Cavitation inception originates from nuclei in a liquid. This paper proposes a Gibbs free energy approach that provides a smooth transition from homogeneous to heterogeneous nucleation when gas is present. The impact of gas content on nucleation is explored. It is found that the gas content stabilises nuclei, a phenomenon not present in pure liquid–vapour systems. This reduces the energy barrier over that required to nucleate a vapour bubble. Different gas saturation levels are studied. Gas content can significantly reduce the energy barrier required for nucleation, and under certain circumstances eliminate it. An analytic solution for the critical radius and activation energy is obtained that accounts for gas content. The classical Blake radius is recovered as a limiting case. The hysteresis between incipience and desinence is explained using the asymmetry observed in the critical radii. The solution is used to obtain the initial bubble radius, given a critical pressure condition in cavitation susceptibility meter experiments. The relationship between initial bubble diameter and critical pressure is described by an analytic solution that accounts for gas content. A model for the derivative of the cumulative nuclei histogram with respect to bubble diameter is proposed. An analytic expression is obtained that shows good agreement with decades worth of experimental data compiled by Khoo et al. (Exp. Fluids, vol. 61, issue 2, 2020, pp. 1–20) from ocean to water tunnels. The expression recovers the $-4$ power law that is observed experimentally.
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