The adverse conditions of the soil such as soft soil can have seismic consequences that may either amplify seismic response or render the structure vulnerable. On one hand, the design and construction of asymmetric structures have become prevalent due to aesthetic considerations and structural space limitations. Studies indicate that structures with geometric irregularities are susceptible to seismic forces, leading to non-uniform distribution of floor drifts, excessive torsional behavior, and more, depending on the degree of irregularity. In this research, the main goal was to investigate the effect of soil and structure interaction on the torsion of asymmetric Mid-Rise Structures. To achieve this goal two asymmetric Steel moment frame system 15-story structures aim to address the effect of interaction between soil and structure on the seismic performance, one with a rigid base and the other with a flexible base, one with a rigid base and the other with a flexible base. To mitigate the settlement of soil-associated structures, a pile-raft system is employed, considering the softness of the soil. Additionally, to study the torsional behavior of these structures, their planes are asymmetrically designed in L-shape and C-shape configurations, subjected to four ground motion excitations in both far and near-field scenarios. Three-dimensional finite element numerical simulations are performed using Abaqus software. Various configurations of the pile-raft system for the asymmetric C-shape structure are examined to assess the effects of pile diameter and length on the torsional irregularity coefficient. The results show that the soil-structure interaction increases the maximum floor rotation angle, placing these structures in critical conditions concerning torsional irregularity under near-field and far-field seismic excitations.