Effect Of Antioxidant Supplementation Research Articles

Effects of vitamin C, vitamin E, selenium, zinc, or their nanoparticles on camel epididymal spermatozoa stored at 4°C.

This study determined the effects of antioxidant supplementation and storage time at cool temperatures on the characteristics of epididymal camel spermatozoa. Camel testes were collected at the abattoir after animal slaughtering and kept at 4°C during transportation and until processing (max 6h). Spermatozoa were retrieved and diluted with SHOTOR extender, split in aliquots, supplemented with the following antioxidants: 200μm/mL vitamin E, 1.0g/L vitamin C, 1μg/mL selenium nanoparticles, 50μg/mL zinc nanoparticles, 2μg/mL sodium selenite, and 100μg/mL zinc sulfate, and stored at 4°C for 2, 48, 96, and 144h. The storage time significantly affected (P < 0.05) the sperms' motility and livability, the sperms' membrane integrity, and the percentages of cytoplasmic droplets as well as the percentage of morphologically normal spermatozoa. Epididymal sperm characteristics (progressive motility, livability, membrane integrity, and abnormalities) were significantly improved (P < 0.05) when the spermatozoa were diluted with antioxidants as compared with the control group, and the best additives were identified as nano-selenium, sodium selenite, nano-zinc, and zinc sulfate. In conclusion, adding nano-sized minerals or inorganic trace elements and vitamins maintained the progressive motility, livability, and membrane integrity, and decreased abnormalities and cytoplasmic droplet percentages of epididymal camel spermatozoa stored at 4°C up to 144h.

Effects of antioxidant supplementation on oxidative stress balance in young footballers- a randomized double-blind trial

BackgroundIntensive physical exercise that competitive sports athletes participate in can negatively affect their pro-oxidative–antioxidant balance. Compounds with high antioxidant potential, such as those present in chokeberry (Aronia melanocarpa), can prevent these adverse changes. We here investigated the effect of antioxidant supplementation on oxidative stress balance in young footballers.MethodsThe study was designed as a double-blind randomized trial. Diet of a group of young football players (male; n = 20; mean age, 15.8 years-old) was supplemented with 200 ml of chokeberry juice per day, for 7 weeks. The players were randomly assigned to the experimental (supplemented, FP-S; n = 12) and control (placebo, FB-C; n = 8) groups. Before and after the supplementation period, the participants performed a beep test. Venous blood was sampled for serum analysis before, immediately after, 3 h, and 24 h after the beep test. Serum levels of thiobarbituric acid reactive products, 8-hydroxy-2′-deoxyguanosine, total antioxidant capacity, iron, hepcidin, ferritin, myoglobin, and albumin, and morphological blood parameters (red blood cells, (RBC), haemoglobin (HGB), haematocrit (HCT) mean corpuscular volume (MCV) mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), and lactic acid) were determined.ResultsChokeberry juice supplementation did not significantly affect the outcome of the beep test. The supplementation did not significantly affect any of the morphological, biochemical, or performance parameters analysed.ConclusionsChokeberry juice supplementation did not affect the measured parameters in the studied population, which may indicate insufficient antioxidant capacity of the juice.

Effect of antioxidant supplementation on skeletal muscle and metabolic profile in aging mice.

Aging induces drastic changes in muscle mass and function (sarcopenia); however, the detailed mechanisms underlying sarcopenia remain poorly understood. Recent studies suggested that age-related increases in oxidative stress induce muscle atrophy. In this study, we investigated the effect of 6-month supplementation of antioxidants, specifically piceatannol (PIC) and enzymatically modified isoquercitrin (EMIQ), on age-related physiological changes, including skeletal muscle weight and quality, in 25-month-old (OLD) mice, compared to in 4-month-old (young, YNG) C57BL/6J mice. Muscle weight corrected by body weight significantly declined in OLD mice, compared to in YNG mice. The control OLD mice also showed changes in the expression of genes related to muscle fiber type, reduced locomotor activity, and increased oxidative stress markers in blood. Consistent with the muscle weight and quality changes, whole-body fat oxidation during sedentary conditions and exercise periods in control OLD mice was significantly lower than that in YNG mice. Interestingly, compared to the control OLD mice, the PIC- or EMIQ-fed OLD mice showed higher fat oxidation. Furthermore, EMIQ, but not PIC, increased locomotor activity, the expression of genes encoding antioxidant enzymes, and suppressed the carbonylated protein in the skeletal muscle of OLD mice. These results suggested that chronic antioxidant intake could alleviate aging-related muscle function changes.

Effect of antioxidant supplements on testicular histo-morphology in adult male guinea pigs (Cavia porcellus)

The study was carried out to evaluate the biopotency of antioxidant supplements on physiological, testicular and oxidative biomarkers in adult male guinea pigs (Cavia porcellus). A total of 60 adult male guinea pigs of three months of age with an average body weight of 500±20g were randomly allocated into three dietary treatment groups of vitamin C, vitamin E and selenium and each comprised four varying levels with five animals per group in a completely randomized design (CRD). Feed and water were provided ad-libitum. The testicular morphology showed a significant (P&lt;0.05) difference in weight of right testis, weight of left testis, paired testis weight, right testis width, testis volume, testis density, right testis length and left testis length of guinea pig supplemented varying dosage of vitamin C, E and Selenium. microphotograph indicated considerable changes in seminiferous tubules density, size, and other morphological characteristics, also intertubular space, basement membrane, leydigs cells and spermatogonia of the guinea pigs supplemented varying dosage of vitamin C, E and Selenium revealed considerable changes. The supplementation of adult male guinea pigs diets with 200 mg vitamin C had the highest values of testicular morphometric followed by 15 mg vitamin E group and 0.3 mg of selenium. Similarly, considerable histo-architectural changes in seminiferous tubules and interstitial cells size and shape occurred in guinea pigs supplemented 200, 15 and 0.3 mg per kg diet vitamin C, E and selenium respectively. Therefore, supplementation of vitamin C, E and Selenium has a profound effect on testicular histo-morphology of adult male guinea pigs. L'étude a été réalisée pour évaluer la biopotence des suppléments antioxydants sur les biomarqueurs physiologiques, testiculaires et oxydatifs chez les cobayes mâles adultes (Caviaporcellus). Un total de 60 cobayes mâles adultes de trois mois avec un poids corporel moyen de 500 ± 20 g ont été répartis au hasard dans trois groupes de traitement diététique de vitamine C, vitamine E et sélénium et chacun comprenait quatre niveaux variables avec cinq animaux par groupe en une conception complètement aléatoire. L'alimentation et l'eau étaient fournies ad libitum. La morphologie testiculaire a montré une différence significative (P &lt;0.05) du poids du testicule droit, du poids du testicule gauche, du poids du testicule apparié, de la largeur du testicule droit, du volume du testicule, de la densité du testicule, de la longueur du testicule droit et de la longueur du testicule gauche du cobaye supplémenté en doses variables de vitamine C, E et sélénium. La microphotographie a indiqué des changements considérables dans la densité, la taille et d'autres caractéristiques morphologiques des tubules séminifères, ainsi que l'espace intertubulaire, la membrane basale, les cellules de 'leydigs' et la spermatogonie des cobayes complétés par des doses variables de vitamine C, E et de sélénium ont révélé des changements considérables. La supplémentation des régimes alimentaires de cobayes mâles adultes avec 200 mg de vitamine C avait les valeurs les plus élevées de morphométrie testiculaire suivie par 15 mg de groupe de vitamine E et 0.3 mg de sélénium. De même, des changements histoarchitecturaux considérables de la taille et de la forme des tubules séminifères et des cellules interstitielles se sont produits chez les cobayes ayant reçu respectivement 200, 15 et 0.3 mg par kg de vitamine C, E et de sélénium. Par conséquent, la supplémentation en vitamine C, E et en sélénium a un effet profond sur l'histomorphologie testiculaire des cobayes males adultes.

Epidermal carotenoid levels in vivo of patients with plaque psoriasis: Effects of narrow-band UVB phototherapy.

Psoriasis is a systemic inflammatory disease characterized by hindered antioxidant defense and increased formation of free radicals. There are limited data on the skin carotenoids in psoriatic skin as well as their modulation during narrow-band UVB (NB-UVB) phototherapy of the disease. The aim of this prospective study is to reveal the skin carotenoids levels during NB-UVB phototherapy of psoriasis in humans. Twenty Caucasian subjects with mild-to-moderate plaque psoriasis (15m; 5f) were enrolled in the study, and nine gender- and age-matched healthy volunteers were recruited for controls of oxidative stress measurements. All psoriasis patients underwent 10 sessions of NB-UVB phototherapy. Measurements were taken at baseline and after 10 sessions of NB-UVB phototherapy. The assessment of carotenoid levels in the skin in vivo was performed by a non-invasive, reflectance spectroscopy-based device. Psoriasis severity was assessed by psoriasis area and severity index (PASI). The dermatology life quality index (DLQI) was evaluated in psoriatic patients. Baseline carotenoid levels were significantly lower in psoriasis patients in comparison to healthy controls. NB-UVB phototherapy insignificantly diminished carotenoid levels in the skin of psoriasis patients, while clinical improvement both in PASI score and DLQI was observed. We showed the levels of skin carotenoids in psoriatic patients are lower than in healthy subjects. NB-UVB did not change significantly skin carotenoid levels. Further studies should elucidate the potential effect of antioxidants supplementation during NB-UVB of psoriasis.

A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation.

Excessive release of inflammatory cytokines and oxidative stress (OS) are triggering factors in the onset of chronic diseases. One of the factors that can ensure health in humans is regular physical activity. This type of activity can enhance immune function and dramatically prevent the spread of the cytokine response and OS. However, if physical activity is done intensely at irregular intervals, it is not only unhealthy but can also lead to muscle damage, OS, and inflammation. In this review, the response of cytokines and OS to exercise is described. In addition, it is focused predominantly on the role of reactive oxygen and nitrogen species (RONS) generated from muscle metabolism and damage during exercise and on the modulatory effects of antioxidant supplements. Furthermore, the influence of factors such as age, sex, and type of exercise protocol (volume, duration, and intensity of training) is analyzed. The effect of antioxidant supplements on improving OS and inflammatory cytokines is somewhat ambiguous. More research is needed to understand this issue, considering in greater detail factors such as level of training, health status, age, sex, disease, and type of exercise protocol.

Inactivation of Hydrogen Peroxide by Vitamin A, Vitamin C, Vitamin E, and Other Commercial Items Through Peroxidase-Catalyzed Reaction

Reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), are highly reactive and can inhibit the normal function of cells. Due to the damage ROS can cause, much interest has been generated around the effects of antioxidant supplements, which could potentially prevent or slow down ROS in the body. In this study, a variety of antioxidants were evaluated for their ability to inactivate H2O2 in a peroxidase-catalyzed reaction. Six of the fourteen antioxidants were significantly effective at inactivating H2O2 compared to the control. This study should be used to further understand how antioxidant supplements could be beneficial in the human diet.

Effect of antioxidant supplementation on the polysulfides of white wines

Sulfur chemistry remains one of the most intriguing and elusive fields in wine science. In particular, the possibility for symmetric and asymmetric glutathionylated and cysteinylated polysulfides to act as latent reservoirs for H2S warrants new research on the factors influencing the formation and accumulation of these molecules.The present research studies the impact of pre-fermentative additions of commonly employed antioxidants: glutathione, ascorbic acid, and ellagic tannin. Musts from four different white grape varieties (Riesling, Pinot gris, Pinot blanc, and Johanniter) were analysed using our comprehensive HPLC-HRMS method. Seven symmetric and asymmetric glutathionylated (G) and cysteinylated (C) polysulfides (GS2C, GS3C, GS4C, GS3G, GS4G, CS3C, and CS4C) were detected in the final 48 wine samples. Finally, this work describes for the first time the impact of an accelerated ageing of wine on the polysulfides present. All variables (Must, Treatment, and Time) were shown to impart statistically significant effects (p = 0.0001) in the PERMANOVA model. The PCAs based on polysulfides present in young and aged wine explained more than 80% of the total variance for each grape variety and showed that Asc or GSH additions have tend to produce lower levels of polysulfides in the resultant wines.

Disparate Effect of Antioxidant Supplements on the Basal Tone and Vascular Remodeling of the Aorta in Hypertensive Rats

Background: Oxidative stress plays an essential role in the vascular tone in hypertension; however, the mechanisms remain unclear. Aim: This study aimed to determine the antioxidant effect of tempol and vitamin C (Vit-C) on the basal tone and vascular remodeling of the aorta in nitric oxide (NO) deficiency-induced hypertensive rats. Method: Male Sprague-Dawley rats were induced to hypertension by Nω-nitro-L-arginine methyl ester (L-NAME). Animals were randomized as follows: vehicle (Control: CR), CR-tempol, CR-Vit-C, L-NAME, L-NAME-tempol, and L-NAME-Vit-C. After 6 weeks of treatment, the basal aortic tone was evaluated by sodium nitroprusside (SNP) and calcium-free medium. Endothelial function, NO, reduced-to-oxidized glutathione (GSH/GSSG) ratio, resting membrane potential (mP), and vascular remodeling were also measured. Results: L-NAME rats showed an increased basal tone that was blunted by both SNP (−547 ± 69; n = 7 vs. CR: −7.5 ± 6.7 mg; n = 7; p < 0.001) and calcium-free medium. Tempol or Vit-C did not reverse hypertension, and the high basal tone was decreased only with tempol. In L-NAME rats, only tempol partially improved endothelial function, GSH-to-GSSG ratio, mP values, and vascular remodeling. Conclusions: Tempol decreased calcium-dependent basal aortic tone and improved vascular homeostasis in L-NAME rats. Vit-C did not lead to a similar effect, suggesting that alterations in the superoxide dismutase pathway may play a role in the basal aortic tone.

Protective effect of quercetin in combination with caloric restriction against oxidative stress-induced cell death of Saccharomyces cerevisiae cells.

Impairment of antioxidant enzymes activities has been well reported in several human diseases. Effective anti-ageing strategies involving antioxidant supplementation and/or caloric restriction (CR) are receiving a great attention to mitigate free radical-mediated oxidative damage in several disease conditions to improve active longevity. Therefore, in this work, we have evaluated the protective effect of quercetin under non restriction (NR) and CR conditions on the sensitivity of Saccharomyces cerevisiae mutant strains (sod1∆, sod2∆, cta1∆, ctt1∆, tsa1∆ and glr1∆) deficient in antioxidant defence systems (superoxide dismutase, catalase, thioredoxin peroxidase and glutathione reductase) against H2 O2 -induced oxidative stress. Our results demonstrate that quercetin in combination with CR has strongly reduced the H2 O2 -mediated stress in the yeast mutant cells compared to NR conditions. Furthermore, we show that quercetin in combination with CR enhanced the percentage viability of yeast cells during chronological ageing. Our research findings suggest that antioxidant supplementation in combination with CR might have potent beneficial effects than individual therapies against free radical-mediated oxidative stress. SIGNIFICANCE AND IMPACT OF THE STUDY: Oxidative stress results from an imbalance between free radicals and antioxidant defense systems in our body. Supplementation with exogenous antioxidants is necessary to neutralize the free radical mediated damage. Polyphenols are a group of naturally occurring plant compounds with strong free radical-scavenging activity and exhibits potent anti-aging property by mitigating oxidative stress. On the other hand, caloric restriction (CR) has been reported to be a popular leading anti-aging approach to ameliorate age-associate macromolecular damages in various chronic human diseases. Evaluation of protective effects of antioxidant supplementation in combination with CR against free radical mediated oxidative stress is pivotal for the development of novel anti-aging strategies to improve active longevity.

Effects of antioxidant supplementation (nano‑selenium, vitamin C and E) on growth performance, blood biochemistry, immune status and body composition of rainbow trout (Oncorhynchus mykiss) under sub-lethal ammonia exposure

This study aimed to investigate the protective effect of diets supplemented with different combinations of three antioxidants (nano‑selenium (NanoSe), vitamin C and E) on rainbow trout (Oncorhynchus mykiss) under sub-lethal concentration of ammonia exposure. For this goal, triplicate groups of 25 fish/tank (11.89 ± 0.34 g) were subjected to ammonia stress (0.024 mg/L) and fed with three experimental diets as T1 (0.1 mg/kg NanoSe, 100 mg/kg vitamin C and 30 mg/kg vitamin E), T2 (0.2 mg/kg NanoSe, 200 mg vitamin C and 60 mg/kg vitamin E), T3 (0.3 mg/kg NanoSe, 300 mg/kg vitamin C and 90 mg/kg vitamin E) and a basal diet as control, for 40 days. The obtained results showed that the fish fed with T2 and T3 diets had significantly higher final weight, weight gain, specific growth rate, protein efficiency ratio and lipid efficiency ratio, when compared to T1 and the control group. Also, all the supplemented diet treatments showed lower food conversion ratio, compared to the control group. Furthermore, while serum catalase showed meaningful decrease in T3 treatment only, all T1, T2 and T3 groups had decreased superoxide dismutase activity. Similarly, a significant decrease was observed in serum malondialdehyde in fish fed the supplemented diets. In addition, while serum total protein increased in T1 and then decreased in T2 and T3, triglyceride levels increased in T2 and T3 treatments. Furthermore, total immunoglobulin levels, serum lysozyme and albumin significantly increased in T2 and T3.. In terms of body crude protein, crude lipid, crude fiber, dry matter, ash and carbohydrates, we observed no significant changes. Totally, our results suggest that diets supplemented with NanoSe, vitamin C and vitamin E in T2 could increase growth performance, antioxidant capacity and immune responses in juvenile rainbow trout exposed to ammonia stress.

Effect of antioxidant supplements on sperm parameters in infertile male smokers: a single-blinded clinical trial.

IntroductionNaturally, in human body, there is a balance between free radicals and the antioxidant system. Yet, cigarette consumption in smokers increases free radicals and decreases antioxidants. A vast body of research showed that the ROS level of seminal fluid is reduced using oral antioxidant complements through enhancing the clearing capacity of free radicals. Thus, the present research aimed to explore the effect of vitamin complement consumption on changing male infertility indices among smokers.MethodsIn the present randomized clinical trial which was single-blinded, 50 infertile oligospermic and asthenospermic men participated. They were selected in a randomized convenient sampling method. Before the study began, a semen sample was taken from all participants for analysis. Subsequently, the patients received 30 mg of Q10 coenzyme, 8 mg of zinc, 100 mg of vitamin C, 12 mg of vitamin E, 400 mg of folic acid for a whole duration of 3 months on a daily basis (once a day) and 200 mg of selenium every other day after lunch. A second sample of seminal fluid was taken from patients and semen parameters were compared between the pre- and post-test. The relevant statistical analyses were conducted in SPSS.23.ResultsA comparison of pre-test and post-test results revealed that all sperm parameters including the volume, morphology, motion, count and progressive motility were significantly increased after the intervention (p ≥ 005). Moreover, a statistically significant improvement was observed in the pH and concentration of seminal fluid.ConclusionThe present research showed that consuming vitamin complements (30 mg of Q10, mg of zinc, 100 mg of vitamin C, 12 mg of vitamin E, 400 mg of folic acid) once a day as well as 200 mg of selenium every other day can effectively improve the qualitative parameters (pH and concentration) and quantitative parameters (volume, motion, morphology, count and progressive motility) in infertile male smokers.

Effect of antioxidant supplementation containing L-carnitine on semen parameters: a prospective interventional study.

Objective:One of the remarkable causes of infertility in men is oxidative stress having a reducing effect on their reproductive function. In the present study, we investigated the efficacy of supplementation with antioxidants and L-Carnitine (contained in Androferti) on semen parameters.Methods:We included 180 infertile male patients diagnosed with idiopathic oligoastenoteratozoospermia (OAT) in this study, and we analyzed the semen sample from 59 patients before and after oral antioxidant treatment, with the commercial name of Androferti (containing 1500 mg of L-Carnitine, 60 mg of vitamin C, 20 mg of coenzyme Q10, 10 mg of vitamin E, 10 mg of zinc, 200 µg of vitamin B9, 50 µg of selenium, 1 µg of vitamin B12). All of the patients received Androferti twice a day for 3 months. Results:There were significant improvements in the sperm concentration (p=0.004) after the antioxidant supplementation. There was also a meaningfully improvement in sperm morphology (p=0.01) after treatment. However, sperm motility was not significantly altered after antioxidant treatment (p=0.2).Conclusions:Antioxidants supplementation containing 1500 mg L-carnitine can improve the semen quality in infertile men diagnosed with idiopathic OAT. However, further studies are required to determine the antioxidant effects on reproduction function.

The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial.

Tinnitus is the perception of sound in the absence of any external stimulus. Oxidative stress is possibly involved in its pathogenesis and a variety of antioxidant compounds have been studied as potential treatment approaches. The objective of the present study was to assess the effects of antioxidant supplementation in tinnitus patients. This is a randomized, double-blind, placebo-controlled clinical trial. Patients (N = 70) were randomly allocated to antioxidant supplementation (N = 35) or to placebo (N = 35) for a total of 3 months. Demographic, anthropometric, clinical, and nutritional data were collected. Serum total antioxidant capacity (TAC), oxidized LDL (oxLDL), and superoxide dismutase (SOD), tinnitus loudness, frequency, and minimum masking level (MML), and scores in Tinnitus Handicap Inventory questionnaire (THI), Tinnitus Functional Index (TFI), and Visual Analogue Scale (VAS) were evaluated at baseline and follow-up. Tinnitus loudness and MML significantly decreased from baseline to post measure (p < 0.001) only in the antioxidant group, the overall change being significantly different between the two groups post-intervention (p < 0.001). THI and VAS decreased only in the antioxidant group. Differences in changes in serum TAC, SOD, and oxLDL post-intervention were insignificant. In conclusion, antioxidant therapy seems to reduce the subjective discomfort and tinnitus intensity in tinnitus patients.

Protective Effects of Antioxidant Supplements on Sperm Parameters, Sperm DNA Damage and Level of Seminal ROS in RPL Patients: A Clinical Trial Study

Background: Recurrent Pregnancy Loss (RPL) is an important medical problem comprising approximately 15% of all pregnancies. Sperm DNA damage and level of seminal ROS may have a role in RPL. Objectives: The main aim of the present study was to appraise the efficacy of antioxidants for improving these parameters in RPL patients. Methods: In a clinical trial, 90 couples suffering from RPL were divided into two groups from April 2014 to December 2015 at the Yazd Research and Clinical Center for Infertility in Iran. Group I received supplemental vitamin E (400 µg) daily in combination with Se (200 µg) and the other group received vitamin E plus zinc for three months. Sperm parameters, sperm DNA damage, and seminal ROS were evaluated before and after treatment and compared between the two groups. Data were analyzed by SPSS and P values of ≤ 0.05 were considered statistically significant. Results: Our results revealed normal sperm parameters in RPL patients. Sperm parameters substantially improved in the two treated groups (P ≤ 0.05). The ROS level dramatically reduced in the two groups (P = 0.01). The evaluation of chromatin integrity with AB staining did not show any remarkable changes in group 1 (P = 0.3), but it showed a considerable rate reduction in group 2 (P = 0.04). Also, it showed significant decreases with TB, CMA3, and TUNEL assays in both groups (P = 0.001). However, we did not find any significant difference between the two groups. Conclusions: Supplemental vitamin E in combination with selenium or zinc may improve semen quality by decreasing the level of seminal ROS and sperm DNA damage in RPL patients. We advocate their use for improving the quality of the men’s sperm DNA.

Antioxidant supplementation for lung disease in cystic fibrosis.

Antioxidant supplementation for lung disease in cystic fibrosis.

A Study on the Effectiveness of Antioxidant Supplementation in Tinnitus

A Study on the Effectiveness of Antioxidant Supplementation in Tinnitus

Antioxidant Supplementation and Adaptive Response to Training: A Systematic Review.

Antioxidant supplementation has become a common practice among athletes to theoretically achieve a reduction in oxidative stress, promote recovery and improve performance. To assess the effect of antioxidant supplements on exercise. A systematic literature search was performed up to January 2019 in MEDLINE via EBSCO and Pubmed, and in Web of Sciences based on the following terms: "antioxidants" [Major] AND "exercise" AND "adaptation"; "antioxidant supplement" AND "(exercise or physical activity)" AND "(adaptation or adjustment)" [MesH]. Thirty-six articles were finally included. Exhaustive exercise induces an antioxidant response in neutrophils through an increase in antioxidant enzymes, and antioxidant low-level supplementation does not block this adaptive cellular response. Supplementation with antioxidants appears to decrease oxidative damage blocking cell-signaling pathways associated with muscle hypertrophy. However, upregulation of endogenous antioxidant enzymes after resistance training is blocked by exogenous antioxidant supplementation. Supplementation with antioxidants does not affect the performance improvement induced by resistance exercise. The effects of antioxidant supplementation on physical performance and redox status may vary depending on baseline levels. The antioxidant response to exercise has two components: At the time of stress and adaptation through genetic modulation processes in front of persistent pro-oxidant situation. Acute administration of antioxidants immediately before or during an exercise session can have beneficial effects, such as a delay in the onset of fatigue and a reduction in the recovery period. Chronic administration of antioxidant supplements may impair exercise adaptations, and is only beneficial in subjects with low basal levels of antioxidants.

Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review.

Increased serum levels of uric acid have been associated with the onset and development of chronic kidney disease (CKD), cardiovascular disease, and mortality, through several molecular pathogenetic mechanisms, such as inflammation and oxidative stress. Oxidative stress is present even in the early stages of CKD, progresses parallelly with the deterioration of kidney function, and is even more exacerbated in end-stage renal disease patients undergoing maintenance hemodialysis. Although acting in the plasma as an antioxidant, once uric acid enters the intracellular environment; it behaves as a powerful pro-oxidant. Exogenous intake of antioxidants has been repeatedly shown to prevent inflammation, atherosclerosis and oxidative stress in CKD patients. Moreover, certain antioxidants have been proposed to exert uric acid-lowering properties. This review aims to present the available data regarding the effects of antioxidant supplements on both oxidative stress and uric acid serum levels, in a population particularly susceptible to oxidative damage such as CKD patients.

PT08.5: Effect of Antioxidant Supplementation During Oncological Treatment on Serum Hemoglobin Levels in Cervical Cancer Patients

PT08.5: Effect of Antioxidant Supplementation During Oncological Treatment on Serum Hemoglobin Levels in Cervical Cancer Patients