0.4 kg, 8-9 months, n=8). Microminipig had shorter PR interval and QRS width than Clawn, whereas no significant difference was detected in JTcF/QTcF between them. Ratios of PR interval, QRS width, and body weight cubic root for microminipigs to Clawn ranged between 0.713 and 0.830. These findings indicate that PR interval and QRS width will depend on distance for excitatory current propagation, whereas JTcF/QTcF may be governed by local electrical activities.

Influences of well contact on multiple-cell upsets in 28 nm SRAM

In order to study the effects of the feature size reduction and well contact placement on the characterization of topology patterns and the charge collection mechanism of device heavy ion single event multiple upset on a nanometer scale, the heavy ion single event effect experiment on the domestic 28 nm static random-access memory (SRAM) is carried out on the experimental platform of HI-13 heavy ion accelerator in Beijing. Based on the mapping relationship between the logical address and physical address of the device, the experimental data are processed, and the 28 nm SRAM heavy ion single event upset cross section curves, multiple upset percentage, and multiple upset topology patterns are obtained. The results are compared with those of heavy ion single event effect experiments in 65 nm SRAM, showing that under the influences of factors such as feature size reduction and lower operating voltage, the heavy ion single event upset threshold and the bit upset saturation cross section of 28 nm SRAM decrease significantly. In the direction perpendicular to the well, owing to the reduced 28 nm SRAM feature size, even if the single nucleon energy of the incident high LET (linear energy transfer) heavy ion is low, its deposited charge is sufficient to affect the three SRAM cells across the well direction due to the combined effect of ion track coverage, well potential modulation caused by the parasitic bipolar amplification effect and carrier diffusion, resulting in the fact that the 28 nm SRAM topology pattern has a shape of &lt;i&gt;n&lt;/i&gt; rows × 3 columns, which poses new challenges and requirements for the anti-radiation hardened technology with scrubbing and EDAC (error detection and correction). Owing to the global well contact deployment, the charge deposited by the incident ions in the well far away from the well contact is difficult to discharge quickly, and the parasitic bipolar amplification effect lasts longer. The charge sharing competition between two p-channel metal oxide semiconductor in SRAM cell causes the single event upset recovery, which is the fundamental reason why the discontinuity of multiple upset topology pattern appears in 28 nm SRAM. This study provides a new anti-radiation hardened idea for suppressing the single event upset by using the parasitic bipolar amplification in the future.