Effects Of Curcumin Supplementation Research Articles

Amendment of Altered Immune Response by Curcumin in Drosophila Model of Huntington's Disease.

Though primarily classified as a brain disorder, surplus studies direct Huntington's disease (HD) to be a multi-system disorder affecting various tissues and organs, thus affecting overall physiology of host. Recently, we have reported that neuronal expression of mutant huntingtin induces immune dysregulation in Drosophila and may pose chronic threat to challenged individuals. Therefore, we tested the polyphenolic compound curcumin to circumvent the impact of immune dysregulation in Drosophila model of HD. The present study examined the molecular basis underlying immune derangements and immunomodulatory potential of curcumin in HD. UAS-GAL4 system was used to imitate the HD symptoms in Drosophila, and the desired female progenies (elav > Httex1pQ25; control and elav > Httex1pQ93; diseased) were cultured on food mixed without and with 10 μM concentration of curcumin since early development. Effect of curcumin supplementation was investigated by monitoring the hemocytes' count and their functional abilities in diseased condition. Reactive oxygen species (ROS) level in cells was assessed by DHE staining and mitochondrial dysfunction was assessed by CMXros red dye. In addition, transcript levels of pro-inflammatory cytokines and anti-microbial peptides were monitored by qRT-PCR. We found that curcumin supplementation commendably reduced higher crystal cell count and phenoloxidase activity in diseased flies. Interestingly, curcumin significantly managed altered plasmatocytes count, improved their phagocytic activity by upregulating the expression of key phagocytic receptors in HD condition. Moreover, substantial alleviation of ROS levels and mitochondria dysfunction was observed in plasmatocytes of diseased flies upon curcumin supplementation. Furthermore, curcumin administration effectively attenuated transcriptional expression of pro-inflammatory cytokines and AMPs in diseased flies. Our results indicate that curcumin efficiently attenuates immune derangements in HD flies and may prove beneficial in alleviating complexities associated with HD.

The effect of curcumin supplementation on circulating adiponectin and leptin concentration in adults: a GRADE-assessed systematic review and meta-analysis of randomised controlled trials.

Curcumin is a phytocompound found in the root of turmeric, a common herbal ingredient in many Asian cuisines. The compound contains anti-inflammatory activity, which is mediated through an upregulation of adiponectin and reduction of leptin. Results of randomised controlled trials (RCT) have shown that the effects of curcumin on adipokines are conflicting. Therefore, the current systematic review and meta-analysis of RCT were conducted with the aim of elucidating the role of curcumin supplementation on serum adiponectin and leptin. The search included PubMed, Embase, Cochrane Library, Scopus, Web of Science and Google Scholar from inception to August 2023. For net changes in adipokines, standardised mean differences (SMD) were calculated using random effects models. Thirteen RCT with fourteen treatment arms were eligible for inclusion in this meta-analysis. Curcumin supplementation was effective in increasing serum adiponectin (SMD = 0·86, 95 % CI (0·33, 1·39), P < 0·001; I2 = 93·1 %, P < 0·001) and reducing serum leptin (SMD = -1·42, 95 % CI (-2·29, -0·54), P < 0·001; I2 = 94·7 %, P < 0·001). In conclusion, curcumin supplementation significantly increased circulating adiponectin and decreased leptin levels in adults.

Effects of Curcumin Supplementation on Inflammation and Metabolic Profiles in Hemodialysis Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Effects of Curcumin Supplementation on Inflammation and Metabolic Profiles in Hemodialysis Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Effects of curcumin on blood pressure: A systematic review and dose-response meta-analysis

AimsThis systematic review and dose-response meta-analysis were conducted to summarize data from available clinical trials on the effects of curcumin supplementation on systolic BP (SBP) and diastolic BP (DBP). Data synthesisUsing related keywords, multiple databases, including the Web of Sciences, Scopus, Embase, PubMed, Cochrane Library, and Google Scholar, were searched until November 2022. We chose the studies that examined the effects of curcumin on systolic blood pressure (SBP) and diastolic blood pressure (DBP). Seventeen eligible studies with a total sample size of 1377 participants were included in the meta-analysis. The findings of the meta-analysis did not indicate any significant effect of curcumin on SBP (WMD = −0.06 mmHg, 95% CI: −0.62, 0.50, p = 0.85; I2 = 44.2%) and DBP (WMD = −0.18 mmHg, 95% CI: −1.17, 0.82, p = 0.62; I2 = 77.2%). Moreover, in our dose-response analysis, we found that the dose and duration of curcumin supplementation were non-significantly associated with the reduction of SBP and DBP. However, subgroup analysis revealed a significant reduction only in DBP levels (WMD: −0.76 mmHg, 95% CI: −1.46,−0.05; P = 0.03) but not in SBP in studies with ≥12-week supplementation. Also, a significant reduction in SBP (WMD: −1.55 mmHg, 95% CI: −2.85, −0.25; P = 0.01) and DBP (WMD: −1.73 mmHg, 95% CI: 2.67, −0.79; P < 0.01) was noticed by curcumin supplementation in studies performed on women. ConclusionsThe current study suggests that consuming curcumin may improve DBP when administered for long durations ≥12 weeks. However, more trials are required to confirm these findings.

The effect of curcumin supplementation on functional strength outcomes and markers of exercise-induced muscle damage: A systematic review and meta-analysis.

Background: Curcumin is a polyphenol derived from the Curcuma longa L (turmeric) plant and has gained attention through its perceived anti-inflammatory characteristics. The potential interaction with exercise-induced muscle damage (EIMD) and delayed onset muscle soreness (DOMS) has led to investigation of curcumin as a post-exercise strategy that may have the potential to lessen acute reductions in functional strength (FS) following physical activity. Aim: The purpose of this review is to assess the evidence examining curcumin in relation to four outcome measures: FS, EIMD, DOMS and inflammation. Methods: A Medline, SPORTDiscus and CINAHL database search was undertaken with no publication date limit. Sixteen papers met the inclusion criteria and were included in this review. Three meta-analyses were completed for EIMD, DOMS and inflammation, respectively, with FS being excluded due to limited research. Results: Effect sizes were as follows: EIMD (0.15, -0.12, -0.04, -0.2 and -0.61 corresponding to 0, 24, 48, 72 and 96 h post-exercise, respectively), DOMS (-0.64, -0.33, 0.06, -0.53 and -1.16 corresponding to 0, 24, 48, 72 and 96 h post-exercise, respectively) and inflammation (-0.10, 0.26, 0.15 and 0.26 corresponding to 0, 24, 48 and 72 h post-exercise, respectively). A 96 h post-exercise inflammation meta-analysis was not conducted due to limited data. Conclusion: No effect sizes were statistically significant for EIMD (p = 0.644, 0.739, 0.893, 0.601 and 0.134), DOMS (p = 0.054, 0.092, 0.908, 0.119 and 0.074) and inflammation (p = 0.729, 0.603, 0.611 and 0.396). Further research is needed to thoroughly examine whether an effect exists.

Effect of curcumin supplementation on inflammatory status and muscle damage in competitive female soccer players: a placebo-controlled, singleblind, nonrandomized, crossover pilot study.

Curcumin, a major component of turmeric, has anti-inflammatory and antioxidative properties, which are associated with protective effects against muscle damage. This study examined the effects of dietary curcumin on inflammation and muscle damage in female competitive soccer players. A single-blinded, placebo-controlled, nonrandomized, crossover pilot study was conducted. Six competitive female soccer players (20.0 ± 2.0 yearsold) who participated in a 2-week preseason training program were assigned to two conditions: placebo and curcumin. The participants ingested a placebo or curcumin dosage (270 mg/day) during 2 weeks of preseason training, with 1 week of washout. Fasting blood samples were collected under resting conditions before (day 0) and after (day 15) the training period to examine changes in the concentration of interleukin 6 (IL-6), an inflammatory marker, and indices reflective of muscle damage. Curcumin decreased the concentration of IL-6 released (mean decrease, -30.2 ± 28.1%), whereas no decrease was observed in the placebo condition (13.4 ± 17.4%). Changes in plasma IL-6 concentrations were significantly greater in the curcumin condition than in the placebo condition (p &lt; 0.05). However, curcumin supplementation had no significant effects on muscle damage indices. The present study shows that curcumin supplementation could attenuate inflammation, as indicated by IL-6 concentrations, in competitive female soccer players during the training period.

Investigation of Oxidative/Antioxidant Effects of Turmeric (Curcuma longa L.) Supplementation on Heart Tissue in Adult Rats

n present study, the effects of curcumin supplementation on oxidative stress and antioxidant defense system in heart tissue in adult rats were investigated. Sixteen rats (8-weeks-old) were selected and divided into two groups. The first group is the experimental group and these rats (n=8) were gavaged with curcumin, dissolved in corn oil, at a dose of 300 mg/kg per day for 28 days. The second group is the control group, rats in this group were given curcumin and equal amount of corn oil to eliminate the porter effect. Euthanasia was performed and total antioxidant capacity (TAS), total oxidant capacity (TOS), malondialdehyde (MDA) and glutathione (GSH) levels were analyzed from heart tissues. Curcumin supplementation resulted in significantly increased GSH levels(P0.05). The total antioxidant capacity (TAS) and total oxidant capacity (TOS) ratios were found to be statistically significant. In the other group supplemented with curcumin, MDA levels tended to decrease compared to the control group, and there was no statistically significant difference between the two groups. Curcumin supplementation protects the heart tissue against oxidative damage and strengthens the antioxidant defense system in adult rats.

Effects of curcumin supplementation on insomnia and daytime sleepiness in young women with premenstrual syndrome and dysmenorrhea: Arandomized clinical trial.

Premenstrual syndrome and primary dysmenorrhea are common gynecological complaints that are associated with psychological disorders. There is increasing evidence for the neuroprotective properties of curcumin, a polyphenolic natural product. This study aimed to assess the effects of curcumin on sleep complications in women with premenstrual syndrome and dysmenorrhea. This triple-masked, placebo-controlled clinical trial comprised 124 patients with both premenstrual syndrome and dysmenorrhea. Participants were randomly assigned to curcumin (n=57) or control (n=60) groups. Each participant received one capsule containing either 500 mg of curcumin plus piperine or placebo, daily, from 7 days before until 3 days after menstruation for three consecutive menstrual cycles. Insomnia and sleepiness were assessed using standard questionnaires. Scores for insomnia and daytime sleepiness were directly correlated with the Premenstrual Syndrome Screening Tool (PSST) score (p<0.05), but not with the visual analogue scale (VAS) score at baseline (p>0.05). There was a non-significant reduction in insomnia and sleepiness scores in both curcumin and placebo groups after the study intervention. Whilst, improvement rate of insomnia status, daytime sleepiness severity, short sleep duration and difficult sleep initiation was not statistically significant between the curcumin and placebo groups. Curcumin does not significantly affect sleep disorders in young women with premenstrual syndrome and dysmenorrhea.

Blood monitoring in the English Premier League: Effect of curcumin supplementation on blood biomarkers of recovery

Blood monitoring in the English Premier League: Effect of curcumin supplementation on blood biomarkers of recovery

The effect of curcumin supplementation on renal function: A systematic and meta-analysis of randomized controlled trials

The effect of curcumin supplementation on renal function: A systematic and meta-analysis of randomized controlled trials

The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A protocol for systematic review and meta-analysis.

Type 2 diabetes mellitus (T2DM) is an ensemble of metabolic diseases that has reached pandemic dimensions all over the world. There is a lack of evidence on the contribution of curcumin in the treatment of T2DM. We conducted a protocol for systematic review and meta-analysis to evaluate whether curcumin supplementation is effective and safe in T2DM patients. The systematic review will follow the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols (PRISMA-P). We will obtain studies through PubMed, Cochrane Library, Embase, Web of Science, and Medline databases. In addition, we will also collect 4 databases of China: China National Knowledge Infrastructure, China Biomedical Literature Database, China Science Journal Database, and Wan-fang Database. Eligible study conference abstracts and reference lists of manuscripts will be searched. The data collection and analysis will be conducted independently by 2 reviewers. Meta-analysis will be performed using Review Manager software, version 5.3 (Update Software Ltd, Oxford, Oxon, UK). The results of this systematic review and meta-analysis will be published in a peer-reviewed journal. The findings of this systematic review may encourage supplementation of curcumin and its preparation specifically in T2DM patients. Nevertheless, the application of curcumin supplementation in clinical practice should be taken with individual's contributing factors.

Effects of Curcumin Supplementation on mRNA Expression of NLRP3 Inflammasome, IL-1β, and NF-κB in Hemodialysis Patients

Effects of Curcumin Supplementation on mRNA Expression of NLRP3 Inflammasome, IL-1β, and NF-κB in Hemodialysis Patients

The Effects of Curcumin Supplementation on Metabolic Biomarkers and Body Mass Index in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Curcumin is one of the most commonly used indigenous molecules endowed with various shielding functionalities that protect the liver. In the present research, we aimed to investigate the effects of curcumin on metabolic factors and body mass index (BMI) in patients with non-alcoholic fatty liver disease (NAFLD) using a meta-analysis of randomized, controlled trials. Online databases PubMed, Embase, Web of Science, and Science Direct were searched until April 2021 to identify eligible articles. Fourteen trials were included. The results showed that curcumin consumption can significantly reduce AST (-0.35, (-0.57 to -0.14)), total cholesterol (-0.81, (-1.34 to -0.27)), TG (-0.49, (-0.71 to -0.27)), and FBS (-0.28, (-0.46 to -0.09)) in patients with NAFLD. However, the improvements in ALT (-0.29, (-0.58 to 0.00)), LDL (-0.48, (-0.97 to 0.01)), HDL (0.03, (-0.38 to 0.44)), and BMI (-0.13, (-0.29 to 0.02)) were not statistically significant. Furthermore, the findings revealed that the optimal dose and duration of curcumin consumption for patients with NAFLD is <500 mg/d for less than 10 weeks. The present study suggests that consuming curcumin can improve liver enzymes, lipid profile, FBS, and BMI in patients with NAFLD. Moreover, curcumin supplementation may provide beneficial effects on metabolic biomarkers and body weight if used at the appropriate dose and duration. Further RCTs are required to confirm our findings.

Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study

BackgroundVitamin D has an established role in female reproduction. There is also evidence for an association between vitamin D levels and menstrual problems such as premenstrual syndrome (PMS) and dysmenorrhea. Curcumin, is a bioactive polyphenol constituent of turmeric, that can potentially interact with vitamin D receptors and its molecular targets. This study evaluated the effects of curcumin on vitamin D levels in young women with PMS and dysmenorrhea.MethodsIn this randomized, triple-blind, placebo-controlled trial, women with PMS and dysmenorrhea were divided randomly into experimental and control groups to receive one capsule (500 mg of curcuminoid+ 5 mg piperine, or placebo) daily, from approximately 7 days before until 3 days after menstruation for three consecutive menstrual cycles. Serum vitamin D levels, renal function, and liver enzymes were also measured before and after intervention.ResultsA total of 76 subjects (38 in each group) were recruited into the trial. Curcumin significantly increased the median (IQR) serum levels of vitamin D [from 12.8 ng/ml (7.0–24.6) to 16.2 ng/ml (6.4–28.8); P = 0.045], compared with placebo [from 18.6 ng/ml (2.2–26.8) to 21.3 ng/ml (5.2–27.1); P = 0.17]. Serum levels of aspartate aminotransferase and direct bilirubin were reduced by the end of trial in the curcumin group (p < 0.05), but did not change significantly in the control group (p > 0.05). Finally, no significant differences in levels of fasting blood glucose were detected between curcumin and placebo groups.ConclusionCurcumin supplementation in women with PMS and dysmenorrhea led to a significant improvement of vitamin D, liver function enzyme test, but did not affect blood glucose.Trial registrationThe trial was registered on Iranian Registry of Clinical Trials registry (Trial ID: IRCT20191112045424N1 on 23 January 2020; available at https://www.irct.ir).

Effect of curcumin supplementation on muscle damage, antioxidant status and inflammatory factors after successive simulated taekwondo competitions

High intensity exercise causes muscle damage, oxidative stress and inflammation. The purpose of this study was to investigate the effect of Curcumin supplementation on muscle damage, antioxidant status and inflammatory factors after successive simulated taekwondo competitions. Eighteen healthy taekwondo men with mean age of 22.27 (0.94) years and Taekwondo experience of 6.47 (1.79) years were recruited based on the inclusion and exclusion criteria and randomly divided into two groups: Curcumin (4 g/day) and placebo (rice flour) groups. Subjects were supplemented 3 days before up to 2 days after the taekwondo competition. Creatine kinase (CK), lactate dehydrogenase (LDH), total antioxidant capacity (TAC), Malondialdehyde (MDA) and IL-6 were measured before the start of the supplementation (Baseline), before the start of the taekwondo competition (Pre), immediately (t 0 ), 24 h (t 1 ) and 48 h (t 2 ) after the competition. Comparisons were performed by repeated measures ANOVA and P˂ 0.05 was considered as significant. CK, LDH and MDA increased significantly after the competition in placebo group compared to Curcumin supplemented group ( P < 0.05). TAC significantly increased in Curcumin supplemented compared to placebo group after the competition ( P < 0.05). No between group differences were observed in serum levels of IL-6 after the competition ( P > 0.05). The effect of time on CK, LDH, TAC, MDA and IL-6 changes was significant ( P < 0.05). Also, the changes of the variables (Ck, LDH, TAC and MDA) in all of the times were significant between groups ( P < 0.05). Based on the results of this study, Curcumin supplementation has positive effects on reducing muscle damage and oxidative stress. Further larger scale trials are needed to confirm these findings. Les exercices de haute intensité provoquent des lésions musculaires, un stress oxydatif et une inflammation. Le but de cette étude était d’examiner l’effet de la supplémentation en curcuma sur les lésions musculaires, le statut antioxydant et les facteurs inflammatoires après la succession des compétitions simulées de taekwondo. Dix-huit hommes spécialistes en taekwondo en bonne santé avec un âge moyen de 22,27 (0,94) ans et une expérience du taekwondo de 6,47 (1,79) ans ont été recrutés sur la base des critères d’inclusion et d’exclusion et répartis au hasard en deux groupes : un groupe curcuma (4 g/jour et un autre placebo (farine de riz). Les sujets ont été supplémentés pendant 5 jours au total (3 jours avant et 2 jours après la compétition de taekwondo. La créatine kinase (CK), la lactate déshydrogénase (LDH), la capacité antioxydante totale (TAC), le malondialdéhyde (MDA) et l’IL-6 ont été mesurés avant le début de la supplémentation (Baseline), avant le début de la compétition de taekwondo (Pré), immédiatement (t0), 24 h (t1) et 48 h (t2) après la compétition. CK, LDH et MDA ont augmenté de manière significative après la compétition dans le groupe placebo par rapport au groupe supplémenté en curcuma ( p < 0,05). Le TAC a augmenté de manière significative chez le groupe supplémenté par rapport au groupe placebo après la compétition ( p < 0,05). Aucune différence entre les groupes n’a été observée dans les taux sériques d’IL-6 après la compétition ( p > 0,05). L’effet du temps sur les changements de CK, LDH, TAC, MDA et IL-6 était significatif ( p < 0,05). En outre, les changements des variables (Ck, LDH, TAC et MDA) dans tous les temps étaient significatifs entre les groupes ( p < 0,05). Sur la base des résultats de cette étude, la supplémentation en curcuma a des effets positifs sur la réduction des dommages musculaires et du stress oxydatif chez les athlètes spécialistes en taekwondo. D’autres essais à plus grande échelle sont nécessaires pour confirmer ces résultats.

Nutritional Enrichment with Curcumin during Perinatal period Alleviates Metabolic Disorders in The Adult Life

Background: The `fetal origins' hypothesis proposes that alterations in fetal nutrition result in a permanent change in physiology and metabolism, thereby predisposing to metabolic disorders in adult life. Turmeric (Curcuma longa L.), the wonder queen of Indian spice and a nutraceutical was extensively used in Ayurveda, Unani, and Siddha for various diseases. Having multiple benefits of Curcumin, we hypothesized that, rats suffered undernutrition during their perinatal period would develop metabolic disorders in their adult life, which would be effectively modulated by Curcumin. Therefore, the present study was designed to investigate the effect of Curcumin supplementation during perinatal life. Methods: It is an experimental study conducted using a rat model. The animals were divided into six groups. The insulin level was estimated by the enzyme-linked immunosorbent assay (ELISA) method. Plasma glucose and lipid profile by autoanalyzer method. HOMA-IR and AI were calculated. The difference was compared between the groups and within the group was done by one-way ANOVA. The p &lt; 0.05 was considered as the level of significance. Results: The Bodyweight mean Triglyceride, Total cholesterol, LDL-C, Glucose, AI, and HOMA-IR was significantly increased (p=0.0001) in the Perun group, whereas HDL-C and Insulin were significantly decreased (p=0.001) as compared to control animals, which was effectively modulated by Curcumin in the animals of PeriCur group. Conclusion: The present study showed that perinatal undernutrition caused metabolic disorders in adult life and was effectively modulated by Curcumin supplementation during the perinatal period.

Ten Days of Curcumin Supplementation Attenuates Subjective Soreness and Maintains Muscular Power Following Plyometric Exercise

Curcumin has become a popular product used to decrease inflammation and enhance recovery from exercise. Purpose: To determine the effects of curcumin supplementation on delayed onset muscle soreness and muscle power following plyometric exercise. Methods: Participants (n = 22; five females, 17 males) consumed either curcumin (500 mg) or placebo twice daily for 10 days (6 days pre, day of and 3 days post exercise). Participants completed 5 x 20 drop jumps on day 7. Blood sampling and recovery tests were assessed at pre-supplementation, 24-hours and immediately pre-exercise, and immediately post-, 24, 48 and 72-hours post-exercise. Blood markers included serum creatine kinase (CK) and erythrocyte sedimentation rate (ESR), while soreness was measured during a squat and post vertical jump. Results: Both groups experienced muscle damage post-exercise with elevated CK (403 ± 390 ul; p < 0.01), soreness with squatting (38 ± 29 mm; p < 0.01), and vertical jump (36 ± 30 mm; p < 0.01). Soreness was greater in placebo vs. curcumin 48 h and 72 h post-exercise (p < 0.01); however, CK was not significantly different between groups (p = 0.28) despite being >200 IU·L −1 greater 24 hr post exercise in placebo vs. curcumin. ESR was significantly greater immediately post-exercise (6.3 ± 5.6 vs. 3.4 ± 2.6 mm/hr; p = 0.03), however these were within the normal range for this test and not significantly different between groups (p = 0.25). Vertical jump decreased over time in the placebo, but not curcumin group (19.8 ± 4.8 vs. 21.4 ± 3.2 in; p = 0.01). Conclusion: These data suggest curcumin reduces soreness and maintains muscular power following plyometric exercise.

Curcumin supplementation in the treatment of patients with cancer: a systematic review

Feeding with high levels of phytochemicals, including curcumin, may be a therapeutic option for diseases such as cancer which is a public health problem. The aim of this study was to systematically review the results of clinical trials investigating the effect of oral curcumin supplementation on anti-inflammatory and antioxidant profiles, reduction of PSA levels and degree of dermatitis in radiotherapy treatment in cancer patients. The review was carried out based on the items of the PRISMA Statement. A bias risk assessment was performed according to Cochrane Collaboration criteria. Six studies met the eligibility criteria and were included in the systematic review. The results of this study are based on those obtained in the literature on the effect of curcumin on the anti-inflammatory profile, on reducing dermatitis, on PSA alteration and on anti-oxidant profile for a total of 450 individuals, comprising 259 in the intervention group and 191 in the control group. Some studies have reported improvement in biochemical and clinical indicators, with limited adverse effects and good tolerance. It was not possible to determine, with the desired degree of evidence, the effect of curcumin supplementation in the treatment of cancer patients. It is important to consider the great heterogeneity and methodological weaknesses of the studies, and that it was not possible to perform a meta-analysis of the data available in the literature.

The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.

Cardiovascular disease is a leading cause of death in many societies. Arterial stiffness is an initial sign of structural and functional changes in the arterial wall. Pulse wave velocity (PWV) is the gold standard for non-invasive evaluation of aortic stiffness and a modifiable cardiovascular risk factor. Curcumin is a major component of turmeric with known anti-inflammatory and anti-oxidative effects. Since arterial stiffness is affected by inflammation and oxidative stress, it may be improved by curcumin supplementation. The purpose of this clinical trial was to investigate the potential effects of curcumin on improving arterial stiffness in patients with metabolic syndrome. This placebo-controlled, double-blind, randomized clinical trial was conducted among metabolic syndrome patients. Sixty-six eligible individuals were randomly assigned to active intervention or control groups. The active intervention group received curcumin supplement at a dose of 500 mg daily for 12weeks, whereas the control group received placebo capsule. Physical activity, daily dietary energy intake, anthropometric body composition, and biochemical hemodynamic and arterial stiffness parameters were evaluated at baseline and at the end of the study. Body weight decreased significantly in the curcumin group compared to placebo. Also, curcumin intervention improved PWV, which remained significant after adjustment for potential confounding factors (p=0.011). The current clinical trial demonstrated that daily intake of 500 mg of curcumin for 12weeks can lead to the improvement of arterial stiffness and weight management among subjects with metabolic syndrome.

Protective effects of curcumin on laying hens fed soybean meal with heat-induced protein oxidation

This study was performed to investigate the effects of curcumin supplementation on intestinal barrier function, serum biochemical index, amino acid profile, and mRNA expression of nutrient transporters in laying hens fed soybean meal with heat-induced protein oxidation. A total of 288 40-week-old Hy-Line Brown laying hens were allocated into one of three treatments with eight replicates of twelve birds each for a 42-day feeding trial. The birds were fed a soybean meal-corn basal diet and a heated soybean meal (HSBM)-corn basal diet supplemented with or without 150 mg/kg curcumin. HSBM increased circulating diamine oxidase activity and D-lactate levels, and curcumin reduced D-lactate concentrations in birds fed HSBM (p < .05). Birds fed HSBM exhibited a decreased mRNA abundance of occludin and claudin 3 in the intestinal mucosa, and downregulation of claudin 3 expression was reversed by curcumin (p < .05). HSBM decreased total protein and albumin levels in the serum, both of these levels being increased with curcumin (p < .05). The administration of curcumin reversed HSBM-induced downregulation of amino acid concentrations in the serum, liver and yolk to control levels (p < .05). Moreover, HSBM decreased mRNA expression levels of amino acid transporters, glucose transporters, and peptide transporters in the intestinal mucosa, and curcumin almost completely reversed these effects, restoring expression levels of these genes to the control values (p < .05). The results of this study indicate that curcumin administration can alleviate the intestinal barrier injury and compromised nutrient absorption induced by HSBM in laying hens. HIGHLIGHTS Protein oxidation of heated soybean meal (HSBM) impaired the intestinal barrier function of laying hens. Curcumin treatment attenuated the intestinal barrier injury induced by HSBM. Curcumin treatment improved the reduced nutrient absorption and transport of hens fed HSBM.