Proliposome are phospholipid-based vesicular drug delivery systems that have specialized applications in drug delivery via various routes of administration. They are widely researched as potential carriers for improving bioavailability through oral administration of drugs with low bioavailability and are composed of the drug, phospholipid, and a water-soluble carrier or porous powder. The technology is based on the inherent ability of hydrated membrane lipids to form liposomal vesicles when exposed to water. It is specifically designed for molecular dispersion and delivery of hydrophilic and hydrophobic drugs to achieve good bioavailability, local, systemic effects, and site-specific drug delivery strategies. By utilizing phospholipids and various carriers, these vesicular systems play critical roles in improving bioavailability and solubility. An in-depth understanding of the physical and biological behavior of Proliposome is required for designing an effective delivery system that will increase drug availability at the anticipated site. Proliposome provide an opportunity to improve drug therapeutic action by modifying drug uptake mechanisms. The Proliposome approach was developed as a simple, repeatable, and dependable manufacturing technique for large-scale production of liposome dispersions. The present review discusses the use of Proliposome to improve the oral bioavailability of poorly water-soluble drugs, components for the formulation, effects of excipients, techniques for preparation, evaluation of Proliposome, and other key issues related to various routes of administration. Proliposome formulation is an alternative, novel solution for liposome stability.