Healing Effect Research Articles

Efficiency of healing of trophic ulcers when using tissue engineering construction in experiment

Chronic trophic ulcers of the foot and the tibia affect up to 2% of the working population of industrially developed countries. In our scientific work we experimentally examined the effectiveness of wound healing with the use of modern tissue engineering construction collagen enriched with fibroblasts in modeled trophic ulcer in rats of the genus Wistar.

Healing mechanism of rural tourism on urban employee unhappiness: a logotherapy theory perspective

This study evaluated the healing benefits of different holiday experiences on employee unhappiness. It developed a model of “Destination Experience–Psychological Recovery–Work Performance” based on liminality and logotherapy theories, which explain how tourism heals employee unhappiness. The researcher employed a weekly diary methodology to collect data from 596 participants, and then utilised partial least squares structural equation modelling (PLS-SEM) methods and multi-group analysis to test the theoretical model. The results indicated that tourism (vs home) and rural (vs urban) tourism destination experiences significantly healed urban employees’ unhappiness. Additionally, this study found that the healing effect of rural tourism destination experiences on urban employee unhappiness was mediated by mastery experiences and moderated by tour duration. To provide a deeper understanding of the hypotheses, semi-structured interviews were conducted to explore urban employees’ rural tourism healing experiences and strategies. This study enhances our understanding of how tourism reduces employee unhappiness and contributes to the literature on the spillover effects of tourism on work. Finally, it presents a significant new paradigm for tourism healing theories and practices for future research.

Tracking healing effect of human Wharton's jelly stem cells labeled with superparamagnetic iron oxide nanoparticles seeded onto poly vinyl alcohol/chitosan/carbon nanotubes in burn wounds by MRI, and Prussian Blue staining.

Regenerative medicine by applying tissue engineering and cell transplantation has provided a new door in wound healing. This study tracked healing effect of human Wharton's jelly stem cells (WJSCs) labeled with superparamagnetic iron oxide nanoparticles (SPIONs) seeded onto poly vinyl alcohol/chitosan/carbon nanotubes (PVA/CS/CNT) in burn wounds by magnetic resonance imaging (MRI) and Prussian Blue staining.&#xD.

Evaluation of wound healing efficiency using collagen matrices on a thermal burn model

Every year dozens of new local wound treatment agents are developed and improved in the world, which undergo preliminary testing on laboratory animals due to the presence of common phases of the wound healing process with humans. Wound healing effect was studied on a thermal burn model on Wistar rats in 4 groups: 1st - control (natural wound healing); 2nd - intact animals (normal, without burn). 3rd - experimental ( collagen treatment ); 4th - experimental 2 , comparison group (" Levomekol "); Wound healing was assessed based on the results of planimetry on the 1st, 3rd, 5th, 7th, 9th and 13th days and histological analysis of skin tissue on the 6th, 13th and 20th days. Results. Thermal skin damage resulted in a IIIA degree burn, accompanied by the development of dry coagulation necrosis. The use of collagen matrices restored the total leukocyte count and reduced the area of the burn wound. Histomorphometric studies confirmed the dynamics of skin tissue recovery after the burn. The effectiveness of the matrices was comparable to the pharmacopoeial drug " Levomekol ". A higher wound-healing effect was noted with the use of collagen. Conclusion. The wound-healing effect of collagen matrices was established on the thermal burn model, as evidenced by the results of restoration of the number of leukocytes, reduction of the burn wound area and restoration of the skin histostructure .

Glucantime and quercetin electrospun nanofiber membranes: Fabrication and their evaluation as dressing for cutaneous leishmaniasis.

Cutaneous leishmaniasis is considered as one of the most concerns of the World Health Organization (WHO). The main objective of this study was to use polycaprolactone (PCL) nanofiber scaffolds in order to provide a topical drug delivery system capable of delivering glucantime (glu) and quercetin (qur) to cutaneous leishmaniasis wounds. First, PCL/glu/qur, PCL/glu, and PCL/qur nanofibers were prepared by an electrospinning method followed by characterization through scanning electron microscopy (SEM) and fourier transform infrared spectroscopy (FTIR). Subsequently, we investigated the release of the drugs from nano-scaffolds and anti-promastigote effects. Lastly, the effect of nanobandage was evaluated on 20 female inbred BALB/c mice infected with the parasite. The nanofibers were bead-free and uniform with an average diameter of 224 ± 25 nm and showed a sustained release. Results from in vivo experiments showed that the number of amastigotes and macrophages infected with the parasite and the infiltration of inflammatory cells in mice treated with PCL/qur and PCL/glu/qur nanofibers significantly decreased as compared with those treated with the PCL/glu and PCL nanofibers. Collectively, PCL/glu/qur and PCL/qur nanofibers have promising therapeutic effects in cutaneous leishmaniasis wound healing.

Block cationic copolymer/quaternary ammonium chitosan-based composite antibacterial hydrogel dressings with NIR photothermal effects for bacteria-infected wound healing.

Wound infections caused by pathogenic bacteria can cause delayed wound healing and even threaten the life of patients. Drug resistance and effectiveness with regard to traditional wound dressings have become urgent issues which need to be addressed. The antibacterial effect of hydrogels, as novel wound dressings, is through contact-active antibacterial was limited by the contact area and time. In this paper, MXene (a 2D carbonitride) has been employed as the substrate and via the in-situ reduction of silver nanoparticles and the polymerization of dopamine on its surface the photothermal agent MXene-Ag-PDA was obtained. This was then introduced into the hydrogel matrix via the block cationic polymer (AM-VBIMBr-AAPBA), oxidized sodium alginate (OSA) and quaternary ammonium chitosan (HACC). Multifunctional composite hydrogels (PNVAO/M-A-P) possessing photo-thermal effects and inherent antibacterial activity were obtained after crosslinking, and were employed as medical materials to promote the healing of infected wounds. The cationic groups contained in the PNVAO/M-A-P were capable of capturing and killing bacteria by electrostatic interactions, and produced local heat killing adsorption and residual bacteria in the surrounding solution under NIR irradiation, thereby shortening the antibacterial cycle and improving the sterilization efficiency. Meanwhile, the introduction of glycerin in the hydrogel improved its anti-freezing and anti-drying properties, enabling the hydrogel to function stably under extreme environments. PNVAO/M-A-P composite hydrogels based on chemical and dynamic crosslinking exhibited the desired mechanical strength, and via their self-healing ability can adapt to dynamic wounds. The hydrogel dressing showed excellent anti-freezing and anti-drying properties, high bovine serum albumin (BSA) adsorption capacity (308.17mg·g-1), good biocompatibility (the cell viability exceeded 100% after 48h of incubation), antioxidant properties and excellent antibacterial activity (the sterilization rate can reach 99.9%). Furthermore, the hydrogel was applied to infected wound treatment and was able to control the wound infection, reduce pro-inflammatory factor production, promote collagen deposition and neovascularization formation, and thus promote wound healing. Therefore, multifunctional composite hydrogels with synergistic antibacterial effects can be used as an novel dressing for the treatment of bacterial infected wounds.

Immunomodulation as the main characteristic of vegetable oils: a review

Known for being a functional food, vegetable oil is widely used because of its nutraceutical activity. It notable that one third of all traditional medicines are intended to treat inflammatory disorders. Vegetable oils are basically composed of linoleic and alpha-linolenic acids, which are polyunsaturated fatty acids (PUFA) classified as essential, and monounsaturated fatty acids (MUFA) such as oleic acid, are classified as non-essential. Olive, sunflower, flaxseed, and chia oil are rich in these fatty acids, and their benefits are directly linked to these fatty acid contents. The benefits in their consumption by the population worldwide is proven, mainly promoting the balance of the lipid profile, cardiovascular aspects, decrease in blood pressure, and healing effects when used topically. Most of these benefits come from the immunomodulatory effects of vegetable oils, mainly the anti-inflammatory activities triggered by the unsaturated fatty acids present in these oils.

Exosomes derived from minor salivary gland mesenchymal stem cells: a promising novel exosome exhibiting pro-angiogenic and wound healing effects similar to those of adipose-derived stem cell exosomes

BackgroundsMinor salivary gland mesenchymal stem cells (MSGMSCs) can be easily extracted and have a broad range of sources. Applying exosomes to wounds is a highly promising method for promoting wound healing. Exosomes derived from different stem cell types have been proven to enhance wound healing, with adipose-derived stem cell (ADSC)-derived exosomes being the most extensively researched. Considering that MSGMSCs have advantages such as easier extraction compared to ADSCs, MSGMSCs should also be a very promising type of stem cell in exosome therapy. However, whether MSGMSC-derived exosomes (MSGMSC-exos) can promote wound healing and how they compare to ADSC-derived exosomes (ADSC-exos) in the wound healing process remain unclear.MaterialsThe effects of MSGMSC-exos and ADSC-exos on angiogenesis in wound healing were investigated in vitro using CCK-8, scratch assays, and tube formation assays. Subsequently, the promotion of wound healing by MSGMSC-exos and ADSC-exos was evaluated in vivo using a full-thickness wound defect model in mice. Immunohistochemistry was used to verify the effects of MSGMSC-exos and ADSC-exos on promoting collagen deposition, angiogenesis, and cell proliferation in the wound. Immunofluorescence staining was performed to investigate the role of MSGMSC-exos and ADSC-exos in modulating the inflammatory response in the wound. Furthermore, proteomic sequencing was conducted to investigate the functional similarities and differences between the proteomes of MSGMSC-exos and ADSC-exos, with key protein contents verified by ELISA.ResultsMSGMSC-exos exhibited similar effects as ADSC-exos in promoting the migration, proliferation, and tube formation of human umbilical vein endothelial cells (HUVECs) in vitro, with a comparable dose-dependent effect. In vivo experiments confirmed that MSGMSC-exos have similar wound healing-promoting functions as ADSC-exos. MSGMSC-exos promoted the neovascularization and maturation of blood vessels in vivo at a level comparable to ADSC-exos. Despite MSGMSC-exos showing less collagen deposition than ADSC-exos, they exhibited stronger anti-scar formation and anti-inflammatory effects. Proteomic analysis revealed that the proteins promoting wound healing in both MSGMSC-exos and ADSC-exos were relatively conserved, with ITGB1 identified as a critical protein for angiogenesis. Further differential analysis revealed that the functions specifically enriched in MSGMSC-exos and ADSC-exos reflected the functions of their source tissue.ConclusionsOur study confirms that MSGMSC-exos exhibit highly similar wound healing and angiogenesis-promoting functions compared to ADSC-exos, and the proteins involved in promoting wound healing in both are relatively conserved. Moreover, MSGMSC-exos show stronger anti-scar formation and anti-inflammatory effects than ADSC-exos. This suggests that MSGMSCs are a promising stem cell source with broad applications in wound healing treatment.

The Association of Periodontitis and different BMI categories with Serum Chemerin Levels -: An Observational Case-Control Study

Background: Chemerin is a adipocytes, epithelial cells, endothelium, fibroblasts, and keratinocytes - derived chemotactic protein. This research was focused on possible connections between glycerin in serum, different body mass indexes (BMI), and appearance of the periodic disease. It is speculated that the findings of our work will help to deepen our comprehension of the interplay of adipokines, obesity, and periodontitis.The purpose of this endeavor is to establish the connections between serum chemerin, the value of BMI, and periodontitis to investigate the association between the indexes associated with the increase in obesity and the onset or aggravation of this disease. Methods: A total of 118 individuals volunteered to be a part of this research. serum obtained before the clinical investigations was the serum sample taken. participants were distributed into six groups: First group (C): 30 subjects with a normal BMI (18.5-24.9 kg/m^2) and a healthy periodontium; second group (Ov): 30 subjects with an overweight BMI (25–29.9 kg/m^2) and a healthy periodontium; third group (Ob): 30 subjects with an obesity BMI (≥ 30) and a healthy periodontium; fourth group (P): 30 periodontitis patients with a normal BMI (18.5-24.9 kg/m^2); fifth group (P+Ov): 30 periodontitis patients with an overweight BMI (25–29.9 kg/m^2) and sixth group (P+Ob): 30 periodontitis patients with obesity BMI (≥ 30). Evaluation of probe debut (PPD), clinical attachment loss (CAL), and bleeding upon probing (BOP) were the methods used in the periodontal test. Results: The findings of the study point out periodontal patients, and in particular, higher body mass index-filled serum levels of chemerin. Among all the study groups, patients with combined very severe obesity and periodontitis (P+Ob) were found to have the highest chemerin levels in their serum. Chemerin (C) of the control group with a weight within the normal range and a healthy area of periodontium was lower in reach. Conclusions: The results suggested that chemerin might be a good indicator biomolecule, which would provide information about the disease progress and deterioration, not only in the cases of overweight subjects but most probably in every person affected. may have a healing effect as its inflammatory effect could be counteracted.

Therapeutic Potential of the Herbal Plant Uncaria gambir: A Systematic Review

Background: Uncaria gambir is an Indonesian medicinal herb with healing effects. This plant contains flavonoids, which can be used as antioxidants and anti-inflammatory agents to accelerate healing. In Indonesia, Uncaria gambir is widely accessible, simple to grow, and has a long history of use as an alternative medicine. Following this, studies are conducted in the medical industry using Uncaria gambir. Objective: This study aimed to comprehensively review the use of Uncaria gambir extract as an herbal plant for treating experimental animals. Methods: This review followed the Preferred Reporting Items for Systematic Reviews and Meta- Analyses guidelines, and the risk of bias was evaluated by modifying the ARRIVE guidelines. Results: A report was presented on review articles from 12 publications sourced from PubMed, ScienceDirect, Wiley Online Library, ProQuest, EBSCO Host, and other relevant studies. The Uncaria gambir isolates tested were catechin and ethyl acetate, used primarily for lesions, pain, edema, and diabetes in experimental Wistar rats. Conclusion: Uncaria gambir is an herbal plant that contains flavonoids, which can be used as antiinflammatory, antioxidant, antibacterial, and hepatoprotective agents and can potentially be applied in the medical field as adjuvant therapy.

Corrigendum to “Mixed silicates with three-dimensional micro-architecture toward accelerate the antibacterial hemostatic effects in wound healing” [Colloids Surf. A Physicochem. Eng. Asp. 705 (2025) 135644

Corrigendum to “Mixed silicates with three-dimensional micro-architecture toward accelerate the antibacterial hemostatic effects in wound healing” [Colloids Surf. A Physicochem. Eng. Asp. 705 (2025) 135644

Bacoside A: A Promising Medication for Treatment of Various Disorders

Abstract: Bacoside A is a triterpenoid saponin and nootropic herb that can be extracted from Bacopa monnieri Linn., Scrophulariaceae. It is a glabrous and succulent herb used traditionally for centuries in treating various illnesses, mainly as a cardiotonic and nerve tonic, and has been considered an eminent Ayurvedic medicine. Various studies reported that the herb consists of a wide range of potentially bioactive, phytochemical constituents with synergistic effects. Bacoside A is a major constituent of B. monnieri, with diverse biological functions and significant therapeutic potential, as given by various researchers and preclinical studies. It possesses various biological activities such as hepatoprotective, anti-osteoporotic, anti-ulcerogenic, anti-inflammatory, anti-tumor, wound healing, and neuroprotective effects. This review compiled the preclinical evidence-based studies and present knowledge of bacoside A's potential benefits and fruitful impact on human health, and we provided a comprehensive perspective of bacoside A in various disease treatments.

A Comprehensive Review on Niosomes as a Strategy in Targeted Drug Delivery: Pharmaceutical, and Herbal Cosmetic Applications.

Niosomes are newly developed, self-assembling sac-like transporters that deliver medication at a specific site in a focused manner, increasing availability in the body and prolonging healing effects. Niosome discovery has increased drugs' therapeutic effectiveness while also reducing adverse effects. This article aims to concentrate on the increase in the worldwide utilization of niosomal formulation. This overview presents a thorough perspective of niosomal investigation up until now, encompassing categories and production techniques, their significance in pharmaceutical transportation, and cosmetic use. The thorough literature review revealed that extensive attention has been given to developing nanocarriers for drug delivery as they hold immense endeavor to attain targeted delivery to the affected area simultaneously shielding the adjacent healthy tissue. Many reviews and research papers have been published that demonstrate the interest of scientists in niosomes. Phytoconstituents, which possess antioxidant, antibiotic, anti-inflammatory, wound healing, anti-acne, and skin whitening properties, are also encapsulated into niosome. Their flexibility allows for the incorporation of various therapeutic agents, including small molecules, proteins, and peptides making them adaptable for different types of drugs. Niosomes can be modified with ligands, enhancing their targeting capabilities. A flexible drug delivery mechanism provided by non-ionic vesicles, which are self-assembling vesicular nano-carriers created from hydrating non-ionic surfactant, cholesterol, or amphiphilic compounds along comprehensive applications such as transdermal and brain-targeted delivery.

Invivo and ex-vivo evaluation and characterization of wound healing effect of topical calendulaofficinalis and turmeric cream in diabetic rats.

Objective: To evaluate wound healing by topically administration of calendulaofficinalis and tumeric cream to diabetic rats. Study Design: Observational Cross-sectional study Setting: Department of Pharmaceutics, Faculty of Pharmacy, BahaUddin Zakariya University, Multan, Pakistan Period: October 2020-march 2021. Method: Different batches of hydrophilic cream bases (C1-C6) were developed and characterized. The optimized base composition (C6) was loaded with calendula Officinal is extract and turmeric powder as an active ingredient (C7) and evaluated the rate at which wounds heal in diabetic rats. Calendula officinal is and turmeric were combined in a cream, as different stability parameters of the creams were analysed at different temperature. Microbiological action of the cream was also examined. Results: The formulation was homogenous, stable with pH 6.29±0.03, viscosity 381± 6.96 Cps and the microbiological quality met the requirements of European pharmacopeia. The total flavonoid content was less than 1. The formulation showed accelerated wound healing with more than 95% wound contraction after tenth day. Conclusion: The result were favorable and suggested that topical administration of Calendula officinal is and turmeric powder combination would enhance wound healing in diabetic rats with potential for diabetic foot ulcer treatment. Moreover, the designed formulation poses good quality emulsion system stabilizing the active ingredient as well as appropriate release of medicinal agents.

Short-Form Video Applications Usage and Functionally Dependent Adults' Depressive Symptoms: A Cross-Sectional Study Based on a National Survey.

This study constructed a theoretical model based on the social compensation theory and used it to investigate the effects of short-form video applications usage on depressive symptoms among functionally dependent adults. An empirical analysis was conducted based on a national sample of 8752 adults aged 45+ from China Family Panel Studies (CFPS) wave 2020. This study examined the effects of short-form video applications usage on depressive symptoms in functionally dependent adults by constructing linear regression models. Further, the mediating effect of interpersonal relationship, and the moderating effect of video games were then sequentially analyzed with the help of macro PROCESS4.0 tool. Results showed that: (1) short-form video applications usage significantly reduced the level of depressive symptoms among functionally dependent adults; (2) interpersonal relationship exerted a mediating effect of 10.36% in the process of short-form video applications usage reducing the level of depressive symptoms among functionally dependent adults; (3) video games attenuated the healing effect of short-form video applications usage on the level of depressive symptoms in functionally dependent adults, but not significantly in the functionally dependent adults aged 60+. New electronic media, represented by short-form video applications, have the potential to intervene in the mental health of functionally dependent adults. Social policymakers should consider adopting relevant e-healing measures to enhance the well-being of vulnerable groups.

Radiotherapies, women, and medical meaning-making in 1930s Korea

Purpose: This study investigates the medical application of X-rays and radium in treating female patients in 1930s Korea.Methods: This research analyzes 1930s newspapers, medical journals, and women’s magazines to explore public perceptions of the healing and harmful effects of therapeutic radiation.Results: This study found that women’s bodies served as key sites for introducing new medical knowledge and technologies. Identified primarily as patients, housewives, and consumers, women contributed to normalizing radiation use in public and domestic settings, despite the lack of established safety standards. The transnational flow of medical devices, expertise, and personnel also highlighted both shared and distinct experiences of radiation therapy across national and imperial boundaries.Conclusion: While no direct causality links those varied experiences, comparing cases such as a Korean woman skeptical of radiation for breast cancer, a Japanese housewife who sued over radiation burns, and an American nurse whose expertise with X-rays conflicted with her caregiving role, offer insights into the meaning of modern medicine in colonial Korea.

Honey as a wound dressing on superficial partial-thickness burn injury in a resource-limited setting: An EBCR at Ende General Hospital

This study aimed to compare the efficacy of honey and conventional SSD cream in accelerating burn wound healing, specifically in resource-limited healthcare settings. A comprehensive literature search was conducted using PubMed and Cochrane databases. Following systematic screening of titles and abstracts based on predetermined inclusion and exclusion criteria, six articles were selected for analysis, comprising four systematic reviews, one randomized controlled trial (RCT), and one cross-sectional study. The methodological quality of the selected studies was critically appraised using validated tools from the Centre for Evidence-Based Medicine, University of Oxford. The analysis included six studies: four systematic reviews, one randomized controlled trial (RCT), and one cross-sectional study. six studies: four systematic reviews, one randomized controlled trial (RCT), and one cross-sectional study. Quality assessment indicated that the systematic reviews and cross-sectional study demonstrated robust methodological quality. These high-quality studies consistently reported significant reductions in burn wound healing time when honey dressings were utilized. However, the included RCT failed to report effect measurements, limiting the interpretation and clinical significance of its findings. Honey has a faster healing effect on superficial thickness burns than SSD cream and is affordable. Therefore, honey can be used as an alternative wound dressing in areas with limited facilities.

The Healing Effects of Poetry Reading on Anxiety Disorders: A Study Design Proposal

The Healing Effects of Poetry Reading on Anxiety Disorders: A Study Design Proposal

Healing Effects of Saroglitazar Gel in Thermally Induced Burn in Rats

Healing Effects of Saroglitazar Gel in Thermally Induced Burn in Rats

EFFECT OF FAT GRAFTING ON IMPROVEMENT OF SCAR-AN INTERVENTIONAL STUDY

Background: Scars are inevitable after effect of wound healing, a natural process that restores tissue integrity following injury, burns or surgery. They can be aesthetically displeasing and functionally impairing, depending on their location, size, and depth. Depending on the severity of the injury, scars can be hypertrophic, atrophic, or keloid. These variations can lead to pain, itching, contractures (limited movement), and psychological distress, impacting a patient's quality of life. Objective was to evaluate the efficacy of autologous fat grafting in improving the appearance and quality of scars, with a focus on patients presenting with facial scars due to burns, trauma, surgery or acne at a tertiary care hospital in Karachi, Pakistan. Methods: In this quasi-experimental study, 30 patients of age 18 years to 60 years, irrespective of gender having facial scar because of burn, trauma, surgery or acne were included in the study. A comprehensive scar assessment was performed using the Patient and Observer Scar Assessment Scale (POSAS) before treatment, and follow-up evaluations were conducted on the seventh day, at three months, and at six months post-fat grafting. Fat grafting was executed using a tumescent technique based on Klein's formula, with the aspirated fat injected into the subdermal plane of the scar. Data analysis was performed using SPSS version 23. Results: The patient cohort had a mean age of 26.77 years, with a predominance of female participants (73.3%). Trauma was the most common cause of scars (50%), with the forehead being the most frequent location (36.67%). Significant improvements in scar quality were observed, with both patient and observer POSAS scores showing notable reductions from baseline to 6 months (p<0.05). All patients (100%) demonstrated an improvement in scar appearance. Conclusion: Fat grafting presents a promising treatment for improving the appearance and quality of facial scars.