To explore the effect of comprehensive nursing intervention on the improvement of clinical symptoms and nursing satisfaction in children with febrile convulsion. 117 children with simple febrile convulsion admitted to our hospital from March 2019 to May 2020 were randomly divided into observation group (59 cases) and control group (58 cases). The control group was given routine nursing intervention, while the observation group was given comprehensive nursing plan. The recovery process, parent’s satisfaction with nursing, vital signs, inflammatory factors and neuroendocrine factors before and after nursing were analyzed. The results showed that the seizure stop time, fever abatement time and hospitalization time of the observation group were shorter than those of the control group (p 0.05). The application of comprehensive nursing in children with febrile convulsion can improve the quality of nursing and parent’s satisfaction, shorten the recovery process of children, more effectively control the level of neuroendocrine factors and inflammatory reaction and promote the recovery of children’s vital signs.